ライフサイエンスコーパス: human skin

1 expression level of heparan sulfate (HS) in human skin.

2 ar chemical agents are irritating or not for human skin.

3 ify Il22 mRNA and IL-22 protein in mouse and human skin.

4 ith aging in a tissue-specific manner and in human skin.

5 Sunlight has important biological effects in human skin.

6 ventral; palmoplantar) and nonvolar (dorsal) human skin.

7 ed in tape-stripped mouse skin and scratched human skin.

8 elivery and subsequent expression of pDNA in human skin.

9 ight on the pathobiological roles of KLK7 in human skin.

10 e and study cutaneous itch-sensing nerves in human skin.

11 the mobilization of melanocyte stem cells in human skin.

12 erties have been identified in the dermis of human skin.

13 keratoses, the major precancerous lesion in human skin.

14 (pCMVbeta and pEGFP-N1) into viable excised human skin.

15 d to the evolution of the unique features of human skin.

16 tion spectrum of UVR-induced mtDNA damage in human skin.

17 rent wavelengths for producing vitamin D3 in human skin.

18 n the differentiating granular cell layer of human skin.

19 d underlie the severe syndromic phenotype in human skin.

20 combating age-associated collagen deficit in human skin.

21 otein expression, and tyrosinase activity in human skin.

22 res were not active at the levels emitted by human skin.

23 otooxidative stress potentially operative in human skin.

24 ssively increase with aging in sun-protected human skin.

25 ex pathways of sex steroid intracrinology in human skin.

26 ) immune surveillance T cells within healthy human skin.

27 ves a critical role in the repair of damaged human skin.

28 oxic alkaloids, topically applied ex vivo to human skin.

29 st closely models the tissue architecture of human skin.

30 taxa, represented by a core archaeome of the human skin.

31 activation or negative immune regulation in human skin.

32 inol (vitamin A)-mediated differentiation of human skin.

33 rmal-epidermal separation in cryosections of human skin.

34 ly delineate the DEJ in RCM stacks of normal human skin.

35 hypopigmentation phenotype in both mouse and human skin.

36 tion is known to augment COX-2 expression in human skin.

37 us 6 (HPyV6) and HPyV7 are commonly found on human skin.

38 e of eccrine glands in the repair of wounded human skin.

39 amples of healthy and experimentally wounded human skin.

40 olation of primary fibroblasts and LECs from human skin.

41 types, including cells of the target tissue-human skin.

42 ignancy can also occur in PIPs within normal human skin.

43 s in paired samples of normal and irradiated human skin.

44 moduli increased with body mass, except for human skin.

45 ions of dietary treatments in both mouse and human skin.

46 onomy of APC subsets found in both mouse and human skin.

47 2A (p16(ink4)) expression in organ-cultured human skin.

48 2 response is operational in acute wounds of human skin.

49 Trypanosome parasites are hiding in human skin, a discovery that may undermine efforts to el

50 e changes in the structure and physiology of human skin abnormalities by non-invasive optical imaging

51 We also show that IL-23 is released in human skin after scratching and polarizes human skin DCs

52 ifferent studies expand our understanding of human skin aging.

53 Integrin FA loss in mouse and human skin also causes a wound-like appearance.

54 en measuring skin permeation through excised human skin, an excellent flux of 2 mug/(cm(2).h) was det

55 h blood vessel networks, over 8 mm x 8 mm of human skin and 5 mm x 5 mm of human areola.

56 cus epidermidis is a ubiquitous colonizer of human skin and a common cause of medical device-associat

57 lassezia species are ubiquitous residents of human skin and are associated with several diseases such

58 phenotypic differences between the mouse and human skin and broadly informs on the prevailing princip

59 is an important protein for pigmentation in human skin and eyes.

60 locus analysis, utilizing RNA-seq data from human skin and found that LCE3B/C-del was associated wit

61 RNA profiling data from psoriatic and normal human skin and from murine miRNA knockout assays.

62 l care products (PCPs) for the protection of human skin and hair from damage by ultraviolet (UV) radi

63 tively expressed in the epidermis of healthy human skin and has been found to be upregulated in chron

64 iptome of clinically relevant sensitizers in human skin and identifies unique pathways preferentially

65 se commensurate with the level released from human skin and in the ratio produced by subject A, the a

66 in vivo as a measure of erythema induced in human skin and is expressed as Sun Protection Factor (SP

67 ermidis is normally a commensal colonizer of human skin and mucus membranes, but, due to its ability

68 Group A Streptococcus (GAS) commonly infects human skin and occasionally causes severe and life-threa

69 from 20% to 165% of that expressed in normal human skin and persisted for 3 months.

70 c receptor, was expressed on nerve fibers in human skin and sensory neurons in dorsal root ganglia.

71 RORalpha and ROR gamma are expressed in human skin and serve as receptors for endogenously produ

72 ify a subset of Tregs that stably resides in human skin and suggest that these cells are qualitativel

73 show that mast cells are a target of DENV in human skin and that DENV infection of skin mast cells in

74 ies from human, zebrafish, and termite guts, human skin and tongue, soil, and estuarine microbial mat

75 Using a bioinformatics approach of human skin and vascular tissue, we determined IFN-gamma

76 is the most prominent inflammasome sensor in human skin, and all pathogenic NLRP1 mutations are gain-

77 onserved developmental pathways in postnatal human skin, and highlight the role of the skin microenvi

78 ed peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in prima

79 fold higher than that of miR-146b in healthy human skin, and it was more strongly induced by stimulat

80 on absorption by chromophores present in the human skin, appears to be a key mechanism of UV-induced

81 ics (such as reversibility and stability) of human skin are affected by the external stimuli, as well

82 ng therapeutic, but its molecular effects in human skin are largely unknown.

83 ationship between complex II and aging using human skin as a model tissue.

84 conducted after UV-A1 irradiation of normal human skin at an academic referral center.

85 as expressed throughout the dermis of intact human skin, at the expanding margins of human keloid sam

86 RNA aptamers can permeate across the intact human skin barrier to therapeutically relevant levels in

87 N2 are markedly elevated in keratinocytes in human skin basal cell carcinoma tumor islands.

88 e the presence of extravascular parasites in human skin biopsies from undiagnosed individuals.

89 Adult human skin biopsies were obtained from volunteers at the

90 scopy have been used to identify features in human skin biopsy samples diagnosed for basal cell carci

91 tic skin biopsy specimens, as well as normal human skin, blood, and primary cells, were used to inves

92 In ex vivo human skin, both melatonin and AFMK-stimulated expressio

93 ve fibroblast population that is abundant in human skin but not in gingiva may drive the profibrotic

94 KCND2 is expressed in human skin, but has not been associated with aging.

95 ngue fever, is transmitted during probing of human skin by infected-mosquito bite.

96 Analyzing digested normal human skin by single-cell RNA sequencing, we explored di

97 a from an ultraviolet radiation (UV)-induced human skin cancer and from a mouse model of urethane-ind

98 monstrated a label-free histology method for human skin cancer diagnosis that provides comparable res

99 DLX3 expression is lost in human skin cancers and is extinguished during progressio

100 that the pump-probe signals from melanin in human skin cancers correlate well with clinical concern,

101 mulus-dependent manner and was detectable in human skin cancers.

102 75, G361, LOX-IMVI) but not in non-malignant human skin cells (Hs27 fibroblasts, HaCaT keratinocytes,

103 d quantitative approach to monitoring normal human skin cells (keratinocytes and fibroblasts) as well

104 ydroxylumisterols inhibited proliferation of human skin cells in a cell type-dependent fashion with p

105 elective killing of P. acnes but not against human skin cells in vitro.

106 environmental-sensitive fluorescent dyes and human skin cells that generate fluorescence spectra patt

107 RORalpha and RORgamma are expressed in human skin cells that produce the noncalcemic 20-hydroxy

108 sue, Schaeffer and colleagues employ ex vivo human skin cells to investigate viral infection.

109 wavelengths, the responsiveness of different human skin cells, the magnitude of inter-individual diff

110 ring human papillomavirus (HPV) infection of human skin cells.

111 drives proliferation and differentiation of human skin cells.

112 ROS/RNS and effectively tune the behavior of human skin cells.

113 It has been suggested that human skin color adapts to balance the need for vitamin

114 The wide range in human skin color results from varying levels of the pigm

115 ated proteins, are important constituents of human skin connective tissue (dermis) and are essential

116 Because in the human skin connexin 26 (Cx26) is co-expressed with other

117 Human skin consists of multiple cell types, including ep

118 Human skin contains an abundant and diverse population o

119 In an ex vivo human model of BP, normal human skin cryosections were incubated with purified hum

120 We characterized the mutational landscape of human skin cutaneous melanoma (SKCM) using data obtained

121 Comparing modules derived from four human skin DC subsets and modules derived from the Immun

122 in human skin after scratching and polarizes human skin DCs to drive an IL-22 response, supporting th

123 complement factor C3 or C5 is synthesized by human skin-derived mast cells and whether their synthesi

124 We examined mature human skin-derived MCs using flow cytometry for expressi

125 D34(+) dermal fibroblasts present in healthy human skin disappear in the skin of systemic sclerosis p

126 olar fibroblasts, we demonstrate that in the human skin disease lichen simplex chronicus, WNT5a and K

127 ghly specific next-generation treatments for human skin diseases.

128 Mutations in K1/K10 are associated with human skin diseases.

129 Last, integrative biological analysis of human skin disorders has revealed unexpected functions f

130 We investigated 322 healthy human skin DNA methylomes associated with total body nev

131 As compared with normal human skin, downregulation of SIRT1 is in parallel with

132 its effectiveness for producing vitamin D in human skin due to the shorter exposure time.

133 rmore, acute applications of testosterone on human skin elicited a cooling sensation.

134 e epidermal barrier of both intact mouse and human skin, enter keratinocytes, and efficiently down-re

135 ation of sex steroids by primary cultures of human skin epidermal keratinocytes and dermal fibroblast

136 Inactivation of AHR activity during human skin equivalent development severely impaired epid

137 nvestigated for the first time using EPISKIN human skin equivalent tissue.

138 ma cleavage, induced psoriasiform changes in human skin-equivalent models.

139 past the epidermis was observed in cultured human skin equivalents and in mice but was found to be i

140 planted normal and SSc fibroblasts and in 3D human skin equivalents, in part by attenuating focal adh

141 relevant quantities of peptide to mouse and human skin even with hydrophobic peptides.

142 We studied the dynamics of DENV infection in human skin explants using quantitative in situ imaging.

143 Cultured donut-shaped human skin explants, subjected to ES, exhibited better e

144 rimary human skin-migratory DCs derived from human skin explants.

145 sis of the perturbation of kinome of GM00637 human skin fibroblast cells induced by arsenite exposure

146 ed the arsenite-induced growth inhibition of human skin fibroblast cells.

147 of the biosensor was tested by using normal human skin-fibroblast.

148 ypothesized that CD26 is highly expressed by human skin fibroblasts (SFBLs), and this associates with

149 r method on a unique age-based sample set of human skin fibroblasts and combined genome-wide transcri

150 ow-microgram quantities of DNA from cultured human skin fibroblasts and human colorectal carcinoma ce

151 We analysed primary human skin fibroblasts and induced neurons from heterozy

152 Focusing on transdifferentiation of primary human skin fibroblasts by forced expression of myogenic

153 ow that mitochondrial complex II activity in human skin fibroblasts decreases with age.

154 a potent ROS scavenging efficacy in cultured human skin fibroblasts derived from healthy donors and f

155 However, exogenous PTX3 helps human skin fibroblasts form the HC-HA-PTX3 complex with

156 Thus, we reprogramed human skin fibroblasts from cognitively normal individua

157 are known to upregulate TRPC3 expression in human skin fibroblasts in vitro.

158 ficantly, ectopic expression of vU1 genes in human skin fibroblasts leads to increases in levels of k

159 sed chimeric dimers fused to enhanced GFP in human skin fibroblasts of X-linked adrenoleukodystrophy

160 itate oxidative phosphorylation in harvested human skin fibroblasts that have been permeabilized with

161 y Western blot analysis, by AM cells but not human skin fibroblasts, despite being cultured in the pr

162 human isoform lacking exon 5 is expressed in human skin fibroblasts, HEK293 cells, and murine heart a

163 Using UV-exposed human skin fibroblasts, we found that, at the dose used,

164 at 5 and 20 min and 1, 2, and 4 h) in normal human skin fibroblasts.

165 podermatosclerosis, a condition of excessive human skin fibrosis.

166 m, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively.

167 ces; it can also be adaptively attached onto human skin for monitoring gentle body motions.

168 mis to the dermis, and its mutations cause a human skin fragility disorder coined recessive dystrophi

169 Using human skin from contact dermatitis patients and a mouse

170 Here we characterize the ILCs in human skin from healthy individuals and from the inflamm

171 on subunits such as DDB2 and XPC protect the human skin from ultraviolet (UV) light-induced genome in

172 wn to give the most effective protection for human skin from ultraviolet (UV) radiation.

173 n, short-term ex vivo cultures of (i) intact human skin, (ii) skin pretreated with tape-strippings an

174 and lymphatic endothelial cells in prenatal human skin in situ using multicolor immunofluorescence a

175 cted cell that was seen after inoculation of human skin in the SCID mouse model or monolayers with hi

176 he system also enhanced penetration of HA in human skin in vitro, penetrating deep into the epidermis

177 However, the molecular effects of UVA1 in human skin in vivo are surprisingly poorly understood.

178 cted PLA2 generates lysophospholipids within human skin in vivo, and polyclonal T cell responses are

179 y (OCT) based lymphangiography (OLAG) within human skin in vivo.

180 egration of wearable electronic devices with human skin in ways that bypass the mechanical and therma

181 udy, we performed IVPT studies using excised human skin (in vitro) and harmonized in vivo human serum

182 The first design mimics the pores in human skin, in which pre-cut flaps open to produce pores

183 rine model for infection that closely mimics human skin infection, we show that the vaccine can prote

184 ing permeability of a given compound through human skin is a principal challenge owing to the highly

185 The human skin is a promising conduit for genetic engineerin

186 Human skin is a remarkable organ.

187 The human skin is an organ with a surface area of 1.5-2 m(2)

188 These results suggest that aging in human skin is associated with a critical mid-life period

189 The localization of memory T cells to human skin is essential for long-term immune surveillanc

190 hypothesis that the abundance of archaea on human skin is influenced by human age and skin physiolog

191 tic system's response to inflammation within human skin is monitored throughout an acne lesion develo

192 However, the folate content of human skin is unknown and may affect the effectiveness o

193 f the most predominant yeasts of the healthy human skin, its cell wall has been investigated in this

194 studies related to its functionality in the human skin, its utility as a tool against UV-induced adv

195 e and sensitive biomarker of UVR exposure in human skin, its wavelength dependency is unknown.

196 ) and apoptosis were observed in PAO-treated human skin keratinocytes NHEK and HaCaT.

197 3IP2-dependent target of IL-17 signalling in human skin keratinocytes, thereby functionally linking t

198 ns were noticed in lewisite-treated cultured human skin keratinocytes.

199 Lightly pigmented human skin (L* >65) was exposed up to 4 times (1 exposur

200 In human skin, large amounts of HA are found in the dermis.

201 in abortively infected cultured cells and a human skin lesion by next-generation sequencing.

202 MOCV infections of several cell lines and a human skin lesion.

203 tions represent a subset of RNAs detected in human skin lesions which mapped to homologs of numerous

204 nity and suppress inflammation to persist in human skin lesions.IMPORTANCE Poxviruses adapt to specif

205 We demonstrate an important role for human skin mast cells in DENV infection and identify a n

206 imulatory effect was consistent in mouse and human skin mast cells.

207 ell proteins by proteome analysis of primary human skin mast cells.

208 een reported for mouse skin, we show that in human skin matriptase is primarily expressed in the basa

209 For this system's proof of concept, human skin measurements on melanocytic nevus, vitiligo,

210 h et al., in a tour-de-force effort, map the human skin metagenomes over time.

211 ghts into the complexity and biogeography of human skin microbes.

212 CPyV may represent a common component of the human skin microbial flora.

213 The human skin microbiome acts as an important barrier prote

214 suggests an integral interaction between the human skin microbiome and ADSCs.

215 The human skin microbiome has been suggested to play an esse

216 Studies of the human skin microbiome suggest that Propionibacterium acn

217 us epidermidis, a commensal bacterium in the human skin microbiome, produces short-chain fatty acids

218 onstant but highly variable component of the human skin microbiome, yet factors that determine their

219 structural and functional composition of the human skin microbiome.

220 rate that cutaneous leishmaniasis alters the human skin microbiota.

221 omparison of the transcriptional profiles of human skin migratory CD1a+ LCs and CD11c+ dermal dendrit

222 lso induces phenotypic maturation of primary human skin-migratory DCs derived from human skin explant

223 t, performed on an in vitro reconstructed 3D human skin model, indicated that MB was safe for long-te

224 pidermal melanocytes, and in a reconstructed human skin model.

225 We used murine and human skin models to address the hypothesis that AHR act

226 RNA knockdown of CAPN12 in three-dimensional human skin models was associated with acanthosis, disorg

227 The barrier function of human skin models was tested by the application of bioti

228 In normal human skin, mTregs preferentially localized to hair foll

229 phic commensal fungus that colonizes healthy human skin, mucosa, and the reproductive tract.

230 Malassezia is the dominant fungus in the human skin mycobiome and is associated with common skin

231 murine dorsal root ganglia (DRG) neurons and human skin nerves.

232 Analysis of 25 samples of normal human skin, nevi, and melanomas revealed a positive corr

233 Here, we report that the human skin odour profile is affected by malaria infectio

234 The varied topography of human skin offers a unique opportunity to study how the

235 Additional sources included human skin oil oxidation by ozone, producing compounds s

236 n human epidermis, we treated organ-cultured human skin, or isolated cultured human epidermal keratin

237 ation of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions

238 These findings combined with our studies on human skin organ cultures strongly indicate that the OR

239 t glands are the most abundant appendages in human skin, outnumbering hair follicles by a factor clos

240 BD-3 transcription in experimentally wounded human skin (P = .003).

241 er when M. sympodialis is cultured at normal human skin pH versus the elevated pH present on the skin

242 tial to open up new avenues in the realms of human skin photobiology.

243 ion in these cells is vital to understanding human skin physiology.

244 Variation in human skin pigmentation evolved in response to the selec

245 Confocal fluorescence microscopy studies of human skin pre-labeled with the NO-imaging probe diamino

246 appear to abrogate photoimmunosuppression in human skin, providing additional support for their chemo

247 melanocytes and fibroblasts isolated from 36 human skins ranging from neonates to 86 years old.

248 Human skin reconstitution employing STRA6KD HaCaT cells

249 Human skin relies on cutaneous receptors that output dig

250 isplaying UVA-driven photodyamic activity in human skin remains largely undefined.

251 of EDA receptor activation are conserved in human skin repair.

252 iptome, of imiquimod-induced inflammation in human skin resembles acute contact dermatitis rather tha

253 Finally, we demonstrate that DETCs and human skin-resident T cells limit DNA damage in keratino

254 Whereas touching the roots with soil or human skin resulted in odor detection, agitating the roo

255 7 response was stimulated in freshly excised human skin resulting in significantly upregulated IL-17f

256 Electron microscopy analysis of human skin samples revealed three lines of evidence supp

257 h normal skin, Sesn2 is up-regulated in both human skin SCC and melanoma.

258 Finally, high-grade and recurrent human skin SCC recapitulated the signaling changes obser

259 to block relapse and metastasis of advanced human skin SCC.

260 reduces tumor growth in a xenograft model of human skin SCC.

261 Compared with normal human skin, SIRT1 is downregulated in both AD and non-AD

262 small (<24 mm(2) for mice and <12 mm(2) for humans) skin specimens that can be readily obtained from

263 ally, we found that SIRT6 was upregulated in human skin squamous cell carcinoma.

264 on changes in cultured melanocytes, modified human skin substitutes, and ex vivo skin.

265 ding on 1-mol/L salt (sodium chloride)-split human skin substrate by indirect immunofluorescence micr

266 ositivity and sequencing analyses of healthy human skin suggest that MCPyV may represent a common com

267 isomiRs had aberrant expression in psoriatic human skin, suggesting their potential function in psori

268 es more efficient in producing vitamin D3 in human skin than the sun in less than 1/60(th) the time.

269 Human skin, the body's largest organ, functions as a phy

270 In full-thickness human skin, the delivery efficiency drastically decrease

271 Already in second-trimester human skin, the phenotype of blood and lymphatic vessels

272 In normal human skin, the SDR9C7 was abundantly expressed in granu

273 When coated on human skin, they are capable of slowing water evaporatio

274 Using genetically engineered human skin tissue in vivo, we demonstrate that diminishe

275 hat autophagosomes were abundant in infected human skin tissues.

276 Biological responses of human skin to UVR including cancer and aging are largely

277 Here we show that in both mouse and human skin, topical application of a mitochondrially tar

278 is is the first study to globally assess the human skin transcriptional response during early Lyme di

279 Sensory receptors in human skin transmit a wealth of tactile and thermal sign

280 DH) expression when the fungus is exposed to human skin, underscoring its potential as a drug target.

281 etration of the aptamer into freshly excised human skin using two different fluorescent labels.

282 e gene expression of exogenous naked pDNA in human skin using volumes that are considered to be stand

283 lude that swine skin is a relevant model for human skin vaccination.

284 itric oxide (NO) metabolites are abundant in human skin, we hypothesized that exposure to UVA may mob

285 f the antiinflammatory drug dexamethasone in human skin, we model the time-dependent drug penetration

286 umulation, whereas in newborn mice and adult human skin, we report LC3 puncta coincident with misshap

287 In vitro drug permeation studies across human skin were carried out to obtain the percent of est

288 induces the infiltration of eosinophils into human skin when injected intradermally.

289 TIP39 was observed in the basal layer of human skin, whereas PTH2R was detected in the spinous to

290 ave the potential to better interface to the human skin, whereas silicon-based electronics are extrem

291 kin is one of the best structural models for human skin, widely used to probe drug transcutaneous pas

292 on for studying the spatial relationships of human skin with hygiene, the microbiota, and environment

293 Infection of human skin with Mycobacterium ulcerans, the causative ag

294 omic analysis that P450 27C1 is localized to human skin, with two proteins of different sizes present

295 igen ovalbumin (OVA) into murine, swine, and human skin within 1h.

296 terized the dynamic change of the miRNome in human skin wounds.

297 In a human skin xenograft transplant model, adoptive transfer

298 f these observations during VZV infection of human skin xenografts in the SCID mouse model of VZV pat

299 We first investigated autophagy in human skin xenografts in the severe combined immunodefic

300 c mutant gB[Y881F] is severely attenuated in human skin xenografts.