ライフサイエンスコーパス: human retina

1 e normal function of ON bipolar cells in the human retina.

2 was used to verify ZBED4 mRNA expression in human retina.

3 macaque retina, which is very similar to the human retina.

4 ossibly present as early as mid-gestation in human retina.

5 le degree of cellular plasticity in the aged human retina.

6 otensin II (Ang II) and its receptors in the human retina.

7 ganglion cells in the normal rat, mouse, and human retina.

8 noid constituting the macular pigment of the human retina.

9 tivity was determined in bovine, rabbit, and human retina.

10 cells undergo activation in the glaucomatous human retina.

11 , supports a photoreceptive role for CRY2 in human retina.

12 lls were isolated from papain-DNase-digested human retina.

13 mes more abundant than CRY1 throughout adult human retina.

14 lso cloned from rat, chicken, zebrafish, and human retina.

15 from a human AMD donor compared with healthy human retina.

16 OX-1 and COX-2 in the normal mouse, rat, and human retina.

17 receptor cells of the peripheral and central human retina.

18 cone photoreceptors of peripheral or central human retina.

19 nd splice variants of MYO3B expressed in the human retina.

20 both the rod and cone photoreceptors in the human retina.

21 -specific monoclonal antibodies in mouse and human retina.

22 mmunoreactivity (IR) in the rabbit, rat, and human retina.

23 as limited to the outer nuclear layer of the human retina.

24 tudy we aimed to characterize the A cells in human retina.

25 es a profile of genes expressed in the adult human retina.

26 is showed that hDGK epsilon was expressed in human retina.

27 angement, and investigated its expression in human retina.

28 ining for CB1 receptors also was detected in human retina.

29 e insoluble interphotoreceptor matrix of the human retina.

30 of small Ras-like GTP-binding proteins from human retina.

31 asive measurement of macular pigments in the human retina.

32 compounds were present in the extracts from human retina.

33 ecause of the fewer number of S-cones in the human retina.

34 caca monkey, a widely accepted model for the human retina.

35 Fibronectin is synthesized in the adult human retina.

36 ividual nerve fibre bundles(5) in the living human retina.

37 ids were also detected in the RPE of healthy human retina.

38 confirm the presence of Bestrophin in normal human retina.

39 ar to A8 amacrine cells described in cat and human retina.

40 ssed in retinoblastoma and in the developing human retina.

41 n the Ca(V)1.4 transcripts isolated from the human retina.

42 mary initiator of visual transduction in the human retina.

43 was expressed in the photoreceptor layer of human retina.

44 pression was increased in diabetic mouse and human retina.

45 erve fiber layer and microvasculature of the human retina.

46 the cone photoreceptor mosaic in the living human retina.

47 he molecular physiology and pathology of the human retina.

48 ion MRI of lamina-specific structures in the human retina.

49 nicotine by itself affects responses in the human retina.

50 ogy of proximal and possibly also the distal human retina.

51 OT, RASSF3 and GNS] are all expressed in the human retina.

52 and to investigate retinal asymmetry in the human retina.

53 ents and blue light filters in the macula of human retina.

54 n how vasomotor function is regulated in the human retina.

55 ARPP-32" is present in rat, cat, monkey, and human retinas.

56 ributing to disease progression in the aging human retinas.

57 ression profiles between normal and diseased human retinas.

58 ression of the USH2A gene in rat, mouse, and human retinas.

59 oung (13-14 years) and elderly (62-74 years) human retinas.

60 fatty acid composition similar to those from human retinas.

61 to the retinal ganglion cells of the rat and human retinas.

62 ion and localization of NOS-1 in the rat and human retinas.

63 labeling was detected with homogenates from human retinas.

64 pression, leading to RGC senescence in adult human retinas.

65 sis of Stargardt disease and is evidenced in human retinas.

66 but absent from the RPE monolayer in normal human retinas.

67 n both the nuclear and cytosolic extracts of human retinas.

68 Immunohistochemistry localized ZBED4 in human retinas.

69 A piece of well-fixed peripheral human retina (10 mm, 35 degrees nasal to the fovea) was

70 How the human retina accommodates mis-specified types and number

71 Humans retinas affected with age-related macular degener

72 ocalized by immunofluorescence microscopy in human retinas, aged 8.4 fetal weeks to adult.

73 In the human retina, all of the components for this circuit exi

74 novel DGK, which we designated DGKiota, from human retina and brain libraries.

75 his antibody reveals AIPL1 to be specific to human retina and cell lines of retinal origin (Y79 retin

76 and L148/R from the published sequences for human retina and liver.

77 xpressed in distinct patterns throughout the human retina and ONH.

78 used to elucidate SPC enzyme activity within human retina and optic nerve head (ONH) tissues.

79 mRNA expression of the SPC family in the human retina and optic nerve head tissues was evaluated

80 n, localization, and activity of SPCs in the human retina and optic nerve head.

81 IL-8 protein expression was found in human retina and optic nerve.

82 q analysis revealed three transcripts in the human retina and relatively higher expression in S-cone-

83 Kir7.1 localized to human retina and retinal pigment epithelium and was espe

84 MS2 gene were both transcribed in rhesus and human retina and retinal pigment epithelium.

85 e found abundant expression of GLP-1R in the human retina and retinas from db/db mice.

86 In the human retina and RPE, the authors could not detect 27-hy

87 s could also be quantified in the bovine and human retina and RPE.

88 RNA derived from human retina and skin was analyzed and alternate 5' exon

89 concentrations in the fovea centralis of the human retina and their role in the prevention of age-rel

90 of the cryptochromes, CRY1 and CRY2, in the human retina and to correlate expression of these putati

91 Two human retina and two retinal pigment epithelium (RPE)/ch

92 that LOC387715/ARMS2 mRNA is detected in the human retina and various cell lines and encodes a 12-kDa

93 in the developing photoreceptor layer of the human retina and within the photoreceptors of the adult

94 Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by com

95 to measure carotenoid levels in flat-mounted human retinas and eyecups and in experimental animal eye

96 Expression of FN-EDA in normal human retinas and PVR membranes was evaluated by immunoh

97 ence of Wilson and Menkes mRNAs in mouse and human retinas and retinal pigment epithelial cell lines.

98 s accumulation is conserved across mouse and human retinas and that the addition of HSPG binding to o

99 entially treatable photoreceptors across the human retinas and the rate of degeneration are not known

100 ly 20:1 in the foveal center (similar to the human retina) and only approximately 1.5:1 in the parafo

101 RGS 9 was isolated from a rat hypothalamus, human retina, and a human kidney (Wilm's) tumor.

102 nt carotenoids in quail retina are absent in human retina, and because of their different packaging (

103 f the timing of key events in the developing human retina, and in particular the factors critical for

104 by immunohistochemistry in cross sections of human retina, and its subcellular localization was deter

105 larities between the marmoset retina and the human retina, and the exceptionally small size of the mo

106 oreceptor activity of single cones in living human retina, and therefore, it may provide diagnostic o

107 In human retina, and those of cat and macaque, these high-r

108 aponica), for comparison with carotenoids in human retina, and to assess the effects of different sap

109 We conclude that in human retina, antibodies against calretinin can be used

110 rtions of IMPDH1 transcripts and proteins in human retina are different from those in mouse retina.

111 Certain cells of the human retina are extremely sensitive to loss of function

112 Hereditary degenerations of the human retina are genetically heterogeneous, with well ov

113 The predominant transcripts of IMPDH1 in human retina are the result of alternate splicing and al

114 limit of quantification for 3'-oxolutein in human retina at a signal-to-noise ratio of 10 was 6 pg.

115 Histologic examination of six human retinas at 20-mum intervals from the temporal and

116 We found isoLG adducts in aged human retina but not in the retina of mice kept under di

117 tential of this gene family expressed in the human retina, but the functional diversity created by th

118 lied hsp27 antibody enters neuronal cells in human retina by an endocytic mechanism.

119 hesized to function as an antioxidant in the human retina by inhibiting the peroxidation of long-chai

120 diameter punches of macula and midperipheral human retina by quantitative RT-PCR.

121 t was detected in rat brain, rat testis, and human retina by RT-PCR.

122 reefold decrease in HSC70 mRNA levels in the human retina by the eighth decade of life.

123 nalysis of their compartmentalization in the human retina, by both GAG chain type and sulfation patte

124 of photoreceptors in the central part of the human retina (called the macula).

125 regulatory protein in the layer of ECM under human retina, called Bruch's membrane.

126 y a combination of large-scale sequencing of human retina cDNA clones and searches of expressed seque

127 ABArho1, two new variants were identified in human retina cDNA libraries.

128 We have cloned and characterized from a human retina cDNA library a mammalian ortholog of Drosop

129 Human retina cDNA library clones were arrayed at high de

130 ification of PhLP1 and the PhLOPs was from a human retina cDNA library, using a PCR product for libra

131 ared with control cultures by using a custom human retina cDNA microarray and were validated by quant

132 of glycosaminoglycans (GAGs) in the healthy human retina, choroid, and sclera.

133 application to image quantitative BF of the human retina/choroid during rest and isometric exercise.

134 Robust BF of the unanesthetized human retina/choroid was detected.

135 MRI detected three layers within the human retina, consistent with MRI findings in rodent, fe

136 male and one female retina revealed that the human retina contains 7283 +/- 237 melanopsin-ir (0.63-0

137 ts and reading is the fact that both rat and human retinas convert bleach patterns into ganglion cell

138 In the normal human retina, COX-1 immunoreactivity is present in micro

139 In the normal human retina, COX-2 immunoreactivity is only present in

140 Cone packing density in the living human retina decreases as a function of age within the f

141 rx expression can promote differentiation of human retina-derived stem cells into light-sensitive pho

142 Proteomic analyses of the human retina detected expression and differential regula

143 have been studied make conclusions about the human retina difficult.

144 The human retina does not replace lost or damaged neurons, u

145 o prominently detectable in the glaucomatous human retinas, downregulated CFH expression in retinal c

146 Cell death occurring in human retina during AMD, high IOP, and diabetic retinopa

147 and extent of neuronal reorganization in the human retina during normal aging.

148 characterization of the visual input to the human retina during normal head-free fixation.

149 I trial indicated that CNTF is safe for the human retina even with severely compromised photorecepto

150 roteins were then studied in isolated intact human retina (ex vivo) and cultured rat retinal cells (i

151 The patient's serum applied to normal human retina exhibited positivity in the inner nuclear l

152 howed aldose reductase immunoreactivity, and human retinas exposed to high glucose in organ culture i

153 In this study, we found that human retina expressed all GRKs except GRK4.

154 Magnetic resonance imaging (MRI) of the human retina faces two major challenges: eye movement an

155 In the adult human retina, fibronectin is present exclusively in the

156 rge animal model of diabetes relevant to the human retina for evaluation of vascular function is also

157 key epochs in the transcriptome dynamics of human retina from fetal day (D) 52 to 136.

158 ecessary to understand the marked changes in human retina from late gestation to early adulthood.

159 titative chromosomal conformation capture on human retinas from two male donors showed that the L/M e

160 al technologies to image cells in the living human retina, GCs remain elusive due to their high optic

161 array was constructed based on the predicted human retina gene expression profile according to expres

162 Embryonic human retina has a pool of precursors (CXCR4(+) and c-Ki

163 evelopmental sequence of plexiform layers in human retina has been characterized, the molecular steps

164 Human retina has limited regenerative power to replace c

165 mental animals; however, localization in the human retina has not been definitive.

166 udies from anesthetized feline, primate, and human retinas have revealed near-infrared fundus reflect

167 he finding that rods flanking laser burns in human retinas have sustained increases in bFGF immunorea

168 In the human retina, identification of Ang II and its bioactive

169 e investigated possible extravasation in the human retina in acute migraine (n = 8) and cluster heada

170 We studied patches of CNS myelin in human retina in vivo to determine the pattern of myelina

171 of tbdn-1 during adult homeostasis in normal human retinas, in a model of choroid-retina endothelial

172 analysis show that IMPG2 is processed in the human retina into multiple alternatively sized transcrip

173 roarrays, the authors show that aging of the human retina is associated with changes in patterns of g

174 n of gene expression variation in the normal human retina is attributable to identifiable biological

175 Aging of the human retina is characterized by progressive pathology,

176 isualization of microvascular changes in the human retina is clinically limited by the capabilities o

177 A more complete knowledge of the human retina is crucial for counteracting the events tha

178 Furthermore, the human retina is devoid of myelin, but inflammation was d

179 e reactivity that the ASL-MRI detects at the human retina is dominated by the choroidal blood flow, a

180 Conversely, the human retina lacks rpgrip1b, and the constitutive transc

181 nomenclature system that is consistent with human retina layer designations to standardize murine OC

182 and 3-hydroxy-beta,epsilon-caroten-3'-one in human retina may be interconverted through a series of o

183 uctive pathways for lutein and zeaxanthin in human retina, may therefore play an important role in pr

184 In both rat and human retinas, NOS-1 is expressed in the inner segments

185 ell cultures and sections of fetal and adult human retina, NRL is present in the nuclei of developing

186 ent carotenoids lutein and zeaxanthin in the human retina occurs early in life.

187 hRPCS were isolated from human retina of 14 to 18 weeks gestational age (GA) and

188 lity and high-resolution anatomic MRI of the human retina on a 3-Tesla (T) MRI scanner.

189 e show that these genes are expressed within human retina, optic nerve and trabecular meshwork and th

190 level in older compared with that in younger human retinas or RPE/choroids.

191 t of oxidative stress on the UPP in cultured human retina pigment epithelial cells.

192 he workflow allowed a detailed view into the human retina proteome highlighting new molecular players

193 The cone-dominant human retina resulting from NR2E3 mutations affords grea

194 of associations with common diseases of the human retina, retinal pigment epithelium and choroid and

195 Normal human retina revealed strongly labeled cone outer segmen

196 d PP7 was identified from cDNA produced from human retina RNA.

197 In human retina, RP2 was localized to the plasma membrane o

198 cted with an approximately 80-kDa protein in human retina, RPE, kidney, and lung.

199 cripts (isoform A and isoform B) in MEFs and human retina-RPE-choroid samples (n = 83).

200 However, proteomic studies investigating on human retina samples are still rare.

201 dentified with high confidence (FDR < 1%) in human retina samples.

202 In the human retina, second-order processing of signals origina

203 -PCR clones derived from 5 fetal and 2 adult human retinas sequenced in our laboratory, revealed that

204 Immunohistochemistry studies in the human retina showed intense labeling of cone inner segme

205 Immunocytochemistry in human retina showed that CRX protein was not detected un

206 vel regulation of the ATPase activity of the human retina specific ATP binding cassette transporter (

207 trategy was used to isolate a 1381-base pair human retina-specific cDNA, human retinal gene 4 (HRG4),

208 In degenerate canine and human retinas, strong immunolabeling appeared in rod and

209 In primate and human retina such classification has so far, not been ap

210 earlier than L/M mRNA or protein across the human retina, suggesting that the two cone types differe

211 he cloning of GRK7 from rod-dominant pig and human retinas, suggesting that this kinase plays a role

212 ein (metabolite of lutein and zeaxanthin) in human retina suggests that lutein and zeaxanthin may act

213 a novel gene from pigment epithelium of the human retina that codes for a PEDF-binding partner, whic

214 of proteins upregulated in the glaucomatous human retina that exhibit many links to TNF-alpha/TNFR1

215 of chromatic and luminance processing in the human retina, the differences that exist between ERGs fr

216 The central region of the human retina, the fovea, provides high-acuity vision.

217 In the human retina, the most abundant mRNA isoforms are derive

218 s data had shown CRX expression in the adult human retina to be photoreceptor-specific; however, we d

219 d from different regions of the dark-adapted human retina to evaluate localized rod function.

220 ducted a microarray-based analysis comparing human retina to hESC-derived retinal cells.

221 In macaque and human retina, two distinct populations of melanopsin cel

222 expression profiles were obtained from five human retinas, two livers, and the cerebral cortical reg

223 ar cells, as well as horizontal cells of the human retina, undergo extensive dendritic reorganization

224 In adult human retina, VEGF-like immunoreactivity (VEGF-IR) is fo

225 The distribution of Vn in the normal adult human retina was examined using antibodies to circulatin

226 An immortalized cell line obtained from human retina was investigated for the expression of know

227 or RT-PCR from rat, chicken, zebrafish, and human retina, was performed to determine the sequence of

228 e the ability of tachyzoites to navigate the human retina, we developed an ex vivo assay, in which a

229 F) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with doubl

230 e loss of RPGR in the all-cone region of the human retina, we used Nrl(-/-) (neural retina leucine zi

231 racterize expression variation in the normal human retina, we utilized a custom retinal microarray to

232 ed from perifoveal and peripheral regions of human retina were found to be of high purity as indicate

233 dissociated Muller cells from the bovine and human retina were studied with the perforated-patch conf

234 High-resolution images of the human retina were successfully obtained with the MMOCT s

235 Vertical cryosections of human retinas were immunostained with antibodies specifi

236 o concurrently elicit ERG responses from the human retina which reflect processing in both chromatic

237 pic cultures of developing mouse, monkey and human retinas, which can be maintained for up to 2 weeks

238 of rhodopsin can be measured locally in the human retina with a widely available SLO.

239 g retina shares many cytologic features with human retinas with retinitis pigmentosa and provides an

240 With approximately 10(6) ganglion cells, the human retina would transmit data at roughly the rate of

241 However, in human retinas, ZBED4 was localized to cone nuclei, inner