ライフサイエンスコーパス: human growth hormone

1 -kDa hPRLBP capable of binding both hPRL and human growth hormone.

2 cytosis, we used PC12 cells transfected with human growth hormone.

3 as determined by serum radioimmunoassay for human growth hormone.

4 in nor syntaxin 2 caused the cells to retain human growth hormone.

5 the minor loop disulfide at Cys182-Cys189 in human growth hormone.

6 te-specifically glycosylated variants of the human growth hormone.

7 of aberrant splicing of transcripts encoding human growth hormone.

8 he location of metal-binding His residues of human growth hormone.

9 ive daily intramuscular doses of recombinant human growth hormone (0.15 mg rhGH/kg/day).

10 domly assigned to receive either recombinant human growth hormone, 0.1 mg/kg of body weight per day (

11 lpha-2b, letrozole, Y-27632, octreotide, and human growth hormone, all delivered at clinically-releva

12 ms addressing the safety and tolerability of human growth hormone analogues.

13 ix D, similar to the first crossover loop in human growth hormone and granulocyte colony-stimulating

14 rombomodulin, as seen for the interaction of human growth hormone and insulin with their receptors.

15 maceutical products, such as erythropoietin, human growth hormone and interferons.

16 protein-protein complexes; barnase-barstar, human growth hormone and its receptor, subtype N9 influe

17 on and refolding of denatured and aggregated human growth hormone and lysozyme, and beta-lactamase in

18 2-K208A inhibited secretion of cotransfected human growth hormone and of noradrenalin.

19 side chains buried at the interface between human growth hormone and the extracellular domain of its

20 verage of a therapeutic protein, recombinant human growth hormone, and in detection of single amino a

21 n molecules within aggregates of recombinant human growth hormone are responsible for the rate-limiti

22 With the use of human growth hormone as a model protein, the potential o

23 In recent years, the use of recombinant human growth hormone as a therapeutic modality has great

24 By contrast, co-expression of Dyn/K44A with human growth hormone as an insulin secretory marker resu

25 beta2-microglobulin, immunoglobulin G1, and human growth hormone as model systems, we demonstrate th

26 Using human growth hormone as the encoded foreign Ag for immun

27 ing DNA from the baboon SP-A2 gene linked to human growth hormone, as reporter) containing TBEs, or w

28 C) demonstrated functional complexation with human growth hormone binding protein (hGHBp) to the diff

29 transplant, early institution of recombinant human growth hormone can promote growth.

30 ottom-up method, for the characterization of human growth hormone degradation products.

31 he large intron of Fgf8 was found to enhance human growth hormone expressed from the Fgf8 promoter 3-

32 tein and cell specificity; newly synthesized human growth hormone expressed in AtT20 cells underwent

33 lubility with time, but albumin did not, and human growth hormone expressed in COS cells underwent le

34 sulted in long term (16 weeks) expression of human growth hormone following intracardiac, yet not int

35 s, increasing the intracellular half-life of human growth hormone from 90 min to 18 h.

36 ts S43D mutant on the regulated secretion of human growth hormone from PC12 cells.

37 Release of human growth hormone from syntaxin 1A-expressing cells w

38 Ca2+-dependent secretion of human growth hormone from transfected PC12 cells was tri

39 ng adenocarcinoma cells together with an SPA:human growth hormone fusion gene (255 base pairs of 5'-f

40 ed by comparing the expression of four Fabpl/human growth hormone fusion genes in multiple pedigrees

41 cific exon I.1 5' flanking DNA linked to the human growth hormone gene (hGH), as reporter, were intro

42 Human growth hormone gene (hGH-N) expression is activate

43 The human growth hormone gene (hGH-N) is regulated by a dist

44 s the mouse metallothionein promoter and the human growth hormone gene (MThGH).

45 ated from an empirical haplotype data set of human growth hormone gene 1.

46 The cDNA was linked to a fragment of the human growth hormone gene and in transgenic animal studi

47 The human growth hormone gene cluster is composed of five cl

48 olymorphism at the neighboring locus for the human growth hormone gene failed to support any role of

49 day C2C12 myotubes utilizing the therapeutic human growth hormone gene formulated in an optimal pepti

50 Transgenic mice generated with the human growth hormone gene fused to 800 bp of the mCC10 p

51 -flanking region of the HL gene fused to the human growth hormone gene were transfected in HepG2 cell

52 a nearby microsatellite polymorphism of the human growth hormone gene, supported a role of the ACE l

53 r in conjunction with sequences encoding the human growth hormone gene.

54 To rescue pancreatic expression, the human growth hormone genomic sequence was co-integrated

55 h adenoviral transduction, we have expressed human growth hormone (GH) as a model of regulated secret

56 y, we have detected mutations in IVS3 of the human growth hormone (GH) gene that affect a putative, h

57 Recombinant human growth hormone (GH) improves in vivo cardiac funct

58 Human growth hormone (GH) is widely used as an antiaging

59 ells by measuring secretion of cotransfected human growth hormone (GH, a reporter for the regulated s

60 For some, like Turner syndrome, recombinant human growth hormone has become the standard of care.

61 Recombinant human growth hormone has been employed to ameliorate gro

62 A high-affinity variant of human growth hormone (hGH(v)) contains 15 mutations with

63 Mutations introduced into human growth hormone (hGH) (Thr175 --> Gly-hGH) and the

64 henylalanine (pAcF) at distinct locations in human growth hormone (hGH) allowed site-specific conjuga

65 It has previously been shown that a human growth hormone (hGH) analog, hGH-G120R, acts as a

66 ntal lactogen (hPL) is highly conserved with human growth hormone (hGH) and both hormones bind to the

67 Human growth hormone (hGH) and bovine neurophysin (bNP)

68 Using human growth hormone (hGH) and human leptin (hLeptin) as

69 allosteric dynamics by conducting studies on human growth hormone (hGH) and pyrin domain (PYD), and t

70 Remodeling of the interface between human growth hormone (hGH) and the extracellular domain

71 - optimized, high-affinity Site 1 variant of human growth hormone (hGH) and two copies of the extrace

72 the constitutive release of marker proteins human growth hormone (hGH) and vesicular stomatitis viru

73 n assay in PC12 cells expressing transfected human growth hormone (hGH) as a reporter protein.

74 Using PC12 cells that express transfected human growth hormone (hGH) as a secreted reporter protei

75 Human growth hormone (hGH) binds lactogenic or somatotro

76 he high affinity binding site (Site1) of the human growth hormone (hGH) binds to its cognate receptor

77 in adult skin and that keratinocyte-derived human growth hormone (hGH) can be produced, secreted, an

78 The five genes of the human growth hormone (hGH) cluster are expressed in eith

79 The human growth hormone (hGH) cluster contains five genes.

80 ach was applied to the high affinity site of human growth hormone (hGH) for binding to its receptor (

81 tivity in the high affinity site (site 1) of human growth hormone (hGH) for binding to its receptor.

82 e is situated between the pituitary-specific human growth hormone (hGH) gene and its locus control re

83 robust and tissue-specific activation of the human growth hormone (hGH) gene cluster in the pituitary

84 The human growth hormone (hGH) gene is controlled by a long-

85 High-level expression of the human growth hormone (hGH) gene is limited to somatotrop

86 An indirect immunoassay format with human growth hormone (hGH) immobilized on the self-assem

87 on from cells that are engineered to secrete human growth hormone (hGH) in response to stimulation by

88 have generated transgenic mice that express human growth hormone (hGH) in their bladder epithelium,

89 The designed G120R mutant of human growth hormone (hGH) is an antagonist and can bind

90 Human growth hormone (hGH) is known to play a functional

91 contrast to rodent growth hormone loci, the human growth hormone (hGH) locus is regulated by a dista

92 The human growth hormone (hGH) minigene used for transgene s

93 The human Growth Hormone (hGH) multigene cluster contains fi

94 Derivatives of human growth hormone (hGH) of increasing size were produ

95 a Pax6 consensus binding site driving either human growth hormone (hGH) or Cre recombinase genes.

96 largely from its structural homology to the human growth hormone (hGH) receptor and known structure

97 The dimer assembly differs from that of the human growth hormone (hGH) receptor complex and suggests

98 e, consisting of the extracellular domain of human growth hormone (hGH) receptor, and the intracellul

99 ptor dimerization, except for studies of the human growth hormone (hGH) receptor.

100 cells was noted to transactivate the genomic human growth hormone (hGH) reporter construct in the abs

101 es of full-length and truncated NGF promoter-human growth hormone (hGH) reporter gene plasmids to inv

102 the human sMtCK gene ligated upstream of the human growth hormone (hGH) reporter gene.

103 Human growth hormone (hGH) stimulates somatogenic and la

104 rus (AAV) vectors, one encoding an inducible human growth hormone (hGH) target gene, and the other a

105 Recombinant human growth hormone (hGH) therapy in children with Prad

106 arison, we contrast IgG binding with that of human growth hormone (hGH) to its receptor (hGH-R) which

107 Here, using in vivo analysis of a human growth hormone (hGH) transgene locus, we report th

108 e rats were immunized with plasmids encoding human growth hormone (HGH) under the control of a cytome

109 ions, we examine the binding of a variety of human growth hormone (hGH) variants to the human growth

110 An injectable sustained-release form of human growth hormone (hGH) was developed by stabilizing

111 Ectopic human growth hormone (hGH) was highly expressed in MIP-C

112 Expression of human growth hormone (hGH) was targeted to growth hormon

113 trol of different promoters directed against human growth hormone (hGH) were constructed and infused

114 This result shows the similarity of hPRL to human growth hormone (hGH), a member of the same family

115 We utilized human growth hormone (hGH), a protein with a well define

116 o Rab11a-positive DFV, but virally expressed human growth hormone (hGH), a secretory protein, was pac

117 Human growth hormone (hGH), and its receptor interaction

118 s erythropoietin (EPO), interleukin-4 (IL4), human growth hormone (hGH), and prolactin (PRL) all form

119 was determined from the X-ray structures of human growth hormone (hGH), LIF, and G-CSF where the ali

120 to direct attachment of a secreted protein, human growth hormone (hGH), to the membranes of COS cell

121 The monomeric protein, human growth hormone (hGH), was fused to the N terminus

122 Signaling in the human growth hormone (hGH)-human GH receptor system is i

123 The human growth hormone (hGH)-receptor interaction was used

124 two-thirds of the contact side chains at the human growth hormone (hGH)-receptor interface have littl

125 the IL-3.IL-3 receptor complex based on the human growth hormone (hGH).hGH soluble receptor complex

126 ve investigated the weak self-association of human growth hormone (hGH, KD = 0.90 +/- 0.03 mM) at neu

127 Human growth hormone (hGH-N) expression in the pituitary

128 Activation of the human growth hormone (hGH-N) gene in pituitary somatotro

129 Expression of the human growth hormone (hGH-N) transgene in the mouse pitu

130 e of secretion of a nonglycosylated protein (human growth hormone [hGH]) that was secreted equally fr

131 ra-high-affinity receptor binding variant of human growth hormone (hGHv) that has been previously aff

132 and numerous recombinant products, including human growth hormone, human erythropoietin and granulocy

133 eased the effective detection sensitivity of human growth hormone in human urine using multiple react

134 ate its use to control circulating levels of human growth hormone in mice implanted with engineered h

135 ed by characterizing the interaction between human growth hormone in solution and the corresponding a

136 detected a trisulfide structure in methionyl human growth hormone in the major loop disulfide Cys53-C

137 ted in consistently high induction levels of human growth hormone in the presence of mifepristone whe

138 The efficacy of recombinant human growth hormone in the treatment of growth hormone

139 ministration of anabolic agents, recombinant human growth hormone, insulin, oxandrolone, or anticatab

140 ergy expenditure, muscle strength, and serum human growth hormone, insulin-like growth factor-I (IGF-

141 urothelium can secrete ectopically expressed human growth hormone into the urine, our data establish

142 Although recombinant human growth hormone is commonly used to treat the short

143 nd clinical testing of a monthly formulation human growth hormone is currently in progress.

144 Human growth hormone is now readily available and approv

145 Human growth hormone is reportedly used to enhance athle

146 Treatment with recombinant human growth hormone likely increases the IGF levels in

147 tion when inserted into the 5'-leader of the human growth hormone mRNA.

148 ion enhancing efficiency of CriticalSorb for human growth hormone (MW 22 kDa) was investigated in the

149 ization of disulfide linkages of recombinant human growth hormone (Nutropin), a therapeutic monoclona

150 leased four pulses of radiolabelled dextran, human growth hormone or heparin in vitro.

151 crosis factor (TNF)-alpha (both P<.002), and human growth hormone (P<.05).

152 ptic digest of bovine serum proteins or to a human growth hormone peptide digest at concentration rat

153 (DQA1*05, DQB1*02, DQB1*03:02 alleles), and human growth hormone (positive control).

154 lic bone disease, and the use of recombinant human growth hormone provide some hope for catch-up grow

155 ate following administration of biosynthetic human growth hormone (r-hGH) to short normal children.

156 f human growth hormone (hGH) variants to the human growth hormone receptor (hGHR) and the human prola

157 Two isoforms of the human growth hormone receptor (hGHR), which differ in th

158 ivation of human erythropoietin receptor and human growth hormone receptor and is supported by eviden

159 Comparison of the structure to that of the human growth hormone receptor, which belongs to a differ

160 a small set of contacts are crucial for the human growth hormone-receptor interaction.

161 ry marker resulted in a marked inhibition of human growth hormone release by glucose, KCl, and a comb

162 s significant reduction in high K(+)-induced human growth hormone release, the S43D mutant fails to i

163 erplasia induced by transgenic expression of human growth hormone-releasing hormone (GHRH) is signifi

164 Some antagonists of human growth hormone-releasing hormone (hGH-RH) synthesi

165 Antagonists of human growth hormone-releasing hormone (hGHRH) with incr

166 hypothesis, metallothionein promoter-driven, human growth hormone-releasing hormone (MT-hGHRH) transg

167 relationship scans of the active fragment of human growth hormone-releasing hormone, [Nle27]-hGHRH(1-

168 Nevertheless, the use of recombinant human growth hormone remains limited in patients with CR

169 others, the ultimate benefit of recombinant human growth hormone remains to be determined.

170 the human E-selectin promoter linked to the human growth hormone reporter gene (pE525-GH).

171 Stable transfection of ES cells, using a human growth hormone reporter gene, was employed to iden

172 -2038 to +15 of the rat LPH gene fused to a human growth hormone reporter gene.

173 cleotides -596 to +21 of Fabpl linked to the human growth hormone reporter, (ii) 4 additional copies

174 Benefits of recombinant human growth hormone (rhGH) alone or combined with gluta

175 t evidence concerning the use of recombinant human growth hormone (rhGH) as a potential therapy in ac

176 Pharmacologic doses of recombinant human growth hormone (rhGH) constitute another potential

177 uma center who were treated with recombinant human growth hormone (rhGH) for > or =7 days.

178 own to promote the absorption of recombinant human growth hormone (rhGH) from the gastrointestinal tr

179 Recombinant human growth hormone (rHGH) has been shown to increase m

180 The structural stability of recombinant human growth hormone (rhGH) has been studied by differen

181 method for the quantification of recombinant human growth hormone (rhGH) in serum has been developed

182 Recombinant human growth hormone (rhGH) reduces visceral adipose tis

183 Recombinant human growth hormone (rhGH) therapy is used in the long-

184 Administration of recombinant human growth hormone (rhGH) to critically ill adults in

185 d children during treatment with recombinant human growth hormone (rhGH), and to ascertain whether de

186 e previously shown that low-dose recombinant human growth hormone (rhGH), given to children after a s

187 e exogenous hormones estrogen or recombinant human growth hormone (rhGH).

188 ng the last decade, we have used recombinant human growth hormone (rhGH; 0.2 mg/kg/day s.q.) to succe

189 Somatropin (i.e., recombinant human growth hormone, rhGH) modified with the chelating

190 and growth retardation received recombinant human growth hormone (rHuGH) for 1 year.

191 1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor.

192 domimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS).

193 tagogue, ghrelin, is a potent agonist at the human growth hormone secretagogue receptor 1a (hGHSR1a).

194 wide range of product variants in samples of human growth hormone secreted from Pichia pastoris.

195 were cotransfected with a plasmid encoding a human growth hormone secretion reporter along with eithe

196 ansfection analyses with plasmids in which a human growth hormone structural gene was under the contr

197 Low-dose recombinant human growth hormone successfully abates muscle cataboli

198 inserted the regulator GLp65 and a regulable human growth hormone target gene containing the 17-mer G

199 erved residues form a compact cluster in the human growth hormone tertiary structure.

200 uthors review the most important trials with human growth hormone that have been carried out recently

201 romoter is linked to the structural gene for human growth hormone that is biologically inactive (AF2-

202 ted efficacy and safety comparable to native human growth hormone therapy but with increased potency

203 Recombinant human growth hormone therapy of children with idiopathic

204 to recognize that the impact of recombinant human growth hormone therapy on adult height has not bee

205 Deciding when to pursue recombinant human growth hormone therapy to increase adult height is

206 ween antiepileptic drugs and the efficacy of human growth hormone therapy, and few data are available

207 A recently designed human growth hormone/transferrin fusion protein (GHT) re

208 Expression of the MIS-human growth hormone transgene (MIS/GH) is restricted to

209 ted the expression of the collagen alpha1(I) human growth hormone transgene containing -2.3 kb of the

210 detected in a mixture containing 20 fmol of human growth hormone tryptic digest mixed with the bovin

211 studies with transgenic mice expressing the human growth hormone under the direction of 5' regulator

212 ensions containing aggregates of recombinant human growth hormone (up to 8.7 mg/ml) and 0.75 M GdmHCl

213 ess the role of dynamics for a high-affinity human growth hormone variant (hGHv) and the wild-type gr

214 Human growth hormone was targeted to and released from s

215 XTEN fusions to exenatide, glucagon, GFP and human growth hormone, we expect that XTEN will enable do

216 oluble, non-native aggregates of recombinant human growth hormone were formed by agitation in buffer

217 esence of an analogous metal-binding site in human growth hormone, which is located in the hydrophobi

218 genous CHGA and SCG2, as well as transfected human growth hormone, while SCG10 siRNA decreased the le