ライフサイエンスコーパス: human microbiome

1 , and is now a vital tool for studies of the human microbiome.

2 arge-scale sequencing efforts to catalog the human microbiome.

3 in tumors that are in close proximity to the human microbiome.

4 the most numerically prominent genera of the human microbiome.

5 ty of commensal microbes, which comprise the human microbiome.

6 ing metabolism and immune homeostasis in the human microbiome.

7 ated an association between the diet and the human microbiome.

8 provide insight into the forces shaping the human microbiome.

9 tivate studies of hypervariation in the full human microbiome.

10 omplex heterogeneous communities such as the human microbiome.

11 ommunities to the symbionts that compose the human microbiome.

12 xenobiotic metabolism to spread through the human microbiome.

13 bitats, ranging from soil collectives to the human microbiome.

14 tics, to maximize sustainable changes in the human microbiome.

15 ve or suppress undesirable components of the human microbiome.

16 esent previously unidentified members of the human microbiome.

17 ontributing to the protective effects of the human microbiome.

18 and converge along an axis toward the modern human microbiome.

19 on the discovery of small molecules from the human microbiome.

20 lations and existing populations such as the human microbiome.

21 e planet, including the trillions within the human microbiome.

22 us growth in the collective knowledge of the human microbiome.

23 and other pathways maintained throughout the human microbiome.

24 oils, extreme environments, bioreactors, and human microbiomes.

25 cific microbial functions within the healthy human microbiome across multiple body sites and can be u

26 both the extent to which these factors alter human microbiome activity and/or structure and the abili

27 tial to improve our understanding of how the human microbiome affects digestive health and disease.

28 Characterizing the human microbiome among hospitalized patients and identif

29 ida albicans is both a member of the healthy human microbiome and a major pathogen in immunocompromis

30 gations focused on the interplay between the human microbiome and cancer development, herein termed t

31 in power in testing the associations between human microbiome and diet intakes and habitual smoking.

32 s have demonstrated associations between the human microbiome and disease, yet fundamental questions

33 enomic evolution, as well as its role in the human microbiome and disease.

34 characterization of microbial communities in human microbiome and environmental samples.

35 e, we jointly analyze the composition of the human microbiome and host genetic variation.

36 as obesity and the interactions between the human microbiome and intestinal cells.

37 One major challenge to studying human microbiome and its associated diseases is the lack

38 h examples of the functional genomics of the human microbiome and its influences upon health and dise

39 The unexpected diversity of the human microbiome and metabolome far exceeds the complexi

40 al microbes influence the development of the human microbiome and the immune system is important to e

41 ces are available for many bacteria from the human microbiome and the ocean (over 800 and 200, respec

42 ey are also found in multiple members of the human microbiome, and may play a beneficial role in trim

43 Studies of the human microbiome, and microbial community ecology in gen

44 variation in shaping the composition of the human microbiome, and provide a starting point toward un

45 ution of small-molecule-encoding BGCs in the human microbiome, and they demonstrate the bacterial pro

46 onal diversity and organismal ecology in the human microbiome, and we determined a core of 24 ubiquit

47 The trillions of bacteria that make up the human microbiome are believed to encode functions that a

48 Pathological shifts of the human microbiome are characteristic of many diseases, in

49 nces in the culture-independent study of the human microbiome are reviewed.

50 associated with the human body, that is, the human microbiome, are complex ecologies critical for nor

51 We explore three core scenarios of human microbiome assembly: development in infants, repre

52 fferent cultures, requiring that the healthy human microbiome be characterized across life spans, eth

53 ity may in turn advance our understanding of human microbiome biology.

54 over the majority of abundant species in the human microbiome but only a small proportion of microbes

55 To demonstrate how dysbiosis of the human microbiome can drive autoimmune disease.

56 Under antibiotic pressure, the human microbiome can undergo rapid shifts on a scale of

57 and immune defense are important drivers of human-microbiome co-evolution.

58 relative complexity of soil, freshwater and human microbiome communities, and suggested that approxi

59 The resulting knowledge of human microbiome composition, function, and range of var

60 The human microbiome consists of bacterial, archaeal, and fu

61 nt joint publications of the findings of the Human Microbiome Consortium and related studies, the con

62 The human microbiome contains diverse microorganisms, which

63 The human microbiome contributes functional genes and metabo

64 The human microbiome could be manipulated by such "smart" st

65 immense diversity of resistance genes in the human microbiome could contribute to future emergence of

66 Overall these studies reveal that human microbiome data has been preserved in some coproli

67 article explores strategies for merging the human microbiome data with multiple additional datasets

68 d misses 60% of the true interactions in the human microbiome data, and, as predicted, most of the er

69 e the use of the package by applying it to a human microbiome dataset, where phylogeny structure amon

70 ion of our approach to bacterial genomes and human microbiome datasets allowed us to significantly ex

71 ontains 20 proteins, all identified from the human microbiome datasets, illustrating the importance o

72 ausation and further characterization of the human microbiome during states of health.

73 The human microbiome encodes vast numbers of uncharacterized

74 cessfully exploited in the natural design of human microbiome evasion of C. difficile, and this metho

75 The human microbiome has become a recognized factor in promo

76 The human microbiome has been linked to various host phenoty

77 The Human Microbiome has been variously associated with the

78 ne microbial and functional diversity in the human microbiome has enabled studies of microbiome-relat

79 Research on the human microbiome has established that commensal and path

80 discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation

81 ition and functional capacity present in the human microbiome has revolutionized many concepts in our

82 uencing of microbes in human ecosystems (the human microbiome) has complemented single genome cultiva

83 To date, however, most studies of the human microbiome have focused on characterizing the comp

84 Comparative analyses of the human microbiome have identified both taxonomic and func

85 in fields such as molecular genetics and the human microbiome have resulted in an unprecedented recog

86 Comparative analyses of the human microbiome have revealed substantial variation in

87 like during African ape diversification, but human microbiomes have deviated from the ancestral state

88 etic approach to reconstruct how present-day human microbiomes have diverged from those of ancestral

89 Relative to the microbiomes of wild apes, human microbiomes have lost ancestral microbial diversit

90 rk specifically in metabolic modeling of the human microbiome, highlighting both novel methodologies

91 ubgingival plaque samples were identified by human microbiome identification microarray.

92 s reported the structure and function of the human microbiome in 300 healthy adults at 18 body sites

93 lso been shown to play a role in shaping the human microbiome in different cultures, requiring that t

94 population-based studies of the role of the human microbiome in disease etiology and exposure respon

95 sformed our understanding of the role of the human microbiome in health and many diseases.

96 nd thus can be considered a component of the human "microbiome" in addition to their role in illness

97 re increasingly acquired in research on the (human) microbiome, in environmental studies and in the s

98 of research on the lung and related areas of human microbiome investigation were reviewed and discuss

99 The human microbiome is a complex biological system with num

100 The human microbiome is a vast reservoir of microbial divers

101 Research on the human microbiome is beginning to address factors associa

102 ions and community membership of the healthy human microbiome is critical to accurately identify the

103 ying novel microbe-based therapeutics in the human microbiome is great.

104 Although the composition of the human microbiome is now well-studied, the microbiota's >

105 ective genetic potential (metagenome) of the human microbiome is orders of magnitude more than the hu

106 nd as we have yet to characterize the entire human microbiome it is likely that many nucleases are ye

107 tion for a unique framework for studying the human microbiome, its organization, and its impact on hu

108 rved in some coprolites, and these preserved human microbiomes match more closely to those from the r

109 red standard test sequences derived from the Human Microbiome Mock Community test sets and compared M

110 The composite human microbiome of Western populations has probably cha

111 The human microbiome plays a key role in a wide range of hos

112 The human microbiome plays a key role in health and disease.

113 The human microbiome plays a key role in human health and is

114 The human microbiome plays an important role in human diseas

115 We included 16S rRNA gene sequences from the Human Microbiome Project (HMP) and from 16 additional st

116 The new algorithm was tested on the human microbiome project (HMP) dataset, currently one of

117 The Human Microbiome Project (HMP) is following in the foots

118 veal new human sequences found in individual Human Microbiome Project (HMP) samples.

119 A primary goal of the Human Microbiome Project (HMP) was to provide a referenc

120 iew of metagenome annotations (IMG/M ER) and Human Microbiome Project (HMP)-specific metagenome sampl

121 expert review of metagenome annotations and Human Microbiome Project (HMP)-specific metagenome sampl

122 body sites on 102 individuals as part of the Human Microbiome Project (HMP).

123 in 88% of the National Institutes of Health Human Microbiome Project (NIH HMP) stool samples, and th

124 Using Human Microbiome Project 16S rRNA gene sequence data for

125 tion sequencing has made it feasible for the Human Microbiome Project and other initiatives to genera

126 rom two large-scale metagenomic studies--the Human Microbiome Project and the Student Microbiome Proj

127 among bacteria more broadly, analysis of the Human Microbiome Project data demonstrate that at least

128 Comparative genomic analysis with Human Microbiome Project data revealed that the human bo

129 the association networks we obtain from the Human Microbiome Project datasets show credible results

130 mining the shotgun metagenomic data from the Human Microbiome Project for host DNA reads, we gathered

131 The National Institutes of Health Human Microbiome Project has provided one of the broades

132 al community surveys such as MetaHit and the Human Microbiome Project have described the composition

133 ased coding algorithm and applying it to the Human Microbiome Project population.

134 The Human Microbiome Project provided a census of bacterial

135 ext-generation sequencing technology and the human microbiome project underway, current sequencing ca

136 The Human Microbiome Project used rigorous good clinical pra

137 a healthy cohort (n = 87) obtained from the Human Microbiome Project were aligned against the NCBI b

138 publicly available dataset obtained from the Human Microbiome Project which associates taxa abundance

139 organism from the high-priority group of the Human Microbiome Project's "Most Wanted" list, and, to o

140 These findings have implications for ongoing Human Microbiome Project(s), and highlight important cha

141 In the application to the data from the Human Microbiome Project, a close evaluation of the biol

142 more than 200 normal adults enrolled in the Human Microbiome Project, and metagenomically determined

143 ys such as MetaHIT and the recently released Human Microbiome Project, detailed investigations of the

144 these tools to 520 oral metagenomes from the Human Microbiome Project, finding evidence of site tropi

145 etagenomic deconvolution to samples from the Human Microbiome Project, successfully reconstructing ge

146 Most recently, the Human Microbiome Project, using new genomic technologies

147 Using simulated and real data from the Human Microbiome Project, we show that such compositiona

148 nOCC to a microbial ecology dataset from the Human Microbiome Project, which in addition to reproduci

149 otgun sequencing data generated from the NIH Human Microbiome Project.

150 the >700 shotgun metagenomic samples of the Human Microbiome Project.

151 tion in 752 metagenomic samples from the NIH Human Microbiome Project.

152 an genome project and marked progress in the human microbiome project.

153 lysis and analysis of genomes related to the Human Microbiome Project.

154 uences being generated for the International Human Microbiome Project.

155 enges will be critical for the International Human Microbiome Project.

156 on a set of 94 metagenomic samples from the Human Microbiome Project.

157 relation network of microbe species from the Human Microbiome Project.

158 ces cerevisiae, and 891 new genomes from the Human Microbiome Project.

159 nd metagenomic sequencing efforts, including human microbiome projects, reveal that microbes often en

160 dress one key question emerging from various Human Microbiome Projects: Is there a substantial core o

161 itope length matches (8-12 amino acids) with human microbiome proteins, suggestive of a possible cros

162 Klebsiella pneumoniae is part of the healthy human microbiome, providing a potential reservoir for in

163 in mice and suggest that alterations in the human microbiome represent a risk factor for PD.

164 The human microbiome represents a vastly complex ecosystem t

165 Human microbiome research is an actively developing area

166 Human microbiome research was larger than any other envi

167 dress many other key questions in animal and human microbiome research.

168 ehensive current model for understanding the human microbiome's role in complex inflammatory disease.

169 DNA templates, cultured bacterial cells and human microbiome samples in the virtual microfluidics sy

170 roduces marked biases both across and within human microbiome samples, and identify sample- and gene-

171 Through human microbiome sequencing, we can better understand ho

172 primarily due to the exponential increase in human microbiome studies and a growing appreciation of o

173 Observations from human microbiome studies are often conflicting or inconc

174 what is, to our knowledge, one of the first human microbiome studies in a well-phenotyped prospectiv

175 In order for human microbiome studies to translate into actionable ou

176 t-microbiota interactions and explore recent human microbiome studies.

177 angulation may be more broadly applicable to human microbiome studies.

178 understanding the ecological dynamics of the human microbiome, such as compositional variability with

179 gous to sequences from bacteria found in the human microbiome than type 1 epitopes.

180 ylogenetically distinct enzymes found in the human microbiome that decarboxylate tryptophan to form t

181 sthma to the composition and function of the human microbiome, the collection of microbes that reside

182 We show that within the human microbiome this ecological architecture continues

183 le intra- and interpersonal variation in the human microbiome, this variation can be partitioned into

184 of temporal variation in the ecology of the human microbiome, this work demonstrates the feasibility

185 fungi in buildings exert an influence on the human microbiome through aerosol deposition, surface con

186 g technologies have enabled the study of the human microbiome through direct sequencing of microbial

187 r, exert tremendous collateral damage to the human microbiome through overuse and broadening spectrum

188 demonstration, local similarity analysis of human microbiome time series shows that core operational

189 e importance of strain-level analysis of the human microbiome to define the role of commensals in hea

190 ans of understanding the contribution of the human microbiome to health and its potential as a target

191 analyze large microbial communities from the human microbiome, uncovering significant variation in di

192 Community composition within the human microbiome varies across individuals, but it remai

193 However, the diversity of the human microbiome varies between body sites, between pati

194 In the human microbiome, we find no overt changes in the richne

195 ated a set of 20 Bacteroidia pilins from the human microbiome whose structures and mechanism of assem

196 suggests translation to communities like the human microbiome will be quite challenging.

197 Studies of metagenomics and the human microbiome will tremendously expand our knowledge

198 More detailed knowledge of the human microbiome will yield next-generation diagnostics

199 ch aim at associating the composition of the human microbiome with other available information, such