ライフサイエンスコーパス: humanized monoclonal antibody

1 Pertuzumab, a recombinant humanized monoclonal antibody (2C4), binds to extracellu

2 Alemtuzumab (Campath-1H) is a humanized monoclonal antibody (Ab) directed against CD52

3 e first strategy involves the development of humanized monoclonal antibodies against the nonconserved

4 Natalizumab, a humanized monoclonal antibody against alpha4 integrin, i

5 open label baseline-to-treatment trial of a humanized monoclonal antibody against CD25 (daclizumab)

6 rch of the mechanisms by which daclizumab, a humanized monoclonal antibody against CD25, inhibits bra

7 We studied the effects of a nonactivating humanized monoclonal antibody against CD3--hOKT3gamma1(A

8 a potential benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF-A

9 Eculizumab, a humanized monoclonal antibody against complement protein

10 Trastuzumab, a humanized monoclonal antibody against HER2, is cytostati

11 eosinophilia of 2% or more were treated with humanized monoclonal antibody against IgE (omalizumab) (

12 Omalizumab, a humanized monoclonal antibody against IgE, is clinically

13 ents were assigned to receive mepolizumab, a humanized monoclonal antibody against interleukin-5, whi

14 his binding can be prevented by MORAb-009, a humanized monoclonal antibody against mesothelin current

15 ve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated

16 RO5323441, a humanized monoclonal antibody against PlGF, showed antit

17 Etrolizumab is a humanized monoclonal antibody against the beta7 integrin

18 Since the approval of trastuzumab, a humanized monoclonal antibody against the extracellular

19 A study of a humanized monoclonal antibody against the high-affinity

20 Trastuzumab is a humanized monoclonal antibody against the human epiderma

21 Tocilizumab is a recombinant humanized monoclonal antibody against the IL-6 receptor

22 cell-anergizing therapy using tocilizumab, a humanized monoclonal antibody against the IL-6 receptor,

23 Daclizumab is a humanized monoclonal antibody against the interleukin 2

24 Daclizumab, a humanized monoclonal antibody against the interleukin-2

25 Bevacizumab, a humanized monoclonal antibody against vascular endotheli

26 Bevacizumab, a recombinant humanized monoclonal antibody against vascular endotheli

27 anted accelerated approval of bevacizumab, a humanized monoclonal antibody against vascular endotheli

28 Combination therapy with bevacizumab, the humanized monoclonal antibody against vascular endotheli

29 efore 6 and 48 h after, three infusions of a humanized, monoclonal antibody against IL-5 (mepolizumab

30 iple sclerosis with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath [regi

31 rials revealed that the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath-1H) i

32 proaches to block RSV replication, including humanized monoclonal antibodies and nucleic acid-based s

33 bB2 antibodies, including (i) trastuzumab, a humanized monoclonal antibody, and (ii) pAb, rabbit poly

34 Here, we describe ponezumab, a humanized monoclonal antibody, and show how it binds spe

35 Immunotherapy with effector cells alone or a humanized monoclonal antibody anti-p185(HER2) (4D5-8) re

36 Initial attempts to block VEGF by using a humanized monoclonal antibody are beginning to show prom

37 ti-vascular endothelial growth factor (VEGF) humanized, monoclonal antibody, bevacizumab, and/or its

38 Efalizumab, a humanized monoclonal antibody, binds to the alpha subuni

39 Inhibition of TNF-alpha by a chimeric humanized monoclonal antibody, cA2, was investigated in

40 The conditioning regimen consisted of the humanized monoclonal antibody CAMPATH-1H, fludarabine, a

41 To test this theory, a humanized monoclonal antibody capable of neutralizing hu

42 mechanism of TcdB neutralization by PA41, a humanized monoclonal antibody capable of neutralizing Tc

43 Humanized monoclonal antibodies directed against specifi

44 We evaluated the efficacy of MEDI-507 (a humanized monoclonal antibody directed against CD2) alon

45 A recently developed, humanized monoclonal antibody directed against complemen

46 Trastuzumab (Herceptin) is a recombinant humanized monoclonal antibody directed against HER-2.

47 Trastuzumab, a humanized monoclonal antibody directed against Her2, rep

48 Trastuzumab is a humanized monoclonal antibody directed against human epi

49 A recombinant humanized monoclonal antibody directed against IgE has p

50 clizumab (Zenapax, Roche Pharmaceuticals), a humanized monoclonal antibody directed against the alpha

51 we investigated the effects of daclizumab, a humanized monoclonal antibody directed against the alpha

52 Trastuzumab, a humanized monoclonal antibody directed against the extra

53 tive effect can be overcome by a recombinant humanized monoclonal antibody directed against VEGF in b

54 such as 2- methoxyestradiol and recombinant humanized monoclonal antibody directed against VEGF may

55 completely inhibited by coincubation with a humanized monoclonal antibody directed at human CD154 (h

56 d the efficacy of Campath-1H (alemtuzumab; a humanized monoclonal antibody directed to CD52), alone a

57 Here, we assessed the efficacy of the humanized monoclonal antibody eculizumab, which blocks t

58 nical cardiac tolerability of trastuzumab, a humanized monoclonal antibody effective in the treatment

59 Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all

60 We compared ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all

61 is, Genentech, South San Francisco, CA) is a humanized monoclonal antibody fragment designed to bind

62 ecific reversing agents include the approved humanized monoclonal antibody fragment idarucizumab for

63 study the antigen-binding site of Fab2C4, a humanized monoclonal antibody fragment that binds to the

64 es, including tyrosine kinase inhibitors and humanized monoclonal antibodies, have increased the comp

65 Conjugates of the anti-CanAg humanized monoclonal antibody huC242 with the microtubul

66 A humanized monoclonal antibody (huMAb 4D5) directed again

67 ly quantified the levels of deamidation of a humanized monoclonal antibody in cynomolgus monkeys over

68 d pharmacokinetics of epratuzumab (anti-CD22 humanized monoclonal antibody) in patients with recurren

69 ety and efficacy of Campath-1H, an anti-CD52 humanized monoclonal antibody, in previously treated T-p

70 GS-5745, a potent, highly selective humanized monoclonal antibody inhibitor of MMP9, has sho

71 phylaxis with hyperimmune globulin or with a humanized monoclonal antibody is expensive, limited to c

72 Humanized monoclonal antibody KD-247 targets the Gly(312

73 ent, which has led to the development of two humanized monoclonal antibodies (mAb) pertuzumab and bev

74 We have developed a humanized monoclonal antibody (mAb hu2c) that completely

75 violet (UV) light irradiation in MEDI-493, a humanized monoclonal antibody (MAb) against respiratory

76 doses of RSHZ19 (also known as SB 209763), a humanized monoclonal antibody (MAb) directed to the fusi

77 Tanezumab, a humanized monoclonal antibody (mAb) specific for NGF, is

78 uated whether a potent neutralizing anti-WNV humanized monoclonal antibody (MAb), hE16, could improve

79 Recently, a recombinant, humanized, monoclonal antibody (mAb) that binds to and n

80 These three Fabs and derived humanized monoclonal antibodies (MAbs) exhibited high ne

81 Two humanized monoclonal antibodies, MEDI-493 and RSHZ19, we

82 This study describes the generation of a humanized monoclonal antibody, MEDI-493, that recognizes

83 post hoc analyses to evaluate the effect of humanized monoclonal antibody mepolizumab in patients wi

84 rolled trial of the alpha4 integrin-specific humanized monoclonal antibody natalizumab in 248 patient

85 Intravenous administration of a humanized monoclonal antibody of IgE (E25) attenuates th

86 only specific treatment available today is a humanized monoclonal antibody (Palivizumab) directed aga

87 ns within 4 months time, paving the way to a humanized monoclonal antibody platform and additional hu

88 Solanezumab, a humanized monoclonal antibody, preferentially binds solu

89 A humanized monoclonal antibody raised against human ovari

90 In this study, we examined the efficacy of a humanized monoclonal antibody recognizing interleukin-2

91 During the characterization of a recombinant humanized monoclonal antibody (referred to as rhuMAb), e

92 These chimeric or humanized monoclonal antibodies, respectively, act by bi

93 sing concentrations of anti-HER2 recombinant humanized monoclonal antibody (rhuMAb) 2C4.

94 The recombinant humanized monoclonal antibody (rhuMAb) HER2 has high aff

95 The glycated form of a basic recombinant humanized monoclonal antibody (rhuMAb) was separated and

96 A recombinant humanized monoclonal antibody (rhuMAb-E25) forms complex

97 verexpression of HER-2 receptor, recombinant humanized monoclonal antibodies (rhuMAbs) to HER-2 recep

98 a on prostate cancer cells utilizing a novel humanized monoclonal antibody -- soon to undergo phase-I

99 xamined whether treatment with daclizumab, a humanized monoclonal antibody specific for the interleuk

100 n-10 is an attractive therapeutic target for humanized monoclonal antibody strategies.

101 te the efficacy and safety of trastuzumab, a humanized monoclonal antibody targeted against the human

102 ellular retention of radiolabeled murine and humanized monoclonal antibodies targeting the CD33 antig

103 Natalizumab, a humanized monoclonal antibody targeting alpha4 integrin,

104 ration and evaluation of (124)I-MORAb-004, a humanized monoclonal antibody targeting an extracellular

105 Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-

106 Pembrolizumab is a humanized monoclonal antibody targeting programmed cell

107 Bococizumab, a humanized monoclonal antibody targeting proprotein conve

108 uvic et al demonstrate that mogamulizumab, a humanized monoclonal antibody targeting the chemokine re

109 , combining bevacizumab (BV)--a recombinant, humanized, monoclonal antibody targeting vascular endoth

110 Humanized monoclonal antibodies that recognize the alpha

111 d pertuzumab (Omnitarg, 2C4) are recombinant humanized monoclonal antibodies that target different ex

112 Solanezumab, a humanized monoclonal antibody that binds amyloid, failed

113 afety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits ne

114 is effectively controlled with eculizumab, a humanized monoclonal antibody that binds complement prot

115 Ibalizumab is a humanized monoclonal antibody that binds human CD4, the

116 Ibalizumab is a humanized monoclonal antibody that binds human CD4--a ke

117 LT1009 (also known as sonepcizumab) is a humanized monoclonal antibody that binds S1P with high a

118 Mepolizumab, a humanized monoclonal antibody that binds to and inactiva

119 an entry portal for HIV-1, and PRO 140 is a humanized monoclonal antibody that binds to CCR5 and pot

120 Daclizumab high-yield process (HYP) is a humanized monoclonal antibody that binds to CD25 (alpha

121 ppression regimen consisted of daclizumab, a humanized monoclonal antibody that binds to the alpha ch

122 HuN901 is a humanized monoclonal antibody that binds with high affin

123 Alemtuzumab is a humanized monoclonal antibody that causes an immediate d

124 Pertuzumab is a humanized monoclonal antibody that inhibits human epider

125 Bococizumab is a humanized monoclonal antibody that inhibits proprotein c

126 Pertuzumab, an anti-HER2 humanized monoclonal antibody that inhibits receptor dim

127 Bevacizumab is a recombinant humanized monoclonal antibody that neutralizes vascular

128 sts of interleukin-2 molecularly linked to a humanized monoclonal antibody that recognizes the GD2 di

129 Ocrelizumab is a humanized monoclonal antibody that selectively depletes

130 We studied ocrelizumab, a humanized monoclonal antibody that selectively depletes

131 udy, we report the development of IPH4102, a humanized monoclonal antibody that targets the immune re

132 Bevacizumab is a humanized monoclonal antibody that targets vascular endo

133 y and efficacy of natalizumab, a recombinant humanized monoclonal antibody to alpha4 integrin, in pat

134 s of short-term administration of Vitaxin, a humanized monoclonal antibody to alphavbeta3, on the res

135 Alemtuzumab is a humanized monoclonal antibody to CD52 and has activity i

136 e to HIT plasma or 5B9, a recently developed humanized monoclonal antibody to PF4/heparin.

137 , a radiotracer for PET derived from a fully humanized monoclonal antibody to STEAP1 in preclinical P

138 iangiogenic agent bevacizumab, a recombinant humanized monoclonal antibody to vascular endothelial gr

139 Bevacizumab, a recombinant humanized monoclonal antibody to VEGF, is being used cli

140 Bevacizumab, a recombinant humanized monoclonal antibody to VEGF, was administered

141 ne the safety and efficacy of a recombinant, humanized, monoclonal antibody to the CD18 subunit of th

142 ponse to B-cell-anergizing therapy using the humanized monoclonal antibody tocilizumab directed again

143 The humanized monoclonal antibody trastuzumab (Herceptin) wa

144 Treatment with the anti-ERBB2 humanized monoclonal antibody trastuzumab and chemothera

145 Targeted therapy with the humanized monoclonal antibody trastuzumab has become a m

146 an epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody trastuzumab improves the o

147 Moreover, the SGN-70 humanized monoclonal antibody, which binds to CD70 (the