ライフサイエンスコーパス: human chromosome

1 romosomes show conserved synteny to a single human chromosome.

2 rates with three copies of neo targeted to a human chromosome.

3 ls when a mouse carries a freely segregating human chromosome.

4 distinguish rhesus macaque chromosomes from human chromosomes.

5 required for the replication of the ends of human chromosomes.

6 eckpoint regulates origins of replication in human chromosomes.

7 rate their viral genomes in the telomeres of human chromosomes.

8 re-replication on single DNA molecules from human chromosomes.

9 predicted in many different genes across all human chromosomes.

10 t of 37 genes sequenced in >1,500 individual human chromosomes.

11 the general loop-array morphology of compact human chromosomes.

12 is of human chromosome 3, one of the largest human chromosomes.

13 variations in chromatin compaction in fixed human chromosomes.

14 members hidden in pericentromeres of several human chromosomes.

15 atellite repeat-containing centromeres of 23 human chromosomes.

16 layed replication and condensation of entire human chromosomes.

17 abeling specific repetitive DNA sequences in human chromosomes.

18 We find that human chromosome 1 (which does not contain BRCA1) contai

19 mapped to CFA7 in a region corresponding to human chromosome 1, region q32.1-q32.2.

20 B gene 5'-flanking region was amplified from human chromosome 1, sequentially deleted, and cloned int

21 earching around transcription start sites in human chromosomes 1 and 2, we predicted 16 novel p53 bin

22 nd mapped ultraviolet damage hotspots across human chromosomes 1 and 6.

23 interchromosomal organization of a subset of human chromosomes (#1, 4, 11, 12, 16, 17, and 18) was ex

24 in, which lies in close proximity to pten on human chromosome 10 and encodes a 20-kDa nuclear protein

25 ial DNA secondary structure formation on the human chromosome 10 sequence, and utilize this analysis

26 A locus at human chromosome 10q26 affects the risk of AMD, but the

27 ctions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the beta-globin locus a

28 s containing either the maternal or paternal human chromosome 11 showed that BORIS preferentially bin

29 moter and the ANO1 gene, lying 68 Mb away on human chromosome 11, which encodes a Ca(2+)-dependent ch

30 sing hybrid hamster cells (A(L)N) containing human chromosome 11.

31 Human chromosome-11 band-q23 translocations disrupting t

32 only G-protein-coupled receptor gene in the human chromosome 11p12-11p14.4 fragment, is the key gene

33 ich localizes within a chromosomal region on human chromosome 11p15 that is commonly lost in Wilms tu

34 f a cluster of maternally expressed genes on human chromosome 11p15.5.

35 CCDC88B maps within one IBD risk locus on human chromosome 11q13.

36 yndromic hearing loss at the DFNB63 locus on human chromosome 11q13.3-q13.4.

37 ouse chromosome 9qA1, the syntenic region of human chromosome 11q22.

38 Human chromosome 11q23 translocations disrupting MLL res

39 The ALL1 (also termed MLL) gene on human chromosome 11q23 was isolated by virtue of its inv

40 Human chromosome 12 contains more than 1,400 coding gene

41 66,000 CpG sites within 2,020 CpG islands on human chromosome 12, chromosome 20, and 34 selected regi

42 lycosylases encoded within a small region of human chromosome 12.

43 ive-trait locus affecting telomere length on human chromosome 12.

44 two GLIPR1L genes (GLIPR1L1 and GLIPR1L2) on human chromosome 12q21 and mouse Rtvp1 (mRTVP-1 or Glipr

45 Allelic deletions on human chromosome 12q24 are frequently reported in a vari

46 Interestingly, this region is homologous to human chromosome 13q34, and some of the same genes were

47 some CFA15 that is syntenic with a region of human chromosome 14 (HSA14q11.2) containing the retiniti

48 b region, with complete syntenic homology to human chromosome 14, that contains no genes or loci know

49 from the bacterium Staphylococcus aureus and human chromosome 14.

50 is located on distal mouse chromosome 12 and human chromosome 14.

51 olog-deiodinase, iodothyronine 3) cluster on human chromosome 14.

52 have surveyed the S/MARs in HeLa S3 cells on human chromosomes 14-18 by array comparative genomic hyb

53 phenotype matrix attached regions (MARs) on human chromosomes 14-18 were identified as a function of

54 structure of the distal serpin subcluster on human chromosome 14q32.1 allow a single gene encoding al

55 Here we present a finished sequence of human chromosome 15, together with a high-quality gene c

56 resent alterations in the positioning of the human chromosomes 15, 18, X and Y between spermatozoa wi

57 aternally inherited and maternally inherited human chromosome 15q, respectively.

58 Human chromosome 15q11-13 is a complex locus containing

59 xpression from the imprinted gene cluster on human chromosome 15q11-q13.

60 snoRNAs and their host transcript, 116HG, on human chromosome 15q11-q13.

61 ndrome, is part of a cluster of genes in the human chromosome 15q11-q13/mouse chromosome 7C region, t

62 Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q syndrome or Dup15

63 overed five structural configurations of the human chromosome 15q13.3 region ranging in size from 2 t

64 modifications across the telomeric region of human chromosome 16 in primary erythroid and nonerythroi

65 the disease trait to the telomeric region of human chromosome 16, which includes the alpha-globin gen

66 ion of the contiguous TSC2 and PKD1 genes on human chromosome 16.

67 y of intrachromosomal duplications blocks on human chromosome 16.

68 Human chromosome 16p11.2 microdeletion is among the most

69 Human chromosome 16p11.2 microdeletion is the most commo

70 member of the large protease gene cluster at human chromosome 16p13.3, which also contains the struct

71 8a, clec18b, and clec18c loci, is located in human chromosome 16q22.

72 Here we report a finished sequence for human chromosome 17, as well as a structural comparison

73 levels of PMP22, as a 1.4 Mb duplication on human chromosome 17, resulting in three copies of PMP22,

74 rotein E2C, which binds a unique sequence on human chromosome 17.

75 the 5' untranslated region of erbB-2 gene on human chromosome 17.

76 tutional chromosomal rearrangements occur on human chromosome 17.

77 ply that the selective advantage produced by human chromosome 17p deletion reflects the combined impa

78 he peripheral myelin protein gene (PMP22) in human chromosome 17p12 are associated with neuropathy: d

79 MNT maps to human chromosome 17p13.3, a region frequently deleted in

80 ike protein isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk fac

81 C17orf37/MGC14832, a novel gene located on human chromosome 17q12 in the ERBB2 amplicon, is abundan

82 One such locus, human chromosome 17q21.31, contains a megabase-long inve

83 strate that a cluster of 5 galectin genes on human chromosome 19 emerged during primate evolution as

84 target AAV integration to a specific site on human chromosome 19, called AAVS1.

85 n of a globin transgene in the AAVS1 site on human chromosome 19.

86 ntegrates its genome into the AAVS1 locus on human chromosome 19.

87 s of the highly repetitive KIR region on the Human chromosome 19.

88 ge gene clusters near centromeric regions of human chromosomes 19 and 7 with smaller clusters or isol

89 an evolutionarily conserved 500-kb domain in human chromosome 19q13.4 and mouse proximal chromosome 7

90 TAF12, NFYC, and RAD54L co-located on human chromosome 1p32-35.3 and mouse chromosome 4qD1-D3

91 Human chromosome 1p35-p36 has long been suspected to har

92 togen-inducible gene 6 (MIG-6) is located in human chromosome 1p36, a locus frequently associated wit

93 osome 1 in mice, and as many as four QTLs on human chromosome 1q have been implicated in human studie

94 As CRB1 is the closest gene on human chromosome 1q known to cause retinal degeneration,

95 replicated linkage peak for BP regulation on human chromosome 1q, homologous to mouse and rat quantit

96 a novel transfer RNA (tRNA) tandem repeat on human chromosome 1q23.3 that shows extensive copy number

97 An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants whi

98 Previous work has shown that the presence of human chromosome 2 increases HIV-1 production in mouse c

99 be corrected by one or more genes present on human chromosome 2 to allow production of infectious HIV

100 Only those containing human chromosome 2 were permissive, which correlated wit

101 s may carry a nonreciprocal translocation on human chromosome 2, in which synchronized double strande

102 nomic region exhibiting conserved synteny to human chromosome 2, which included one of the three dilu

103 s and around the site of ancestral fusion in human chromosome 2.

104 Human chromosome 20q12-q13.1 has been linked to type 2 d

105 ns 14 WFDC genes organized in two subloci on human chromosome 20q13.

106 al heart disease (CHD); however, trisomy for human chromosome 21 (Hsa21) alone is insufficient to cau

107 s caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is the most common genet

108 esults from an extra copy of the long arm of human chromosome 21 (HSA21) and the increased expression

109 The genomic regions on human chromosome 21 (Hsa21) are syntenic to three region

110 functionally trisomic for approximately 120 human chromosome 21 (HSA21) classical protein-coding gen

111 Moreover, human chromosome 21 (Hsa21) encodes several negative reg

112 vealed that trisomy for only 33 orthologs of human chromosome 21 (Hsa21) genes was sufficient to coop

113 ioinformatic annotation has established that human chromosome 21 (Hsa21) harbors five microRNA (miRNA

114 Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS

115 Trisomy of human chromosome 21 (Hsa21) results in Down syndrome (DS

116 The factors on human chromosome 21 (Hsa21) that confer this predisposin

117 The Tc1 human chromosome 21 (Hsa21) transchromosomic mouse model

118 mbryonic stem cells (ESCs)) bearing an extra human chromosome 21 (HSA21)) we analyzed the early stage

119 Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of

120 nd ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated i

121 ng in mice carrying a genetically rearranged Human Chromosome 21 (Hsa21).

122 and an isogenic control that is disomic for human chromosome 21 (HSA21).

123 d DYRK1A , lie within the critical region of human chromosome 21 and act synergistically to prevent n

124 The GART gene is located on human chromosome 21 and is aberrantly regulated and over

125 The underlying gene, SYNJ1, maps to human chromosome 21 and is thus a candidate for involvem

126 isorder caused by full or partial trisomy of human chromosome 21 and presents with many clinical phen

127 for orthologs of about half of the genes on human chromosome 21 and provide a genetic model for DS.

128 ndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent gen

129 ing the pathogenic role of trisomic genes on human chromosome 21 and the genotype-phenotype relations

130 The regions on human chromosome 21 are syntenically conserved in three

131 We identified a 3-megabase region on human chromosome 21 containing 6 candidate genes associa

132 This region of human chromosome 21 contains 6 candidate genes for herpe

133 ty of dentate gyrus-CA3 networks to aberrant human chromosome 21 gene expression and delineate hippoc

134 of mouse chromosome 16 that is homologous to human chromosome 21 has been triplicated.

135 tocytes were recapitulated across the entire human chromosome 21 in the mouse hepatocyte nucleus.

136 e so-called Down syndrome critical region of human chromosome 21 is an important region for this phen

137 the mouse nucleus, hundreds of locations on human chromosome 21 newly associate with activating hist

138 hich carry a duplication spanning the entire human chromosome 21 orthologous region on mouse chromoso

139 itsn1, synj/synj1, and nla/dscr1, located on human chromosome 21 play important roles in DS neurons.

140 most cases, DS results from an extra copy of human chromosome 21 producing deregulated gene expressio

141 A study in this issue of Oncogene, defines human chromosome 21 sequences that alter hematopoiesis a

142 ed a 22.9 Mb duplication spanning the entire human chromosome 21 syntenic region on mouse chromosome

143 are trisomic for approximately 56.5% of the human chromosome 21 syntenic region on mouse chromosome

144 use strain produce viable sperm and transmit human chromosome 21 to create aneuploid offspring.

145 ytes from an aneuploid mouse strain carrying human chromosome 21 to determine, on a chromosomal scale

146 transmits an almost complete single copy of human chromosome 21 via the female germline, we show tha

147 odel, the Tc1 mouse, which carries a copy of human chromosome 21 was produced in 2005.

148 syndrome is caused by a genomic imbalance of human chromosome 21 which is mainly observed as trisomy

149 ated kinase 1A (DYRK1A) gene is localized in human chromosome 21, and its overexpression has been ass

150 Down's syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of

151 Because it is located on human chromosome 21, RCAN1 has been postulated to contri

152 red with mice derived from female passage of human chromosome 21, the chromatin condensation during s

153 ly relevant published datasets that included human Chromosome 21, the human lipoprotein lipase (LPL)

154 risomic for 132 genes homologous to genes on human chromosome 21, triplication of Usp16 reduces the s

155 When applied to >23,000 transcripts from human chromosome 21, using biologically reasonable filte

156 binant region of interest on the long arm of human chromosome 21, with a multipoint logarithm of odds

157 ariations in hypermutable CpG regions across human chromosome 21.

158 lls and in rodent cells that contain part of human chromosome 21.

159 associated with a region on the long arm of human chromosome 21.

160 Down syndrome (DS) is caused by trisomy of human chromosome 21.

161 oded in the Down syndrome critical region of human chromosome 21.

162 logs for nearly half of the genes located on human chromosome 21.

163 etic condition caused by the triplication of human chromosome 21.

164 itulated in aneuploid mouse neurons carrying human chromosome-21, implicating promoter/enhancer seque

165 harbor a chromosomal duplication syntenic to human chromosome 21q.

166 triplication of only 31 genes orthologous to human chromosome 21q22 confers mouse progenitor B cell s

167 )A(+/-) mice, which model a microdeletion on human chromosome 22 (22q11.2) that constitutes one of th

168 We provide evidence, using alignments of human chromosome 22 against a five-species alignment fro

169 a 1.5- to 3-megabase hemizygous deletion on human chromosome 22, results in dramatically increased s

170 seven cytidine deaminase genes is present on human chromosome 22.

171 ts agree with established gene annotation on human chromosome 22.

172 e of the link between hemizygous deletion of human chromosome 22q11.2 and high rates of social behavi

173 Genes and a 3-Mb deletion mapping to human chromosome 22q11.2 have been implicated in 22q11.2

174 Duplication of human chromosome 22q11.2 is associated with elevated rat

175 Deletion or duplication of the human chromosome 22q11.2 is associated with many behavio

176 The human chromosome 22q11.2 region is susceptible to rearra

177 and mouse model studies on rare CNVs within human chromosome 22q11.2, we propose that alterations of

178 n maps to mouse chromosome 17, syntenic with human chromosome 2p21-22.

179 Here, we map in human chromosome 2q31 the 3D configuration of 200 kb of

180 OBSL1 is located on human chromosome 2q35 within 100 kb of SPEG, another gen

181 The GIGYF2 gene maps to human chromosome 2q37 within a region linked to familial

182 POP2 is a 294 nt single exon gene located on human chromosome 3 encoding a 97-aa protein with sequenc

183 e we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes

184 on of miR-26a located in the locus 3p21.3 of human chromosome 3.

185 emokine receptor genes of the CCR cluster on human chromosome 3p21 play important roles in humoral an

186 a novel tumor suppressor gene identified in human chromosome 3p21.3 region.

187 e new collagen VI genes at a single locus on human chromosome 3q22.1.

188 rs located on CFA34, in a region syntenic to human chromosome 3q26.

189 of synteny between macaque chromosome 5 and human chromosome 4.

190 isoforms, NHA1 and NHA2, found in tandem on human chromosome 4.

191 regions identified in autoimmune patients on human chromosomes 4q21-31, 5q31-33, 16q22-24, 17p11-q12,

192 atrial fibrillation susceptibility locus on human chromosome 4q25 in close proximity to the paired-l

193 e association studies implicated a region of human chromosome 4q25 in familial AF and AFL, approximat

194 s associated with D4Z4 repeat contraction on human chromosome 4q35.

195 lly ordered gene maps for equine homologs of human chromosome 5 (HSA5), viz., horse chromosomes 14 an

196 ndidate gene within the homologous region on human Chromosome 5, which is linked to systolic and dias

197 an interstitial deletion of the long arm of human chromosome 5.

198 C is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syn

199 some A1q in a region of conserved synteny to human chromosome 5q15.

200 mplex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of d

201 mplex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of d

202 mplex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of d

203 cluster of highly polymorphic genes found on human chromosome 6 and mouse chromosome 17.

204 The HLA gene complex on human chromosome 6 is one of the most polymorphic region

205 method to the 4.5-Mb extended MHC region on human chromosome 6, combining 8 assembled haplotypes, th

206 or inversion of which delayed replication of human chromosome 6.

207 The MHC on human chromosome 6p21 encodes the HLA genes that govern

208 studies have shown that genetic material on human chromosome 6q16.3-q23 is essential for KiSS-1 expr

209 expression, as a result of the gross loss of human chromosome 6q16.3-q23, provokes increased tumor me

210 ivator protein DRIP-130, which is encoded by human chromosome 6q16.3-q23, results in reduced KiSS-1 p

211 range haplotypes spanning a 153-Mb region of human chromosome 7 and found evidence of rare mitotic re

212 xamined 47 sequences from a 1.8-Mb region of human chromosome 7 for silencer and EB activities.

213 hypersensitive segments in the HOXA locus in human chromosome 7.

214 omosome 6qA3 with conservation of synteny to human chromosome 7q32.2.

215 lly, we suggest that aberrations that affect human chromosome 7q36, including XRCC2, correlate with g

216 enhancer of the Sonic Hedgehog (SHH) gene at human chromosome 7q36.3.

217 y number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie suscept

218 polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psorias

219 entified tumor suppressor that exists at the human chromosome 8p21.3 locus.

220 cting, telomerase inhibitor 1) is located at human chromosome 8p23, a region frequently exhibiting he

221 MCPH1 is located on human chromosome 8p23.1, where human cancers frequently

222 n studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated

223 Recently, common variants on human chromosome 8q24 were found to be associated with p

224 Defects in FAM83H on human chromosome 8q24.3 cause autosomal-dominant hypocal

225 se alterations to the locus of E-NTPDase2 on human chromosome 9 cause severe head and eye defects, in

226 This mouse QTL is syntenic with human chromosome 9p.

227 Noncoding variants at human chromosome 9p21 near CDKN2A and CDKN2B are associa

228 h 3D FISH data and known knowledge about the human chromosome and genome, such as, chromosome territo

229 R shows an average 10x speedup on any single human chromosome and has the ability to process the whol

230 oid mouse embryonic stem cells with an extra human chromosome and human induced pluripotent stem cell

231 e of centromeric epialleles on an endogenous human chromosome and suggest genomic complexities underl

232 llite DNA in pericentromeric regions of most human chromosomes and a dynamic chromatin state of gamma

233 are few rearrangements that distinguish ape-human chromosomes, and rates of single-base-pair change

234 Human chromosomes are captured along microtubule walls (

235 KAP complex in the end-on conversion process.Human chromosomes are captured along microtubule walls a

236 presentations for the rat, the mouse and the human chromosomes at different levels of detail.

237 Human chromosomes attach initially to lateral walls of m

238 The HYDIN gene located in human chromosome band 16q22.2 is a large gene encompassi

239 urrent 1.55-1.83 Mb heterozygous deletion on human chromosome band 7q11.23.

240 andidate tumor suppressor located within the human chromosome band 7q22 that is frequently deleted in

241 within local regions spanning all autosomal human chromosomes based on Haplotype Map variation data.

242 impanzee and gorilla chromosomes differ from human chromosomes by the presence of large blocks of sub

243 In human chromosomes, centromeric regions comprise megabase

244 Most human chromosomes contain multiple alpha satellite array

245 terminal regions, juxtaposed to telomeres on human chromosomes, contain a high density of segmental d

246 Aberrations in human chromosome copy number and structure are common an

247 tion, we tracked the segregation of a single human chromosome during cell division by using LacI-GFP

248 Human chromosome end-capping and telomerase regulation r

249 the single-stranded G-rich DNA overhangs at human chromosome ends and suppresses unwanted DNA repair

250 Human chromosome ends are capped by shelterin, a protein

251 Human chromosome ends are protected by shelterin, an abu

252 with the Atomic Bomb Casualty Commission on human chromosomes, for which he is best known.

253 ins comprehensive annotation on 20 of the 24 human chromosomes, four whole mouse chromosomes and arou

254 (NFkappaB) to the appropriate sites on four human chromosomes generates protein clusters analogous t

255 alization of the mosaic structure of admixed human chromosomes gives results similar to another visua

256 Although most human chromosomes have a single higher-order repeat (HOR

257 At least half of all human chromosomes have two or more distinct HOR alpha sa

258 13% in COSMIC noncoding datasets across all human chromosomes, higher than previously reported.

259 m chicken chromosomes (GGA) Z and 4 and from human chromosomes (HSA) 9, 4, X, 5, and 8 were linked an

260 hromosomes, enabling us to localize specific human chromosomes in live cells.

261 Chromosome 17 is unusual among the human chromosomes in many respects.

262 Here, we examine the fate of dicentric human chromosomes in telomere crisis.

263 pecific telomeres/subtelomeres of individual human chromosomes in two embryonic stem (ES) cell lines

264 This provides a model to study human chromosome inactivation and creates a system to in

265 ntally observed higher-order architecture of human chromosomes, including average scaling properties

266 Strikingly, insertion of a human chromosome into mouse revealed that promoter-assoc

267 lts indicate that the overall structure of a human chromosome is dictated by the spatial confinement

268 rase (IN) for integration of viral cDNA into human chromosome is established, studies with IN mutants

269 Haplotyping of human chromosomes is a prerequisite for cataloguing the

270 iated wall-removing event, we establish that human chromosome-microtubule attachment is achieved thro

271 hod for multilocus long-range haplotyping on human chromosome molecules in vitro based on the DNA pol

272 pecific technical difficulties of assaying a human chromosome on a mouse background where highly cons

273 We find that human chromosomes operate at the border of the dense ste

274 Using the sequence data from a human chromosome, our results show that Tiger can achiev

275 Common fragile sites are regions of human chromosomes prone to breakage.

276 The reference sequence for each human chromosome provides the framework for understandin

277 have re-annotated the repetitive content of human chromosomes, providing evidence for a recent expan

278 Recent studies have shown that human chromosome region maintenance 1 (hCRM1) stimulates

279 se lines showed multigenic enrichment in ten human chromosome regions linked to HLHS.

280 d variants that occur only once among the 80 human chromosomes sampled, occur preferentially at the c

281 d fluorescence-contrast images of Pt-stained human chromosome samples.

282 ano-channel arrays to analyze large terminal human chromosome segments extending from chromosome-spec

283 ated for the multiple alignment of assembled human chromosome sequences from four individuals.

284 Human chromosomes terminate in telomeres, repetitive DNA

285 ic markers in the centromere of 23 of the 24 human chromosomes that allow for rapid PCR assays capabl

286 FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluoro

287 oinformatics tool (methBLAST) for mapping to human chromosomes, the results of which indicated random

288 PURPOSE OF REVIEW: Chromosome 22, the first human chromosome to be completely sequenced, is prone to

289 genetic algorithm to construct 3D models of human chromosomes, using chromosomal contact data.

290 Coexpression of cytokeratin and human chromosome was observed at 7 and, to a lesser exte

291 omosomal spatial positionings of a subset of human chromosomes was examined in the human breast cell

292 more than 3,400 unique clones that span all human chromosomes was used for large-scale discovery exp

293 the effects of gamma radiation on an entire human chromosome, which gives some mechanistic insight i

294 As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplicat

295 rithms, we were able to optimally decode all human chromosomes with N-SCAN, which increased its accur

296 phoribosyltransferase (HPRT) gene located on human chromosome X.

297 s separated by two introns and is located on human chromosome Xp11.23.

298 A familial 1.1 Mb deletion of human chromosome Xq22.1 associates with epilepsy, cleft

299 family (CT47) within an unresolved region of human chromosome Xq24.

300 proteins) to active and inactive regions of human chromosomes yields rosettes, topological domains a