ライフサイエンスコーパス: human-type

1 ntains ancient mitochondrial DNA of a modern human type.

2 composed of the extracellular portion of the human type 1 (p55) tumor necrosis factor receptor (TNFR)

3 The human type 1 (placenta, breast tumors, and prostate tumo

4 Human type 1 3 beta-hydroxysteroid dehydrogenase/isomera

5 are present in the primary structure of the human type 1 3beta-HSD/isomerase.

6 r understanding of the structure/function of human type 1 and 2 3beta-HSD/isomerase may lead to the d

7 six sulfonamide inhibitors to two isozymes (human type 1 and bovine type 2) was analyzed by both The

8 enes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes ra

9 n NOD mice, evidence of their involvement in human type 1 diabetes (T1D) has been circumstantial.

10 Events defining the progression to human type 1 diabetes (T1D) have remained elusive owing

11 Human type 1 diabetes (T1D) is an autoimmune disease ass

12 Nonobese diabetic (NOD) mice and some human type 1 diabetes (T1D) patients manifest low to hig

13 about its involvement in the development of human type 1 diabetes (T1D).

14 genic disease that resembles in many aspects human type 1 diabetes (T1D).

15 R) gene is associated with susceptibility to human type 1 diabetes (T1D).

16 ZnT8) is a major target of autoantibodies in human type 1 diabetes (T1D).

17 NOD mice model human type 1 diabetes and are used to investigate tolera

18 of PTPN22 as a novel susceptibility gene in human type 1 diabetes and continued progress in defining

19 This is relevant for human type 1 diabetes and has implications for the use o

20 tivator of transcription (STAT) 1 pathway in human type 1 diabetes and in mouse models, especially in

21 CD8(+) T cells are critical in human type 1 diabetes and in the NOD mouse.

22 r response to the (B9-23) insulin epitope in human type 1 diabetes and suggests that the mouse and hu

23 may be an antigen for pathogenic T cells in human type 1 diabetes and, thus, a new, potential target

24 imal models is well-established, but data on human type 1 diabetes are tentative and based on studies

25 es with NOD mice, increased understanding of human type 1 diabetes can be gained by evaluating the pa

26 In the current study, a human type 1 diabetes candidate region on chromosome 1q4

27 These data in human type 1 diabetes emphasize the role of Th1/Th17 pla

28 ne diabetes to provide valuable insights for human type 1 diabetes in terms of pancreatic histopathol

29 Human type 1 diabetes is associated with defects in the

30 Human type 1 diabetes mellitus (T1DM) arises through aut

31 immune insulin-dependent diabetes similar to human type 1 diabetes mellitus (T1DM), whereas the BBDR+

32 In human type 1 diabetes pancreatic islets, fasting conditi

33 Numerous aspects of human type 1 diabetes pathogenesis are recapitulated in

34 reviously utilized a novel bioassay in which human type 1 diabetes sera were used to induce a disease

35 Like the human type 1 diabetes signature, the DRlyp/lyp signature

36 ate of blood NK cells at different stages of human type 1 diabetes, and whether genetic or phenotypic

37 in different autoimmune diseases, including human type 1 diabetes, but their relationship to changes

38 The pathogenesis of human type 1 diabetes, characterized by immune-mediated

39 class II gene most commonly associated with human type 1 diabetes, direct in vivo experimental evide

40 NOD mice, a model strain for human type 1 diabetes, express proinsulin (PI) in the th

41 ce, the most widely studied animal model for human type 1 diabetes, failed to prevent the development

42 ecule showing the strongest association with human type 1 diabetes, in the diabetes-predisposing mili

43 ite its importance as a major autoantigen in human type 1 diabetes, it is not required for the develo

44 key determinant of genetic susceptibility to human type 1 diabetes, spontaneous diabetes has been obs

45 Also similar to human type 1 diabetes, the canonical canine disorder app

46 ing a nonobese diabetic (NOD) mouse model of human type 1 diabetes, we investigated whether tolerance

47 ese diabetic (NOD) mouse is a good model for human type 1 diabetes, which is characterized by autorea

48 (UK93) indicated a similar genetic basis for human type 1 diabetes, with the major genetic component

49 dichotomy for the involvement of viruses in human type 1 diabetes.

50 and is a major autoantigen in both mouse and human type 1 diabetes.

51 great potential for immune intervention for human type 1 diabetes.

52 iabetes in the NOD mouse, an animal model of human type 1 diabetes.

53 candidates for determining susceptibility to human type 1 diabetes.

54 ding T cell metabolism in the progression of human type 1 diabetes.

55 al determinants of genetic susceptibility to human type 1 diabetes.

56 D) mice provides for their use as a model of human type 1 diabetes.

57 oimmunity and impaired beta cell function in human type 1 diabetes.

58 in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes.

59 L-17 on human islets have been implicated in human type 1 diabetes.

60 3 and IL-7 for the treatment of recent-onset human type 1 diabetes.

61 opment of type 1 diabetes in NOD mice and in human type 1 diabetes.

62 serpinB13 was associated with early onset of human type 1 diabetes.

63 rediabetic NOD mice-the prototypic model for human type 1 diabetes.

64 rogressive beta-cell failure in NOD mice and human type 1 diabetes.

65 utoimmune responses in NOD mice, a model for human type 1 diabetes.

66 be a promising strategy for interventions in human type 1 diabetes.

67 h a macrophage subpopulation in NOD mice and human type 1 diabetic samples and, hence, potentially a

68 ouses the genomic sequence data for both the human type 1 H strain and the bovine type 2 IOWA strain

69 f a novel TGF-beta-responsive element in the human type 1 plasminogen activator inhibitor promoter th

70 large N-terminal extracellular domain of the human type 1 PTH receptor (hP1Rc-WT) with residues 1-9 o

71 An animal model for human type 1 VWD, the RIIIS/J mouse strain, exhibits a p

72 These results suggest that in humans, type 1 responses play an important role in mucos

73 h-level IL-12p70 secretion characteristic of human type-1 polarized dendritic cells.

74 LC30A8) is a major target of autoimmunity in human type 1A diabetes and is implicated in type 2 diabe

75 n implicated in the regulation of murine and human type 1a diabetes.

76 ously reported for circulating iNKT cells in human type 1a diabetes.

77 F1D, showed highest (70.5%) homology to the human type 1D receptor.

78 ll interference RNA transfection of cultured human type 2 cells blocked processing of 35S-labeled pro

79 ion-PCR, both forms were detected in primary human type 2 cells.

80 Human type 2 cytokine responsiveness to schistosome anti

81 We performed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a nove

82 Islet amyloid accumulation is a hallmark of human type 2 diabetes (T2D).

83 as been implicated in the pathophysiology of human type 2 diabetes (T2DM).

84 eatic duodenal homeobox (PDX1) are linked to human type 2 diabetes and maturity-onset diabetes of the

85 ly-regulated hepatokine that is increased in human type 2 diabetes and obesity.

86 We focused on Spry2-a gene implicated in human type 2 diabetes by genome-wide association studies

87 tional network to induce genes identified in human type 2 diabetes genome-wide association studies li

88 A small number of susceptibility genes for human type 2 diabetes have been identified by candidate

89 Human type 2 diabetes is characterized by defects in bot

90 pted genetically determined rodent model for human type 2 diabetes is the Goto-Kakizaki (GK) rat; how

91 d provide a unique in vitro system emulating human type 2 diabetes mellitus.

92 or have long been suggested to contribute to human type 2 diabetes mellitus.

93 PPARgamma ligands, used to treat human type 2 diabetes, also down-regulate most immune sy

94 of diabetes mellitus that closely resembles human type 2 diabetes, including the formation of amyloi

95 Obesity predisposes to human type 2 diabetes, the most common cause of diabetic

96 slet MMP-9 activity may also be decreased in human type 2 diabetes, thereby contributing to increased

97 n deficiency in adipocytes in mice resembles human type 2 diabetes, with early insulin resistance and

98 e strain BKS.Cg-m +/+ Lepr(db)/J, a model of human type 2 diabetes.

99 expression in the impaired islet function of human type 2 diabetes.

100 lar mechanisms underlying the development of human type 2 diabetes.

101 they would exhibit a phenotype more akin to human type 2 diabetes.

102 S-2 may contribute to the pathophysiology of human type 2 diabetes.

103 n could contribute to the islet phenotype of human type 2 diabetes.

104 inhibitors are virtually independent for the human type 2 enzyme.

105 eplaced by Arg and Gln, respectively, in the human type 2 enzyme.

106 ichthyosis mouse mutation is very similar to human type 2 harlequin ichthyosis for which it may be a

107 periments with the Tritrichomonas foetus and human type 2 IMPDHs using tiazofurin and ADP, which bind

108 Although a putative human type 2 iodothyronine deiodinase (D2) gene (hDio2)

109 anges in gene expression similar to those in human type 2 islets.

110 Samples from human type 2 NHBD and BDD were obtained at the end of co

111 acid protein that most closely resembles the human Type 2 phosphatidic acid phosphatase PAP-2c.

112 Studies of the human type 2 receptor (AGTR2) gene in two independent co

113 in little change in the binding affinity for human type 2 receptor.

114 n-incompetent adenoviral vector encoding the human type 2 somatostatin receptor (Ad5-CMVhSSTr2).

115 lication-incompetent adenovirus encoding the human type 2 somatostatin receptor (hSSTr2) and the herp

116 In humans, type 2 diabetes generally occurs when insulin-se

117 Human type 3 3alpha-hydroxysteroid dehydrogenase, or ald

118 Purified recombinant human type 4 phosphodiesterase B2B (HSPDE4B2B) exists in

119 s were infected with a replication-deficient human type 5 adenovirus containing cDNA for SOD2.

120 A recombinant human type 5 adenovirus containing the murine MIP-1alpha

121 hypothesis we produced replication deficient human type 5 adenoviruses containing cDNAs for the rat a

122 oyed the blood group A and B antigenicity of human type A and B erythrocytes, but also released A-Tri

123 ociation constant of the GS-I isolectins for human type A erythrocytes increases with increasing vale

124 ffinity displayed by the GS-I isolectins for human type A erythrocytes is dependent on their multival

125 es and is identical to a previously reported human type A/B hnRNP except for a 47-residue insertion a

126 e was present in type A strains from healthy humans, type A strains causing CPE-associated antibiotic

127 ur-coordinate cob(II)alamin, variants of the human-type ACA enzyme from L. reuteri (LrPduO) were kine

128 d the high-resolution crystal structure of a human-type ACA from Lactobacillus reuteri with a four-co

129 me promotes catalysis, several variants of a human-type ACA from the lactic acid bacterium Lactobacil

130 site residues in the reaction catalyzed by a human-type ACA.

131 es exhibit a strong shift toward binding to "human-type" alpha2-6 sialosides but with notable differe

132 (9 of 9), and AB (4 of 4) RBCs; however, few human type B RBC samples (4 of 14) were hemagglutinated.

133 The mouse model of human type B Tay-Sachs disease recently engineered by th

134 an alternative catabolic pathway for GM2 in human type B Tay-Sachs patients.

135 Aged canines (dogs) accumulate human-type beta-amyloid (Abeta) in diffuse plaques in th

136 ASH (Drosophila, Arabidopsis, Synechocystis, Human)-type cryptochromes (cry-DASH) belong to a family

137 o acid mutations also alter binding to minor human-type glycans, suggesting that host adaptation may

138 trate specificity was similar to that of the human Type I 5PTase.

139 o, presumably by MIP-133 degradation of both human type I and human type IV collagen.

140 Zucker diabetic fatty (ZDF) rats, models of human type I and type II diabetes, respectively.

141 Ofatumumab is a human type I anti-CD20 antibody approved by the US Food

142 arginase is 58% identical to the sequence of human type I arginase but is 71% identical to the sequen

143 ical plasma membrane protein specific to the human type I cell, is a biochemical marker for lung inju

144 egions of different helical stability within human type I collagen and discussed their role in interm

145 , capillary-like networks by overlaying with human type I collagen followed by a second overlay of co

146 e, the more complex heterotrimeric C-telo of human type I collagen has been built from the correct se

147 mics simulations to explore the structure of human type I collagen in the vicinity of the collagenase

148 ed in several recombinant proteins including human Type I collagen polypeptides.

149 When a six-triplet human type I collagen sequence containing GFPGER was int

150 sequence for the alpha1 and alpha2 chains of human type I collagen, and the known amino acid sequence

151 s platelet-specific receptor to its ligands, human type I collagen, collagen-related peptide (CRP), a

152 8(+) T cell clone of pathogenic relevance in human type I diabetes recognizes >one million distinct d

153 e diabetic (NOD) mouse is an animal model of human type I diabetes with a strong genetic component th

154 acute onset of hyperglycemia reminiscent of human type I diabetes.

155 onstitutes the first reported structure of a human type I IFN bound to a therapeutic antibody.

156 Interestingly, the interaction between the human type I IFN receptor and STAT1 is not direct but me

157 The cytoplasmic domain of the human type I IFN receptor chain 2 (IFNAR2c or IFN-alphaR

158 alphas) and the extracellular (EC) domain of human type I IFN receptor subunit 2 (IFNAR2) was analyze

159 Studies have indicated that ZIKV evades the human type I IFN response, suggesting a role for the ada

160 The crystal structures of two human type I IFN ternary signaling complexes containing

161 Sixteen human type I IFN variants signal through the same cell-s

162 for STAT4 recruitment and activation by the human type I IFNAR (IFN-alphabetaR), it is not sufficien

163 The human type I IFNs include one IFN-beta and multiple IFN-

164 e I interferons (IFNs), bovine IFNAR-1 binds human Type I IFNs with moderate (nM) affinity, and can b

165 required for the antiproliferative effect of human type I IFNs.

166 regulating the growth inhibitory effects of human type I IFNs.

167 ative effects of murine IFNalphabeta but not human type I IFNs.

168 ey was capable of binding and activating the human type I IL-1 receptor.

169 aliana) plants constitutively expressing the human type I inositol polyphosphate 5-phosphatase (InsP

170 ana tabacum) cells were transformed with the human type I inositol polyphosphate 5-phosphatase (InsP

171 show that the constitutive expression of the human type I InsP 5-ptase in tobacco cells leads to an u

172 he promoter and proximal DNA segments of the human type I InsP3 receptor gene.

173 We have mapped 36 SARs in the human type I interferon (IFN) gene complex on chromosome

174 Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E.

175 novel set of inborn errors of immunity, the human type I interferonopathies.

176 an IFNAR-1 has a weak intrinsic affinity for human Type I interferons (IFNs), bovine IFNAR-1 binds hu

177 The human type I interferons, IFN-alpha, IFN-beta, and IFN-o

178 to the existence of the mouse equivalent of human type I keratin 16 (K16).

179 e cotranslational maturation pathway for the human type I membrane glycoprotein tyrosinase.

180 were engineered with a constitutively active human type I Nodal receptor (caACVR1b) to mimic activati

181 Depletion of the human type I phosphatidylinositol 4-phosphate 5-kinase b

182 In this study, the mechanisms of human type I PKG-alpha (PKG-Ialpha) gene expression were

183 A novel human Type I procollagen C-proteinase enhancer protein-l

184 oduce both propeptide chains that constitute human type I procollagen.

185 in, which associates with both SmRK1 and the human type I TGF beta receptor (T beta RI); overexpressi

186 K1 joined to the intracellular domain of the human type I TGF-beta receptor was used.

187 The alpha(2)-I protein bound human types I and III collagen in a saturable and divale

188 sing simulated data for three model species: humans (type I survival), sparrow (type II), and barnacl

189 We show that in humans, type I interferons induce TH1 development and ca

190 nd greatest on NIH 3T3 cells over-expressing human type-I IGF receptor.

191 PH); and 2) the ligand-binding domain of the human type-I IP3R (IP3R224-605).

192 Mutations of the human type Ialpha regulatory subunit (RIalpha) of cyclic

193 ructural and mechanistic properties with the human type IB enzyme (hTopo) and is important for viral

194 ly available structures for the vaccinia and human type IB enzymes.

195 Previously we showed that infection of human type II airway epithelial (A549) cells with purifi

196 for induction of the CXC chemokine IL-8, in human type II alveolar (A549) cells by RSV infection and

197 tant demonstrated decreased adherence to the human type II alveolar cells, reduced nasopharyngeal col

198 n extended to deficiency of adherence to the human type II alveolar cells.

199 A549 cells, a human type II alveolar epithelial cell line, was exposed

200 of RSV-induced RANTES promoter activation in human type II alveolar epithelial cells (A549 cells).

201 n the induction of RANTES gene expression in human type II alveolar epithelial cells (A549), followin

202 nucleotide (I) is a potent inhibitor of both human type II and Escherichia coli IMPDH.

203 competitive inhibition of the mitochondrial human type II arginase by N(omega)-hydroxy-L-arginine, t

204 We also demonstrate the inhibition of human type II arginase by the boronic acid-based transit

205 The predicted sequence of human type II arginase is 58% identical to the sequence

206 BEC are classical, competitive inhibitors of human type II arginase with K(i) values of 0.25 and 0.31

207 as with prominent nuclear atypia, resembling human Type II cancers.

208 terleukin (IL)-8 from monolayers of cultured human type II cells was assessed.

209 with cartilage proteoglycan aggrecan (PG) or human type II collagen (CII) emulsified with Freund's co

210 tions of human cartilage gp-39 (HC gp-39) or human type II collagen (CII).

211 mmune arthritis induced by immunization with human type II collagen (hCII).

212 the immune response to collagen, recombinant human type II collagen (rCII) was produced using a yeast

213 mplexed with a candidate RA autoantigen, the human type II collagen peptide CII (259-273).

214 QB3 (H2A(q)) mice susceptible to porcine and human type II collagen-induced arthritis.

215 rotein was identified by Western blot with a human type II collagen-specific antibody.

216 ice when they are immunized with porcine and human type II collagen.

217 ith the primary collagenase cleavage site of human type II collagen.

218 h individual synthetic peptides representing human type II collagen.

219 EPCs were isolated from human type II diabetics (n=20) and age-matched control s

220 orated random abasic sites into plasmid DNA, human type II enzymes can locate lesions even within a b

221 and stimulated DNA scission mediated by both human type II enzymes.

222 od vessels and mutations of the ALK1 gene in human type II hereditary hemorrhagic telangiectasia pati

223 Human type II hydroxyacyl-CoA dehydrogenase/amyloid-beta

224 human IL-1alpha and IL-1beta to the soluble human type II IL-1 receptor by approximately 100-fold, w

225 ormation of NADH bound to the active site of human type II IMPDH (IMPDH-h2).

226 up-regulated in rapidly proliferating cells, human type II IMPDH is actively targeted for immunosuppr

227 2.9-A structure of a ternary complex of the human type II isoform of IMPDH.

228 ntribute to the observed selectivity for the human Type II isoform.

229 for brain development and is associated with human type II lissencephaly.

230 A recombinant system was used to prepare human type II procollagen containing the substitution of

231 tably transfected NIH 3T3 cells expressing a human type II procollagen gene under the control of the

232 nces corresponding to various regions of the human type II procollagen gene were used to analyze the

233 e functional analysis of all six recombinant human type II skeletal muscle myosin isoforms.

234 ave selectively expressed a kinase-deficient human type II TGFbeta receptor (TbetaRIIDeltak) in fibro

235 had relatively low potency for inhibition of human type II topoisomerases alpha and beta.

236 Inhibition of one or both of the human type II topoisomerases by antibacterial compounds

237 he cellular and pharmacological functions of human type II topoisomerases.

238 model for the use of divalent metal ions by human type II topoisomerases.

239 Exposure of the human-type II cell alveolar epithelial cells (A549) to D

240 The catalytic mechanism of the human type-II IMPDH isozyme has been studied by measurem

241 soforms in SCLC lines, as compared to normal human type-II pneumocytes.

242 spect, we have stably overexpressed FRA-1 in human type-II-like alveolar malignant cell line (A549) a

243 The crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)

244 ded 57 peptides derived from the sequence of human type III collagen and 9 peptides derived from the

245 olysis, varying numbers of GXY triplets from human type III collagen around the collagenase cleavage

246 model the imino acid-poor 785-796 region of human type III collagen just C-terminal to the matrix me

247 identified a high affinity binding region in human type III collagen recognized by alpha(1)I and alph

248 rminal quarter, 252 residues, of the natural human type III collagen was attached to (GPP)7 with the

249 murine leukemia virus, this receptor is the human type III sodium-dependent inorganic phosphate tran

250 tency and mechanism of block on the neuronal human type III voltage-gated sodium channel expressed in

251 Anti-human type IV collagen basement membrane immunoreactivit

252 On the basis of our findings that human type IV collagen binds BMP4, we predict that this

253 The NC1 domains of human type IV collagen, in particular alpha3NC1, are inh

254 MIP-133 degradation of both human type I and human type IV collagen.

255 milar to the consensus sequence are found in human type IV collagen.

256 ng metabolic characteristics associated with human Type IV hyperlipidemia.

257 present during the late elicitation phase of human type IV hypersensitivity reactions.

258 In this study, we mutated human-type LT and STa genes, which are highly homologous

259 This study demonstrated that human-type LT(1)(9)(2)-STa(1)(3) fusions induce neutrali

260 r oligosaccharides into structurally uniform human-type N-glycans.

261 ents evidence that in cells that express the human-type Na,K-ATPase, dopamine inhibits and phorbol es

262 ic acid-containing receptors, referred to as human-type (NeuAcalpha2-6Gal) and avian-type (NeuAcalpha

263 The rNV VLPs hemagglutinated all human type O (11 of 11), A (9 of 9), and AB (4 of 4) RBC

264 ti-H type 2 antibody inhibited rNV VLP HA of human type O RBCs.

265 igen functions as the rNV VLP HA receptor on human type O RBCs.

266 these antigens also inhibited rNV VLP HA of human type O RBCs.

267 ylation pathway and can produce well defined human-type O- and N-linked glycans on recombinant therap

268 ereby accomplishes the conversion of regular human type-O blood into a potential blood substitute for

269 and phylogenetic analysis indicate that the human type of apo(a) evolved from a duplicated plasminog

270 generation of SM6 decorated with sialylated human-type oligosaccharides, comparable to plasma-derive

271 olated several mutants that maintained their human-type receptor-binding preference but acquired an a

272 receptor-binding domain conferred binding to human-type receptors but reduced HA stability.

273 Remarkably, these human-type receptors with elongated branches have the po

274 the ectodomain of an H5 HA (altered to bind human-type receptors) to three rounds of treatment at 50

275 reassortant virus preferentially recognized human-type receptors, replicated efficiently in ferrets,

276 The ability to bind to human-type receptors, together with physical stability a

277 s possessing HA-222D preferentially bound to human-type receptors, while those encoding HA-222G bound

278 se encoding HA-222G bound to both avian- and human-type receptors.

279 ses no longer have strict specificity toward human-type receptors.

280 binding site, which is critical for binding human type sialic acid receptors.

281 nd that H3N2 viruses have in fact maintained human-type specificity, but they have evolved preference

282 Probing for the human-type telomere (TTAGGG)n also revealed no signal.

283 cDNA library, using the N-terminal region of human type V adenylyl cyclase (hACV) as bait, we identif

284 ics of Galpha(s) and Galpha(i) regulation of human type V and type VI adenylyl cyclase (AC V and AC V

285 cts with the N-terminal segments of hACV and human type VI adenylyl cyclase (hACVI).

286 displayed dipeptidase activity and degraded human type VI collagen and fibrinogen, but not salivary

287 se skin resulted in the stable expression of human type VII collagen at the mouse DEJ.

288 In this study, we have dissected the human type VII collagen gene (COL7A1) promoter to charac

289 The human type VII collagen gene (COL7A1) recently has been

290 bullous disorders caused by mutations in the human type VII collagen gene (COL7A1).

291 y suggest that autoantibodies that recognize human type VII collagen in EBA are pathogenic.

292 In this study, we produced recombinant human type VII collagen in stably transfected human 293

293 study, we produced the entire NC1 domain of human type VII collagen in the stably transfected human

294 d skin specimens showed strong expression of human type VII collagen restricted to the basement membr

295 n-collagenous amino-terminal domain (NC1) of human type VII collagen, the domain known to contain imm

296 of normal human fibroblasts can generate new human type-VII collagen and anchoring fibrils at the DEJ

297 N6 viruses have acquired a high affinity for human-type virus receptor.

298 The long variant form of human type XII collagen, a member of the fibril-associat

299 We now have cloned the entire human type XVII collagen gene (COL17A1) and have elucida

300 tal structure of the trimerization domain of human type XVIII collagen, a member of the multiplexin f