ライフサイエンスコーパス: human lung

1 were remarkably similar to the native adult human lung.

2 ylate cyclase is expressed in the developing human lung.

3 uryl alcohol and methyleugenol in samples of human lung.

4 cterize the major NK cell populations in the human lung.

5 tively little is known about NK cells in the human lung.

6 s most efficiently in the alveolar region of human lungs.

7 cosystems ranging from soil to freshwater to human lungs.

8 but could potentially establish infection in human lungs.

9 that potentially access inhaled antigens in human lungs.

10 s but has limited or no expression in normal human lungs.

11 colin has been demonstrated to be present in human lungs.

12 d has been partially explored in porcine and human lungs.

13 ery in small (rodent) and large (porcine and human) lungs.

14 f engineered nanoparticles (NPs) on cultured human lung A549 cells directly from the gas phase.

15 monary endothelial cells, a cell type in the human lung accessible to influenza virus following damag

16 ted the finding of reduced CD8(+) content in human lung ADCA.

17 nes including human hepatocarcinoma (Huh-7), human lung adenocarcinoma (A549), and human fibrosarcoma

18 e cell-lethal phenotype of ADAR1 deletion in human lung adenocarcinoma A549 cells is rescued by CRISP

19 d a high level of expression of miR-155 in a human lung adenocarcinoma A549R cell line that is highly

20 e determined that miR-31 is overexpressed in human lung adenocarcinoma and this overexpression indepe

21 del and invasion and replication assays with human lung adenocarcinoma cell line A549.

22 (S1PR3) are increased in a panel of cultured human lung adenocarcinoma cell lines, and that S1PR3-med

23 c expression of S1PR3 promotes the growth of human lung adenocarcinoma cells in animals.

24 iferation, soft agar growth, and invasion of human lung adenocarcinoma cells in vitro In the present

25 n drug-stressed human and mouse melanoma and human lung adenocarcinoma cells.

26 we discovered that poor patient prognosis in human lung adenocarcinoma is associated with low miR-26

27 D1/integrin beta3 axis, was also detected in human lung adenocarcinoma specimens.

28 he present study, we examine S1PR3 levels in human lung adenocarcinoma specimens.

29 Here we show that human lung adenocarcinoma tissue expresses high levels o

30 gly, tumors with reduced IRS-1 staining in a human lung adenocarcinoma tissue microarray displayed a

31 Analysis of human lung adenocarcinoma tissues revealed that the cDDP

32 combined tumor barcoding in a mouse model of human lung adenocarcinoma with unbiased genomic approach

33 d immunodeficiency mice bearing H2009 tumor (human lung adenocarcinoma) xenografts.

34 in-modifying genes are frequently mutated in human lung adenocarcinoma, but the functional impact of

35 first show, using primary cell cultures from human lung adenocarcinoma, that the effectors of the Hip

36 ssor pathways that are frequently altered in human lung adenocarcinoma.

37 Human lung adenocarcinomas (LUAD) contain mutations in E

38 potential impact of 19 well-defined DCAFs in human lung adenocarcinomas (LuADCs) using integrative om

39 typic complexity of the immune infiltrate in human lung adenocarcinomas and renal cell carcinomas can

40 In human lung adenocarcinomas and squamous cell carcinomas,

41 rcinoma (Kras(LA1)), here we postulated that human lung adenocarcinomas containing Thy-1(+) CAFs have

42 Here we show that mouse and human lung adenocarcinomas display hierarchical features

43 licated in activation of the PI3K pathway in human lung adenocarcinomas driven by EGFR mutations.

44 initiating oncogenic event in almost half of human lung adenocarcinomas is still unknown, a fact that

45 vels of S1PR3 are significantly increased in human lung adenocarcinomas when compared with normal lun

46 est that levels of S1PR3 are up-regulated in human lung adenocarcinomas, at least in part due to the

47 verage mutational frequency than observed in human lung adenocarcinomas.

48 , S1PR3 activity promotes the progression of human lung adenocarcinomas.

49 xamined the location of Thy-1(+) CAFs within human lung adenocarcinomas.

50 Treatment of human lung airway explants with recombinant NPY increase

51 MCs (non-Fib MCs), MCs derived from fibrotic human lung allografts (Fib-MCs) demonstrated increased p

52 ation of miR-221 in total RNA extracted from human lung and breast cancer cell lines, discriminating

53 ompetent cancer (LCC) cells from early stage human lung and breast carcinoma cell lines and defined t

54 ve MRC-5 cells compared with TRAIL-sensitive human lung and colon cancer cells.

55 In human lung and colorectal tumors, RAS pathway activation

56 onstruction map on a radiological image of a human lung and forms an interactive resource for the sci

57 Consistently, in human lung and head and neck carcinomas, STAT3 acetylati

58 ALK, ROS1, RET, and NTRK1 act as drivers in human lung and other cancers.

59 unctional characteristics of NK cells in the human lung and peripheral blood at the single-cell level

60 r phagocytes isolated from whole nondiseased human lungs and lung-draining lymph nodes.

61 l Ag-presentation molecule HLA-DR within the human lung, and that this expression can be recapitulate

62 ata are available on NiV pathogenesis in the human lung, and the relative contribution of the innate

63 ited waterpipe use has broad consequences on human lung biology and health.

64 multaneous analysis of the 16 DNA adducts in human lung biopsy specimens.

65 has been validated by a preliminary test on human lung biopsy, which has confirmed the ex-vivo CK17

66 ue capability to examine brain metastasis of human lung, breast and melanoma cells and their therapeu

67 e report the identification of 555 piRNAs in human lung bronchial epithelial (HBE) and non-small cell

68 present study shows that As(3+)-transformed human lung bronchial epithelial BEAS-2B cells (AsT cells

69 MEG-01 cells to be higher than those in the human lung but lower than in the human pancreas.

70 al load, implying that CD8+ Trm cells in the human lung can confer protection against severe respirat

71 miniaturized probes were validated in single human lung cancer A549 cells to demonstrate applicabilit

72 Evaluation of human lung cancer and adjacent nontumor tissues revealed

73 s generated by injection of a LH2-expressing human lung cancer cell line into nude mice.

74 Lewis lung carcinoma (LLC1) and 10 different human lung cancer cell lines (adenocarcinoma, squamous c

75 zed both our Kras/p53 mutant mouse model and human lung cancer cell lines to demonstrate that upon mi

76 n-small-cell lung cancers and in Ras-mutated human lung cancer cell lines.

77 r SLUG or SOX9 sufficiently inhibits CSCs in human lung cancer cells and attenuates experimental lung

78 o(LA)2-PTX was approximately 2.3 nM for A549 human lung cancer cells, equipotent with PTX in vitro.

79 acetylase, mediates TGF-beta1-induced EMT in human lung cancer cells.

80 3 promotes growth, survival, and invasion of human lung cancer cells.

81 en tested in vitro and in vivo on murine and human lung cancer cells.

82 5-induced growth inhibition and apoptosis in human lung cancer cells.

83 In human lung cancer data sets, the p63-CYGB interaction si

84 To interrogate a human lung cancer database for the presence of Thy-1(+)

85 Analysis of human lung cancer datasets showed that GLI1 mRNA was hig

86 In human lung cancer datasets, TAp73 strongly predicts good

87 formed a transcriptome analysis of the major human lung cancer entities.

88 tage of human cancer cell lines, and primary human lung cancer samples and recurrent mutations in all

89 In human lung cancer samples, tumor MPhi infiltration and C

90 llagen fibrils in the extracellular space in human lung cancer specimens and in orthotopic lung tumor

91 pared with lung ADCA, which was validated in human lung cancer specimens.

92 Here, using human lung cancer tissue microarrays and fresh frozen ti

93 Utilizing resected human lung cancer tissues and a p21CIP1/WAF1-deficient,

94 tly, NatD is commonly upregulated in primary human lung cancer tissues where its expression level cor

95 l activation of this pathway was detected in human lung cancer tissues with concomitant downregulatio

96 More importantly, CDK20 is overexpressed in human lung cancer tissues, as determined by immunostaini

97 VEGF siRNA delivery for VEGF knockdown in a human lung cancer xenograft, leading to enhanced tumour

98 as confirmed in three subtypes of orthotopic human lung cancer xenografts (A549, H460, and H520) in m

99 tration of Y4 effectively inhibits growth of human lung cancer xenografts and murine breast cancer me

100 ensity and restrained growth of desmoplastic human lung cancer xenografts and syngeneic murine pancre

101 human EphA5 sensitized lung cancer cells and human lung cancer xenografts to radiotherapy and signifi

102 In human lung cancer, the expression of TTF-1 and GM-CSF ex

103 h high ACLY expression and poor prognosis in human lung cancer.

104 tigen-presenting cells (APCs) in early-stage human lung cancer.

105 SRP), an ARE-BP, is robustly up-regulated in human lung cancer.

106 TL3 in promoting translation of oncogenes in human lung cancer.

107 rrence-free survival and overall survival in human lung cancer.

108 ) may provide a useful prognostic marker for human lung cancer.

109 presents a promising prognostic biomarker in human lung cancer.

110 n that adversely impacts clinical outcome in human lung cancer.

111 ation during glucose deprivation and that in human lung cancers this pathway is activated in vivo.

112 Human lung cancers with KRAS mutations had significantly

113 TA-TLSs have been described in human lung cancers, but their function remains to be det

114 In human lung cancers, high NFATc2 expression predicted poo

115 ortantly, G6PD glycosylation is increased in human lung cancers.

116 UBQLN family members have been identified in human lung cancers.

117 as a potential therapeutic for KRas-induced human lung cancers.

118 e widespread environmental pollutants, known human lung carcinogens, and potent mammary carcinogens i

119 ion induced a significant increase of ROS in human lung carcinoma A549 cells.

120 enic in animals, but promote tumor growth of human lung carcinoma and CNT-transformed lung epithelial

121 which allowed for preferable elimination of human lung carcinoma cells (capital A, Cyrillic549) as c

122 itionally, the seal H3N8 virus replicated in human lung carcinoma cells.

123 A and H localize in the mitochondria of H292 human lung carcinoma cells.

124 EGF-induced EC migration and tumor growth in human lung carcinoma xenografted in immunodeficient mice

125 This device mimics human lung cell exposure to NPs due to a low horizontal

126 NAVETTA is a novel option for mimicking human lung cell exposure to NPs, complementing existing

127 layed almost no toxicity when tested against human lung cells and erythrocytes.

128 t PA-241Y contributes to virus adaptation to human lung cells and mammalian hosts.

129 he replicative efficiency of H5N1 viruses in human lung cells and to high virulence in mice.

130 Exposing human lung cells at the air-liquid interface (ALI) to am

131 Head-to-head comparison in human lung cells by NGS revealed that the two viruses ge

132 xamined the life cycle of the two viruses in human lung cells in vitro.

133 Furthermore, A549 human lung cells infected with GAS mutants lacking SP-PT

134 Exposing human lung cells to particulate matter smaller than 10 m

135 duct per 10(11) nucleotides (1 adduct per 10 human lung cells) using 40 mug of human lung DNA.

136 In human lung cells, UPF1 depletion increased expression of

137 Using a guinea pig model and human lung cells, we show that oxidant(s) present in tob

138 ficient replication of avian H5N1 viruses in human lung cells.

139 fficient to induce severe adverse effects in human lung cells.

140 Immunofluorescence of human lungs confirmed our in vivo data and showed an inc

141 that further testing is needed to look into human lung consequences.

142 ainties in risk assessment for NA is whether human lung CYP2A13 and CYP2F1 can mediate NA's respirato

143 severely compromised MERS-CoV infection into human lung-derived cells, but had little effect on infec

144 ing human stem cell models for understanding human lung development and disease.

145 s can now be used to study hidden aspects of human lung development and pediatric lung disease.

146 c mouse lung is a widely used substitute for human lung development.

147 lung disease, drug screening and studies of human lung development.

148 nal state of these cells in experimental and human lung diseases, providing newer insights into their

149 indings to the pathogenesis and treatment of human lung diseases.

150 mechanism by which Fam13a may contribute to human lung diseases.

151 Twenty-nine human lung DNA samples resulted in 20 positive measureme

152 uct per 10 human lung cells) using 40 mug of human lung DNA.

153 ns revealed that the exposures of the NPs to human lung due to the abrasion of the textiles were lowe

154 del in which the majority of NK cells in the human lung dynamically move between blood and the lung r

155 created a microdevice for culturing primary human lung endothelial cells under physiological flow co

156 A/wild bird/Anhui/82/2005, virus Wb/AH82) in human lung epithelial A549 cells (however, the reassorta

157 duces Moraxella adherence to and invasion of human lung epithelial A549 cells.

158 cken/Vietnam/TY31/2005 [Ck/TY31]) to grow in human lung epithelial A549 cells.

159 rearrangement, detachment, and death in the human lung epithelial cell line A549.

160 rounding and detachment of cells of the A549 human lung epithelial cell line as well as the Xps-media

161 eposition of diesel exhaust aerosol (DEA) on human lung epithelial cells (A549) in a prototype exposu

162 ive gene, in mouse lung tissue as well as in human lung epithelial cells (A549).

163 factor, to the neoplastic-like properties of human lung epithelial cells chronically exposed to a low

164 ced in vivo were compared with those made by human lung epithelial cells infected in vitro with RV16.

165 Knockdown of Nur77 in human lung epithelial cells resulted in a marked increas

166 In accordance, RV16 infection of human lung epithelial cells upregulated TSLP and IL-33 e

167 In LPS-stimulated A549 human lung epithelial cells, kallistatin attenuated apop

168 has profound effects upon gene expression in human lung epithelial cells, some of which are epigeneti

169 In human lung epithelial cells, the microRNA-150 (miR-150)

170 OMP reduces bacterial adhesion and uptake by human lung epithelial cells, thus protecting M. catarrha

171 c models for normal and oncogene-transformed human lung epithelial cells.

172 n cell apoptosis or interferon expression in human lung epithelial cells.

173 ig on the micro RNA (miRNA) transcriptome in human lung epithelial cells.

174 aspase-8 and induces apoptotic cell death in human lung epithelial cells.

175 e of a multi-cellular model representing the human lung epithelial tissue barrier via multi-colour fl

176 In murine and human lungs, FAM13A is expressed in airway and alveolar

177 (BR+) as well as L1210 cells and WI38 normal human lung fibroblast cells (biotin-receptor negative: B

178 or cell lines and are less toxic in a normal human lung fibroblast, WI38.

179 nduced the expression of FN and alpha-SMA in human lung fibroblast.

180 glycans to interact with the cell surface of human lung fibroblasts (HLF).

181 We evaluated the response of normal human lung fibroblasts (NHLFs) to stimulation with mtDNA

182 ecreted collagens in the lung and in primary human lung fibroblasts (phLF).

183 L33 protein segments and variants in primary human lung fibroblasts and HEK293T cells, we show that F

184 brotic TGF-beta activity in murine cells and human lung fibroblasts as well as in vivo with no demons

185 Silencing of Rpn6 in primary human lung fibroblasts counteracted TGF-beta-induced myo

186 re, siRNA-mediated reduction of BMPER in the human lung fibroblasts impaired cell migration and invas

187 These results indicate a novel role for human lung fibroblasts in contributing to responses agai

188 ivation in a PI3K-dependent manner in normal human lung fibroblasts in vitro Mechanistically, TRPV4 m

189 apl1) production as well as proliferation by human lung fibroblasts in vitro.

190 Analysis of human lung tissues and primary human lung fibroblasts indicates that this fate switchin

191 toration in human lung H460 cells and normal human lung fibroblasts on the activation and functional

192 ir proximity in tissue, we hypothesized that human lung fibroblasts play an important role in modulat

193 Direct regulatory effects of RELM-beta on human lung fibroblasts were examined using primary cultu

194 solid tumors, reduced collagen production by human lung fibroblasts with EC50 of 150 nM.

195 reserve capacity was observed in murine and human lung fibroblasts with genetic deficiency (or silen

196 To test the hypothesis, we exposed human lung fibroblasts with various doses of nicotine an

197 Using human lung fibroblasts, we found increased stimulated Wn

198 Wnt pathway differences were explored in human lung fibroblasts.

199 g factor for collagen enhancer activation in human lung fibroblasts.

200 -to-myofibroblast differentiation in primary human lung fibroblasts.

201 eta1-driven myofibroblast differentiation in human lung fibroblasts.

202 fferentiation potential compared with normal human lung fibroblasts.

203 e priorities include develop newer models of human lung fibrosis, engage current and new stakeholders

204 athogen because of its ability to persist in human lungs for long periods of time.

205 stomoses (IPAVA) have been known to exist in human lungs for over 60 years.

206 on of the microbial and chemical makeup of a human lung from a cystic fibrosis patient.

207 rt that MMP10 is expressed by macrophages in human lungs from patients with cystic fibrosis and induc

208 veal that the FAM13A gene is associated with human lung function and a variety of lung diseases, incl

209 show that NiV-B replicated to high titers in human lung grafts and caused similar cytopathic effects

210 d NiV Bangladesh strain (NiV-B) infection of human lung grafts from human immune system-reconstituted

211 Using human lung grafts in a human immune system-reconstituted

212 showed that NiV replicates to high titers in human lung grafts in NOD-SCID/gamma mice, resulting in a

213 Human lung growth and development begins with preconcept

214 h on the early stages of normal and abnormal human lung growth that influence adult outcome.

215 vestigated the effects of Asc restoration in human lung H460 cells and normal human lung fibroblasts

216 lls made up the vast majority of NK cells in human lungs, had a more differentiated phenotype, and mo

217 ear phagocytes from fully intact nondiseased human lungs (including the major blood vessels and drain

218 ith this robust in vitro method for modeling human lung inflammatory disorders, it is possible to det

219 between interleukin-17A and inflammation in human lung injury is unknown.

220 Data from in-vitro, animal, and human lung injury models suggest that keratinocyte growt

221 tive stress is an established model to mimic human lung injury.

222 The human lung is constantly exposed to spores of the enviro

223 we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse p

224 Finally, we scaled our approach to the human lung lobe and achieved efficient cell delivery, ma

225 We examined whether human (lung, lymph node, and blood) and mouse lung ILC2s

226 ages (AMs), are routinely used in studies on human lung macrophages, are long-lived cells, and exhibi

227 Human lung mast cells (HLMCs) play a central role in ast

228 Human lung mast cells readily recover from a desensitize

229 ation of IgE-mediated histamine release from human lung mast cells was explored by methods that parti

230 that mouse models can be used to interrogate human lung metabolome changes.

231 Our results provide insights into the human lung microbiota composition and function and their

232 ay samples suggest the existence of a viable human lung microbiota.

233 r of specific types of MWCNT, we developed a human lung microtissue array device that allows real-tim

234 coding a single guide RNA (sgRNA) in primary human lung microvascular ECs (HLMVECs) disrupted the exp

235 lates lamellipodia formation and motility of human lung microvascular endothelial cells (HLMVECs) via

236 l4) in adherent human blood monocytes and in human lung microvascular endothelial cells, providing a

237 ans and mice, and in supernatants of primary human lung microvascular endothelial cells.

238 in animal models and in an ex vivo perfused human lung model.

239 ings of this study establish how to identify human lung mononuclear phagocytes and how they function

240 mouse model uncovering the role of TIMP3 in human lung morphogenesis and functions.

241 Here we show that the human lung mucosa influences M. tuberculosis interaction

242 However, the effects of LXA4 on primary human lung myofibroblasts (HLMFs) have not previously be

243 omposition, differentiation, and function of human lung NK cells is critical to better understand the

244 Despite this, human lung NK cells were hyporesponsive toward target ce

245 MTb colonizes the human lung, often entering a non-replicating state befor

246 ously we have demonstrated that hPSC-derived human lung organoids (HLOs) resembled human fetal lung t

247 Transplanting bioengineered human lung organoids into mice could lead to a humanized

248 lung development are expressed in primordial human lung progenitors and revealed a CD47hiCD26lo cell

249 YY1 suppressed CD24 expression and growth of human lung, prostate, and breast cancer cells.

250 We found that human lung recipients who suffer respiratory viral infec

251 at c-kit(+) progenitor cells resident in the human lung regenerate epithelial lineages upon transplan

252 After enzymatic dispersion of rat or human lung samples into a cellular suspension, CD31-expr

253 scular compartment of decellularized rat and human lung scaffolds with human cells, including endothe

254 howed that GLI1 mRNA was highly expressed in human lung SCC and portended a poor prognosis.

255 but low H3K27me3 mark, is also prevalent in human lung SCC and SCC regions within ADSCC tumours.

256 Inhibition of GLI1 in human lung SCC cell lines suppressed tumor cell clonogen

257 t the parenchymal rEos found in nonasthmatic human lungs (Siglec-8+CD62L+IL-3Rlo cells) were phenotyp

258 60-2770, triggered bronchodilation in normal human lung slices and in mouse airways.

259 ve, and identical changes to sGC occurred in human lung slices or in human airway smooth muscle cells

260 Here we describe the development of a human lung 'small airway-on-a-chip' containing a differe

261 thoroughly tested for their toxicity in the human lung.Solid-state emissions from coal burning remai

262 pression quantitative trait locus effects in human lung specimens and blood, as well as associations

263 We also confirmed by micro-CT of human lung specimens that structural differences are ass

264 ession profiling to analyze TLS formation in human lung squamous cell carcinoma (LSCC) and in an expe

265 tems of interest, ranging from damage to the human lung surfactant layer to the aging of atmospheric

266 Macrophages in both mouse and human lungs that have been subjected to cold ischemic st

267 Although reported to be present in the human lung, their specific presence and functional orien

268 limitations in acquiring cells from healthy human lung, these subsets remain poorly characterized tr

269 ther and here we show that in the developing human lung this hypercalcaemia acts on the extracellular

270 NK cells in human lung tissue and matched peripheral blood from 132

271 r BI2536 on influenza virus replication in a human lung tissue culture model and observed strong inhi

272 bited TRAP activity in murine macrophage and human lung tissue extracts.

273 MicroRNA array profiling of human lung tissue found elevation of microRNAs associate

274 Staining of fibrotic and normal human lung tissue localized DSP to airway epithelia.

275 The human lung tissue microbiota remains largely uncharacter

276 In human lung tissue specimens both DP1 and DP2 receptors w

277 duct 9.5 (PGP9.5) and, for the first time in human lung tissue, 200-kD neurofilament subunit.

278 Here, we evaluated infection of ex vivo human lung tissue, defining a valuable approach for char

279 immunofluorescence approach, rarely used in human lung tissue, was used with antibodies specific to

280 and in vivo grown HLOs with fetal and adult human lung tissue, we found that in vivo transplanted HL

281 d mouse models of lung fibrosis and fibrotic human lung tissue.

282 Analysis of human lung tissues and primary human lung fibroblasts in

283 We harvested human lung tissues in which we assessed calcification le

284 In human lung tissues, intercellular adhesion molecule-1, v

285 In mouse and human lung tissues, the expression level and location of

286 nal analysis of transbronchial biopsies from human lung transplant recipients demonstrated an associa

287 In bronchoalveolar lavage fluid from human lung transplant recipients, NETs were more abundan

288 Here, we used viable human lung tumor slices and autologous tumor antigen-spe

289 Fzd9 expression was low in human lung tumors and in progressive dysplasias.

290 derlies this sensitivity was also present in human lung tumors, indicating that this therapeutic appr

291 1 activation is found in non-KRAS-associated human lung tumors.

292 ression is observed at the invasive front of human lung tumors.

293 on between loss of IPO11 and PTEN protein in human lung tumors.

294 o been identified in a subset of KRAS-driven human lung tumours.

295 Human lungs were assessed by using immunohistochemistry

296 CA-G1 deposition into the alveolar region of human lungs, where ricin aerosol particles mostly accumu

297 Last, tissue slices from human lung with usual interstitial pneumonia submitted t

298 ytokine IL-6 is consistently up-regulated in human lungs with emphysema and in mouse emphysema models

299 Complete and durable regression of human lung xenograft tumors was observed with the combin

300 eukocytes interact with NiV and cause ALI in human lung xenografts is crucial for identifying therape