ライフサイエンスコーパス: humanization

1 andom location (so-called KO-plus-transgenic humanization).

2 rine lungs and spleens indicating successful humanization.

3 2.5-A resolution and used as a template for humanization.

4 rent and random location; KO-plus-transgenic humanization.

5 facilitate further antibody optimization and humanization.

6 f immunodeficient mouse strains suitable for humanization.

7 ts were allowed to heal on naive mice before humanization.

8 e changes necessary to regain activity after humanization.

9 and also suggest a possible means of enzyme "humanization."

10 We present the humanization, affinity maturation, and epitope mapping o

11 A method for simultaneous humanization and affinity maturation of monoclonal antib

12 uld not be identified by sequential in vitro humanization and affinity muturation strategies.

13 We report the humanization and characterization of monoclonal antibody

14 the Ebola virus now provides a framework for humanization and development of a postexposure immunothe

15 the immunogenicity of rodent antibodies via humanization and generation of antibodies in transgenic

16 gn strategy could be applied during antibody humanization and library design for in vitro display met

17 Here, we report the humanization and testing of these antibodies for clinica

18 Here, we present data on the identification, humanization, and in vitro pharmacology of an antidote f

19 ovides a detailed description of our genetic humanization approach, and the companion paper reports t

20 stant regions intact, using a unique in situ humanization approach.

21 rparts at the same genetic location (in situ humanization), but such efforts involved laborious proce

22 oach (i) provides a rapid route for antibody humanization constraining the content of original mouse

23 ht chain Ig loci, by far the largest genetic humanizations ever described.

24 Humanization had as a consequence that efficacy studies

25 notransplantation with human immune systems (humanization) has been problematic because C57BL/6 SIRPa

26 Heretofore, most genetic humanizations have involved disruption of the endogenous

27 One important example of genetic humanization involves mice humanized for their Ig genes,

28 e development of a new strategy for antibody humanization is described.

29 mAb discovery is rapid and humanization is straightforward, establishing the utilit

30 of its high affinity and its high degree of humanization, JC-7U IgG1 is an excellent drug candidate

31 in the CDRs, which are typically avoided in humanization methods.

32 Humanization of a potent neutralizing mouse anti-human I

33 y technology, we recently reported the first humanization of a rabbit monoclonal antibody.

34 y either exogenous catestatin replacement or humanization of Chga mice.

35 Humanization of E06 was carried out by converting over 6

36 Here we demonstrate marked effects of this humanization of Foxp2 on learning and striatal neuroplas

37 Improvement of affinity, as well as humanization of GNC92H2, would be advantageous in immuno

38 it immune repertoires for the generation and humanization of monoclonal antibodies that bind with str

39 Here, we report the humanization of mouse 38C2 based on rational design guid

40 hain variable regions (VH), is important for humanization of mouse antibodies.

41 This approach was applied to the humanization of mouse mAb LM609 that is directed to huma

42 designed combinatorial V gene libraries, the humanization of mouse monoclonal antibody LM609 directed

43 In this report, we describe the humanization of muMAb VEGF A.4.6.1. by site-directed mut

44 The humanization of rabbit antibodies, however, has not been

45 Humanization of rhLCV with EBV gp350 also confers suscep

46 rived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage libraries.

47 ural information and computational tools the humanization of rodent antibodies for clinical use often

48 In addition, we determined that humanization of SCID mice following engraftment and vasc

49 provides a framework for further design and humanization of shark IgNARs.

50 We have applied this method to humanization of the anti-vascular endothelial growth fac

51 es, such as cocaethylene, and for additional humanization of the antibody.

52 We report the humanization of the glycosylation pathway in the yeast P

53 themes emerged: 1) a feeling of support, 2) humanization of the medical system, 3) an opportunity fo

54 r findings have significant implications for humanization of the mouse IgG1 currently in clinical tri

55 Homozygous humanization of TPO led to increased levels of human eng

56 ell-binding antibodies, these data show that humanization offers a significant reduction in immunogen

57 Antibody humanization often requires the replacement of key resid

58 tibody-derived antibody sequence used during humanization, only the CDR3 region from a murine antibod

59 hus overcoming the major drawback of current humanization procedures, the requirement to construct an

60 ut these systems involve a long and variable humanization process, are expensive, and require the use

61 The best available methods for liver humanization rely on cell transplantation into immunodef

62 cells and stromal cells occurs 2 weeks after humanization, so investigators should expect to observe

63 The novel humanization strategy described here provides a robust a

64 ndogenous epithelium with subsequent stromal humanization takes 1 month.

65 highly successful in the clinic, all current humanization techniques have potential limitations, such

66 The best available model of liver humanization, the uroplasminogen-activator transgenic mo

67 for very large, in situ, and precise genetic humanization using large compound bacterial artificial c

68 e to HCV entry in vitro, we attempted murine humanization via a genetic approach.

69 because of the manner in which their genetic humanization was carried out.

70 immunodeficiency virus, type 1 disease, its humanization was desired to minimize the potential for i

71 Humanization was performed by adoptive transfer of human

72 For rabbit antibody humanization, we then used a selection strategy that com

73 Genetic humanization, which involves replacing mouse genes with