ライフサイエンスコーパス: human milk

1 ULITE and SimulTRAC-SNB) for B12 analysis in human milk.

2 abor intensive and requires large volumes of human milk.

3 ere is a need to quantify arsenic species in human milk.

4 health benefits that are similar to those of human milk.

5 al needs of these infants from the intake of human milk.

6 of an infant exclusively from the intake of human milk.

7 fluence the bacterial communities inhabiting human milk.

8 lactoglobulin (BLG), which is not present in human milk.

9 are found in premature infants fed fortified human milk.

10 des are the third most abundant component in human milk.

11 ld standard for measuring the fat content of human milk.

12 ccharides are the third largest component of human milk.

13 ecretory antibodies and prebiotic factors in human milk.

14 establish the profile of boron metabolism in human milk.

15 in most human mucosal secretions, including human milk.

16 nly the complexed matriptase was detected in human milk.

17 idly from the chylomicrons of the blood into human milk.

18 f dietary fatty acids from chylomicrons into human milk.

19 significance of oligosaccharide variation in human milk.

20 d significantly less phosphocholine than did human milk.

21 able in secretions such as saliva, tears and human milk.

22 moiety in milk) and phosphocholine than did human milk.

23 palmitic and oleic acids similar to those of human milk.

24 hocholine and glycerophosphocholine exist in human milk.

25 low birth weight infants discharged home on human milk.

26 y 6% of infants were discharged on exclusive human milk.

27 Most importantly, this activity is unique to human milk.

28 l roles that sIgA and its components play in human milk.

29 uisition and that this activity is unique to human milk.

30 undant and structurally diverse component in human milk.

31 of two octasaccharide antigens isolated from human milk, 1 and 2, and their corresponding allyl glyco

32 d the top contributors were formula (71.7%), human milk (22.9%), and commercial baby foods (2.2%).

33 soups (6.1%), pasta mixed dishes (4.0%), and human milk (3.9%).

34 mg GAE/L), sheep (167.6+/-58.77mg GAE/L) and human milk (82.45+/-12.3mg GAE/L).

35 rkup and is useful in defining variations in human milk acidic oligosaccharides and investigating the

36 In studies using pooled human milk, addition of increasing amounts of authentic

37 omes from foods other than infant formula or human milk after the age of 6 mo.

38 sialylated acidic oligosaccharides of pooled human milk agreed with the results of previous studies e

39 ipitation studies also detected the PRLBP in human milk albeit at lower concentrations than found in

40 benefits observed in infants fed unfortified human milk also are found in premature infants fed forti

41 We hypothesize that hyaluronan from human milk also enhances innate antimicrobial defense.

42 addressing DHA intakes by lactating women or human milk amounts of DHA at levels above those typical

43 Five infants were fed human milk and 26 infants received formulas that provide

44 d disaccharides to considerably more complex human milk and blood oligosaccharides.

45 e the fractional absorption of zinc (FAZ) in human milk and CF by dual-isotope ratios in urine.

46 ion and lactation stage may be exploited for human milk and dairy product consumption.

47 oic acid (PFOA), analysed by HPLC-ESI-MS, in human milk and food samples from the city of Siena and i

48 method for the determination of parabens in human milk and food with relative recoveries in the rang

49 Our results suggest that both human milk and helminth parasites may share a ligand-spe

50 cated that differences in the composition of human milk and infant formula yield benefits in cognitiv

51 Adiponectin is present in human milk and its concentrations are associated with du

52 mixture of N-glycoproteins from unprocessed human milk and O-glycoproteins from very-low-density-lip

53 -containing immunomodulatory glycan found in human milk and on parasitic helminths, improves glucose

54 cto-N-fucopentaose III (LNFPIII) is found in human milk and on the Th2 driving helminth parasite Schi

55 matrix interferences by haptocorrin (HC) in human milk and serum show that past analyses of vitamin

56 ted flame retardants that have been found in human milk and serum throughout the world, but have rece

57 des from relevant biological sources such as human milk and serum.

58 ublished data on whether it is detectable in human milk and therefore consumed by breastfed infants.

59 determine whether adiponectin is present in human milk and to characterize maternal factors associat

60 bnormalities with insulin and adiponectin in human milk and to compare the concentrations of these ho

61 ontaining at least one trans double bond) in human milk and to identify relations between individual

62 is, but not A or B antigens, were present in human milk and were responsible for blocking NV binding

63 ficantly more bioavailable GABA than cow and human milks and are able to activate GABArho receptors.

64 low birth weight infants discharged on "any human milk") and the independent variables (nurse work e

65 s of milk (raw and UHT cows' milk as well as human milk) and infant formulations.

66 harides found on helminths also are found in human milk, and both helminths and milk have been shown

67 Cytomegalovirus is commonly shed in human milk, and cytomegalovirus-seropositive women can t

68 o find that lysozyme from chicken egg white, human milk, and human neutrophils and RNase A from bovin

69 Lactoferrin is a major protein component of human milk, and it binds iron with high affinity.

70 Human milk, and particularly human colostrum, is the gol

71 Additionally, egg yolks and human milk appear to be bioavailable sources.

72 The calcium and phosphorus in human milk are adequate for infants in the first six mon

73 vided in variable amounts to infants through human milk are cholesterol and gangliosides.

74 ble (soluble) fraction of infant formula and human milk are employed.

75 The acidic oligosaccharides of human milk are predominantly sialyloligosaccharides.

76 oclast formation, the expression of TRAIL in human milk as a function of vitamin D status in mothers

77 f diverse unconjugated glycans that exist in human milk as one of the major components.

78 The WHO refers to human milk as the nutritional gold standard for term inf

79 murine exudates, regenerating planaria, and human milk as well as macrophages that stimulate tissue

80 The low zinc intake from human milk at approximately 6 mo of age predicts the dep

81 o was marginally associated with the rate of human milk at discharge (p=.056).

82 ion and immunological protection provided in human milk at discharge is an issue of health care quali

83 The amount of variability in human milk attributable to diet remains mostly unknown.

84 on the nucleotide contents in samples from a human milk bank.

85 d LCP supplementation in amounts typical for human milk (based on local and worldwide surveys) in a l

86 c digestion of lipids and some proteins from human milk but did affect lactoferrin and alpha-lactalbu

87 oic acid (DHA) and arachidonic acid (ARA) in human milk but not in infant formula, coupled with lower

88 incomplete about not only the composition of human milk, but also the maternal nutritional needs to s

89 itrypsin and antichymotrypsin are present in human milk, but little is known about their roles in pro

90 , immortalized mammary epithelial cells, and human milk, but not in cultured fibroblasts nor in fibro

91 an antimicrobial protein highly expressed in human milk, but not ruminant milk, and is thought to hel

92 ve a strong effect on the mineral content of human milk, but physiologic changes in milk and the infa

93 cates that metabolic hormones are present in human milk, but, to our knowledge, no studies have inves

94 of arsenic species at low concentrations in human milk by HPLC/ICPMS.

95 Lactoferrin present in human milk can inhibit growth of Candida albicans, there

96 The 12 major peaks in human milk coeluted with authentic oligosaccharide stand

97 BCDs), and tetrabromobisphenol-A (TBBP-A) in human milk collected in 2010-2011 from 10 first-time mot

98 r pasteurization has been reported to modify human milk composition and structure by inactivating bil

99 In our study, mature human milk contained more phosphocholine and glycerophos

100 Human milk contains a 46 kDa mucin-associated glycoprote

101 Human milk contains a large diversity of free glycans be

102 Human milk contains an abundance of biologically active

103 Human milk contains an unexpected abundance and diversit

104 Human milk contains complex carbohydrates that are impor

105 Human milk contains hyaluronan (HA), a glycosaminoglycan

106 Human milk contains many immunomodulatory compounds, inc

107 Human milk contains many substances that stimulate the g

108 In addition to essential nutrients, human milk contains several classes of bioactive factors

109 Human milk contents of DHA are dependent on diet, and in

110 Zinc from human milk contributed <25% of TAZ for all groups.

111 ntrations of persistent organic chemicals in human milk decrease over the course of lactation.

112 Furthermore, oral administration of human milk-derived HA to adult, wild-type mice results i

113 The range of human milk docosahexaenoic acid (DHA) concentrations wor

114 Here we define the concentration of HA in human milk during the first 6 months postpartum.

115 Endogenous human milk epitopes are recognized by specific IgE from

116 n changed the original volatile compounds of human milk, even more than HoP.

117 The beneficial effects of human milk extend to the feeding of premature infants, b

118 uman milk is protective against NEC, and the human milk factor erythropoietin (Epo) has been shown to

119 l-in-water IF emulsion was formulated with a human milk fat analogue enriched with docosahexaenoic ac

120 derived from fat, we estimated from the TFA human milk fat data that TFA intake of Canadian breastfe

121 tween the percentage of TFAs in the diet and human milk fat established by Craig-Schmidt et al, and a

122 therefore examined the effect of recombinant human milk fat globule-EGF factor 8 (rhMFG-E8) in mitiga

123 Human milk fat globules, by enveloping cell contents dur

124 The trans FA composition of human milk fat must be examined to establish its influen

125 Human milk fatty acids are among the nutrients that show

126 om effects on neurodevelopment solely due to human milk fatty acids is complex, particularly when neu

127 gy density, will aid in understanding of the human milk fatty acids that best support neurological de

128 Preterm human milk-fed infants often experience suboptimal growt

129 n intake results in less growth faltering in human milk-fed preterm infants.

130 ral protein supplementation in predominantly human milk-fed preterm infants.

131 The use of fortifiers designed for human-milk-fed infants or specially designed high-minera

132 e the Bifidobacterium amounts as observed in human-milk-fed infants.

133 provide an overview on the use of exclusive human milk feeding and the utility of this approach in p

134 Human milk feeding is an important recommendation for pr

135 n of human milk or the functional aspects of human milk feeding.

136 nt is assessed after the period of exclusive human milk feeding.

137 has implications for the timing of sampling human milk for exposure assessment purposes.

138 mothers to establish and sustain a supply of human milk for their infants.

139 has little or no effect on many nutrients in human milk; for others, human milk may not be designed a

140 We assessed the effect of human milk fortified with a higher-protein HMF on growth

141 erience suboptimal growth despite the use of human milk fortifier (HMF).

142 n/100 mL of breast milk through a commercial human milk fortifier; n = 30) or a higher-protein group

143 he composition and structures of TAGs in the human milk from mothers with different food choices and

144 namic behavior of protein phosphorylation in human milk from the first month of lactation.

145 er, calculated transfer of contaminants from human milk fully explained the attenuated growth.

146 haride samples equivalent to 1 microliter of human milk give optimum chromatographic separation and r

147 hese same HMOs established using the shotgun human milk glycan microarray (HM-SGM-v2) showed fair-to-

148 gun glycan microarray prepared from isolated human milk glycans (HMGs), and our studies on their reco

149 the structures of soluble glycans within the human milk glycome by matching predicted structures base

150 tment of HT-29 colonic epithelial cells with human milk HA at physiologic concentrations results in t

151 nt of cultured colonic epithelial cells with human milk HA enhances resistance to infection by the en

152 Previous studies have shown that human milk has a role in the gastrointestinal, neural, a

153 Donor pasteurized human milk has been suggested as a proxy for the mother'

154 Human milk has little vitamin D, and supplemental vitami

155 late that erythropoietin (EPO), a hormone in human milk, has a role in the prevention of HIV transmis

156 ferrin (Lf), a major iron-binding protein in human milk, has been suggested to have multiple biologic

157 ding bone minerals at greater levels than in human milk have not been shown.

158 Preterm infants fed fortified human milk (HM) grow more slowly than those fed preterm

159 Accumulating evidence suggests that human milk (HM) may attenuate the transfer of obesity fr

160 Most American mothers who feed human milk (HM) now use pumps to produce some of the HM

161 ge: 0.1-17.2%) found previously for Canadian human milk in 1992.

162 on of the 12 major sialyloligosaccharides of human milk in a single 35-min run.

163 In a recent study on the TFA content of human milk in a sizable group of mothers at the sixth we

164 The 42-kDa glycopolypeptide purified from human milk in CA inhibitor affinity chromatography share

165 onstrate the presence of both PQQ and IPQ in human milk in nanomolar to micromolar concentrations.

166 However, the proportion of (unsupplemented) human milk in the neonatal diet was significantly positi

167 nalyses, the proportion of enteral intake as human milk in the neonatal period was inversely related

168 Oligosaccharides in human milk inhibit enteric pathogens in vitro and in viv

169 Lactoferrin, a glycoprotein present in human milk, inhibits EPEC adherence to mammalian cells.

170 A greater proportion of human milk intake in infancy was associated with lower r

171 Human milk intake was significantly associated with lowe

172 higher whole-body bone mass associated with human milk intake, despite its very low nutrient content

173 Human milk is a complex fluid comprised of myriad substa

174 Human milk is a potential source of lead exposure.

175 h it is known that the fatty acid profile of human milk is altered by diet, the rapidity with which t

176 Protection against rotavirus by human milk is associated with the glycoprotein lactadher

177 Human milk is generally accepted as the best nutrition f

178 Bioavailability of copper from human milk is high, whereas it is lower from cow milk an

179 bility of complex glycostructures present in human milk is linked to changing infants' needs.

180 reas the intake of these phytoestrogens from human milk is negligible (<0.01 mg/d).

181 ination of free nucleotide monophosphates in human milk is proposed.

182 Several studies have demonstrated that human milk is protective against H. influenzae colonizat

183 Human milk is protective against NEC, and the human milk

184 articular, the composition of fatty acids in human milk is quite variable.

185 this review we show that the composition of human milk is rather variable and is dependent on factor

186 Human milk is recommended as the optimal nutrient source

187 Human milk is rich in oligosaccharides, some of which in

188 When accepting that human milk is the optimal nutrition for healthy term inf

189 -chain n-3 fatty acid in plasma, tissues, or human milk is to supplement with the fatty acid of inter

190 Human milk is typically low in vitamin D activity (VDA).

191 on impacted the microstructure of undigested human milk, its gastrointestinal disintegration and tend

192 Our results demonstrated that human milk lactoferrin efficiently extracted the IgA1 pr

193 These results suggest that human milk lactoferrin may attenuate the pathogenic pote

194 Although present in human milk, LCPUFA have until recently been absent from

195 a" is unclear, environmental contaminants in human milk may be of relevance.

196 Human milk may decrease the incidence of NEC by decreasi

197 impact of pasteurization on the digestion of human milk may have nutritional relevance in vivo and po

198 on many nutrients in human milk; for others, human milk may not be designed as a primary nutritional

199 We found that the human milk microbiome changes over lactation.

200 Fewer infants (42%) received human milk mixed with fortifier or formula.

201 Aware of the important benefits of human milk, most U.S. women initiate breastfeeding but d

202 In human milk, NAD levels were significantly affected by th

203 findings reveal an unrecognized function of human milk, namely, its capacity to influence neonatal m

204 rmulas should be based on the composition of human milk needs revision.

205 a-3) fatty acids from the maternal diet into human milk occurs with little interconversion of 18:2n-6

206 ison of the three methods was conducted with human milk of varying fat content.

207 we describe a method for the quantitation of human milk oligosaccharide (HMO) structures employing LC

208 Conjugates of PADRE covalently linked to the human milk oligosaccharide, lacto-N-fucopentose II or a

209 easured for natural abundance samples of the human milk oligosaccharides "lacto-N-fucopentaose" (LNF-

210 Human milk oligosaccharides (HMO) are believed to have a

211 These antigens are also found on human milk oligosaccharides (HMO), an abundant and struc

212 estine has been linked to the utilization of human milk oligosaccharides (HMO).

213 , probably due to its large concentration of human milk oligosaccharides (HMO).

214 es of structurally heterogeneous mixtures of human milk oligosaccharides (HMOs) and bovine milk oligo

215 The prebiotic nature of human milk oligosaccharides (HMOs) and increasing eviden

216 of rapidly identifying interactions between human milk oligosaccharides (HMOs) and their protein rec

217 Human milk oligosaccharides (HMOs) are a family of diver

218 Accordingly, human milk oligosaccharides (HMOs) are minimally digeste

219 ption, bacteria were grown in a medium using human milk oligosaccharides (HMOs) as the only carbon so

220 obtain a treated milk with 7.0 g/L GOS - the human milk oligosaccharides (HMOs) concentration is betw

221 ed whether differences in the composition of human milk oligosaccharides (HMOs) correlate with infant

222 The affinities of thirty-two free human milk oligosaccharides (HMOs) for four human galect

223 Analysis of human milk oligosaccharides (HMOs) from 6-month-postpart

224 Human milk oligosaccharides (HMOs) have important nutrit

225 olute quantitation method for measuring free human milk oligosaccharides (HMOs) in milk samples was d

226 Studies have detected the presence of human milk oligosaccharides (HMOs) in urine of breast-fe

227 Human milk oligosaccharides (HMOs) play an important rol

228 collection of 60 asymmetric, multiantennary human milk oligosaccharides (HMOs), which were used to d

229 of immunologically active factors, including human milk oligosaccharides (HMOs).

230 roup of complex carbohydrates referred to as human milk oligosaccharides (HMOs).

231 few decades it has become apparent that the human milk oligosaccharides are composed of thousands of

232 Most human milk oligosaccharides are fucosylated, and their p

233 Thus, human milk oligosaccharides may have therapeutic potenti

234 ive and quantitative individual variation of human milk oligosaccharides, a sensitive method for rout

235 e molecular sizes and prebiotic functions of human milk oligosaccharides.

236 Human-milk oligosaccharides can serve as prebiotics beca

237 tures that have prebiotic effects similar to human-milk oligosaccharides include galacto-oligosacchar

238 ated the impact of pasteurization of preterm human milk on its gastrointestinal kinetics of lipolysis

239 the present study, we examined the effect of human milk on the H. influenzae IgA1 protease and Hap ad

240 is available on B vitamin concentrations in human milk or on how they are affected by maternal B vit

241 milk, and a supplement of pasteurized donor human milk or preterm formula is required.

242 ned specifically to mimic the composition of human milk or the functional aspects of human milk feedi

243 ase in the fraction of infants discharged on human milk (p<0.001).

244 ase in the fraction of infants discharged on human milk (p<0.05).

245 crease in the fraction infants discharged on human milk (p<0.05).

246 We sought to determine the impact of human milk pasteurization on gastric digestion (particul

247 A minimum of one human milk peptide was recognized by IgE antibodies from

248 Genuine sensitization to human milk peptides in the absence of IgE to bovine milk

249 towards specific IgE being detected to more human milk peptides in those infants who did not respond

250 in] and the corresponding, highly homologous human milk peptides were labelled with sera from 15 brea

251 ion of raw human milk (RHM) with pasteurized human milk (PHM).

252 -G, immunoglobulin-M, and an undiluted crude human milk preparation were tested in vitro for their ab

253 ndividual and interindividual variability of human milk protein and energy content potentially contri

254 We found that HAMLET, a human milk protein-lipid complex, kills Streptococcus pn

255 device was used to analyze trypsin-digested human milk proteins with mass spectrometry.

256 n the neonate gut and abundant in bovine and human milk provides a basis for age-restricted tropism a

257 rition can lead to substantial variations in human milk quality.

258 esembling non-digestible oligosaccharides in human milk reduce the development of atopic disorders.

259 Lactoferrin in human milk removes or cleaves Hap and another autotransp

260 On the basis of scientific insights from human-milk research, a specific mixture of nondigestible

261 up in comparing the gastric digestion of raw human milk (RHM) with pasteurized human milk (PHM).

262 For method validation, a human milk sample was spiked with defined amounts of dim

263 Analysis of Finnish and Chinese pooled human milk samples revealed hundreds of regioisomeric TA

264 The quantitation method was applied to 20 human milk samples to determine the variations in HMO co

265 Human milk samples were analyzed by LC-ESI-MS/MS for TBB

266 as further tested by analyzing two Norwegian human milk samples where arsenobetaine, dimethylarsinate

267 We characterized the interaction of human milk samples with recombinant virus-like particles

268 optimised method, applied to the analysis of human milk samples, included their dilution (1:5) with w

269 applied to the quantification of lysozyme in human milk samples.

270 presence of calcium, iron, and zinc bound to human milk secretory IgA (sIgA) was investigated.

271 he nondigestible oligosaccharides present in human milk show a clear bifidogenic effect on the gut mi

272 ir host mucosal surfaces may be inhibited by human milk sialyloligosaccharides, but testing this hypo

273 Such autoreactive, human milk-specific IgE antibodies appear to have functi

274 (European Childhood Obesity Trial, Norwegian Human Milk Study, and Prevention of Coeliac Disease) tha

275 ghlight the importance of structure specific human milk substitutes and the careful selection of the

276 targeted preventive measures in addition to human milk, such as prebiotics and probiotics, to the ma

277 Human milk supplements, or fortifiers, are available to

278 ly fucosylated neutral oligosaccharides from human milk that are based on the iso-lacto-N-octaose cor

279 the protein cost of non-protein nitrogen in human milk, the recommended increment in protein is abou

280 preserved the original volatile compounds of human milk, this novel process may be an alternative to

281 The critical importance of human milk to infants and even human civilization has be

282 infant on complementary foods in addition to human milk to meet iron and zinc requirements after 6 mo

283 corpus callosum; every additional 10 days of human milk use were associated with a three weeks or gre

284 of caffeine therapy, and greater duration of human milk use were independent favorable factors.

285 A pool of preterm human milk was digested as raw or after Holder pasteuriz

286 essure treatments on the volatile profile of human milk was less intense than that caused by HoP.

287 ations on the growth of C. albicans in whole human milk was studied.

288 Human milk was the richest source of nicotinamide mononu

289 study, using active matriptase isolated from human milk, we demonstrate that matriptase is able to cl

290 nt formulas serve as the best alternative to human milk when breastfeeding is not possible.

291 or constituent of an innate immune system of human milk whereby the mother protects her infant from e

292 Human milk whey had similar effects on Aae from A. actin

293 Supplementing human milk with DHA at a dose of approximately 1% of tot

294 , and HB-2) derived from cells cultured from human milk, with three breast cancer cell lines (MCF-7,

295 these fatty acids increased significantly in human milk within 6 h of consumption of the test formula