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1                       Compounds can activate human ether-a-go-go-related gene 1 (hERG1) channels by s
2                                              Human ether-a-go-go-related gene 1 (hERG1) channels medi
3                                Activators of human ether-a-go-go-related gene 1 (hERG1) channels, suc
4                                          The human ether-a-go-go-related gene 1 (hERG1) encodes the p
5                                Activation of human ether-a-go-go-related gene 1 (hERG1) K(+) channels
6                                     Block of human ether-a-go-go-related gene 1 (hERG1) K(+) channels
7                                              Human ether-a-go-go-related gene 1 (hERG1) K(+) channels
8                                Activation of human ether-a-go-go-related gene 1 (hERG1) K(+) channels
9 ucleotide polymorphism 2660 G-->A within the human ether-a-go-go-related gene 1 coding sequence, whic
10 ingle-nucleotide polymorphisms (SNPs) in the human ether-a-go-go-related gene 1, hERG1, are associate
11                                              Human ether-a-go-go-related gene-1 (hERG1) K(+) channels
12 ts of mutations in the S4-S5 linker of HERG (human ether-a-go-go-related gene), a human delayed recti
13 an cardiac K(+) channel alpha subunits HERG (human ether-a-go-go-related gene) and KCNQ1 by suppressi
14 me ion channels and in particular, the hERG (human Ether-a'-go-go-Related Gene) cardiac potassium cha
15 nonrodent species, had no cytochrome P450 or human ether-a-go-go related gene channel issues, and was
16 limiting to a defined range of cLogP avoided human ether-a-go-go-related gene channel inhibition.
17 is of our previous studies of a mutant HERG (human ether-a-go-go-related gene) channel, we hypothesiz
18                We further engineered a hERG (human ether-a-go-go-related gene) channel, which, when u
19  unintentional blockade of the Kv11.1 (hERG [human ether-a-go-go-related gene]) channel are a major s
20 overexpression of the human K+ channel HERG (human ether-a-go-go-related gene) could enhance repolari
21                                          The human ether-a-go-go-related gene encodes hERG, a cardiac
22                                        HERG (human ether-a-go-go-related gene) encodes a delayed rect
23                                    The hERG (human ether-a-go-go-related gene) encodes the alpha subu
24                                    HERG, the human ether-a-go-go-related gene, encodes a K(+)-selecti
25 ll-derived cardiomyocytes (hESC-CMs) and the human ether-a-go-go-related gene expressing human embryo
26                                              Human ether a go-go related gene (hERG) potassium channe
27 yndrome type 2 is caused by mutations in the human ether a go-go-related gene (hERG) potassium channe
28 alters cardiac excitability by inhibition of human ether a-go-go related gene (hERG) trafficking and
29 ed rectifier current I(Kr) is encoded by the human ether a-go-go related gene (HERG).
30 2 long QT syndrome involves mutations in the human ether a-go-go-related gene (hERG or KCNH2).
31                                          The human ether a-go-go-related gene (HERG) encodes a K+ cha
32 ssion of the cardiac potassium channel I(Kr)/human ether a-go-go-related gene (hERG).
33 ct blockade of the cardiac potassium channel human ether a-go-go-related gene (hERG).
34 l lines expressing high levels of functional human ether-a go-go-related gene (HERG) channels.
35 tion of the current-voltage relationship for human ether-a'-go-go-related gene (hERG) channels.
36 tage sensor movement to the S6 domain in the human ether-a'-go-go-related gene (hERG) K+ channel.
37 ding activity but also significantly reduced human ether-a-go-go related gene (hERG) and sodium chann
38                                          The human ether-a-go-go related gene (hERG) can be inhibited
39 inking beta-adrenergic signaling and altered human ether-a-go-go related gene (HERG) channel activity
40           The proton and Zn2+ effects on the human ether-a-go-go related gene (HERG) channels were st
41                                 The KCNH2 or human ether-a-go-go related gene (hERG) encodes the Kv11
42 e compounds, they displayed affinity for the human ether-a-go-go related gene (hERG) ion channel.
43 The cardiac potassium channel encoded by the human ether-a-go-go related gene (HERG) is blocked by a
44                                     Block of human ether-a-go-go related gene (hERG) K(+) channels by
45                                              Human ether-a-go-go related gene (hERG) potassium (K(+))
46 seizure (sei), the Drosophila homolog of the human Ether-a-go-go Related Gene (hERG) potassium channe
47  often due to the off-target blockade of the human ether-a-go-go related gene (hERG) potassium channe
48 ly express wild-type (WT) and mutant (G601S) human ether-a-go-go related gene (hERG) potassium channe
49 onist with a high degree of selectivity over human ether-a-go-go related gene (hERG) potassium channe
50                                          The human ether-a-go-go related gene (hERG) potassium channe
51 +)(o)) and extracellular Na(+) (Na(+)(o)) in human ether-a-go-go related gene (HERG)-encoded K(+) cha
52 , which is characterized by mutations in the human ether-a-go-go related gene (hERG).
53 ividuals harbor mutations in either KCNQ1 or human ether-a-go-go related genes (hERG), which encode t
54             The effects of a mutation in the human ether-a-go-go-related gene (HERG) (Ser631 to Ala,
55                                  Activity of human ether-a-go-go-related gene (hERG) 1 voltage-gated
56 ort that alternate mRNA transcripts encoding human ether-a-go-go-related gene (hERG) 1a and 1b subuni
57  expression of the cardiac potassium channel human ether-a-go-go-related gene (HERG) at clinically re
58 irect block of the cardiac potassium channel human ether-a-go-go-related gene (hERG) but via disrupti
59                             Mutations in the human ether-a-go-go-related gene (hERG) cause chromosome
60                             Mutations in the human ether-a-go-go-related gene (HERG) cause chromosome
61                             Mutations in the human ether-a-go-go-related gene (HERG) cause long QT sy
62                        Many mutations in the Human Ether-a-go-go-Related Gene (HERG) cause type 2 con
63 T syndromes associated with loss and gain of human ether-a-go-go-related gene (hERG) channel activity
64  III antiarrhythmic compound that blocks the Human Ether-a-go-go-Related Gene (HERG) channel and its
65                      Mutations involving the human ether-a-go-go-related gene (HERG) channel are resp
66 patch-clamp electrophysiology to measure the human ether-a-go-go-related gene (hERG) channel block (t
67 silico approaches are widely used to predict human ether-a-go-go-related gene (hERG) channel blockade
68 uoromethyl-phenyl)-urea [NS1643 (NS)] on the human ether-a-go-go-related gene (hERG) channel expresse
69                                              Human ether-a-go-go-related gene (hERG) channel inhibiti
70        We want to apply this approach to the human ether-a-go-go-related gene (HERG) channel, whose o
71 embling those of the structurally dissimilar human ether-a-go-go-related gene (HERG) channel.
72 tide toxin purified from sea anemone, on the human ether-a-go-go-related gene (hERG) channel.
73                                              Human ether-a-go-go-related gene (hERG) channels lack th
74 unctional effects of extracellular Cd(2+) on human ether-a-go-go-related gene (HERG) encoded K(+) cha
75                                          The human ether-a-go-go-related gene (hERG) encodes a K(+) c
76                                          The human ether-a-go-go-related gene (HERG) encodes a K+ cha
77                                              Human ether-a-go-go-related gene (HERG) encodes the pore
78                                          The human ether-a-go-go-related gene (hERG) encodes the pore
79                                          The human ether-a-go-go-related gene (hERG) encodes the pore
80                                          The human ether-a-go-go-related gene (hERG) encodes the pore
81                                          The human ether-a-go-go-related gene (hERG) encodes the rapi
82                                              Human ether-a-go-go-related gene (HERG) encodes the rapi
83                  Ion channels encoded by the human ether-a-go-go-related gene (HERG) give rise to the
84  of the human voltage-dependent K(+) channel human ether-a-go-go-related gene (hERG) in myeloid leuke
85                  Unfortunately, 1 has potent human ether-a-go-go-related gene (hERG) inhibitory activ
86             Both CHK1 potency and off-target human ether-a-go-go-related gene (hERG) ion channel inhi
87                                          The human ether-a-go-go-related gene (HERG) is one locus for
88               The bulk of charge movement in human ether-a-go-go-related gene (hERG) is slow, as is r
89 prolongation directly target and inhibit the human ether-a-go-go-related gene (HERG) K(+) channel at
90  with QTc prolongation on the ECG target the human ether-a-go-go-related gene (HERG) K(+) channel by
91    Defective functional PM expression of the human ether-a-go-go-related gene (hERG) K(+) channel lea
92  of prolonged alpha1A-AR and PKC activity on human ether-a-go-go-related gene (HERG) K(+) channels (K
93                                              Human ether-a-go-go-related gene (HERG) K(+) channels ar
94                      The unusual kinetics of human ether-a-go-go-related gene (HERG) K(+) channels ar
95                                              Human ether-a-go-go-related gene (hERG) K(+) channels ha
96 0.5,act)) and inactivation (V(0.5,inact)) of human ether-a-go-go-related gene (hERG) K(+) channels.
97  (NS1643) is a newly discovered activator of human ether-a-go-go-related gene (hERG) K(+) channels.
98 clic nucleotide binding domain (CNBD) of the human ether-a-go-go-related gene (HERG) K+ channel are a
99  The molecular determinants of high-affinity human ether-a-go-go-related gene (HERG) potassium channe
100 emistry data demonstrate that RNF207 and the human ether-a-go-go-related gene (HERG) potassium channe
101                            Voltage-activated human ether-a-go-go-related gene (hERG) potassium channe
102            It promotes the maturation of the human ether-a-go-go-related gene (HERG) potassium channe
103                                    The human human ether-a-go-go-related gene (hERG) potassium channe
104                                              Human ether-a-go-go-related gene (hERG) potassium channe
105 T prolongation is usually caused by block of human ether-a-go-go-related gene (HERG) potassium channe
106                                          The human ether-a-go-go-related gene (HERG) product forms th
107 yndrome (LQT2) is caused by mutations in the human ether-a-go-go-related gene (HERG) that encodes the
108 ties in luciferase folding and repression of human ether-a-go-go-related gene (HERG) trafficking that
109  caused by loss-of-function mutations in the human ether-a-go-go-related gene (hERG) voltage-gated po
110 ryonic kidney cell line 293 cells expressing human ether-a-go-go-Related gene (hERG), a Food and Drug
111  with LQT, we identified a novel mutation in human ether-a-go-go-related gene (HERG), a voltage-gated
112                             Mutations in the human Ether-a-go-go-Related gene (HERG), encoding the pr
113 -rectifier K(+)-current (IKr) encoded by the human ether-a-go-go-related gene (hERG), is therefore re
114 HERG USO, a C-terminal splice variant of the human ether-a-go-go-related gene (HERG), the gene encodi
115 om mutations in several genes, including the human ether-a-go-go-related gene (HERG), which encodes a
116 channel, cause the disease, Mutations in the human ether-a-go-go-related gene (HERG), which encodes a
117 ctifier K(+) channel (IKr) is encoded by the human ether-a-go-go-related gene (hERG), which is import
118 en illustrated with the cloning of zebrafish human ether-a-go-go-related gene (HERG), which shows nea
119                                          The human Ether-a-go-go-related gene (hERG)-encoded K(+) cur
120 e the mechanism and site of action whereby a human ether-a-go-go-related gene (HERG)-specific scorpio
121 yndrome type 2 is caused by mutations in the human ether-a-go-go-related gene (hERG).
122  type 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG).
123                           The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcrip
124                                          The human ether-a-go-go-related gene (hERG; or KCNH2) encode
125                                         Both human ether-a-go-go-related gene (hERG1) and the closely
126 n the trafficking of subunits encoded by the human ether-a-go-go-related gene (hERG1) can lead to cat
127                 Alternate transcripts of the human ether-a-go-go-related gene (hERG1) encode two subu
128                                       Type 1 human ether-a-go-go-related gene (hERG1) potassium chann
129  lead compound 3, which had off-target hERG (human ether-a-go-go related gene) inhibition activity, l
130 dified to include dynamic drug-hERG channel (human Ether-a-go-go-Related Gene) interactions.
131                 Drug-induced blockade of the human ether-a-go-go-related gene K(+) channel (hERG) rep
132 the functional role of the C-terminus of the human ether-a-go-go-related gene K(+) channel HERG was i
133 hypothesis that anti-Ro Abs target the HERG (human ether-a-go-go-related gene) K(+) channel, which co
134 )) located in the S4-S5 linker endowed HERG (human ether-a-go-go-related gene) K(+) channels with the
135  report here inhibition by 4-AP of HERG (the human ether-a-go-go-related gene) K+ channels expressed
136 voltage-gated potassium channel subtype 11.1 human ether-a-go-go related gene (Kv11.1) (hERG) channel
137 lectivity over the serotonin 2A receptor and human ether-a-go-go-related gene potassium ion channel.
138      Drug-induced block of the cardiac hERG (human Ether-a-go-go-Related Gene) potassium channel dela
139                                              Human ether-a-go-go-related gene product (HERG) is a car
140                                    The HERG (human ether-a-go-go-related gene) protein, which underli
141 n that the unusually long S5-P linker lining human ether a-go-go related gene's (hERG's) outer vestib
142  responses more accurately than the standard human ether-a-go-go-related gene test or healthy control
143         Another possible target is HERG, the human ether-a-go-go-related gene that expresses a delaye
144                 Outward current conducted by human ether-a-go-go-related gene type 1 (hERG1) channels
145   The toxin had no effect on hKv1.4, hKv1.5, human ether-a-go-go-related gene type 1 (hERG1), or huma
146 g3 (Rg3) is a steroid glycoside that induces human ether-a-go-go-related gene type 1 (hERG1, Kv11.1)
147 , LQT2, results from mutations in HERG1, the human ether-a-go-go-related gene, which encodes a voltag

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