ライフサイエンスコーパス: humanized mice

1 ed long-lived protection in conventional and humanized mice.

2 , and for anti-tumor efficacy in xenografted humanized mice.

3 ival was confirmed in a huMoDC reconstituted humanized mice.

4 l models of intestinal injury and the use of humanized mice.

5 reduced circulating levels of vemurafenib in humanized mice.

6 DC) in the blood, spleen, and bone marrow of humanized mice.

7 ups of patients replicated in culture and in humanized mice.

8 erent genotypes, both in cell culture and in humanized mice.

9 red HCV RNA from the circulation of infected humanized mice.

10 maRs and assessed their activity in FcgammaR-humanized mice.

11 efficiently blocked by an anti-SR-BI mAb in humanized mice.

12 tured primary neurons from the brains of the humanized mice.

13 nt and maintenance of the HIV-1 reservoir in humanized mice.

14 immunity to lymphotropic virus infections in humanized mice.

15 ected cells from the liver of HLA-transgenic humanized mice.

16 tro and in an antibody therapy experiment in humanized mice.

17 s- but not bacillus Calmette-Guerin-infected humanized mice.

18 oving human intrahepatic immune responses in humanized mice.

19 f HIV-infected T cells in the lymph nodes of humanized mice.

20 m in a comparable range of concentrations in humanized mice.

21 ensitive to pegIFNalpha in immunocompromised humanized mice.

22 or the poor human platelet reconstitution in humanized mice.

23 mphoid and nonlymphoid tissues of humans and humanized mice.

24 as a therapeutic modality in HIV-1-infected humanized mice.

25 ed by expression of human GM-CSF and IL-4 in humanized mice.

26 eral blood, spleen, and lymph nodes of these humanized mice.

27 neuronal integrity after HIV-1 infection in humanized mice.

28 r 20 hr after termination of NA exposure, in humanized mice.

29 explants, and in the female genital tract of humanized mice.

30 cell chimerism in the periphery of recipient humanized mice.

31 d antiretroviral responses in HIV-1-infected humanized mice.

32 , intestine, and kidney from only the CYP2D6 humanized mice.

33 fgs-null, CYP2A13-humanized, and CYP2A13/2F1-humanized mice.

34 ining their capacity to engraft in vivo into humanized mice.

35 ss early HIV-1 spread in lymphoid tissues in humanized mice.

36 ophages in the skin and lymphatic tissues of humanized mice.

37 vivo therapeutic activity in HIV-1-infected humanized mice.

38 vely assessed after severe burn injury using humanized mice.

39 ervoir, both in vitro and in patient-derived humanized mice.

40 volution during long-term infection in these humanized mice, a key feature of the natural infection,

41 Using humanized mice, a preclinical model relevant to human ph

42 nulomas of bacillus Calmette-Guerin-infected humanized mice administered with a TNF-neutralizing TNF

43 We then infected these humanized mice (AFC8-hu HSC/Hep) with primary HCV isolat

44 broadly neutralizing antibody b12 protected humanized mice against repetitive intravaginal infection

45 A new generation of humanized mice aims to tighten the gap between mouse and

46 because in vivo neutralization of IL-17A in humanized mice ameliorated hepatic and intestinal damage

47 the patient tumor than to those grown in non-humanized mice-an effect partially facilitated by human

48 d virus load substantially in HIV-1-infected humanized mice and also provided complete protection whe

49 In this study, we use T cell-deficient humanized mice and an adoptive transfer approach to demo

50 Thus, we have identified defects in humanized mice and devised approaches to correct these d

51 mise for modelling haematopoietic disease in humanized mice and for therapeutic strategies in genetic

52 e analyzed human myeloid cell development in humanized mice and found that it was blocked at the prom

53 ecent progress in the development and use of humanized mice and highlights their utility for the stud

54 pleen, bone marrow, and peritoneal cavity of humanized mice and included distinct populations display

55 r, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred.

56 lpha (pegIFNalpha) against HEV infections in humanized mice and modelled intrahepatic interferon stim

57 n prevent infection and suppress viraemia in humanized mice and nonhuman primates, but their potentia

58 ing on the two most promising model systems: humanized mice and nonhuman primates.

59 chronic HCV infection in the livers of both humanized mice and patients, and direct-acting antiviral

60 mental autoimmune encephalomyelitis (EAE) in humanized mice and proteolipid protein 139-151-induced E

61 tial genetic drift seen after passage on non-humanized mice and provide a more accurate tumor model t

62 e of such cells in the spleens of humans and humanized mice and report on a protocol to generate them

63 onocyte/macrophage development is blocked in humanized mice and reveals overlapping and distinct func

64 wever, anti-HA protects against infection in humanized mice and strongly selects for nnAb-resistant v

65 al human ILC3s develop in lymphoid organs of humanized mice and that persistent HIV-1 infection in th

66 ent pathogenetic mechanisms in wild-type and humanized mice and the possible benefit of including hum

67 developed a murine skin transplant model in humanized mice and used it to test human monoclonal anti

68 genous IL-21 limits early HIV-1 infection in humanized mice, and lower viremia in vivo is associated

69 can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeut

70 nd early postnatal life can be reproduced in humanized mice, and they suggest that onset of human thy

71 Humanized mice are a powerful tool for the study of huma

72 Although all DC subsets in humanized mice are efficient at presenting peptide to CD

73 Humanized mice are permitting significant progress in st

74 subsets generated after FLT3-L treatment of humanized mice are phenotypically and functionally simil

75 In this way, humanized mice are providing a powerful small animal mod

76 Humanized mice are versatile tools for the study of HIV

77 -alpha3NC1 autoantibodies injected into FCRN-humanized mice as effectively as genetic ablation of FcR

78 ved macrophages, primary CD4(+) T cells, and humanized mice at a level comparable to that for the wil

79 , virus carrying this mutation replicated in humanized mice at levels indistinguishable from those of

80 In this study, we show that in humanized mice, B cells are immature, and there is a com

81 we examined the effect of Abeta challenge in humanized mice bearing this allele.

82 lungs from bacillus Calmette-Guerin-infected humanized mice but not in nonhumanized infected controls

83 o the low density lipoprotein density in the humanized mice but not in wild-type mice.

84 resented in this study show that only CYP2D6 humanized mice but not wild-type mice display significan

85 2) were differentially expressed between the humanized mice, but circadian clock genes were not.

86 s of bacteria, can induce MS-like disease in humanized mice by crossreacting with a T cell receptor (

87 Our data indicate that humanized mice can be used as a model to study the forma

88 Our results demonstrate that humanized mice can be used as a small-animal model to st

89 This study provides "proof of concept" that humanized mice can be used to examine the effects of imm

90 These results indicate that humanized mice can be used to study HHV-6A in vivo infec

91 The data support the idea that humanized mice can provide a means to examine the multif

92 HIV-1-infected NOD/scid-IL-2Rgamma(c)(null) humanized mice can, at least in part, recapitulate lenti

93 Here we found that humanized mice carrying the 118GG allele (h/mOPRM1-118GG

94 We generated humanized mice carrying the respective human OPRM1 A118G

95 When applied intravaginally to humanized mice, CD4-AsiCs protected against HIV vaginal

96 Here we show that this also applies to humanized mice coexpressing both human P2X7R variants.

97 In humanized mice, combinations of monoclonal antibodies ha

98 dependency of viral particles isolated from humanized mice compared to cell culture-produced virus.

99 ificantly reduced (6.9 +/- 1.6 h), in CYP2D6 humanized mice compared with wild-type animals (15.2 +/-

100 ylococcus aureus infection was aggravated in humanized mice, compared with wild-type or nonengrafted

101 Paradoxically, humanized mice contained higher mycobacterial numbers in

102 to cross the interspecies barrier to infect humanized mice correlates with their phylogenetic distan

103 evious metabolomics studies, indicating that humanized mice could be a highly relevant small-animal m

104 Finally, when dosed in humanized mice, Cpd 1 blocked the rise of glucose levels

105 4alpha, DEB 4-hydroxylase activity in CYP2D6 humanized mice decreased more than 50%.

106 We demonstrate that such minimally humanized mice develop normally, express the modified ge

107 ockout, bone marrow, liver, thymus (TKO-BLT) humanized mice develop organized lymphoid tissues includ

108 Based on studies in humanized mice, diet can affect GI transit through micro

109 In addition, the humanized mice display abnormal erythropoiesis, which wa

110 The humanized mice display prolonged and increased responses

111 Humanized mice displayed a more pronounced AHR and bronc

112 The humanized mice displayed a significantly reduced surviva

113 However, these humanized mice do not make any significant level of IgG

114 Studies in humanized mice document an interaction between estrus cy

115 ore, we analyzed human antiviral immunity in humanized mice during a hepatotropic adenovirus infectio

116 Thus, humanized mice engineered to express human cytokines wil

117 Humanized mice engrafted with human hematopoietic stem c

118 fective to human hepatocytes in vitro and to humanized mice engrafted with human hepatocytes in vivo

119 markedly inhibited acute HIV-1 infection in humanized mice, even when activation of NK cells by IL-1

120 cell population, and engrafted B-1 cells in humanized mice exhibit an Ig-usage pattern comparable to

121 Humanized mice exhibit normal reversal of CD45 isoform e

122 ges at the sites of infection, M-CSF-treated humanized mice exhibited an enhanced protection against

123 nly the wild-type mice and not the PPARalpha-humanized mice exhibited hepatocellular proliferation as

124 BV infection and assessed tumor formation in humanized mice exposed to wild-type virus and a viral mu

125 CD141(+) DC in humanized mice express C-type lectin-like receptor 9A, X

126 We showed that humanized mice expressing HLA-DR4 (DR0401) molecules and

127 lass II molecules, we studied the ability of humanized mice expressing human HLA class II molecules t

128 Humanized mice expressing Human Leukocyte Antigen (HLA)

129 We have generated humanized mice expressing the multiple sclerosis-associa

130 Analysis of gut motility revealed that humanized mice fed a standard polysaccharide-rich diet h

131 g wild-type, Cyp2abfgs-null, and CYP2A13/2F1-humanized mice following inhalation exposure at an occup

132 unctionality of monocytes/macrophages in the humanized mice following M-CSF expression provide a supe

133 the first to demonstrate the suitability of humanized mice for injury research.

134 nd T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy.

135 n the bone marrow and suggest the utility of humanized mice for studying human hematopoiesis.

136 tope in the viral E2 glycoprotein to protect humanized mice from a patient-derived HCV challenge.

137 orm, human lymphocyte apoptosis, and rescued humanized mice from CLP-induced mortality.

138 emonstrate that VIP is capable of protecting humanized mice from intravenous as well as vaginal chall

139 om a single injection of VRC01 mRNA protects humanized mice from intravenous HIV-1 challenge, demonst

140 However, newer versions of humanized mice generated in severely immunodeficient mic

141 In this study, we show that these humanized mice had extremely low levels of human platele

142 Humanized mice have emerged as a promising model to stud

143 Humanized mice have emerged as a testing platform for HI

144 In particular, humanized mice have enabled studies of the pathogenesis

145 is effort and bone marrow-liver-thymus (BLT) humanized mice have recently emerged as a powerful small

146 Studies in humanized mice have shown that HIV-1 lacking Vif express

147 functional human cells and tissues, that is, humanized mice, have become increasingly important as sm

148 Humanized mice historically have not been good models of

149 Humanized mice (HM) allow researchers to examine xenogra

150 Recent advances in the development of humanized mice hold great promise to advance our underst

151 s observed in Cyp2abfgs-null and CYP2A13/2F1-humanized mice; however, the extent of NA-induced lung i

152 Here, we optimized humanized mice (Hu-mice) reconstituted with a functional

153 IFN-alpha/beta receptor (IFNAR) signaling in humanized mice (hu-mice) that were persistently infected

154 We have developed a humanized mice (Hu-mice) tuberculosis model system to in

155 In humanized mice (hu-mice), control of viremia can be achi

156 estigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV o

157 serum metabolic profiling from a model using humanized mice (humice) with DENV serotype 2 infection a

158 Here, we show that humanized mice, i.e., animals engrafted with components

159 FcRn-null and -humanized mice immunized with alpha3NC1 developed no alb

160 We previously showed that humanized mice immunized with long-lived induced-dendrit

161 d mice and the possible benefit of including humanized mice in future studies involving S. aureus as

162 n vivo model of ART in BM/liver/thymus (BLT) humanized mice in order to better understand the ability

163 cently begun to use MP-IVM in lymph nodes of humanized mice in order to examine HIV infectious spread

164 We have used humanized mice, in which human immune cells differentiat

165 lar to those of tumor-derived lines from the humanized mice, including reduced CXCL10 secretion.

166 rom cytometry by time-of-flight analysis and humanized mice indicating that human CD49e(-) NK cells a

167 CD4(-) cells, were significantly modified in humanized mice infected by cell-associated transmission.

168 od, Tezuka et al report the establishment of humanized mice infected by human T-cell leukemia virus t

169 Blunting antiviral immunity in genetically humanized mice infected with HCV results in measurable v

170 preventative and postexposure setting, that humanized mice infected with HCV variants exhibiting inc

171 In humanized mice, INK128 decreased plasma HIV RNA by >2 lo

172 ever) and erythema (rash) in comparison with humanized mice inoculated with cell culture medium only.

173 ncreasingly permissive, and progress towards humanized mice is advancing rapidly.

174 Recent progress in developing genetically humanized mice is exciting, but these models only permit

175 A major limitation of humanized mice is the poor development and function of h

176 the development of immune-disease specific "humanized" mice is that optimal adaptive immune response

177 In humanized mice, lethal disease develops, characterized b

178 o prevent and treat lentivirus infections in humanized mice, macaques, and humans.

179 Humanized mice may be useful for understanding the mecha

180 Ultimately, use of humanized mice may lead to the implementation of truly p

181 These new humanized mice may offer attractive models to study immu

182 hese results suggest that the development of humanized mice may provide a framework to assess the con

183 e, humoral, and cellular immune responses in humanized mice (mice with a human immune system [HIS mic

184 us NS3-expressing adenovirus, HLA-transgenic humanized mice mounted an HLA-A*0201-restricted hepatiti

185 As heterologous Ag in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse I

186 In macrophage cultures derived from TNF humanized mice MYSTI could capture the secreted hTNF, li

187 Additionally, as evaluated in TNF humanized mice, MYSTI was superior to an otherwise analo

188 a graft-versus-host disease (GvHD) model of humanized mice (NOD/SCID/IL-2Rgammac(-/-) [NSG] mice).

189 Thus, humanized mice offer a useful model for studying evoluti

190 "Humanized" mice offer a window into aspects of human phy

191 c fragments to wild-type or Fcgamma receptor-humanized mice prevented platelet consumption triggered

192 As a result, these cytokine-treated humanized mice produced significant levels of Ag-specifi

193 These results show that CLP in humanized mice provides a model to study human sepsis, H

194 This AR allelic series in humanized mice provides an experimental paradigm to diss

195 We show that humanized mice receiving VIP appear to be fully protecte

196 Humanized mice reconstituted with a human immune system

197 anded human cord blood-derived NK cells into humanized mice reconstituted with autologous human cord

198 dies administered to infected individuals or humanized mice reported poor control of virus replicatio

199 Humanized mice represent a novel lethal model for studie

200 Therefore, RAG2(-/-)gamma(c)(-/-) TPO-humanized mice represent a useful model to study human h

201 The CYP2D6 humanized mice represent an attractive model for future

202 ort hairpin (sh)RNA in B cells developing in humanized mice resulted in a failure to remove autoreact

203 on of the RDTR/SCF-LVs into the BM cavity of humanized mice resulted in the highly selective transduc

204 pecific T-cell receptor were introduced into humanized mice, resulting in the generation of a sizeabl

205 NP-IDV-BMMs administered to HIV-1-challenged humanized mice revealed reduced numbers of virus-infecte

206 The PPARalpha-humanized mice should serve as models for use in drug de

207 These "humanized" mice should assist us in the development of d

208 CYP2A13/2F1-humanized mice showed greater sensitivity to NA than Cyp

209 The humanized mice showed systemic repopulation with a compr

210 Recently, partial transmissions to humanized mice showed that the zoonotic potential of scr

211 del, human skin or HSE was transplanted onto humanized mice so that graft survival could be analyzed.

212 Promising early results from studies in humanized mice suggest great potential and enthusiasm fo

213 so detected in the serum from HIV-1-infected humanized mice suggesting that TAR RNA may be stable in

214 Moreover, administration of 25HC in humanized mice suppressed HIV replication and reversed T

215 Similar to human infants with CA, fully humanized mice survived postnatally by synthesizing pred

216 for HCV research owing to the development of humanized mice susceptible to HCV infection.

217 r in the terminal bronchioles of CYP2A13/2F1-humanized mice than in Cyp2abfgs-null mice.

218 By combining human RBC supplementation and humanized mice that are optimized for human immune cell

219 The creation of humanized mice that carry partial or complete human phys

220 n in the bone marrow of the cytokine-treated humanized mice that express both NK cell marker CD56 and

221 Humanized mice that express the entire UGT1 locus (hUGT1

222 ant induces an "abortive" lytic infection in humanized mice that is compatible with continued cell gr

223 We therefore created humanized mice that transgenically express the entire 16

224 against HIV-1 in vitro We now demonstrate in humanized mice that, when delivered at the same high cli

225 Here we show, in humanized mice, that the TLR-7-mediated response of huma

226 absence of the human Vlambda locus in these humanized mice, the dominance of Vlambda pairing with hu

227 lyzed, by using lung tissues from humans and humanized mice, the role of human CD1c(+) and CD141(+) D

228 luding recent advances in the development of humanized mice, the trafficking of human immune cells fo

229 n overview of some of the emerging models of humanized mice, their use in the study of infectious dis

230 We generated Chga and humanized mice through transgenic insertion of a human C

231 Here, we evaluated the ability of these humanized mice to develop antigen-specific, T cell-depen

232 Here, we utilized bone marrow/liver/thymus humanized mice to evaluate the in vivo HIV-inhibitory ac

233 Here, we genetically humanized mice to permit the growth of primary human pre

234 oietic stem cells, and 4) the ability of the humanized mice to reject human islet allografts.

235 These findings validate the use of humanized mice to study acute and persistent HAdV infect

236 Here we review the growing ability of humanized mice to support the study of human humoral imm

237 ssion of in vivo HIV-1 infection observed in humanized mice treated with the IL-15 superagonist, demo

238 We have found that reconstituted "humanized" mice treated with anti-CTLA-4 Ab (ipilimumab)

239 d Cd36 induction were also seen in the hPXR "humanized" mice treated with the hPXR agonist rifampicin

240 Finally, in liver chimeric humanized mice, TROS antagonizes inflammation in a model

241 o prevent intravenous transmission of HIV in humanized mice using broadly neutralizing antibodies.

242 In humanized mice, viral replication was less evident, but

243 CNS disease in humanized mice was characterized by gliosis, meningitis,

244 Using FcgammaR-humanized mice, we demonstrate that anti-tumor human (h)

245 Using HIV-infected humanized mice, we demonstrated that in vivo blockade of

246 Using DNA immunization of humanized mice, we identified nine HLA-A2-restricted ZnT

247 In addition, using COL7-humanized mice, we provide in vivo evidence of pathogeni

248 Using humanized mice, we show that broadly neutralizing antibo

249 PPARalpha-humanized mice were also protected, whereas Ppara-null m

250 In some cases, humanized mice were also treated with activating anti-CD

251 activities in OM and lung of the CYP2A13/2F1-humanized mice were primarily contributed by, respective

252 r, peripheral T cells developed in the FOXP3-humanized mice were quantitatively reduced and hyporespo

253 In this study, humanized mice were treated with Smoothened Agonist (SAG

254 While humanized mice were unaffected in their behavioral reper

255 A matured HMAb protected humanized mice when challenged with an infectious HCV hu

256 ibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing

257 P2F1 are active toward NA in the CYP2A13/2F1-humanized mice, where they play significant roles in NA-

258 pping grafted human classical monocytes into humanized mice, which were able to differentiate sequent

259 Humanized mice with a functional human immune system wou

260 regs were depleted by denileukin diftitox in humanized mice with chronic HIV-1 infection.

261 ion, and treatment of MBP-induced EAE in the humanized mice with copolymers FYAK and VWAK ameliorated

262 a serum metabolomics study on a model using humanized mice with dengue infection that had significan

263 the equivalent of a mosquito bite) of these humanized mice with eight low-passage-number strains pro

264 Humanized mice with faster transit due to administration

265 s reconstitute the gastrointestinal tract of humanized mice with human CD4(+) T cells rendering them

266 We developed humanized mice with human immune system and liver tissue

267 We immunized IgH- and Igkappa-humanized mice with the AE.A244 gp120 Env.

268 t viral escape mutants in HIV-1YU-2-infected humanized mice, with viremic control exhibited when a th

269 ymphoma models and against human lymphoma in humanized mice without any detectable toxic side effects

270 survive and possibly proliferate in vivo in humanized mice without exogenous cytokine administration