ライフサイエンスコーパス: human genetics

1 e to Mendelian disease is a major unknown in human genetics.

2 iety of America and the American Society for Human Genetics.

3 ses provide clues to the future direction of human genetics.

4 ecting phenotype pose a unique challenge for human genetics.

5 ields such as cancer biology, evolution, and human genetics.

6 tics and may directly facilitate progress in human genetics.

7 amed microRNAs, has changed the landscape of human genetics.

8 plicability of studies of canine behavior to human genetics.

9 mained an unanswered fundamental question in human genetics.

10 patients remains a significant challenge in human genetics.

11 umerous applications in empirical studies of human genetics.

12 o help to revolutionize our understanding of human genetics.

13 for analyzing polygenic traits as an aid in human genetics.

14 neous solution may be useful in the field of human genetics.

15 ward portal to the burgeoning information in human genetics.

16 1989 represents a landmark accomplishment in human genetics.

17 known routes of neurotoxicant metabolism and human genetics.

18 locus (QTL) represents a major challenge in human genetics.

19 torial disease genes is a major challenge in human genetics.

20 Canadian members of the American Society of Human Genetics.

21 hes conditions for the application of GMS to human genetics.

22 nheritance), has been a focus of interest in human genetics.

23 ng techniques have driven recent progress in human genetics.

24 ng the tools of modern molecular biology and human genetics.

25 s been a long-standing goal in mammalian and human genetics.

26 biomedical research, stem cell biology, and human genetics.

27 cing (WGS) data have ushered in a new era in human genetics.

28 s essential for a variety of applications in human genetics.

29 ed in the etiology of Alzheimer's disease by human genetics.

30 gions in the human genome is a major goal in human genetics.

31 cations for evolution, applied breeding, and human genetics.

32 icacy, but little is known about the role of human genetics.

33 f noncoding variants is a major challenge in human genetics.

34 greatly contributed to our understanding of human genetics.

35 of several new genes and genetic factors in human genetics.

36 , past and present, of this facile system to human genetics.

37 us genetic variation is a major challenge in human genetics.

38 ant and animal breeding, and increasingly in human genetics.

39 n is a fundamental question in evolution and human genetics.

40 lays a significant role in various fields of human genetics.

41 ng is becoming the primary discovery tool in human genetics.

42 atopoietic system, as evidenced by mouse and human genetics.

43 that will deliver mechanistic insights from human genetics.

44 breeding and is also receiving attention in human genetics.

45 disease; their exploration is a frontier in human genetics.

46 Taken together, these data from human genetics and animal models support a role for PDGF

47 ransmitted chromosomes, the implications for human genetics and disease are potentially considerable.

48 s of emphasis in ASD research, starting from human genetics and exploring how mouse models of human m

49 Human genetics and failed clinical trials have created s

50 This review summarizes the human genetics and genomic approaches that have shed lig

51 An important goal of human genetics and genomics is to understand the complet

52 this dire need, specifically in the area of human genetics and genomics, but knock-on effects are en

53 tudies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds

54 njunction more personally meaningful than in human genetics and medicine.

55 o disease phenotypes is a major challenge in human genetics and medicine.

56 ateral sclerosis has emerged from studies of human genetics and mouse models.

57 understanding of ASD from the standpoint of human genetics and neuropathology.

58 Studies of human genetics and pathophysiology have implicated the r

59 d by profound disparities between animal and human genetics and physiology.

60 tion is a key focus of evolutionary biology, human genetics and plant breeding.

61 Human genetics and stem cell biology have advanced neuro

62 -range position effect found in the field of human genetics and the first report of a patient with CD

63 nderstanding the complex interaction between human genetics and the microbiome in the context of huma

64 se findings recapitulate certain features of human genetics and therefore establish a novel cell cult

65 Recent advances in molecular biology, human genetics, and functional genomics tremendously inc

66 The combination of human genetics, animal models, and induced pluripotent s

67 Study sample sizes in human genetics are growing rapidly, and in due course it

68 Advances in human genetics are leading to the discovery of new disea

69 ation, especially those with applications to human genetics, are not well developed.

70 will be an important test of the utility of human genetics as a starting point for drug discovery in

71 Here we use human genetics as an approach to identify an angiogenic

72 n genomes, bringing even deeper insight into human genetics as well as the genetics of millions of ot

73 llitus (T1D) onset is mediated by individual human genetics as well as undefined environmental influe

74 his white paper from the American Society of Human Genetics (ASHG) Ancestry and Ancestry Testing Task

75 In 1995, the American Society of Human Genetics (ASHG) and American College of Medical Ge

76 To respond, an American Society of Human Genetics (ASHG) workgroup developed this position

77 ase, scientists from the American Society of Human Genetics (ASHG), the Genetics Society of America (

78 creative essay as a novel tool for teaching human genetics at the college level.

79 Ps) have been the focus of much attention in human genetics because they are extremely abundant and w

80 bolism is being elucidated through mouse and human genetics, biochemistry, and cell biology.

81 productive Medicine, Asia Pacific Society of Human Genetics, British Society for Genetic Medicine, Hu

82 in particular, summarizes recent findings in human genetics broadly that are driving the reevaluation

83 source for a large number of applications in human genetics, but computationally inferred haplotypes

84 ion of rare variants is an important goal of human genetics, but resequencing of a sample large enoug

85 Human genetics can help advance the therapeutic enterpri

86 (e.g., the NF-kappaB signaling pathway), and human genetics can subset disease into clinically meanin

87 These examples demonstrate the ways in which human genetics can validate candidate genes, as well as

88 ses from the National Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) consortium.

89 The human genetics community needs robust protocols that ena

90 orically received prominent attention in the human genetics community, primarily related to the searc

91 laying an increasingly important role in the human genetics community.

92 Using human genetics data and postmortem gene expression data,

93 Human genetics data point to a key role for microglia in

94 nt in vivo functional evidence together with human genetics data strongly suggest that mutations in a

95 rtantly, superimposition of these results to human genetics data suggests a previously underappreciat

96 Consistent with our human genetics data, suppression of the exon 41 ortholog

97 e Online Mendelian Inheritance in Man (OMIM) human genetics database and other protein databases for

98 The three-way interactions between human genetics, diet, and the microbiota fundamentally s

99 ublished recently in Cell bring the power of human genetics, Drosophila genetics, and genomics to bea

100 Paralleling the major advances in human genetics during recent decades, we have come to un

101 at we believe must be addressed to translate human genetics efficiently into new therapeutics for bra

102 rs in Asia, and Southern African Society for Human Genetics, endorsed the final statement.

103 tical, epidemiological, and quantitative and human genetics fields.

104 Here, we review the human genetics findings coalescing on molecular mechanis

105 tor creates a direct phenotypic link between human genetics (G versus A alleles cause Cys529 versus T

106 in sperm may have widespread applications in human genetics, genetic toxicology, and reproductive med

107 onsidered in the context of other aspects of human genetics, gut bacterial genetics, and environmenta

108 Human genetics has been haunted by the mystery of "missi

109 Human genetics has indicated a causal role for the prote

110 We also discuss how progress in human genetics has led to the generation of mouse models

111 Human genetics has seen a surge of interest in genetic v

112 The combination of mouse and human genetics has the potential to identify and validat

113 Meanwhile, the field of human genetics has undergone a series of rapid transitio

114 ical, and social implications of research in human genetics have been discussed in depth, particularl

115 Tremendous advances in human genetics have been made in recent years, as the fr

116 Human genetics have been used to recently 'validate' gen

117 Advances in human genetics have dramatically expanded our understand

118 Recent advances in human genetics have identified dominant mutations in the

119 Human genetics have implicated the 5-lipoxygenase enzyme

120 families and explore how mouse genetics and human genetics have intersected to advance our knowledge

121 acterial molecular genetics, immunology, and human genetics have yielded insight into the molecular d

122 examples of genetically modified food and of human genetics help to illustrate the issues involved.

123 isting bioinformatics structures relevant to human genetics, HGMD has established itself as the centr

124 approaches inform disease biology by placing human genetics in a molecular systems and neurobiologica

125 s of gHAT epidemics and evidence implicating human genetics in HAT epidemiology.

126 f host-pathogen interactions and the role of human genetics in influencing the outcome of infections.

127 The focus of human genetics in recent years has shifted toward identi

128 Africa but little is known about the role of human genetics in susceptibility.

129 osis, have not previously been implicated by human genetics in the molecular mechanisms of this pheno

130 g radiation has been a long-standing goal of human genetics in the past 50 years.

131 udies on Mental Disorders, also known as the Human Genetics Initiative (HGI).

132 s in the National Institute of Mental Health Human Genetics Initiative linkage samples for bipolar di

133 from the National Institute of Mental Health Human Genetics Initiative Repository, and the Prechter R

134 be an approach to translate discoveries from human genetics into functional and therapeutic hypothese

135 Human genetics is a rational starting point for target i

136 ains more than 1,000 different proteins, and human genetics is identifying new ciliopathy genes at an

137 A major challenge in human genetics is identifying the molecular basis of com

138 Human genetics is now at a critical juncture.

139 A major challenge in human genetics is pinpointing which non-coding genetic v

140 An important question in human genetics is the extent to which genes causing mono

141 Currently, a major focus of human genetics is the utilization of single-nucleotide p

142 A major interest in human genetics is to determine whether a nonsynonymous s

143 A major challenge in human genetics is to devise a systematic strategy to int

144 One of the central goals of human genetics is to discover the genes and pathways dri

145 ajor focus of current sequencing studies for human genetics is to identify rare variants associated w

146 ide association studies, a critical focus of human genetics is to understand how genetic variation at

147 ide association studies, a critical focus of human genetics is to understand how genetic variation at

148 One goal of human genetics is to understand the genetic basis of dis

149 The central goal of human genetics is to understand the inherited basis of h

150 A major goal in human genetics is to understand the role of common genet

151 ide polymorphisms (SNPs), a central issue in human genetics is whether it is now possible to use link

152 netic modifications or regulators, and these human genetics lessons have demonstrated the importance

153 tion studies is difficult and, especially in human genetics, likely to result in underestimating the

154 power for the sample sizes commonly used in human genetics linkage studies, minor QTL effects often

155 We have also surveyed the human genetics literature for associations to disease ca

156 junction with the annual American Society of Human Genetics meeting, participants explored new approa

157 in the past few years, and a new chapter of human genetics, "mitochondrial genetics," has opened up

158 Despite recent advances in human genetics, model organisms are indispensable for hu

159 Advancements in human genetics now poise the field to illuminate the pat

160 elopments that have occurred in the field of human genetics of infectious diseases from the second ha

161 Here I review the history of the field of human genetics of infectious diseases from the turn of t

162 The human genetics of left ventricular noncompaction cardiom

163 Human genetics offers new possibilities for understandin

164 aordinary technical advances in the field of human genetics over the past few years have catalyzed an

165 The remarkable achievements in human genetics over the years have been due to technolog

166 Studies of human genetics, particularly genome-wide association stu

167 d relationships between clinical parameters, human genetics, pharmacokinetics, and human immunodefici

168 the relevant entries in online databases for human genetics, protein and nucleic acid sequence data a

169 as reference genome sequences revolutionized human genetics, reference maps of interactome networks w

170 etic risk prediction is an important goal in human genetics research and precision medicine.

171 One concern in human genetics research is maintaining the privacy of st

172 the major tasks associated with contemporary human genetics research.

173 integration of findings from mouse models to human genetics resulted in considerable progress toward

174 some societal and legal ramifications of the human genetics revolution.

175 otic cell death; and they also contribute to human genetics since mitochondria have a functional geno

176 etics, British Society for Genetic Medicine, Human Genetics Society of Australasia, Professional Soci

177 Large-scale human genetics studies have begun to reveal molecular pa

178 Despite two decades of mouse immunology and human genetics studies, the pathogenesis of Crohn's dise

179 Recent human-genetics studies have come to different conclusion

180 ominantly European ancestry in the DiscovEHR human genetics study.

181 tion, evidence from model organisms and from human genetics suggests that cohesin is involved in the

182 This paper highlights changes in human genetics that support a curricular reorganization,

183 id the foundation for profound insights into human genetics, the intricacies of regulation and develo

184 the recent increase in study sample sizes in human genetics, there has been growing interest in infer

185 Human genetics thus identifies TRAIP as a component of t

186 tion, including a range of approaches to use human genetics to inform drug discovery and make better

187 Here, we summarize a strategy for applying human genetics to neuroscience drug discovery.

188 y, a confluence of discoveries in areas from human genetics to physiology, cell biology, and biophysi

189 he symptoms of RA highlights the promises of human genetics to provide insights in the disease biolog

190 sease models are converging with advances in human genetics to shed new light on puzzling clinical ph

191 One of the grand challenges of human genetics to systematically map by gene-association

192 the power of linking proteomic networks and human genetics to uncover critical disease pathways.

193 summarizes recent developments in the use of human genetics to validate candidate genes in lipoprotei

194 ts remains one of the greatest challenges in human genetics today.

195 Modeling human genetics using a high-throughput pluripotent stem

196 olutionary history, protein localization and human genetics, we have identified a conserved mitochond

197 th growing evidence from transgenic mice and human genetics, we propose that Abeta40 plays a critical

198 ussed is available in Mendel 9.0 at the UCLA Human Genetics web site.

199 e most essential and fundamental concepts of human genetics were first decoded in the fly.

200 tral to the scientific and clinical goals of human genetics, which are to understand disease aetiolog

201 c phases of associative learning we combined human genetics with experimental gene expression studies

202 In this study, we coupled human genetics with functional validation in zebrafish a