ライフサイエンスコーパス: humanized

1 ysiological bone 'organ', which is partially humanized.

2 , which differ between mice and humans, were humanized.

3 e domain antibody (NaLi-H1: Nanobody Library Humanized 1).

4 p a strategy for the generation of mice with humanized adaptive immune systems, complete with tissue

5 Mice bearing the humanized alleles formed normal tight junctions and did

6 in vivo generation of gp41-specific IgA1 in humanized alpha1KI mice to produce chimeric IgA1.

7 ecipients were treated with either IDEC-131 (humanized alphaCD154, n = 9), 5C8H1 (mouse-human chimeri

8 ron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals sp

9 Using a humanized AML model, we demonstrate that upregulation of

10 ory mucosa (OM) from Cyp2abfgs-null, CYP2A13-humanized, and CYP2A13/2F1-humanized mice.

11 Crenezumab is a humanized anti-Abeta monoclonal IgG4 that binds multiple

12 Recently, a novel humanized anti-CD20 mAb obinutuzumab (GA101) has been im

13 ibodies are mainly based on steroids and the humanized anti-CD20 monoclonal antibody rituximab.

14 s of cold ischemia, and then perfused with a humanized anti-CD47 monoclonal antibody (CD47mAb) in the

15 Further, delivery of a humanized anti-CD98 antibody blocks growth of patient-de

16 As a new approach to migraine treatment, humanized anti-CGRP monoclonal antibodies (CGRP-mAbs) we

17 Recently, a new class of such drugs, humanized anti-CGRP monoclonal antibodies (CGRP-mAbs), w

18 Eculizumab, a humanized anti-complement C5 monoclonal antibody (mAb) f

19 , an antibody-drug conjugate consisting of a humanized anti-folate receptor alpha (FRalpha) monoclona

20 We also showed that two humanized anti-GPC3 antibodies (hYP7 and hYP9.1b) in the

21 This was achieved by combining the humanized anti-hapten monoclonal antibody (mAb) h38C2 wi

22 tigated the therapeutic efficacy of a partly humanized anti-HMGB1 monoclonal antibody (mAb; h2G7) and

23 ten monoclonal antibody (mAb) h38C2 with the humanized anti-human CD3 mAb v9 in a clinically investig

24 Humanized anti-IL-5 antibodies are effective in treating

25 y, we assessed the therapeutic effect of the humanized anti-Jagged1/2-blocking antibody CTX014 on MDS

26 s a clinically optimized RIT consisting of a humanized anti-mesothelin Fab fused to domain III of Pse

27 nses to melanoma and can be blocked with the humanized anti-PD-1 monoclonal antibody pembrolizumab.

28 s and that these effects were blocked by the humanized anti-ROR1 mAb cirmtuzumab (UC-961).

29 vival, and can be targeted by cirmtuzumab, a humanized anti-ROR1 mAb.

30 mmune modulators (exogenous glucocorticoids, humanized antibodies against cytokines) may decrease dep

31 oxin were grafted into different CDRs of the humanized antibodies BVK and Synagis (Syn) using both be

32 rapeutics based on blocking eosinophils with humanized antibodies that neutralize IL-5, a potent eosi

33 In conclusion, H3L2 is an ideal humanized antibody that inhibits tumor growth through ta

34 zumab is a glycoengineered, type 2 anti-CD20 humanized antibody with single-agent activity in relapse

35 The humanized anticarcinoembryonic antigen (anti-CEA) monocl

36 In a humanized BC CML mouse model, combined JAK2 and BCR-ABL1

37 Here we show that humanized bone marrow, thymus, and liver (hu-BLT) mice a

38 e responses in HCMV latently-infected huBLT (humanized Bone marrow-Liver-Thymus) mice.

39 nteractions between human cancer cells and a humanized bone microenvironment in vivo.

40 SC-coated scaffolds can be modulated to form humanized bone tissue, which was also able to support hu

41 We have developed a protocol to engineer humanized bone within immunodeficient hosts, which can b

42 pecific mechanism in wild-type or BK channel-humanized Caenorhabditis elegans.

43 to deal with basic diabetes practical needs, humanized care, and acted as mediators between services

44 We demonstrate that the humanized CD81 and OCLN were expressed at physiological

45 FICANCE STATEMENT Recently, we reported that humanized CGRP monoclonal antibodies (CGRP-mAbs) prevent

46 ha7-acetylcholine-binding protein (AChBP), a humanized chimera of a snail AChBP, which has 71% sequen

47 A partially humanized chimeric LO1-Fab-Cys localized similarly to th

48 We observed similar results in the humanized, endothelialized microfluidic system.

49 Using this method, a humanized engraftable BM microenvironment can be formed

50 We found that by providing a humanized environment, stem cell self-renewal properties

51 he MERS-CoV receptor, we generated mice with humanized exons 10-12 of the mouse Dpp4 locus.

52 scuss several potential applications for the humanized Fab/scFv.

53 k containing OVA-IgG-IC induced tolerance in humanized FcRn mice.

54 eration and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding se

55 By using a mouse model humanized for its FcgammaRs and CD40, we revealed that F

56 ated in anaphylaxis and mice that have been "humanized" for some of these elements.

57 a collection of stocks that are, in effect, 'humanized' for p53 variants.

58 The humanized form of Rh-alpha4beta7, vedolizumab, is a high

59 exhibits altered dopamine concentrations in humanized Foxp2 mice.

60 Heterozygous animals express mutant humanized FUS protein at physiological levels and have a

61 Here, we describe a new humanized FUS-ALS mouse with a frameshift mutation, whic

62 e report the potential utility of MK-4166, a humanized GITR mAb selected to bind to an epitope analog

63 er it activates B cells expressing the fully humanized gl3BNC60 B-cell receptor (BCR), we immunized m

64 Our approach was to establish humanized glial chimeric mice using glial progenitor cel

65 The mouse anti-HMGB1 mAb (m2G7) was partly humanized (h2G7) by merging variable domains of m2G7 wit

66 iatric patients on FVIII immunogenicity in a humanized HA murine model with variable tolerance to rec

67 Moreover, immunization of humanized HLA-A*02:01 transgenic mice with the three CD8

68 report describing the generation of a partly humanized HMGB1-neutralizing antibody with validated the

69 al candidates and efficacy in HIV-1-infected humanized [human peripheral blood lymphocyte (Hu-PBL)] m

70 oantibody-mediated BP blister formation in a humanized IgE receptor mouse model of BP.

71 idation in the Fc regions of fully human and humanized IgG1 mAbs as well as of Fc-fusion proteins.

72 We compared risankizumab (BI 655066), a humanized IgG1 monoclonal antibody that inhibits interle

73 Ramucirumab (named RamAb), a fully humanized IgG1 monoclonal antibody, was conjugated to 2-

74 Our study forms a strong basis for using humanized IL-27 toward the treatment of post-menopausal

75 gh ICOSL to control airway inflammation in a humanized ILC2 mouse model.

76 ist reduces cytokine production and AHR in a humanized ILC2 mouse model.

77 ot toward human hematopoietic progenitors in humanized immune reconstituted mice.

78 del for animal research and a step towards a humanized in vivo model for tissue engineering.

79 genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour re

80 Here we report the engineering of humanized intestinal grafts by repopulating decellulariz

81 In addition, a humanized liver Fah(-/-) /Rag2(-/-) /Il2rg(-/-) (FRG) mo

82 ntly, BI-2536 administration to HBV-infected humanized liver FRG mice strongly inhibited HBV infectio

83 served in untreated HEV gt3 and gt1 infected humanized livers compared to control chimeric mice, irre

84 lture and the serum of avatar mice harboring humanized livers.

85 rst fully synthetic phage display library of humanized llama single domain antibody (NaLi-H1: Nanobod

86 Eculizumab is a humanized mAb approved for treatment of patients with pa

87 a neutralizing monoclonal antibody, PA50, a humanized mAb with both potent and broad-spectrum neutra

88 ith new and powerful chemotherapy agents and humanized mAbs present with nonclassical symptoms of ana

89 Humanized mice (HM) allow researchers to examine xenogra

90 IFN-alpha/beta receptor (IFNAR) signaling in humanized mice (hu-mice) that were persistently infected

91 We have developed a humanized mice (Hu-mice) tuberculosis model system to in

92 estigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV o

93 serum metabolic profiling from a model using humanized mice (humice) with DENV serotype 2 infection a

94 e, humoral, and cellular immune responses in humanized mice (mice with a human immune system [HIS mic

95 broadly neutralizing antibody b12 protected humanized mice against repetitive intravaginal infection

96 because in vivo neutralization of IL-17A in humanized mice ameliorated hepatic and intestinal damage

97 d virus load substantially in HIV-1-infected humanized mice and also provided complete protection whe

98 mise for modelling haematopoietic disease in humanized mice and for therapeutic strategies in genetic

99 ecent progress in the development and use of humanized mice and highlights their utility for the stud

100 pleen, bone marrow, and peritoneal cavity of humanized mice and included distinct populations display

101 lpha (pegIFNalpha) against HEV infections in humanized mice and modelled intrahepatic interferon stim

102 ing on the two most promising model systems: humanized mice and nonhuman primates.

103 chronic HCV infection in the livers of both humanized mice and patients, and direct-acting antiviral

104 wever, anti-HA protects against infection in humanized mice and strongly selects for nnAb-resistant v

105 Humanized mice are a powerful tool for the study of huma

106 Humanized mice are permitting significant progress in st

107 Humanized mice are versatile tools for the study of HIV

108 ved macrophages, primary CD4(+) T cells, and humanized mice at a level comparable to that for the wil

109 , virus carrying this mutation replicated in humanized mice at levels indistinguishable from those of

110 Our results demonstrate that humanized mice can be used as a small-animal model to st

111 The data support the idea that humanized mice can provide a means to examine the multif

112 Here we show that this also applies to humanized mice coexpressing both human P2X7R variants.

113 to cross the interspecies barrier to infect humanized mice correlates with their phylogenetic distan

114 evious metabolomics studies, indicating that humanized mice could be a highly relevant small-animal m

115 We demonstrate that such minimally humanized mice develop normally, express the modified ge

116 Humanized mice displayed a more pronounced AHR and bronc

117 Studies in humanized mice document an interaction between estrus cy

118 Humanized mice engrafted with human hematopoietic stem c

119 cell population, and engrafted B-1 cells in humanized mice exhibit an Ig-usage pattern comparable to

120 Humanized mice expressing Human Leukocyte Antigen (HLA)

121 g wild-type, Cyp2abfgs-null, and CYP2A13/2F1-humanized mice following inhalation exposure at an occup

122 the first to demonstrate the suitability of humanized mice for injury research.

123 nd T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy.

124 tope in the viral E2 glycoprotein to protect humanized mice from a patient-derived HCV challenge.

125 om a single injection of VRC01 mRNA protects humanized mice from intravenous HIV-1 challenge, demonst

126 Humanized mice have emerged as a testing platform for HI

127 Studies in humanized mice have shown that HIV-1 lacking Vif express

128 We previously showed that humanized mice immunized with long-lived induced-dendrit

129 rom cytometry by time-of-flight analysis and humanized mice indicating that human CD49e(-) NK cells a

130 Ultimately, use of humanized mice may lead to the implementation of truly p

131 hese results suggest that the development of humanized mice may provide a framework to assess the con

132 In macrophage cultures derived from TNF humanized mice MYSTI could capture the secreted hTNF, li

133 Humanized mice reconstituted with a human immune system

134 anded human cord blood-derived NK cells into humanized mice reconstituted with autologous human cord

135 Humanized mice represent a novel lethal model for studie

136 CYP2A13/2F1-humanized mice showed greater sensitivity to NA than Cyp

137 so detected in the serum from HIV-1-infected humanized mice suggesting that TAR RNA may be stable in

138 r in the terminal bronchioles of CYP2A13/2F1-humanized mice than in Cyp2abfgs-null mice.

139 We therefore created humanized mice that transgenically express the entire 16

140 against HIV-1 in vitro We now demonstrate in humanized mice that, when delivered at the same high cli

141 Here, we genetically humanized mice to permit the growth of primary human pre

142 These findings validate the use of humanized mice to study acute and persistent HAdV infect

143 CNS disease in humanized mice was characterized by gliosis, meningitis,

144 activities in OM and lung of the CYP2A13/2F1-humanized mice were primarily contributed by, respective

145 r, peripheral T cells developed in the FOXP3-humanized mice were quantitatively reduced and hyporespo

146 In this study, humanized mice were treated with Smoothened Agonist (SAG

147 While humanized mice were unaffected in their behavioral reper

148 A matured HMAb protected humanized mice when challenged with an infectious HCV hu

149 regs were depleted by denileukin diftitox in humanized mice with chronic HIV-1 infection.

150 a serum metabolomics study on a model using humanized mice with dengue infection that had significan

151 We immunized IgH- and Igkappa-humanized mice with the AE.A244 gp120 Env.

152 ymphoma models and against human lymphoma in humanized mice without any detectable toxic side effects

153 survive and possibly proliferate in vivo in humanized mice without exogenous cytokine administration

154 functional human cells and tissues, that is, humanized mice, have become increasingly important as sm

155 In humanized mice, lethal disease develops, characterized b

156 o prevent and treat lentivirus infections in humanized mice, macaques, and humans.

157 Additionally, as evaluated in TNF humanized mice, MYSTI was superior to an otherwise analo

158 absence of the human Vlambda locus in these humanized mice, the dominance of Vlambda pairing with hu

159 Using HIV-infected humanized mice, we demonstrated that in vivo blockade of

160 P2F1 are active toward NA in the CYP2A13/2F1-humanized mice, where they play significant roles in NA-

161 pping grafted human classical monocytes into humanized mice, which were able to differentiate sequent

162 the patient tumor than to those grown in non-humanized mice-an effect partially facilitated by human

163 ensitive to pegIFNalpha in immunocompromised humanized mice.

164 ining their capacity to engraft in vivo into humanized mice.

165 ss early HIV-1 spread in lymphoid tissues in humanized mice.

166 ophages in the skin and lymphatic tissues of humanized mice.

167 vivo therapeutic activity in HIV-1-infected humanized mice.

168 ival was confirmed in a huMoDC reconstituted humanized mice.

169 r 20 hr after termination of NA exposure, in humanized mice.

170 d antiretroviral responses in HIV-1-infected humanized mice.

171 fgs-null, CYP2A13-humanized, and CYP2A13/2F1-humanized mice.

172 s observed in Cyp2abfgs-null and CYP2A13/2F1-humanized mice; however, the extent of NA-induced lung i

173 e development of schizophrenia and provide a humanized model for its in vivo assessment.

174 man lung organoids into mice could lead to a humanized model for pre-clinical studies of lung disease

175 fibrinolysis and bleeding were examined in a humanized model of pulmonary embolism.

176 This is the first report of a humanized model of the DEK-NUP214 disease and provides a

177 cell neoplasia and illustrate the utility of humanized models for understanding the functional divers

178 nd complement inhibitory effect of TNT009, a humanized monoclonal anti-C1s antibody.

179 a potential benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF-A

180 Etrolizumab is a humanized monoclonal antibody against the beta7 integrin

181 Since the approval of trastuzumab, a humanized monoclonal antibody against the extracellular

182 mechanism of TcdB neutralization by PA41, a humanized monoclonal antibody capable of neutralizing Tc

183 ecific reversing agents include the approved humanized monoclonal antibody fragment idarucizumab for

184 ly quantified the levels of deamidation of a humanized monoclonal antibody in cynomolgus monkeys over

185 GS-5745, a potent, highly selective humanized monoclonal antibody inhibitor of MMP9, has sho

186 post hoc analyses to evaluate the effect of humanized monoclonal antibody mepolizumab in patients wi

187 Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-

188 Pembrolizumab is a humanized monoclonal antibody targeting programmed cell

189 Bococizumab, a humanized monoclonal antibody targeting proprotein conve

190 Bococizumab is a humanized monoclonal antibody that inhibits proprotein c

191 We studied ocrelizumab, a humanized monoclonal antibody that selectively depletes

192 Ocrelizumab is a humanized monoclonal antibody that selectively depletes

193 Treatment with the anti-ERBB2 humanized monoclonal antibody trastuzumab and chemothera

194 We constructed a humanized monoclonal IgG1 against human adenovirus type

195 rated by phage display or derived from human/humanized monoclonals, with constant regions.

196 nhibited in vivo HIV-1 and SHIV infection in humanized mouse and macaque models, respectively, includ

197 n immunodeficiency virus (SHIV) infection in humanized mouse and macaque models, respectively, includ

198 Human gene expression levels in humanized mouse livers were analyzed by qPCR and Nanostr

199 Two studies in this issue of the JCI use a humanized mouse model and demonstrate that type I interf

200 henotypically characterized a novel knock-in humanized mouse model carrying the severe, MECD-associat

201 Our humanized mouse model may thus be useful for preclinical

202 Importantly, using a humanized mouse model of allergic asthma, we demonstrate

203 nt of betaT in the gammabeta(0)/gammabeta(A) humanized mouse model of betaT.

204 sts of anti-human GITR antibody MK-4166 in a humanized mouse model of cancer mimicked many of the eff

205 We previously generated a humanized mouse model of HD, Hu97/18, by intercrossing B

206 but significant decrease in GAS fitness in a humanized mouse model of impetigo; the DeltafbaA mutant

207 In a humanized mouse model of pseudoxanthoma elasticum, we in

208 ere with the development of nephropathy in a humanized mouse model of SCD.

209 Using a humanized mouse model of TSS and human cells, we herein

210 ll lymphomas in a newly developed cord blood-humanized mouse model that allows EBV-infected B cells t

211 Here we established a humanized mouse model that reproduces features of acute

212 We developed a novel humanized mouse model to evaluate in vivo human NK cell-

213 Here, we utilized a humanized mouse model to recapitulate the low immunogeni

214 e recently used a newly developed cord blood-humanized mouse model to show that EBV can cooperate wit

215 er immunotherapy and provide a translational humanized mouse model to test the lifespan, safety, and

216 r fibrosis, we utilized a recently developed humanized mouse model with autologous human immune and l

217 In a genetically humanized mouse model, active immunization with sE2 effi

218 to induce B cell lymphomas in the cord blood-humanized mouse model, although the simultaneous loss of

219 roved the immunogenicity of the H7 HA in the humanized mouse model, leading to a greater than 4-fold

220 In the humanized mouse model, T-cell infiltration into the sali

221 Using a novel humanized mouse model, we demonstrated that LSEVh-LS-F r

222 strains using immunoinformatics tools and a humanized mouse model.

223 y image human immune responses in a relevant humanized mouse model.

224 ction against HCV infection in a genetically humanized mouse model.

225 a formation elicited by vascular injury in a humanized mouse model.

226 ells undergo tolerance, we developed a novel humanized mouse model.

227 at requires Fcgamma receptor engagement in a humanized mouse model.

228 is in a hematopoietic stem cell-transplanted humanized mouse model.

229 nt receptor expression and localization in a humanized mouse model.

230 SPA70 inhibits hPXR in human hepatocytes and humanized mouse models and enhances the chemosensitivity

231 ts associated with non-human primate models, humanized mouse models containing chimeric human livers

232 Here, we describe the major humanized mouse models currently in use, and some recent

233 Host & Microbe, McHugh et al. (2017) develop humanized mouse models for EBV/KSHV co-infection and ide

234 This Review summarizes the contribution that humanized mouse models of HIV infection have made to the

235 Using several relevant humanized mouse models, we demonstrate that TCR-transduc

236 ected, we used 3 different but complementary humanized mouse models.

237 wn can control rejection of human tissues in humanized mouse models.

238 ve Abs when those cells were introduced into humanized mouse models.

239 lls were assayed from both participants in a humanized mouse outgrowth assay.

240 he early stages of acute co-infection in the humanized mouse, infection with HIV exacerbates the pro-

241 ctor (G-CSF) and stem cell factor (SCF) in a humanized murine model of Friedreich's ataxia.

242 -pembrolizumab was further investigated in a humanized murine model.

243 A humanized murine monoclonal antibody (palivizumab) is ap

244 Palivizumab, a humanized murine monoclonal antibody that recognizes ant

245 Humanized, murine Por-deficient PIRF mice can thus predi

246 fibres and a knockin (KI) model expressing a humanized mutant AR gene.

247 ked and AAV-packaged AONs to the retina of a humanized mutant Cep290 mouse model, carrying the intron

248 Using humanized myeloid-only mice (MoM), we demonstrate that H

249 GF-beta1 activity with a TGF-beta1-specific, humanized, neutralizing monoclonal antibody (TGF-beta1 m

250 gulated Fas and miR-375 of human islets in a humanized NOD scid gamma (NSG) mouse model, whose immune

251 ably prevented viral rebound in HIV-infected humanized NOD scid IL-2Rgamma(-/-) bone marrow-liver-thy

252 , MAIThighHLA-DR4+ bone marrow chimeras, and humanized NOD-scid IL-2Rgammanull mice to demonstrate fo

253 that can cure a P. falciparum infection in a humanized NOD/SCID mouse model system.

254 In this report, humanized NOD/scid-IL2Rgammac(null) mice were used to es

255 Humanized nonobese diabetic severe combined immunodefici

256 We reveal that humanized nucleosomes are positioned according to endoge

257 The humanized organ bone model has been well characterized a

258 This humanized ossicle xenotransplantation approach provides

259 The humanized ossicles are formed by in situ differentiation

260 notransplantation model bearing subcutaneous humanized ossicles with an accessible BM microenvironmen

261 be a complete workflow for the generation of humanized ossicles with an accessible BM microenvironmen

262 emyelination has never been studied within a humanized pathological context that would recapitulate m

263 the efficacy and safety of pembrolizumab, a humanized PD-1-blocking antibody, at a dose of 200 mg ev

264 retroviral drug atazanavir, the Por-deleted humanized PIRF mice develop higher levels of the major h

265 As humanized polypeptides, they are non-immunogenic, substr

266 ical activity of atezolizumab (MPDL3280A), a humanized programmed death-ligand 1 (PD-L1) antibody, in

267 eclinical studies showed that new-generation humanized recombinant anti-CEA x antihistamine-succinyl-

268 The DC-targeting vaccines, humanized recombinant monoclonal antibodies fused to Env

269 of (1) collaboration and cooperativity, (2) humanized relationships and mentorship, and (3) operatio

270 ons of BF cholinergic neurons were traced by humanized Renilla green fluorescent protein (hrGFP).

271 Importantly, hMSC-coated humanized scaffolds were able to support the growth of l

272 itors in reversing vasoocclusion in nude and humanized SCD mouse models of acute vasoocclusive episod

273 In the humanized SCID mouse, local injection of Netrin-1 into s

274 to AD Second-generation mouse models contain humanized sequences and clinical mutations in the endoge

275 Caplacizumab, an anti-von Willebrand factor humanized single-variable-domain immunoglobulin (Nanobod

276 However, all humanized strains representing common alleles found in c

277 Finally, participants humanized strangers who were low in humanity if they ima

278 Based on a humanized synthetic single domain antibody (hs2dAb) scaf

279 sensitivity is dependent on APOE genotype in humanized targeted replacement mice.

280 ating the mdx(4cv)/mTR(G2) mouse model with "humanized" telomere lengths, the devastating dilated car

281 e in fertility and meiotic recombination, we humanized the DNA-binding domain of PRDM9 in C57BL/6 mic

282 us immunoreactivity complications, and when "humanized," these antibodies may exhibit reduced neutral

283 The model can be further humanized through the engraftment of human hematopoietic

284 sing neonatal human monocyte-derived DCs and humanized TLR8 mouse bone marrow-derived DCs enabled ben

285 e formulation was evaluated in vivo by using humanized TLR8 neonatal mice.

286 ties of pulmonary surfactant from individual humanized transgenic mice expressing human SP-A1, SP-A2,

287 is on the development of CNS autoimmunity in humanized transgenic mice expressing the MS-associated M

288 ork is the first report of a newly generated humanized transgenic mouse model engineered to express h

289 iggyBac opens opportunities for expansion of humanized transgenic rat models in the future to advance

290 Using a "humanized" transgenic mouse model of nasal colonization,

291 Humanized UGT1 (hUGT1) mice develop SNH spontaneously, w

292 When neonatal humanized UGT1 (hUGT1) mice, which exhibit severe levels

293 Finally, we developed a highly humanized variant of C8 that retains opsonophagocytic ac

294 Furthermore, we report the structures of a humanized variant of VcINDY in complexes with succinate

295 Palivizumab is an engineered humanized version of a murine mAb targeting antigenic si

296 ls in different mouse models, including mice humanized with lymphocytes from patients, leading to res

297 rtions of IL-10(+) Tregs compared with mice "humanized" with microbiota from healthy controls.

298 njury but more likely by systemic insults, a humanized xenograft model of FSGS resulted in an expansi

299 Here we used assays in humanized yeast models and G protein activity biosensors

300 These humanized yeasts (including H3.3) pose fundamental new q