ライフサイエンスコーパス: human cell

1 bacteria to virtually every organelle in the human cell.

2 li and co-localizes with R-loops in cultured human cells.

3 bcellular localization, exists as trimers in human cells.

4 4G, and PABP and of the decay factor DDX6 in human cells.

5 acteria, and eukaryotes, including fungi and human cells.

6 ersion and establishes guidelines for PGE in human cells.

7 POLD1-R689W allele is strongly mutagenic in human cells.

8 tin maintenance in p21 checkpoint-proficient human cells.

9 oduction and spread of the mutant viruses in human cells.

10 een the RNA and protein decay machineries in human cells.

11 SUV39H1 with constitutive heterochromatin in human cells.

12 ontaining plasmid was replicated in cultured human cells.

13 roteasome system soon after DSB induction in human cells.

14 i, and targeted knockout of the HPRT gene in human cells.

15 g the rRNA methyl-transferase fibrillarin in human cells.

16 s in the replication of 3-MeA-damaged DNA in human cells.

17 o tune the expression of endogenous genes in human cells.

18 fficiency and accuracy of DNA replication in human cells.

19 riggered remodeling of the 26S proteasome in human cells.

20 d to identify regulators of let-7 targets in human cells.

21 of these observations for TLS mechanisms in human cells.

22 and synthesis rates of many glycoproteins in human cells.

23 port of anthrax lethal and edema toxins into human cells.

24 ere is required for new CENP-A deposition in human cells.

25 biquitinase TRABID to enrich for chains from human cells.

26 imates and decreased Ca(2+) concentration in human cells.

27 yclin-dependent kinase Cdk1 in yeast through human cells.

28 loop formation influence genome stability in human cells.

29 ses and the role of filovirus IID in bat and human cells.

30 nd post-transcriptional regulation in normal human cells.

31 how aberrant ITS formation is suppressed in human cells.

32 l) and provide evidence that it may exist in human cells.

33 ene expression in asthma-relevant murine and human cells.

34 ently been described in immune and nonimmune human cells.

35 ssary to inhibit MNV replication in mice and human cells.

36 se deprivation to inhibit mTORC1 in cultured human cells.

37 promotes gene editing at endogenous loci in human cells.

38 ll switches" for live vaccines or engineered human cells.

39 reconstituted Nv-TLR-to-NF-kappaB pathway in human cells.

40 single-stranded DNA incorporation pathway in human cells.

41 s, directly from the intact receptor in live human cells.

42 te repertoire of rhomboid protease RHBDL2 in human cells.

43 oduce pore-forming toxins to attack and kill human cells.

44 y without compromising on-target activity in human cells.

45 ments (both indirect and direct) in dividing human cells.

46 rrecting or disease-suppressing mutations in human cells.

47 cient pathway, which can be reconstituted in human cells.

48 regulating PRR-initiated outcomes in primary human cells.

49 ause DNA damage and repeat-length changes in human cells.

50 lic complex for glucose metabolism in living human cells.

51 ly, with enhanced activities in vitro and in human cells.

52 significant senolytic activity in mouse and human cells.

53 licates DNA in a highly error-free manner in human cells.

54 ell-cycle proteins in asynchronously cycling human cells.

55 single-copy, estrogen-inducible transgene in human cells.

56 ts in fission yeast and reduced viability in human cells.

57 forward genetic screening for NMD factors in human cells.

58 lesions that have been difficult to model in human cells.

59 chores in Caenorhabditis elegans embryos and human cells.

60 d PGE using Cas9 and its nickase variants in human cells.

61 chromatin structure at pol III promoters in human cells.

62 sor cells in vitro, in animal models, and in human cells.

63 f electrophilic modifications on proteins in human cells.

64 s; these were evident in brains, livers, and human cells.

65 genetic screening for NMD pathway defects in human cells.

66 t compounds for the A2A and A2B receptors in human cells.

67 for factors that modulate rearrangements in human cells.

68 ation, resulting in type I IFN production in human cells.

69 itotic fractions from asynchronously growing human cells.

70 serial vaccinia virus infections in primary human cells.

71 ) and GrpEL2, modulate mtHsp70's function in human cells.

72 1 or Mad1 abrogate the spindle checkpoint in human cells.

73 curs in C. elegans, primary rat neurons, and human cells.

74 rgistic and combinatorial gene expression in human cells.

75 ctuations at short time scales of seconds in human cells.

76 acyl-ACP synthase to these drugs in infected human cells.

77 s completely abolished HTTex1 aggregation in human cells.

78 lated DNA lesions perturb DNA replication in human cells.

79 py-based approach to image CHIKV nsP3 inside human cells.

80 ited or when the DNA-PKcs gene is deleted in human cells.

81 viability of C. trachomatis-infected primary human cells.

82 serve the horizontal transfer of PERVs among human cells.

83 s in cargo binding and PTS protein import in human cells.

84 ated by host factors, enhancing infection of human cells.

85 epair may contribute to tumor suppression in human cells.

86 namics of the nuclear RNAi process in living human cells.

87 riptional readthrough upon osmotic stress in human cells.

88 LPS-induced TNF-alpha and PCNA increases in human cells.

89 es the ability of poxviruses to replicate in human cells.

90 D1 (OTUD2) as a novel interactor of TRAF6 in human cells.

91 transcriptional repression in single living human cells.

92 ibacterial mechanisms, and are non-toxic for human cells, a prerequisite for using them as novel anti

93 determined the spectrum of SNVs in a single human cell after ultraviolet radiation, revealing their

94 type human SOD1 and the ALS-linked mutant in human cells also require the diacidic residues.

95 earch caused by mix-ups and contamination in human cell and tissue cultures.

96 addition, through cross-linking analysis in human cells and biochemical reconstitution, we show that

97 ps) and double strand breaks in rat neurons, human cells and C9orf72 ALS patient spinal cord tissues.

98 Here, we show that both in human cells and Caenorhabditis elegans, the Polo-like ki

99 that chitosan-coated microparticles can lyse human cells and capture the released DNA in a single mec

100 In hyperhomocysteinemic human cells and cystathionine beta-synthase-deficient mo

101 oligomerization, aggregation and toxicity in human cells and Drosophila neurons.

102 y upstream regulator of end-on conversion in human cells and establish a late role for Astrin-SKAP co

103 o maintain GJs upon elevated IIS in cultured human cells and in flies, and to rescue age-related loss

104 ce-associated secretory phenotype in primary human cells and in mice.

105 3 decreased claudin-18 expression in primary human cells and in mice.

106 development and maintenance of malignancy in human cells and mice.

107 trictly required for flavivirus infection of human cells and mosquitoes: RPLP1 and RPLP2 (RPLP1/2).

108 s by introducing fluorescent protein tags in human cells and mouse embryos using PCR fragments.

109 a-synuclein species capable of templating in human cells and neurons.

110 n impairs PNKP recruitment to damaged DNA in human cells and provides a possible disease mechanism.

111 Each of the 852 mutants was expressed in human cells and screened for antigenicity using four dif

112 to either MARV or EBOV infection in bat and human cells and the role of viral interferon-inhibiting

113 and hemolytic activities of the AMPs against human cells and their immunomodulatory potential in huma

114 munodeficient mice engrafted with functional human cells and tissues, that is, humanized mice, have b

115 tein interaction landscape of BIA 10-2474 in human cells and tissues.

116 nd physically proximal to DNA:RNA hybrids in human cells, and can efficiently unwind R-loops in vitro

117 nd interferes with cell-cycle progression in human cells, and it causes cell-cycle deficits of radial

118 nd progenitor cell expansion in CD patients, human cells, and preclinical mouse models.

119 of protein kinases regulate key processes in human cells, and protein kinases play a pivotal role in

120 We now confirm that PERVs infect human cells, and we observe the horizontal transfer of P

121 ane of kinetochore-microtubule attachment in human cells are not known.

122 Studies in human cells are revealing the ways in which these pathwa

123 Levels of HIV-1 RNA and DNA in human cells, as well as replication-competent-virus-prod

124 otency gains in primary in vitro and ex vivo human cell assays, using PBMCs from type 1 diabetes pati

125 sto-blood group antigens (HBGA) receptors on human cells at CDots concentration of 5 microg/mL, with

126 However, human cell-based PanIN models with defined mutations are

127 ains, TAK1 activation, or IL-8 production in human cells, because Pellino1 and Pellino2 generate the

128 In human cells, biotin-dependent carboxylases catalyze key

129 ironmental factors impacts the metabolism of human cells, but neither traditional culture media nor m

130 Consistently, complexes exist in yeast and human cells, but not in bacteria, and correlate with coo

131 substantially reduced off-target cleavage in human cells, but the mechanism of target discrimination

132 t on TLR signaling pathways was confirmed in human cells by CRISPR/Cas9-mediated gene inactivation.

133 found that functional miRNAs are degraded in human cells by the endonuclease Tudor-SN (TSN).

134 In human cells, C-box deletion of MAF1 leads to increased M

135 olic extract was able to efficiently protect human cells (Caco-2, SHSY-5Y and K562) against t-BHP-ind

136 Many human cells can sense the presence of exogenous DNA duri

137 hole-body imaging of metastasis generated by human cells, clinical biopsies or endogenously deregulat

138 In vitro studies with human cells confirmed the pivotal role of CXCR7 in pulmo

139 Human cells contain five topoisomerases in the nucleus a

140 ssel formation, remodeling and function in a human cell context.

141 binding protein in membrane preparations of human cells corresponds to a glycoprotein with a molecul

142 est that transcriptional stochasticity among human cells could be useful for predicting and engineeri

143 mals models of autoimmunity and Th17-skewing human cell culture in vitro.

144 Caenorhabditis elegans as well as murine and human cell culture models of lysosomal diseases.

145 een pancreatic cancer and its TAS in primary human cell culture models.

146 Human cell culture provides an alternative, but many fun

147 Here we demonstrate that RPE degeneration in human-cell-culture and mouse models is driven by a nonca

148 Effector cells were evaluated with in vitro human cell cultures.

149 In human cells, cytoplasmic dynein-1 is essential for long-

150 (55)Fe-radiolabeling experiments with human cells depleted of CIA1, CIA2A, CIA2B, or MMS19 rev

151 urprisingly, deletion of beclin1 in in vitro human cells did not block an autophagy response, but att

152 NA splicing of U12-type introns functions in human cell differentiation, but it is not known whether

153 CMMPs (derived from human cells) do not stimulate T-cell infiltration in imm

154 uggest that extending the lifespan of normal human cells due to inactivation of STAG2 could promote t

155 ated genes 54 and 56, which were detected in human cells ectopically expressing bat IFN-alpha and IFN

156 isely respond to a changing external milieu, human cells efficiently translate upstream signals into

157 imidinic endonuclease-1 (APE1) and APE1 from human cell extracts efficiently process an rAP site in D

158 ation, these efficient nanofactories protect human cells from toxic reactive oxygen species for up to

159 n, although additional studies are needed on human cells from W1282X subjects.

160 we find that formaldehyde detoxification in human cells generates formate, and thereby promotes nucl

161 Track structures and resulting DNA damage in human cells have been simulated for hydrogen, helium, ca

162 Human cells have twenty-three pairs of chromosomes.

163 al. identify a peroxisome-ER contact site in human cells held together by a tethering complex of VAPA

164 Furthermore, mCAT1 overexpression in human cells impaired the infectivity of both the F-MLV d

165 stringently repressed in telomerase-negative human cells in a histone deacetylase (HDAC)-dependent ma

166 Orthotopic implant of CCA human cells in the liver of immunodeficient mice resulte

167 nvironmental exposure to viruses that infect human cells in vitro Feline leukemia viruses (FeLVs) ran

168 s), which indicates low compound toxicity to human cells in vitro.

169 d a clonal cell, HAP1-A12, from near-haploid human cells, in which ATP5G1, ATP5G2, and ATP5G3 were di

170 efficient sequence-specific interventions in human cells, including targeted gene delivery to the CCR

171 bset, with broad reactivity against stressed human cells, including tumor cells.

172 er 40 bp followed a DNA 'hopping' pathway in human cells, indicating that authentic sliding does not

173 fungal therapeutic effects in both mouse and human cells infected with C. albicans, indicating that J

174 Gene delivery to primary human cells is a technology of critical interest to both

175 immunodeficiency virus (SIV) replication in human cells is restricted at early postentry steps by ho

176 In human cells, its depletion affects gene expression and i

177 elta-tubulin and epsilon-tubulin null mutant human cells lack triplet microtubules and fail to underg

178 Dysregulation of this DDT pathway in human cells leads to increased mutation rates that may c

179 sing siRNA-mediated knockdown of KIF20B in a human cell line and fixed and live imaging, we show that

180 H3K4me3, which coprecipitated with RAG2 in a human cell line model, laying the molecular basis for re

181 We describe the use of a human cell line that has the properties of a sensory neu

182 In this study, A549 cells, a human cell line with a robust innate response, were infe

183 is study, using acute myeloid leukemia (AML) human cell lines and a custom CRISPR/Cas9 screening plat

184 e introduced increasing passenger loads into human cell lines and immunocompromised mouse models.

185 endogenous Tspan5 associates with ADAM10 in human cell lines and in mouse tissues where it is the mo

186 particularly inhibited in ataxin-3-depleted human cell lines and mouse primary neurons, and in vivo

187 ng IFNB1 (IFN-beta) and CXCL10 expression in human cell lines and primary leucocytes following treatm

188 viral replication and polymerase activity in human cell lines and virulence and multiorgan disseminat

189 d enhanced JAK2 signaling and cell growth in human cell lines as well as primary murine HSPCs.

190 and their endogenous forms were detected in human cell lines as well.

191 Here, we screened a library of human cell lines individually lacking ZDHHCs 1-24 and fo

192 These lines include near-haploid human cell lines isolated from a patient with chronic my

193 Genes identified as essential in human cell lines or knockout mice may be distinct from t

194 characterized inducible CRISPR/Cas9 knockout human cell lines targeting 209 genes involved in diverse

195 demonstrate that HHV-6A/B integrated in most human cell lines tested, including telomerase-positive (

196 susceptibilities of primary and established human cell lines to FeLV-B, the most likely zoonotic var

197 PR-Cas9 screening strategies in two distinct human cell lines to provide a genome-wide survey of gene

198 In this study three human cell lines, Caco-2 (colorectal adenocarcinoma), HT

199 Many different human cell lines, including both normal and cancer cells

200 In a study of mouse and human cell lines, organoids, and tissues, we found cIAP1

201 In human cell lines, overexpression of active HYPE similarl

202 e restriction of HIV-1 and -2 replication in human cell lines, primary macrophages, and peripheral bl

203 25 is required for the viability of multiple human cell lines, suggesting that it could play a key ro

204 elevance of genetic dependencies observed in human cell lines, we performed a secondary screen in a s

205 ls and their human TERC knockout-derived ALT human cell lines, we show that ALT cells harbor more fra

206 how that RBM25K77me1 is abundant in multiple human cell lines.

207 and validated in vivo by ChIP-seq data from human cell lines.

208 ensitive to MEK inhibitors in both mouse and human cell lines.

209 be successful propagation of VA1 in multiple human cell lines.

210 rom approximately 3,000 CF-MS experiments on human cell lines.

211 orming genome-wide landscapes in a series of human cell lines.

212 s were further validated using breast cancer human cell lines.

213 nfirm the low toxicity of A toward different human cell lines.

214 pulated its expression in several murine and human cell lines.

215 ors for DENV, YFV, and ZIKV infection in two human cell lines: A549 lung adenocarcinoma and HuH-7 hep

216 ting methods using evaluation sets from four human cell-lines and eighteen transcription factors and

217 In human cells, little is known about how long noncoding RN

218 The role of PTX3 was evaluated in cultured human cells, liver tissue slices, and mice with acute-on

219 l-free in vitro translation assay containing human cell lysate and purified target mRNA fused to a re

220 the activity of ITPA in bacterial, yeast and human cell lysates.

221 Here we show that human cells make this fundamental cell-cycle entry or ex

222 he use of engineered biomaterials to control human cell manufacturing.

223 We generated a human cell model of CHS using Clustered Regularly Inters

224 Here, we generated a robust human cell model of LAM by reprogramming TSC2 mutation-b

225 Human cell modeling demonstrated reduced expression from

226 In our human cell models, TRAP1 overexpression is protective, r

227 ent to testing ASD hypotheses is the lack of human cell models.

228 with histone H3K4 methylation genome-wide in human cells, mouse embryonic stem cells, and Drosophila

229 ituations analyzed, including nontransformed human cells, normal mouse intestinal epithelia and adeno

230 d interferon response associated with T21 in human cells of different origins, consistent with overex

231 st of immunodeficient mice transplanted with human cells or reconstituted with a near-complete human

232 nsplant biopsies with AMR and in an extended human cell panel to determine their selectivity.

233 ive frequency of transcription initiation in human cells ('pause-initiation limit').

234 ovide new insight into how folate influences human cell physiology and may have implications for our

235 Human cells producing mutant UMOD were susceptible to TN

236 ions, and show immunostimulant properties in human cells, promoting the expression of co-stimulatory

237 tified, in total, more than 9,000 lysines in human cell proteomes and have identified several hundred

238 in ETAA1 is an important activator of ATR in human cells, providing insights into how the ATR pathway

239 Acute silencing of caspase-2 in cultured human cells recapitulated these results.

240 e requirements for cell-cycle progression in human cells remain incompletely understood.

241 d long-range haplotypes in genomes of single human cells remains very challenging.

242 on of the lagging and the leading strands in human cells, respectively.

243 purified the major E3 ubiquitin ligases from human cells responsible for regulation of NEIL1 by ubiqu

244 Unexpectedly, experiments in bacterial and human cells reveal that head-on replication-transcriptio

245 inally, studies using RNAi-rescue systems in human cells revealed that intact PIN domain and Zinc fin

246 methylated DNA lesions on DNA replication in human cells, revealed the roles of individual translesio

247 In human cells, RNA foci form by phase separation of the re

248 Human cell-seeded GelMA hydrogels promoted the establish

249 nes encoding mitochondrial CARSs in mice and human cells shows that CARSs have a crucial role in endo

250 t tension stimulation can be translated to a human cell source to generate anisotropic human neocarti

251 Here, we establish the landscape of human cell-specific microRNA expression.

252 ns, optimize parameters of FCM algorithm for human cell-specific transcriptomic data and identify rob

253 was also observed, consistent with previous human cell studies.

254 caused telomere shortening in both mouse and human cells, suggesting BRD4 plays a role in telomere ma

255 filovirus infection in bat cells but not in human cells, suggesting host species specificity of the

256 , rmIFN exhibited high antiviral activity on human cells, suppressing HIV replication and inducing th

257 the HR and tumor suppressor gene, BRCA2, in human cells synergistically reduces HR - indicating that

258 In human cells, tailored S1mplexes increase the ratio of pr

259 Human cells that lack a subunit in their origin recognit

260 STAG2 silencing in normal human cells that lack telomerase led to increased recomb

261 In human cells, the ARS2 protein has been implicated in suc

262 In human cells, the constituent glycoforms differ mostly in

263 In human cells, the CST complex (CTC1-STN1-TEN1) also funct

264 immune-related gene networks in circulating human cells, their interactions with metabolites, and th

265 esidues was observed to extensively exist in human cells through global and site-specific analysis of

266 Fragment-based screening in human cells thus provides an extensive proteome-wide map

267 xogenous CtBP2 transformed primary mouse and human cells to anchorage independence similarly to mutan

268 ze the immediate transcriptional response in human cells to celastrol, a compound derived from tradit

269 d genome-wide genetic screen in near-haploid human cells to uncover cellular processes that regulate

270 n contrast, BRCA2 exerts its effect on HR in human cells together with HsRAD51, potentially explainin

271 coid receptor expression was also blunted in human cells treated with plasma from septic patients.

272 t the cellular level with the most prevalent human cell-tropic FeLV variant, FeLV-B.

273 We harmonized 1822 pure human cell type transcriptomes from various sources and

274 Since cells derived from other normal human cell types are fully supportive of FeLV replicatio

275 ole-genome functional annotation maps in 127 human cell types by integrating data from studies of mul

276 of approximately 570 microbial species and 3 human cell types metabolically interacting through >4,40

277 Here we predict and confirm in several human cell types that DNA:RNA hybrids form at many subte

278 of plasmid DNA lipoplexes in several primary human cell types.

279 omoters of chromosomal rearrangements across human cell types.

280 n human organs, rather than only in isolated human cell types.

281 We investigated the stability of hm(5)C in human cells using bio-isotopologues and LC-MS/HRMS.

282 We quantified actin filament order in human cells using fluorescence polarization microscopy a

283 act to maintain homeostasis in proliferating human cells, using fluorescent reporters for AMPK activi

284 expression of PGBD5 in primary immortalized human cells was sufficient to promote cell transformatio

285 llowing gene inactivation and replacement in human cells, we demonstrate that CENP-A mutants that can

286 cilitate the study of cellular mechanisms in human cells, we established several human stem cell line

287 Analyzing beta-catenin ChIP sequencing in human cells, we found the 11-bp NREs co-localizing with

288 to understand how these viruses replicate in human cells, we previously conducted genome-scale RNA in

289 ching (FRAP) and single-molecule tracking in human cells, we show that Scc2 binds dynamically to chro

290 JURP up-regulation in transformed murine and human cells, we used a CRISPR/Cas9 approach.

291 r RNAi occurs and modulates transcription in human cells, we used live-cell imaging to detect and tra

292 ms of alpha-synuclein (alphaS) aggregates in human cells, we visualized alphaS aggregation, endo-lyso

293 Human cells were detected in cell suspensions of murine

294 cling of GJs was also stimulated in cultured human cells when IIS was reduced.

295 retained infectivity when it was produced by human cells, which naturally lack mCAT1 expression, but

296 adily induce an interferon (IFN) response in human cells, while LASV infection usually triggers an un

297 of repair of thymine glycol in a variety of human cells with a high degree of sensitivity.

298 MS), we analyzed the inorganic components of human cells with isogenic backgrounds in distinct states

299 me-dependent inhibition of GFP expression in human cells with VLP-RNAi.

300 ntly to G*C (approximately 50% efficiency in human cells) with high product purity (typically at leas