ライフサイエンスコーパス: human adenovirus

1 EBER(I) (from Epstein-Barr) and VA(I) (from human adenovirus).

2 I) (from Epstein-Barr virus) and VA(I) (from human adenovirus).

3 DNA viruses mouse cytomegalovirus (MCMV) and human adenovirus.

4 y resembles hexon, the equivalent protein in human adenovirus.

5 these are limited by preexisting immunity to human adenoviruses.

6 s disease burden results from infection with human adenoviruses.

7 PCR using primers designed to amplify known human adenoviruses.

8 detection, identification, and serotyping of human adenoviruses.

9 understanding of pathoepidemiology among the human adenoviruses.

10 d-type and replication-incompetent bovine or human adenoviruses.

11 found to be similar in overall structure to human adenoviruses.

12 , PLDLS, conserved among the E1A proteins of human adenoviruses.

13 at may contribute to persistent infection by human adenoviruses.

14 associated antigen presentation proposed for human adenoviruses.

15 gnaling, a function found to be conserved by human adenoviruses.

16 ent life cycles in these genetically distant human adenoviruses.

17 he latter activity of which was conserved by human adenoviruses.

18 disease (ARD) associated with subspecies B2 human adenovirus 11a (HAdV-11a) infection were detected

19 atory disease (ARD) among military recruits, human adenovirus 14 (HAdV-14) has historically been cons

20 and H10N8; variant influenza A H3N2 virus), human adenovirus-14, and Middle East respiratory syndrom

21 fluenza H3N2 variant virus in the USA, and a human adenovirus 14p1 also in the USA.

22 identical to that of the prototype strain of human adenovirus 16 [HAdV-16], Ch79) was isolated in Arg

23 The three-dimensional structure of the human adenovirus-2 proteinase complexed with its 11 amin

24 ndicate that the E4ORF1 peptide derived from human adenovirus 36 (Ad36) interacts with cells from adi

25 nucleotide sequences with a high homology to human adenovirus 41 (HAdV-41) and simian adenovirus 1 (S

26 lification reaction of DNA from two viruses (Human adenovirus 41, Phi X 174) and the bacterium Entero

27 (+/-19)%, as model organism, as well as for human adenoviruses 42.4 (+/-3.4)% and murine noroviruses

28 s) by inoculation of a replication-defective human adenovirus 5 (Ad5) vector expressing IFNs can effe

29 -gamma) delivered by a replication-defective human adenovirus 5 (Ad5) vector protected swine when cha

30 Mutants of human adenovirus 5 (Ad5) with enhanced oncolytic activit

31 cells with a replication-competent strain of human adenovirus 5 (Ad5dl309) results in cytotoxicity.

32 derived from common human serotypes, such as human adenovirus 5 (AdHu5), is the high prevalence of vi

33 The cell-transforming activity of human adenovirus 5 (hAd5) E1A is mediated by the N-termi

34 ur unbiased proteomic analysis revealed that human adenovirus 5 (HAdv5) L-E1A was associated with man

35 endent neutralizing antibody in complex with human adenovirus 5 hexon and show how these properties i

36 The possibility that vaccination with a human adenovirus 5 vector increased mucosal T cell activ

37 bovine migrating DC to show that recombinant human adenovirus 5 vectors efficiently transduce afferen

38 ed five immunization strategies that include Human adenovirus-5 (AdHu5), Chimpanzee adenovirus-6 (AdC

39 edicted to encode proteins homologous to the human adenovirus (Ad) 100-kDa, 33kDa and DNA-binding pro

40 The human adenovirus (Ad) early protein E4-ORF3 forms a uniq

41 Products of human adenovirus (Ad) early region 3 (E3) inhibit both s

42 Replication-defective human adenovirus (Ad) group C transducing vectors, most

43 Human adenovirus (Ad) is extensively used for a variety

44 The human adenovirus (Ad) serotype 5 has been tested in mala

45 respiratory illnesses associated with a rare human adenovirus (Ad) serotype, Ad14.

46 Human adenovirus (Ad) serotypes Ad3, Ad7, Ad11, and Ad14

47 s to the fiber gene that could differentiate human adenovirus (Ad) species A through F in a single am

48 g a variety of mammalian pathogens including human adenovirus (Ad), whose genomes encode a gene for m

49 Human adenoviruses (Ad) are double-stranded DNA (dsDNA)

50 chanisms that control cell-to-cell spread of human adenoviruses (Ad) are not well understood.

51 Early region 3 (E3) of group C human adenoviruses (Ad) encodes several inhibitors of tu

52 Human adenovirus (AdHu)-based candidate AIDS vaccine can

53 Species B human adenoviruses (Ads) are often associated with fatal

54 The E3 transcription unit of human adenoviruses (Ads) encodes immunomodulatory protei

55 Human adenoviruses (Ads) generally cause mild self-limit

56 The E3-19K protein from human adenoviruses (Ads) retains class I MHC molecules i

57 Human adenoviruses (Ads) typically cause mild illnesses

58 Mammalian cells infected with human adenoviruses (Ads) undergo an apoptotic response a

59 Human adenoviruses (AdV) have been implicated in a wide

60 nfection of non-enveloped viruses, including human adenoviruses (AdV), papillomaviruses (HPV), and po

61 apability of this approach to rapidly type a human adenovirus and several strains of human rhinovirus

62 ubiquitous source of polymorphic markers for human adenoviruses and demonstrates their use through an

63 ngue virus), DNA viruses (vaccinia virus and human adenovirus), and retroviruses (HIV).

64 on of herpes simplex virus 1 (HSV-1), HSV-2, human adenovirus, and human cytomegalovirus in cultured

65 rs are susceptible to infection with certain human adenoviruses, and the pathology accompanying these

66 Human adenoviruses are double-stranded DNA viruses respo

67 basis of these results, it is proposed that human adenoviruses are potentially useful for cancer gen

68 Some human adenoviruses are tumorigenic in rodents.

69 We use human cells infected with human adenovirus as a complex and dynamic model to demon

70 Use of potently immunogenic human adenoviruses as vaccine vectors could overcome thi

71 munogenic, providing a viable alternative to human adenoviruses as vaccine vectors for human use.

72 transmembrane-containing proteins encoded by human adenoviruses, as a model system to survey the extr

73 cteriophage PRD1 and the double-stranded DNA human adenoviruses, as well as the viral proteins VP2-VP

74 G and IgM antibodies against influenza A and human adenoviruses based on the color and position of th

75 nt-like models that allow direct analysis of human adenovirus-based conditionally replicative adenovi

76 Adenovirus type 9 (Ad9) is distinct among human adenoviruses because it elicits solely mammary tum

77 Despite human adenoviruses being a common and, in some instances

78 that human defensin HD5 inactivates specific human adenoviruses by binding to capsid proteins and blo

79 ction limits of 1 x 10(3) virus particles of Human adenovirus C (HAdV), Human astrovirus (HAstV), and

80 Human adenovirus C (HAdV-C) species are a common cause o

81 HAdV-5 (Human adenovirus C) vectors are more immunogenic than ch

82 in encoded by the E3 transcription region of human adenoviruses called E3-13.7, which diverts recycli

83 show that recombinant replication-defective human adenovirus can transfect primary cardiac cultures

84 Human adenovirus contains a virion-associated proteinase

85 Early region 3 genes of human adenoviruses contribute to the virus life cycle by

86 mpared with known E3 sequences of most other human adenoviruses deposited in GenBank, the sequences o

87 immunodeficient xenograft tumor models since human adenoviruses do not replicate effectively in murin

88 Human adenoviruses do not replicate in mice.

89 We have recently shown that E1A protein of human adenovirus downregulates epidermal growth factor r

90 n chimpanzee adenovirus vectors from species Human adenovirus E (ChAdOx1 and AdC68) in mice, though t

91 of Ad9 are closely related to those of other human adenovirus E1 regions.

92 The human adenovirus E1A 243 amino acid oncoprotein possesse

93 Human adenovirus E1A oncoprotein activates or represses

94 Human adenovirus E1A protein abrogated cotransactivation

95 The CR3 activation domain of the human adenovirus E1A protein stimulates transcription by

96 Although it has been proposed that human adenovirus E1A recruits the Mediator complex to tr

97 for Sur2-E1A interaction, as is the case for human adenovirus E1A.

98 One important function of the human adenovirus E1B 55-kDa protein is induction of sele

99 The human adenovirus E1B gene encodes a 55-kilodalton protei

100 The human adenovirus E3/19K protein is a type I transmembran

101 The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), i

102 4 ORF1 and dUTPase proteins, we propose that human adenovirus E4 ORF1 genes have evolved from an ance

103 a genomic location analogous to that of the human adenovirus E4 ORF1s, was a genuine dUTPase enzyme.

104 Our findings indicate that most, if not all, human adenovirus E4-ORF1 proteins share a conserved mole

105 was carried out to investigate whether other human adenovirus E4-ORF1 proteins share this mechanism o

106 human T-cell leukemia virus type 1 Tax, and human adenovirus E4-ORF1, the functional consequences fo

107 Most human adenoviruses encode two virus-associated (VA) RNAs

108 Studies have revealed that human adenovirus-encoded E1A protein promotes cell proli

109 The E4-ORF1 gene of human adenoviruses encodes a 14-kDa protein that promote

110 Although species C human adenoviruses establish persistent infections, the

111 A549 (an epithelial-like cell line) using a human adenovirus expressing a beta-galactosidase reporte

112 udy was to alter the broad native tropism of human adenovirus for virus targeting to c-erbB2-positive

113 in MCF10A cells infected with each wild-type human adenovirus from subgroups A to D.

114 new type but also represented a new species (human adenovirus G).

115 Subgroup A and B human adenoviruses generally induce sarcomas in both mal

116 Outbreaks of human adenovirus (HAdV) acute respiratory illness (ARI)

117 ctively to screen for the likely presence of human adenovirus (HAdV) and norovirus (NoV).

118 Several serotypes of human adenovirus (HAdV) cause acute respiratory disease

119 The genome of human adenovirus (HAdV) D30 was sequenced in depth.

120 timicrobial peptides capable of neutralizing human adenovirus (HAdV) in vitro by binding capsid prote

121 Human adenovirus (HAdV) infection mimics Kawasaki diseas

122 Severe human adenovirus (HAdV) infections are an increasing thr

123 Human adenovirus (HAdV) types are associated with distin

124 overage, all 13 viral proteins present in an human adenovirus (HAdV) vector.

125 however, an appropriate viral surrogate for human adenovirus (HAdV), a medium-sized virus with a dou

126 ange of waterborne viral pathogens including human adenovirus (HAdV), but the mechanisms by which fre

127 ay has improved sensitivity for detection of human adenovirus (HAdV), compared to an earlier version

128 vity of NVC-422 against several serotypes of human adenovirus (HAdV), coxsackievirus A24, enterovirus

129 For viruses that lack envelopes, such as human adenovirus (HAdV), other, less well defined, mecha

130 The search for human adenovirus (HAdV)-specific antiviral drugs for the

131 tion and deposition (adsorption) behavior of human adenovirus (HAdV).

132 Recombination in human adenoviruses (HAdV) may confer virulence upon an o

133 Both drugs reduced the yields of four human adenoviruses (HAdV-A31, -B35, and -C5 and a specie

134 Subspecies B1 human adenoviruses (HAdV-B1s) are important causative ag

135 permissive for the replication of species C human adenoviruses (HAdV-C).

136 Human adenoviruses (HAdVs) are highly contagious pathoge

137 Human adenoviruses (HAdVs) are highly contagious pathoge

138 Human adenoviruses (HAdVs) are ubiquitous double-strande

139 Novel human adenoviruses (HAdVs) arise from genome recombinati

140 Human adenoviruses (HAdVs) contain seven species (HAdV-A

141 The role of human adenoviruses (HAdVs) in chronic respiratory diseas

142 Human adenoviruses (HAdVs) shut down host cellular cap-d

143 As one of the first five human adenoviruses (HAdVs) to be sequenced, type 17 was

144 We have recently reported that a group of human adenoviruses (HAdVs) uses desmoglein 2 (DSG2) as a

145 The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms unde

146 in IX molecules is conserved among different human adenoviruses (HAdVs), but not in non-HAdVs.

147 myocarditis, and the species specificity of human adenoviruses has limited the development of animal

148 eak of pneumonia associated with an emerging human adenovirus (human adenovirus serotype 14 [HAdV-14]

149 n, the first demonstration of replication of human adenoviruses in New World monkeys.

150 t time, we report that E4-ORF1 proteins from human adenoviruses in subgroups A to D evolved a conserv

151 adenoviruses differ substantially from other human adenoviruses in their host range; i.e., they repli

152 ly detect a wide range of known serotypes of human adenovirus, including all of subgroups A to C.

153 ithin rhesus macaques is complicated because human adenoviruses, including human adenovirus type 5 (H

154 The subgroup C human adenoviruses induce selective export of newly synt

155 Human adenovirus infection activates intracellular signa

156 imicrobial peptides are potent inhibitors of human adenovirus infection.

157 ted in fatal disseminated disease resembling human adenovirus infections in immunocompromised patient

158 Unlike human adenovirus infections, however, mouse adenovirus t

159 volutionarily conserved target of E4-ORF3 in human adenovirus infections.

160 Human adenoviruses interfere with a number of cellular p

161 Recombinant human adenovirus is a useful gene delivery vector for cl

162 The E1A gene of species C human adenovirus is an intensely investigated model vira

163 tribute of the E4-ORF3 proteins of different human adenoviruses is the ability to disrupt PML nuclear

164 demonstrate that the 5' noncoding region of human adenovirus late mRNAs, known as the tripartite lea

165 g suggests that immune evasion strategies of human adenoviruses may be directed, in part, toward prot

166 Genes within the E3 transcription unit of human adenoviruses modulate host immune responses to inf

167 We used MAV-1 to establish a mouse model of human adenovirus myocarditis, providing the means to stu

168 A human adenovirus, ONYX-015, which has a deletion in the

169 Mature human adenovirus particles contain four minor capsid pro

170 ron tomography reconstructions of individual human adenovirus particles.

171 While human adenoviruses primarily produce self-limited acute

172 The interaction of the human adenovirus proteinase (AVP) and AVP-DNA complexes

173 The interactions of the human adenovirus proteinase (AVP) with polymers with hig

174 The interaction of the human adenovirus proteinase (AVP) with various DNAs was

175 tein of bacteriophage PRD1 resembles that of human adenovirus raised the unexpected possibility that

176 We found that human adenovirus replicates well in Syrian hamster cell

177 immunocompetent model that is permissive to human adenovirus replication in tumors as well as normal

178 rous mouse tissues are poorly permissive for human adenovirus replication.

179 endent pathway through which the E1A gene of human adenovirus sensitizes mouse and human cells to apo

180 ssociated with an emerging human adenovirus (human adenovirus serotype 14 [HAdV-14]) occurred on a ru

181 (i) the discovery of a new mechanism used by human adenovirus serotype 3 to overcome innate antiviral

182 es that priming with a replication-defective human adenovirus serotype 35 (Ad35) vector encoding circ

183 Human adenovirus serotype 4 (HAdV-4) is a reemerging vir

184 The human adenovirus serotype 5 (Ad5) is used widely for app

185 ulated plasmid DNA and replication-defective human adenovirus serotype 5 (Ad5) vaccine vectors expres

186 Using a human adenovirus serotype 5 (Ad5) vector and genetically

187 o-associated virus serotype 6 (AAV-po6), and human adenovirus serotype 5 (Ad5) vector, in a short-ter

188 Here, we show that an adjuvanted human adenovirus serotype 5 (Ad5)-vectored vaccine (Ad5-

189 f the most frequently used vector prototype, human adenovirus serotype 5 (Ad5).

190 Using wild-type and protein VI-mutated human adenovirus serotype 5 (HAdV-C5), we show that caps

191 , we describe the development of recombinant human adenovirus serotype 5 and modified vaccinia virus

192 In contrast, the same Ag vectored by human adenovirus serotype 5 induced clonotypic expansion

193 e was used to boost Ab responses primed by a human adenovirus serotype 5 vaccine recombinant for the

194 This human adenovirus serotype 5-protein regimen also induced

195 neutralized from sera of mice immunized with human adenovirus serotypes 2, 4, 5, 7, and 12.

196 Vaccine strains of human adenovirus serotypes 4 and 7 (HAdV-4vac and HAdV-7

197 -associated (VA) RNA species of all 47 known human adenovirus serotypes and of one simian virus, SA7.

198 f E4-ORF1 proteins encoded by representative human adenovirus serotypes from subgroups A to D induce

199 y affected by preexisting immunity to common human adenovirus serotypes, such as 2, 4, 5, 7, and 12.

200 Binding occurs in multiple human adenovirus serotypes.

201 d that desmoglein 2 (DSG2) is a receptor for human adenovirus species B serotypes Ad3, Ad7, Ad11, and

202 E3 transcription unit for 38 viruses within human adenovirus species D (HAdV-D) revealed distinct an

203 Human adenovirus species D type 19 (HAdV-D19) has been a

204 The E4-ORF1 protein encoded by human adenovirus stimulates viral replication in human e

205 Humans are infected by common serotypes of human adenovirus such as AdHu5 early in life and a signi

206 and destroyed in cells infected by species C human adenoviruses, such as type 5.

207 (simian adenoviruses) rather than with other human adenoviruses, suggesting a recent origin of HAdV-4

208 MPORTANCE Early region 3 proteins encoded by human adenoviruses that attenuate immune-mediated pathol

209 w adenovirus was so divergent from the known human adenoviruses that it was not only a new type but a

210 In the case of human adenovirus, this proteolytic cleavage is mediated

211 Human adenovirus type 12 (Ad12) E1A protein (E1A-12) is

212 Early region 1A of human adenovirus type 12 encodes a protein that inhibits

213 viruses (CVB) cause human myocarditis, while human adenovirus type 2 (Ad2) is implicated as an agent

214 The human adenovirus type 2 E2 early (E2E) transcriptional c

215 The circulation of human adenovirus type 21 (HAdV21) in the United States h

216 Human adenovirus type 36 (Ad-36) increases adiposity but

217 Experimental infection of rats with human adenovirus type 36 (Ad-36) promotes adipogenesis a

218 tes cellular glucose and lipid metabolism by human adenovirus type 36.

219 Human adenovirus type 37 (HAdV-37) is a major etiologic

220 uences for open reading frames (ORFs) of the human adenovirus type 41 (Ad41) early region 3 (E3) gene

221 The human adenovirus type 5 (Ad5) E1B 55-kDa protein is requ

222 The human adenovirus type 5 (Ad5) E1B 55-kDa protein modulat

223 Human adenovirus type 5 (Ad5) encoding rat insulin promo

224 possibility of cross-species replication of human adenovirus type 5 (Ad5) in canine cells.

225 opy, we have determined the structure of the human adenovirus type 5 (Ad5) to 3.6-A resolution and ha

226 le using a recombinant replication-defective human adenovirus type 5 (Ad5) vector, Ad5-boIFN-lambda3,

227 -molecular-weight (100K) assembly protein of human adenovirus type 5 (Ad5-100K) was previously define

228 structed a humanized monoclonal IgG1 against human adenovirus type 5 (AdV5) and a panel of Fc-enginee

229 Decoration of human adenovirus type 5 (hAd5) with folate, a known canc

230 icated because human adenoviruses, including human adenovirus type 5 (HAdV-5), are not endogenous to

231 ry of the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested

232 ansforming human embryonic kidney cells with human adenovirus type 5 (HAV5) early region 1 (E1) seque

233 city of vaccines encoded by live recombinant human adenovirus type 5 (rAdHu5).

234 ctron counting, we improved the structure of human adenovirus type 5 and confirmed our previous model

235 cted by an E1B 55-kDa protein-null mutant of human adenovirus type 5 carry a large number of posttran

236 Priming with replication-deficient human adenovirus type 5 constructs and boosting with ex

237 eered DNA plasmids and replication-deficient human adenovirus type 5 constructs encoding large sectio

238 ontrast, infection with influenza B virus or human adenovirus type 5 did not induce significant level

239 in to investigate the mechanism by which the human adenovirus type 5 E1B 55-kDa protein protects agai

240 We show that human adenovirus type 5 encodes three proteins, named RI

241 ture, and swine inoculated with 10(9) PFU of human adenovirus type 5 expressing porcine IFN-alpha (Ad

242 Here, we have examined the L4P of human adenovirus type 5 in detail and have defined its t

243 e observation that the early region (E1A) of human adenovirus type 5 is directly linked to and may in

244 B-55K protein plays an important role during human adenovirus type 5 productive infection.

245 tem fabricated to deliver a live recombinant human adenovirus type 5 vaccine vector (AdHu5) encoding

246 Human adenovirus type 5 vectors (rAd5) encoding ebolavir

247 nstructed recombinant, replication-defective human adenovirus type 5 vectors containing either porcin

248 The nine known promoters from human adenovirus type 5 were analyzed for inherent DNA s

249 evaluate its efficacy, an adenovirus vector (human adenovirus type 5) encoding a green fluorescent pr

250 VA (Modified Vaccinia virus Ankara) and Ad5 (human adenovirus type 5) vectors both expressing Ag85A i

251 viral protein expression and replication by human adenovirus type 5, and dysregulates cellular gluco

252 Working with human adenovirus type 5, we showed previously that two p

253 iently transcomplemented by the E1 region of human adenovirus type 5.

254 (epidemic period) 85% of typed isolates were human adenovirus type 8 (HAdV-D8), whereas only low leve

255 Major oncogenic determinants for human adenovirus type 9 (Ad9) and high-risk human papill

256 The major oncogenic determinants for human adenovirus type 9 (Ad9) and high-risk human papill

257 Human adenovirus type 9 (Ad9) elicits exclusively estrog

258 In contrast, subgroup D human adenovirus type 9 (Ad9) induces estrogen-dependent

259 Human adenovirus type 9 (Ad9) is unique among oncogenic

260 Among oncogenic adenoviruses, human adenovirus type 9 (Ad9) is unique in eliciting exc

261 of estrogen-dependent rat mammary tumors by human adenovirus type 9 (Ad9) requires the Ad9 E4 open r

262 ssential oncogenic determinant of subgroup D human adenovirus type 9 (Ad9), which uniquely elicits es

263 Human adenovirus type 9 exclusively elicits mammary tumo

264 ted that the E4-ORF1 protein from subgroup D human adenovirus type 9 upregulates and oncogenically ac

265 ediates oncogenic cellular transformation by human adenovirus type 9, augments viral protein expressi

266 , 50, and 50 genomic copies per reaction for human adenovirus type B3 (HAdV-B3), HAdV-E4, HAdV-B7, HA

267 ermined in triplicate assays by incubating 9 human adenovirus types (1, 2, 3, 4, 5, 7a, 8, 19, and 37

268 d on the newly refined crystal structures of human adenovirus types 2 (Ad2) and Ad5 hexon.

269 le recombinant integrin alphavbeta5 bound to human adenovirus types 2 and 12 (Ad2 and -12) has been d

270 Early region 3 of human adenovirus types 2 and 5 encodes a 19-kDa glycopro

271 Similar to Ad5, E1A12S from human adenovirus types 2, 3, 9 and 12 suppressed EGFR, w

272 Human adenoviruses typically cause mild infections in th

273 not TFIIIA-independent transcription of the human adenovirus VA RNA gene.

274 IFN-alpha/beta) with a replication-defective human adenovirus vector (adenovirus 5 [Ad5]) can sterile

275 vestigations of the efficiency and safety of human adenovirus vector (AdV)-mediated gene transfer in

276 es the fidelity of the DNA polymerase into a human adenovirus vector.

277 Here, we report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by c

278 nant vesicular stomatitis viruses (VSVs) and human adenoviruses was also evaluated.

279 Ad-2, another human adenovirus, was used as a negative control.

280 Ad-2, a nonadipogenic human adenovirus, was used as a negative control.

281 nse and the E3 immunoregulatory genes of the human adenovirus were unknown until now.

282 The VA RNA gene regions of 43 human adenoviruses were amplified and sequenced, and the

283 replication of P1/HRV2 in mice, recombinant human adenoviruses were used to express bicistronic mRNA

284 nslation and poliovirus tropism, recombinant human adenoviruses were used to express bicistronic mRNA

285 to show that pVIn is associated with mature human adenovirus, where it binds at the base of peripent

286 d by the immunologic heterogeneity of the 51 human adenoviruses, which are grouped from A to F on the

287 ry using a replication-defective recombinant human adenovirus with an early large T-antigen, had a mu

288 length and is most similar to subgroup E of human adenovirus, with 90% identity in most adenovirus t