ライフサイエンスコーパス: human brain

1 n cause substantial damage to the developing human brain.

2 ission through a simple network model of the human brain.

3 racers to image tau aggregates in the living human brain.

4 mage hyperpolarized (129)Xe dissolved in the human brain.

5 4R-tau, which is equally expressed in adult human brain.

6 ding the neurobiology of the opiate-addicted human brain.

7 ing gene regulation in cells and post-mortem human brain.

8 representation of social interactions in the human brain.

9 forms in the development and function of the human brain.

10 the human body, including astrocytes in the human brain.

11 activity in the primary visual cortex of the human brain.

12 nment is a fundamental modus operandi of the human brain.

13 nd OT genes at the OT-releasing sites in the human brain.

14 esulted in a higher A1AR availability in the human brain.

15 lication facilitates insulin delivery to the human brain.

16 nal properties of expression reversal in the human brain.

17 al system that undoubtedly possesses it: the human brain.

18 o correlate negatively with the tau level in human brain.

19 y of predictive processing signatures in the human brain.

20 titute an enriched environment affecting the human brain.

21 linergic innervation in the evolution of the human brain.

22 odulating striatal dopamine signaling in the human brain.

23 cus contributes to MICALL2 expression in the human brain.

24 importance of sleep to maintain LRTCs in the human brain.

25 but could not address gene expression in the human brain.

26 expression in lymphoblastoid cell lines and human brain.

27 rposefully explore and effectively treat the human brain.

28 t reflect unconscious processing (C0) in the human brain.

29 g the organization of semantic memory in the human brain.

30 on the regulation of gene expression in the human brain.

31 the nature of visual representations in the human brain.

32 ctions, while, ideally, oscillating like the human brain.

33 led insight into the serotonin system of the human brain.

34 alyses in human neural stem cells and in the human brain.

35 umans and found these genes are expressed in human brain.

36 derstanding of information processing in the human brain.

37 ality was identified for 4 loci in the adult human brain.

38 are expressed in the developmental and adult human brain.

39 illness risk genes exist in the macaque and human brain.

40 y-specific perceptual representations in the human brain.

41 ed to neuronal precursor cells (NPCs) in the human brain.

42 ulation in health and disease, especially in human brain.

43 to-nondisplaceable uptake) of (11)C-ER176 in human brain.

44 underlying these rhythms, especially in the human brain.

45 multimodal information is represented in the human brain.

46 examine how color selectivity emerges in the human brain.

47 al activity in subcortical structures in the human brain.

48 deprivation reorganizes neurocircuits in the human brain.

49 by strengthening task representations in the human brain.

50 1 gene (DNHD1) which is highly expressed in human brain.

51 ocessing of continuous speech unfolds in the human brain.

52 ward anterior superior temporal gyrus in the human brain.

53 of neurons in cortical microcircuits of the human brain.

54 overy of 10 novel transcripts of GAD1 in the human brain.

55 ced differences between the foetal and adult human brain.

56 al tool for in vivo molecular imaging of the human brain.

57 teristic feature found in, for instance, the human brain.

58 cal signature of olfactory processing in the human brain.

59 sentations in scene-selective regions of the human brain.

60 ns of functional modules and networks in the human brain.

61 s the primary inhibitory neurotransmitter in human brain.

62 lso seen in the ischemic areas of postmortem human brains.

63 rning to forget: a key feature of animal and human brains.

64 animal model of depression, and post-mortem human brains.

65 anization of healthy and diseased individual human brains.

66 Contrary to findings in the human brain, (18)F-FDG PET shows cerebral hypermetabolis

67 The amygdala from 32 postmortem human brains (7-46 years of age) were stained using a Go

68 In the human brain, a network of visual-processing regions is s

69 ls to study LTP in both healthy and diseased human brains, a previously unattainable goal.

70 es of the phylogenetic reorganization of the human brain across multiple levels, with relevance for b

71 n spontaneous BOLD signal variability in the human brain across the lifespan.

72 The most widespread measures of human brain activity are the blood-oxygen-level dependen

73 Patterns of intrinsic human brain activity exhibit a profile of functional con

74 ures provide complementary information about human brain activity, and we infer that features of the

75 ons of genetic variability in this system to human brain activity.

76 ction in EEG and MEG recordings of task-free human brain activity.

77 of white matter fiber tracts associated with human brain aging thus appears to be one pathophysiologi

78 bellum comprise over half the neurons in the human brain and are thought to be critical for learning.

79 New NIH definitions classify virtually all human brain and behavioral research as clinical trials.

80 ession of microRNAs miR-181a and miR-181b in human brain and blood, greater nucleus accumbens reactiv

81 depression and with PPM1F expression in both human brain and blood.

82 using unique transcriptomic data from Allen Human Brain and BrainSpan atlases.

83 tion of music and language processing in the human brain and confirm a specific role of the right STG

84 re of the cold allodynia pain percept in the human brain and illustrate why ciguatera sufferers often

85 sequent to global initiatives in mapping the human brain and investigations of neurobiological marker

86 Zika virus (ZIKV) infects fetal and adult human brain and is associated with serious neurological

87 s expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expre

88 elated alterations in gene expression in the human brain and that genes encoding for neuronal synapti

89 umans, and suggests an interplay between the human brain and the inflammatory response of the periphe

90 regarding value and saliency encoding in the human brain and their category independence, lending str

91 AQP4 localization are features of the aging human brain and to define their association with AD path

92 w directions, velocities, and volumes in the human brain and upper spinal canal.

93 Nrf2 levels have been reported in postmortem human brains and animal models of AD.

94 ult to reconcile with postmortem analysis of human brains and connectome-mapping studies.

95 hromosome conformation studies in developing human brains and implicated three additional genes: SLC3

96 izable spatiotemporal-expression patterns in human brains and laminar-expression profiles in the deve

97 d seasonal rhythms of gene expression in the human brain, and show their relationship with parallel r

98 , little is known about how tDCS affects the human brain, and some studies have concluded that it may

99 ghtly coupled sensorimotor processing in the human brain, and support frameworks like embodied cognit

100 ingredient of probabilistic learning in the human brain, and that the right inferior frontal gyrus h

101 ocessing of somatosensory information in the human brain, and will be vital in better understanding t

102 tau and amyloid-beta (Abeta) proteins in the human brain are 2 pathologic hallmarks of Alzheimer dise

103 ephalographic recordings from the developing human brain are characterized by spontaneous neuronal bu

104 ational and post-translational events in the human brain are essential to improving our understanding

105 h phenotypic or transcriptomic traits in the human brain are located within transcription factor bind

106 in which anatomical and functional images of human brains are collected using techniques such as func

107 Lanthionine has been detected in human brain as the downstream metabolite lanthionine ket

108 relevant in the cortical progenitor zones of human brain, as suggested by HUWE1 immunofluorescence an

109 ic assumption, we used fMRI to study how the human brain assigns values to available options.

110 nables the transformation of the PET-derived human brain atlas into a protein density map of the sero

111 (PET)- and magnetic resonance imaging-based human brain atlas of important serotonin receptors and t

112 across all 20,737 genes present in the Allen Human Brain Atlas showed the set of top 100 strongest co

113 SCZ risk genes were extracted from the Allen Human Brain Atlas, and their average profile across the

114 egional PET binding measures with postmortem human brain autoradiography outcomes showed a high corre

115 ological signatures of such processes in the human brain (both female and male).

116 s of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet full

117 ronal nuclei isolated from frozen postmortem human brain by fluorescence-activated nuclear sorting (F

118 Anatomical subdivisions of the human brain can be associated with different neuronal fu

119 sets containing images from freshly resected human brain cancer and from a silica phantom acquired by

120 lioblastoma (GBM) is the most lethal type of human brain cancer, where deletions and mutations in the

121 tial of genomic rearrangements identified in human brain cancers.

122 Therefore, task representations in the human brain cannot account for the performance costs ass

123 different human endothelial cell types (the human brain capillary endothelial cell line hCMEC/D3 and

124 sites in distinct populations of postmortem human brain cells and further our understanding of the r

125 (3) Consistently, expression of MYT1L in the human brain coincided with neuronal maturation and inver

126 diffusion imaging is central to the study of human brain connectivity.

127 ingle lesions at unique locations within the human brain connectome.

128 Macroscopic human brain connectomes are usually derived from neuroim

129 The human brain contains approximately 60 billion cerebellar

130 Based on a simulated human brain data set with ground truth tracts, we organi

131 r and global information coordination in the human brain, demonstrating the cognitive relevance of re

132 In vitro studies were conducted using adult human brain-derived oligodendrocytes challenged by metab

133 esponses using dissociated cultures of adult human brain-derived oligodendrocytes.

134 transcriptome-based lineage map for studying human brain development and modeling developmental disor

135 Cerebral organoids recapitulate human brain development at a considerable level of detai

136 ial and temporal patterning events governing human brain development can be recapitulated in vitro.

137 plasticity in mice, but its requirement for human brain development has not yet been established.

138 e research findings from the rodent model to human brain development is uncertain.

139 3D organoids enable in vitro human brain development models, but they have not yet re

140 ping the temporal expression of genes during human brain development provides vital insight into gene

141 This work reveals a possible mechanism of human brain development that preferentially optimizes dy

142 During human brain development, multiple signaling pathways gen

143 proven to be vastly useful in investigating human brain development, the haemodynamic response funct

144 ssion patterns of dystrophin isoforms across human brain development, using unique transcriptomic dat

145 ince little is known about the role of RB in human brain development, we investigated its function in

146 s with other proteins structurally to impact human brain development.

147 r understanding of both typical and atypical human brain development.

148 eeper insight into molecular dynamics during human brain development.

149 ons for RB in the cerebral organoid model of human brain development.

150 distinctive differentiation pathways during human brain development.

151 a process equating to the earliest stage of human brain development.

152 As the human brain develops, it increasingly supports coordinat

153 orts to understand the roles of microglia in human brain diseases.

154 nds are now being developed for treatment of human brain disorders by direct delivery inside the bloo

155 nto the brain's memory management system and human brain disorders that alter active forgetting mecha

156 This suggests that the human brain does not use levels in the investigated hier

157 With this novel approach, we reveal that the human brain during resting state operates at maximum met

158 t to give a comprehensive account of how the human brain dynamically handles the flow of propriocepti

159 downregulated by TNFalpha and IFNgamma in a human brain endothelial cell line, hCMEC/D3.

160 the barrier-protective properties of EPCR in human brain endothelial cells in vitro.

161 The 3D BBB models were constructed with human brain endothelial cells, human astrocytes, and hum

162 the regulation of firm leukocyte adhesion to human brain endothelium by two different brain endotheli

163 Parasitic larvae invade the human brain, establish, and eventually resolve, leaving

164 Furthermore, it reveals that, in the human brain, even general purpose and fundamental neural

165 largest and most detailed shape analysis of human brains ever conducted.

166 The molecular mechanisms underlying human brain evolution are not fully understood; however,

167 In-silico analysis of human brain expression and network data provides evidenc

168 y quantitative mass spectrometry proteins in human brain extract that bind to oligomeric Abeta1-42 (o

169 ever, the fundamental inaccessibility of the human brain for invasive studies has limited a precise u

170 ed by the fundamental inaccessibility of the human brain for invasive studies.

171 observation of increased urea in postmortem human brain from HD cases.

172 and CAMK2B and their auto-phosphorylation in human brain function and expand the phenotypic spectrum

173 gene regulatory regions, also acts to shape human brain function associated with risk for mental ill

174 lity to individualize faces is a fundamental human brain function.

175 used non-invasive tool to study and modulate human brain functions.

176 lear, however, which processes contribute to human brain gamma frequency activity, or their dynamics

177 tein interactions, transcription factors and human brain gene expression, and translate findings to l

178 to reveal fundamental principles of how the human brain generates large-scale activity observable by

179 tivity of L1s can further impact the somatic human brain genome.

180 In addition, Gd deposition in the human brain has been reported following contrast, and th

181 The human brain has evolved for group living [1].

182 and concur with theories proposing that the human brain has evolved mechanisms dedicated to control

183 nia, the transcript structure of GAD1 in the human brain has not been fully characterized.

184 miRNA profiling in the human brain has revealed miR-132 as one of the most seve

185 and structural or functional measures of the human brain, has become increasingly important in recent

186 In human brain images, we could identify 3 main T 2 compone

187 au isoforms are balanced in the normal adult human brain, imbalances in 3R:4R ratio have been tightly

188 long-term impact of abdominal surgery on the human brain immune system by positron emission tomograph

189 cessfully applied in multiple studies of the human brain in health and disease, and here, we especial

190 signals emanating from three compartments in human brain in vivo: intracellular (compartment 1), extr

191 information is integrated, we found that the human brain integrates social information according to i

192 on of the microstructural environment in the human brain is discussed from the tensor model to the ge

193 Here, we investigated how the human brain is engaged when viewing a moral dilemma betw

194 t the proportion of prefrontal cortex in the human brain is greatly increased relative to that of oth

195 d the impact of L1 retrotransposition in the human brain is likely much higher than previously though

196 form of the RL algorithms implemented in the human brain is not yet well determined.

197 The human brain is organized into large-scale functional mod

198 These findings suggest the human brain is protected by the daily circadian cycles i

199 sterior superior temporal gyrus (STG) in the human brain is specialized for aspects of music processi

200 The human brain is the elemental paradigm of an efficient ro

201 eln mutations may cause more subtle forms of human brain malformation than classic lissencephalies.

202 mendations on behalf of the Organization for Human Brain Mapping and identify barriers that impede th

203 inally, occipital white (OWM) and gray (OGM) human brain matter were quantified in vivo using the 5D

204 Somatic mosaicism in the human brain may alter function of individual neurons.

205 nderstanding prion strain propagation in the human brain may impact research on the molecular factors

206 a primary neurodegenerative disorder of the human brain may incorporate concepts of prion-like sprea

207 The human brain may rapidly and alternately activate and dea

208 integrity of white matter tracts within the human brain (measured using diffusion tensor imaging) wi

209 Human brain microvascular endothelial cells (hBMVECs) th

210 These exosomes alone can activate human brain microvascular endothelial cells to stimulate

211 Similar effects were observed in human brain microvascular endothelial cells.

212 Therefore, white matter integrity in the human brain, more than age per se, determines the magnit

213 To detect the linguistic signal, human brains must form hierarchical representations from

214 potential framework for the understanding of human brain network dynamics.

215 These findings reveal how flexibility in human brain networks is integral to achieving successful

216 k has shown that flexible reconfiguration of human brain networks over short timescales supports cogn

217 The model is applied to learn how human brain networks vary across individuals with differ

218 There is increasing interest in learning how human brain networks vary as a function of a continuous

219 Here we studied how human brains of both sexes respond to signals under cond

220 ver 80,000 individual cells isolated from 31 human brain organoids.

221 et from 150 neuropathologically normal adult human brains, our method identifies eQTLs that were unde

222 tentiating effects, and components affecting human brain parasitism and diseases.

223 computational process is implemented in the human brain, participants underwent fMRI while learning

224 ques, we have the opportunity of mapping the human brain pathways in vivo at unprecedented resolution

225 ain endothelial cells, human astrocytes, and human brain pericytes in mono-, co-, and tricultures.

226 onance imaging (fMRI) to investigate how the human brain plans the shortest path to a goal in novel m

227 to develop and test a realistically complex human brain plasma membrane (PM) lipid model and extend

228 A parallel question, how visual areas in the human brain process information distributed over time, h

229 Every night, the human brain produces thousands of downstates and spindle

230 proteomic survey of regions of the postnatal human brain, ranging in age from early infancy to adulth

231 data that were acquired from both postmortem human brain regions (BP case/control: 45/50) and periphe

232 ception, but how they are represented in the human brain remains a matter of contention.

233 maternal behavior influences the developing human brain remains limited.

234 spatial planning paradigm, we reveal how the human brain represents sequential choices during plannin

235 The human brain requires a wide variety of experiences and e

236 ed characterization of the cell types in the human brain requires scalable experimental approaches to

237 ugh SES has long been used as a covariate in human brain research, in recognition of its potential to

238 We used fMRI to test whether human brain responses during initial viewing of negative

239 We also apply these privacy methods to human brain resting-state fMRI data from a study of majo

240 ltidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, an

241 Investigations of the human brain's connectomic architecture have produced two

242 5-HT system not only provides insight in the human brain's regional protein synthesis, transport, and

243 We performed array tomography on human brain samples from five patients with dementia wit

244 d revealing cellular diversity, but archived human brain samples still pose a challenge to current hi

245 The human brain sets itself apart from that of its primate r

246 om-up account of speech comprehension in the human brain.SIGNIFICANCE STATEMENT We know that, during

247 Immunohistochemical staining of mice and human brain slices shows DAM with intracellular/phagocyt

248 We used postmortem human brain specimens from a homogeneous European Caucas

249 Cyp46a1(-/-), and two wild type strains) and human brain specimens.

250 tudies has provided significant insight into human brain structure and organization.

251 s and interpret how developmental changes in human brain structure relate to cognition, affect, and m

252 Discovering genetic variants associated with human brain structures is an on-going effort.

253 disease-associated DNA elements in distinct human brain structures.

254 >3x) across two large independent postmortem human brain studies of schizophrenia and also removes po

255 to cause severe developmental defects in the human brain, such as microcephaly.

256 ducing some of the inherent functions of the human brain, such as the high synaptic connectivity ( 10

257 The proteome of human brain synapses is highly complex and is mutated in

258 pikes may induce long-lasting changes in the human brain that can be sensitively detected by electroe

259 enging to localize regions in the developing human brain that contribute to spontaneous waves of neur

260 identified for the first time regions in the human brain that exhibit multivariate patterns of activi

261 g methods to investigate the pathways in the human brain that mediate CE.

262 neuroimaging study has revealed that, in the human brain, the occipital place area detects the number

263 ws direct access to pathological and control human brain tissue based on an individual's genetic arch

264 feasibility of directly imaging perfusion of human brain tissue by using magnetic resonance (MR) imag

265 ntly, the abundance of alphaSyn oligomers in human brain tissue correlated with cognitive impairment

266 ssion variability with the MDSeq on the GTEx human brain tissue data has identified pathways associat

267 ally labeled pathological tau in post-mortem human brain tissue from Pick disease, progressive supran

268 een in very recent years that such data from human brain tissue have been made available from various

269 Substantial TrkB/C-specific binding in human brain tissue is observed in vitro, with specific r

270 Remarkably, CQ stains Abeta plaques in human brain tissue over co-existing tau aggregates and n

271 Aha1 colocalized with tau pathology in human brain tissue, and this association positively corr

272 PFC subareas in histological preparations of human brain tissue, determine sulci most consistently re

273 in glioblastoma tissue compared with normal human brain tissue.

274 We also carried out biochemical analyses of human brain tissues and studied the effects of the aggre

275 Transcriptome profiles of normal human brain tissues showed that the novel candidate ID g

276 lobal gene expression profiling from healthy human brain to develop a disease gene prediction model a

277 cruits CTCF in lymphoblastoid cell lines and human brain to influence CTCF-mediated long-range chroma

278 similar coding scheme is implemented by the human brain to process social signals and guide complex,

279 tigate the processing steps performed by the human brain to transform natural speech sound into meani

280 odel, which is representative of the healthy human brain transcriptome by using data from the Allen B

281 Inspection of the Human Brain Transcriptome Project database confirms that

282 and (11)C-AMT were obtained for mice bearing human brain tumors 1-7 d apart.

283 ogenesis, although few in vivo data exist in human brain tumors.

284 In the adult human brain, two tau isoforms are found in equal amounts

285 The human brain undergoes rapid growth in both structure and

286 However, the mechanisms by which the human brain updates specific goals on the fly, and trans

287 that finding, we demonstrate that postmortem human brain urea levels are elevated in a larger cohort

288 y activity can be recorded directly from the human brain using intracranial electrodes implanted in p

289 t or alternating currents are applied to the human brain via scalp electrodes.

290 ay cause severe developmental defects in the human brain via unknown mechanisms.

291 llenge through the analysis and modelling of human brain voltage activity recorded simultaneously acr

292 Human brain volume can be altered, by either rare disrup

293 elationships among intrinsic networks of the human brain, we recruited seven neurosurgical patients (

294 better understand what this parasite does to human brains, we performed a comprehensive systems analy

295 RD2 availability and dopamine release in the human brain, which could account for its association wit

296 revealed the dynamical cortical core of the human brain, which is driving the activity of the rest o

297 ed matriptase mRNA in several regions of the human brain with an enrichment in neurons.

298 tor processing is a critical function of the human brain with multiple cortical areas specialised for

299 copy number variant analysis on 1511 frozen human brains with a diagnosis of Alzheimer's disease (AD

300 t alphaS aggregates isolated from postmortem human brains with diffuse Lewy body disease (DLBD) prefe