ライフサイエンスコーパス: human cytomegalovirus

1 , infections with HIV, hepatitis C virus, or human cytomegalovirus).

2 en described by us to inhibit replication of human cytomegalovirus.

3 ial target for antiviral development against human cytomegalovirus.

4 donors are always serologically positive for human cytomegalovirus.

5 Alignment of HSV UL37 with the human cytomegalovirus and Epstein-Barr virus UL37 homolo

6 e findings help explain the broad tropism of human cytomegalovirus and indicate that PDGFRalpha and t

7 applied to two herpesvirus genomes, those of human cytomegalovirus and Kaposi's sarcoma-associated he

8 herpesvirus family: varicella zoster virus, human cytomegalovirus, and Epstein-Barr virus.

9 al load testing are discussed in relation to human cytomegalovirus, BK virus, and Epstein-Barr virus,

10 However, human cytomegalovirus can manipulate this central innate

11 Human cytomegalovirus causes significant medical problem

12 nt of the 1st WHO International Standard for human cytomegalovirus (CMV) and the introduction of comm

13 Human cytomegalovirus (CMV) antigens have been identifie

14 Expression of human cytomegalovirus (CMV) antigens in GBM tissues prov

15 Human cytomegalovirus (CMV) belongs to those viruses tha

16 Human cytomegalovirus (CMV) enters its host via the oral

17 The prototypic beta-herpesvirus human cytomegalovirus (CMV) establishes life-long persis

18 The prototypic betaherpesvirus human cytomegalovirus (CMV) establishes life-long persis

19 d that transcriptional activators accelerate human cytomegalovirus (CMV) gene expression in single ce

20 Previous studies indicate that the human cytomegalovirus (CMV) gene, UL79, is required for

21 Human cytomegalovirus (CMV) has historically been the ma

22 Coinfection with genetic variants of human cytomegalovirus (CMV) in transplant recipients has

23 HC complexes on the T-cell repertoire during human cytomegalovirus (CMV) infection and demonstrate th

24 Human cytomegalovirus (CMV) infection is associated with

25 Human cytomegalovirus (CMV) is a herpesvirus that causes

26 Congenital infection with human cytomegalovirus (CMV) is a major cause of morbidit

27 The UL128 complex of human cytomegalovirus (CMV) is a major determinant of vi

28 Infection with human cytomegalovirus (CMV) is a significant cause of mo

29 Human cytomegalovirus (CMV) is a significant contributor

30 Human cytomegalovirus (CMV) is prevalent in older adults

31 Congenital infection of human cytomegalovirus (CMV) is the leading cause of chil

32 The replication cycle of human cytomegalovirus (CMV) leads to drastic reorganizat

33 Furthermore, Human Cytomegalovirus (CMV) miRNAs that target specific

34 Studies of T-cell immunity to human cytomegalovirus (CMV) primarily reflect anti-CMV p

35 Infection and disease caused by human cytomegalovirus (CMV) remain a significant burden

36 Human cytomegalovirus (CMV) represents one of the leadin

37 The human cytomegalovirus (CMV) UL11 open reading frame (ORF

38 Acquisition of human cytomegalovirus (CMV) usually occurs by contact be

39 Strikingly, infection with human cytomegalovirus (CMV), but not with other common h

40 Persistence of human cytomegalovirus (CMV), the prototypical betaherpes

41 Human cytomegalovirus (CMV)-induced adaptive natural kil

42 , including experiments described here using human cytomegalovirus, demonstrate a more nuanced intera

43 Vaccination with human cytomegalovirus-derived noninfectious particles, o

44 The human cytomegalovirus developed distinct evasion mechani

45 uclease and is an attractive target for anti-human cytomegalovirus drug development.

46 Therefore, anti-human cytomegalovirus drugs from novel targets are neede

47 Food and Drug Administration-approved anti-human cytomegalovirus drugs mainly target the viral poly

48 ssociation with nonintegrin receptors (i.e., human cytomegalovirus EGFR), to dictate species-specific

49 Human cytomegalovirus-encoded UL91 is a betagamma gene t

50 Human cytomegalovirus-encoded UL92 plays an essential ro

51 Human cytomegalovirus encodes 2 viral cytokines that are

52 The UL111A gene of human cytomegalovirus encodes a viral homologue of the c

53 Human cytomegalovirus encodes at least 25 membrane glyco

54 Human cytomegalovirus encodes several immune modulatory

55 bers of subfamily Betaherpesvirinae, such as human cytomegalovirus (genus Cytomegalovirus) and human

56 The human cytomegalovirus glycoprotein gp68 functions as an

57 structure at 2.9 angstrom resolution of the human cytomegalovirus GPCR US28 in complex with the chem

58 the cellular antiviral response and that the human cytomegalovirus has developed a mechanism by which

59 egrase, can inhibit the nuclease function of human cytomegalovirus (HCMV terminase) in vitro.

60 Human cytomegalovirus (HCMV) acquires its membrane in an

61 Human cytomegalovirus (HCMV) activation is associated wi

62 onstrated to act as a restriction factor for human cytomegalovirus (HCMV) and herpes simplex virus 1

63 r, as recently demonstrated by our group for human cytomegalovirus (HCMV) and herpes simplex virus 1

64 mechanistic insight into host recognition of human cytomegalovirus (HCMV) and subsequent immune evasi

65 tage of infection of certain cell types with human cytomegalovirus (HCMV) and that THY-1 is important

66 The genomes of DNA viruses such as human cytomegalovirus (HCMV) are devoid of histones with

67 a complex of two proteins, whose homologs in human cytomegalovirus (HCMV) are UL50 and UL53.

68 nt (cVAC) is an important step for efficient human cytomegalovirus (HCMV) assembly.

69 Human cytomegalovirus (HCMV) can cause serious morbidity

70 Human cytomegalovirus (HCMV) can establish latent infect

71 Recent studies have shown that human cytomegalovirus (HCMV) can induce a robust increas

72 Human cytomegalovirus (HCMV) causes birth defects and it

73 Human cytomegalovirus (HCMV) causes significant morbidit

74 ects in the central nervous system caused by human cytomegalovirus (HCMV) congenital infection, the m

75 Human cytomegalovirus (HCMV) counteracts host defenses t

76 Human cytomegalovirus (HCMV) deregulates the cell cycle

77 In lung transplant recipients (LTRs), human cytomegalovirus (HCMV) DNA detection in the bronch

78 lar proteins required for replication of the human cytomegalovirus (HCMV) DNA genome are poorly under

79 New data show that human cytomegalovirus (HCMV) DNA is detected in the nucl

80 Human cytomegalovirus (HCMV) down-regulates PVR expressi

81 Human cytomegalovirus (HCMV) employs numerous strategies

82 The DNA virus human cytomegalovirus (HCMV) encodes a viral Cdk (v-Cdk)

83 Human cytomegalovirus (HCMV) encodes one conventional pr

84 133-138 locus present in clinical strains of human cytomegalovirus (HCMV) encodes proteins required f

85 Human cytomegalovirus (HCMV) encodes the UL37 exon 1 pro

86 Neutralizing antibodies (NAb) targeting the human cytomegalovirus (HCMV) envelope pentamer complex (

87 Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persiste

88 accepted that, following primary infection, human cytomegalovirus (HCMV) establishes lifelong latenc

89 Human cytomegalovirus (HCMV) exhibits surprisingly high

90 nsible for the hematogenous dissemination of human cytomegalovirus (HCMV) following a primary infecti

91 m and is a critical host factor activated by human cytomegalovirus (HCMV) for successful infection.

92 ere, evidence is provided demonstrating that human cytomegalovirus (HCMV) gB depends on the S-palmito

93 Human cytomegalovirus (HCMV) gene expression during infe

94 The human cytomegalovirus (HCMV) gene UL111A encodes cytomeg

95 Human cytomegalovirus (HCMV) genome replication requires

96 by genes within a polycistronic locus of the human cytomegalovirus (HCMV) genome that regulate cell t

97 al unit within the ULb' region (ULb') of the human cytomegalovirus (HCMV) genome, and UL97, a viral p

98 Human cytomegalovirus (HCMV) gH/gL can be bound by gO or

99 Human cytomegalovirus (HCMV) gH/gL can be bound by the U

100 Human cytomegalovirus (HCMV) gH/gL can be incorporated i

101 The human cytomegalovirus (HCMV) gH/gL can exist as either t

102 Human cytomegalovirus (HCMV) has emerged as a clinically

103 The strict species specificity of Human Cytomegalovirus (HCMV) has impeded our understandi

104 Human cytomegalovirus (HCMV) has many effects on cells,

105 We report that the human cytomegalovirus (HCMV) high-molecular-weight tegum

106 we have shown that MCMV protein pM79 and its human cytomegalovirus (HCMV) homologue pUL79 are require

107 components PML, Sp100, hDaxx, and ATRX while human cytomegalovirus (HCMV) IE protein IE1 targets PML

108 Expression of the human cytomegalovirus (HCMV) IE1 and IE2 proteins is cri

109 Human cytomegalovirus (HCMV) immediate early protein IE1

110 Human cytomegalovirus (HCMV) immediate-early (IE) protei

111 DNA detection of human cytomegalovirus (hCMV) in cerebrospinal fluid (CSF

112 The kidney is a target organ for human cytomegalovirus (hCMV) in such patients, but it is

113 Reactivation of human cytomegalovirus (HCMV) in transplant recipients ca

114 Human cytomegalovirus (HCMV) induces numerous changes to

115 Double-stranded RNAs (dsRNA) produced during human cytomegalovirus (HCMV) infection activate the anti

116 The reactivation of latent human cytomegalovirus (HCMV) infection after transplanta

117 Human cytomegalovirus (HCMV) infection and periodic reac

118 Human cytomegalovirus (HCMV) infection causes disease in

119 Human cytomegalovirus (HCMV) infection causes severe dis

120 Primary human cytomegalovirus (HCMV) infection during pregnancy

121 Human cytomegalovirus (HCMV) infection has been shown to

122 described in 2002, the presence and role of human cytomegalovirus (HCMV) infection in glioblastoma (

123 Although human cytomegalovirus (HCMV) infection increases the abu

124 ate and mature during the human life course; human cytomegalovirus (HCMV) infection is a known driver

125 Congenital human cytomegalovirus (HCMV) infection is a leading caus

126 Congenital human cytomegalovirus (HCMV) infection is a major cause

127 Congenital human cytomegalovirus (HCMV) infection is a significant

128 tional and are directly antiviral.IMPORTANCE Human cytomegalovirus (HCMV) infection is carried for a

129 Human cytomegalovirus (HCMV) infection is endemic within

130 Human cytomegalovirus (HCMV) infection is limited by HCM

131 , but the biological impact in patients with human cytomegalovirus (hCMV) infection is not well defin

132 Human cytomegalovirus (HCMV) infection is present in >90

133 Congenital human cytomegalovirus (HCMV) infection is the leading ca

134 f the developing brain.IMPORTANCE Congenital human cytomegalovirus (HCMV) infection is the most commo

135 Human cytomegalovirus (HCMV) infection is the most commo

136 Human cytomegalovirus (HCMV) infection is transmitted fr

137 Human cytomegalovirus (HCMV) infection of multiple cell

138 Human cytomegalovirus (HCMV) infection of myeloid cells

139 Human cytomegalovirus (HCMV) infection of the developing

140 Here, we demonstrate that human cytomegalovirus (HCMV) infection rapidly promotes

141 Primary human cytomegalovirus (HCMV) infection usually goes unno

142 3's antiviral role extends to wild-type (wt) human cytomegalovirus (HCMV) infection, as its plaque-fo

143 Following primary human cytomegalovirus (HCMV) infection, the production o

144 cking expression of signaling proteins after human cytomegalovirus (HCMV) infection.

145 of the metabolic alterations induced during human cytomegalovirus (HCMV) infection.

146 ducted large-scale transcriptome analyses of human cytomegalovirus (HCMV) infection.

147 iclovir (GCV), the first line of therapy for human cytomegalovirus (HCMV) infections, induces chain t

148 ccine based on dense bodies (DB) produced by human cytomegalovirus (HCMV) infections, we evaluated sc

149 Human cytomegalovirus (HCMV) infects a variety of cell t

150 Human cytomegalovirus (HCMV) infects over half of the po

151 Human cytomegalovirus (HCMV) infects peripheral blood mo

152 Human cytomegalovirus (HCMV) is a betaherpesvirus that i

153 Human cytomegalovirus (HCMV) is a common agent of congen

154 Human cytomegalovirus (HCMV) is a complex DNA virus with

155 Human cytomegalovirus (HCMV) is a herpesvirus that infec

156 Human cytomegalovirus (HCMV) is a herpesvirus with both

157 Human cytomegalovirus (HCMV) is a highly prevalent patho

158 Human cytomegalovirus (HCMV) is a large, double-stranded

159 Human cytomegalovirus (HCMV) is a leading cause of birth

160 Human cytomegalovirus (HCMV) is a major cause of birth d

161 Human cytomegalovirus (HCMV) is a major cause of morbidi

162 Human cytomegalovirus (HCMV) is a major cause of morbidi

163 Human cytomegalovirus (HCMV) is a major human pathogen,

164 Human cytomegalovirus (HCMV) is a member of the beta-her

165 Human cytomegalovirus (HCMV) is a member of the betaherp

166 Human cytomegalovirus (HCMV) is a pathogen found worldwi

167 Human cytomegalovirus (HCMV) is a risk factor for many h

168 Reactivation of human cytomegalovirus (HCMV) is a significant cause of d

169 Human cytomegalovirus (HCMV) is a significant human path

170 Human cytomegalovirus (HCMV) is a ubiquitous pathogen an

171 The human cytomegalovirus (HCMV) is a ubiquitous, human path

172 Human cytomegalovirus (HCMV) is a widespread pathogen th

173 Human cytomegalovirus (HCMV) is able to reconfigure the

174 Human cytomegalovirus (HCMV) is an enveloped double-stra

175 Human cytomegalovirus (HCMV) is an important human patho

176 Human cytomegalovirus (HCMV) is an important, ubiquitous

177 The 235-kilobase genome of human cytomegalovirus (HCMV) is by far the largest of an

178 Human cytomegalovirus (HCMV) is exquisitely adapted to t

179 Primary infection with human cytomegalovirus (HCMV) is generally asymptomatic i

180 serine/threonine-protein kinase 2 (RIPK2) by human cytomegalovirus (HCMV) is known to up-regulate ant

181 Human cytomegalovirus (HCMV) is normally carried without

182 Human cytomegalovirus (HCMV) is not only an important pa

183 Congenital infection of human cytomegalovirus (HCMV) is one of the leading cause

184 e most abundantly produced virion protein in human cytomegalovirus (HCMV) is the immunodominant phosp

185 Human cytomegalovirus (HCMV) is the leading cause of con

186 Human cytomegalovirus (HCMV) is the leading viral cause

187 Human cytomegalovirus (HCMV) is the major viral cause of

188 Human cytomegalovirus (HCMV) is the major viral etiology

189 Human Cytomegalovirus (HCMV) is the most common cause of

190 As human cytomegalovirus (HCMV) is the most common infectio

191 Human cytomegalovirus (HCMV) is the most common viral in

192 Human cytomegalovirus (HCMV) is the prototypical human b

193 In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively i

194 7-DMAG treatment abrogates expression of the human cytomegalovirus (HCMV) kinase UL97 in HCMV-infecte

195 Human cytomegalovirus (HCMV) kinase UL97 is required for

196 The establishment of human cytomegalovirus (HCMV) latency and persistence rel

197 successful establishment and maintenance of human cytomegalovirus (HCMV) latency is dependent on the

198 interfering with horizontal transmission of human cytomegalovirus (HCMV) leading to primary and cong

199 and differentiation state-dependent onset of human cytomegalovirus (HCMV) lytic gene expression.

200 Human cytomegalovirus (HCMV) lytic phase gene expression

201 The requirement for PRC2 in suppressing the human cytomegalovirus (HCMV) lytic transcriptional progr

202 The human cytomegalovirus (HCMV) major immediate early (MIE)

203 nd regulatory pathways that effectively link human cytomegalovirus (HCMV) major immediate early (MIE)

204 nt knowledge of the targets and functions of human cytomegalovirus (HCMV) miRNAs and their functional

205 combinant herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV) mutants harboring the rever

206 combinant herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV) mutants harboring the rever

207 The identification in human cytomegalovirus (HCMV) of a viral endoplasmic reti

208 the minimum number of Sendai virus (SeV) and human cytomegalovirus (HCMV) particles required to activ

209 Human cytomegalovirus (HCMV) persists in the majority of

210 Human cytomegalovirus (HCMV) poses a significant threat

211 For example, the human cytomegalovirus (HCMV) pp71 protein induces the pr

212 For example, the human cytomegalovirus (HCMV) pp71 protein induces the pr

213 essing cells, and increase the efficiency of human cytomegalovirus (HCMV) productive replication.

214 Most notably, human cytomegalovirus (HCMV) protein pUL21a was recently

215 adoxically, while PABP accumulation promotes human cytomegalovirus (HCMV) protein synthesis, we show

216 eric complex (PC), in particular homologs of human cytomegalovirus (HCMV) proteins UL128, UL130, and

217 Human cytomegalovirus (HCMV) pUL93 is essential for viru

218 and phosphatases for their importance during human cytomegalovirus (HCMV) replication and identified

219 irement for the viral protein kinase UL97 in human cytomegalovirus (HCMV) replication that maps to th

220 abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigate

221 tion about the cellular factors required for human cytomegalovirus (HCMV) replication.

222 the capacity to block HAdV and, in addition, human cytomegalovirus (HCMV) replications at low micromo

223 manner classically defined as inactivation, human cytomegalovirus (HCMV) requires the presence of th

224 Human cytomegalovirus (HCMV) resides latently in hematop

225 recently reported that induction of NOD2 by human Cytomegalovirus (HCMV) resulted in virus inhibitio

226 simplex virus 1 (HSV-1) large terminase and human cytomegalovirus (HCMV) small terminase.

227 Clinical human cytomegalovirus (HCMV) strains invariably mutate w

228 Human cytomegalovirus (HCMV) strains that have been pass

229 The human cytomegalovirus (HCMV) terminase complex consists

230 The ability of human cytomegalovirus (HCMV) to establish lifelong persi

231 ey role in the hematogenous dissemination of human cytomegalovirus (HCMV) to target organ systems.

232 We have found that the human cytomegalovirus (HCMV) U(L)26 protein antagonizes

233 Here we identify the human cytomegalovirus (HCMV) UL141 glycoprotein as neces

234 The human cytomegalovirus (HCMV) UL34 proteins localize to t

235 The human cytomegalovirus (HCMV) UL97 protein is a viral CDK

236 The human cytomegalovirus (HCMV) UL97 protein kinase is requ

237 The human cytomegalovirus (HCMV) US12 family consists of ten

238 paradigm, but as a recent clinical trial of human cytomegalovirus (HCMV) vaccination demonstrated, t

239 The human cytomegalovirus (HCMV) virion envelope contains a

240 228) doses (60, 120, and 240 mg/day) against human cytomegalovirus (HCMV) was evaluated in a recent p

241 us and others show that microRNAs encoded by human cytomegalovirus (HCMV) were readily detected in hu

242 Human cytomegalovirus (HCMV), a betaherpesvirus being in

243 Human cytomegalovirus (HCMV), a betaherpesvirus, can cau

244 In this study, we report that human cytomegalovirus (HCMV), a large human DNA virus, e

245 genetic diversity over the entire genome of human cytomegalovirus (HCMV), a significant pathogen for

246 Human cytomegalovirus (hCMV), a ubiquitous beta-herpesvi

247 While many viruses, including human cytomegalovirus (HCMV), blunt host antiviral defen

248 e been identified in individuals infected by human cytomegalovirus (HCMV), but little is known about

249 Herpesviruses, including human cytomegalovirus (HCMV), encode multiple microRNAs

250 Herpesviruses, including human cytomegalovirus (HCMV), Epstein-Barr virus (EBV),

251 enon observed among several viruses, such as human cytomegalovirus (HCMV), Epstein-Barr virus, and HS

252 oduction and action, many viruses, including human cytomegalovirus (HCMV), evade host defenses.

253 unique feature of the herpesviruses, such as human cytomegalovirus (HCMV), is that they can undergo l

254 Similar to human cytomegalovirus (HCMV), rat cytomegalovirus (RCMV)

255 Human cytomegalovirus (HCMV), the prototypical betaherpe

256 During infection by human cytomegalovirus (HCMV), the tumor suppressor prote

257 In the important human pathogen human cytomegalovirus (HCMV), this complex consists of n

258 two laboratory strains (AD169 and Towne) of human cytomegalovirus (HCMV), which are known to use cel

259 The human cytomegalovirus (HCMV)-encoded viral cyclin-depend

260 c function than KIR2DS1- dNK when exposed to human cytomegalovirus (HCMV)-infected decidual stromal c

261 have an increased frequency in the blood of human cytomegalovirus (HCMV)-infected individuals.

262 , and IE2 are present at high frequencies in human cytomegalovirus (HCMV)-seropositive individuals, a

263 The role of human cytomegalovirus (HCMV)-specific T-cell responses i

264 on of the unrelated IE1 and pp71 proteins of human cytomegalovirus (HCMV).

265 ively as those of herpes simplex virus 1 and human cytomegalovirus (HCMV).

266 the manipulation of host cell metabolism by human cytomegalovirus (HCMV).

267 MP), for the detection and quantification of human cytomegalovirus (hCMV).

268 rse agonist activity on the US28 receptor of human cytomegalovirus (HCMV).

269 ring infection of triple-depleted cells with human cytomegalovirus (HCMV).

270 Human cytomegalovirus (HCMV, or human herpesvirus 5 [HHV

271 n factor and inhibits viral DNA replication (human cytomegalovirus [HCMV] and human papillomavirus [H

272 human antibody response to cytomegalovirus (human cytomegalovirus, HCMV) infection and found that an

273 Human cytomegalovirus immediate-early protein pUL37 x 1

274 The human cytomegalovirus immediate-early protein pUL37x1 in

275 irus 1 (HSV-1), HSV-2, human adenovirus, and human cytomegalovirus in cultured cells, and topical app

276 idates likely to influence the production of human cytomegalovirus in cultured human fibroblasts, inc

277 Human cytomegalovirus infection in individuals lacking a

278 Human cytomegalovirus infection in transplant recipients

279 I16 is not essential for the IFN response to human cytomegalovirus infection.

280 Importance: Human cytomegalovirus infects the majority of the Americ

281 ontrol of four important viral infections in humans: cytomegalovirus, influenza virus, HIV-1, and hep

282 ization of the majority of the population by human cytomegalovirus is a direct result of the virus's

283 The human cytomegalovirus opening reading frame UL144 is an

284 We investigated human cytomegalovirus pathogenesis by comparing infectio

285 The US11 gene product of human cytomegalovirus promotes viral immune evasion by h

286 The human cytomegalovirus protein US11 exploits this ER-asso

287 ng unrelated at the sequence level, ICP0 and human cytomegalovirus proteins IE1 and pp71 share some f

288 at this pUL89 endonuclease inhibitor blocked human cytomegalovirus replication at a relatively late t

289 ocalization of proteins and viral DNA within human cytomegalovirus replication compartments is not we

290 L89 endonuclease activity that also inhibits human cytomegalovirus replication in cell culture.

291 We have previously shown that the human cytomegalovirus signal-anchored protein known as v

292 The human cytomegalovirus terminase complex cleaves concatem

293 One component of the human cytomegalovirus terminase complex, pUL89, provides

294 In human cytomegalovirus, the complex consists of two prote

295 For example, in human cytomegalovirus, the nucleotide diversity estimate

296 The human cytomegalovirus UL34 gene encodes a sequence-speci

297 To understand the localization of the human cytomegalovirus viral replication factor UL84 rela

298 on or superinfection with hepatitis B virus, human cytomegalovirus virus, influenza, and Epstein-Barr

299 ural killer cells among donors infected with human cytomegalovirus with one or two copies of the alle

300 We recently reported a replication-defective human cytomegalovirus with restored pentameric complex g