1 SC) biology and function in the context of a
humanized mouse.
2 A
humanized mouse air-pouch model showed that intravenous
3 nhibited in vivo HIV-1 and SHIV infection in
humanized mouse and macaque models, respectively, includ
4 n immunodeficiency virus (SHIV) infection in
humanized mouse and macaque models, respectively, includ
5 A
humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) prot
6 human breast tissue will be able to generate
humanized mouse glands within 3 months.
7 The hematopoietic
humanized mouse (
hu-mouse) model is a powerful resource
8 he early stages of acute co-infection in the
humanized mouse,
infection with HIV exacerbates the pro-
9 Creation of this
humanized mouse is the first step toward development of
10 esponse between mice and humans, a PPARalpha-
humanized mouse line was generated in which the human PP
11 In the future, use of "
humanized" mouse lines, containing a human AHR or CYP1 a
12 Human gene expression levels in
humanized mouse livers were analyzed by qPCR and Nanostr
13 Using a
humanized mouse model (denoted Hu-mice) reconstituted wi
14 iNKT cells, we recently developed the first
humanized mouse model (hCD1d-KI) with human CD1d knocked
15 Two studies in this issue of the JCI use a
humanized mouse model and demonstrate that type I interf
16 t the rejection of islets of Langerhans in a
humanized mouse model and examined the mechanisms involv
17 h tissue engineering, we sought to develop a
humanized mouse model based on the facile and ectopic im
18 henotypically characterized a novel knock-in
humanized mouse model carrying the severe, MECD-associat
19 Furthermore, the
humanized mouse model described here may prove valuable
20 f a potent and selective chemical tool and a
humanized mouse model described in this report should fa
21 Similar to humans, this
humanized mouse model developed a subset of CD8alphabeta
22 ates for the first time the application of a
humanized mouse model for functional analysis of human m
23 Recent advances in the development of a
humanized mouse model for HIV-1 infection might provide
24 coronavirus (MERS-CoV) and development of a
humanized mouse model for MERS-CoV infection, which was
25 Here, we studied bone homeostasis in a
humanized mouse model for SCD.
26 is protocol describes our recently developed
humanized mouse model for studying HCV and other hepatot
27 viral surveillance and the relevance of this
humanized mouse model for the studies of HIV-1 pathobiol
28 hese studies demonstrate the utility of this
humanized mouse model for the study of human Treg ontoge
29 ive activity of human Treg in vitro and in a
humanized mouse model in vivo.
30 X chromosome dosage and sex hormones using a
humanized mouse model in which male or female NOD-SCID-b
31 We established a
humanized mouse model incorporating FLT3-ligand (FLT3-L)
32 This
humanized mouse model may be used to model the human imm
33 Our
humanized mouse model may thus be useful for preclinical
34 Recently, we developed a
humanized mouse model of allergen-induced IgE-dependent
35 ll activation on pulmonary inflammation in a
humanized mouse model of allergic airway inflammation.
36 Importantly, using a
humanized mouse model of allergic asthma, we demonstrate
37 Furthermore, in a
humanized mouse model of allergy using PBMC-engrafted NO
38 In a chimeric
humanized mouse model of allograft rejection, medial imm
39 to inhibit vascular allograft rejection in a
humanized mouse model of arterial transplantation.
40 In this study, we used a
humanized mouse model of arthritis in an attempt to dete
41 A preclinical
humanized mouse model of beta thalassemia major or Coole
42 nt of betaT in the gammabeta(0)/gammabeta(A)
humanized mouse model of betaT.
43 sts of anti-human GITR antibody MK-4166 in a
humanized mouse model of cancer mimicked many of the eff
44 A novel
humanized mouse model of Cooley's Anemia (CA) was genera
45 We previously developed a
humanized mouse model of DF in which mice transplanted w
46 ion will likely enhance HCV infection in the
humanized mouse model of HCV infection and replication.
47 We previously generated a
humanized mouse model of HD, Hu97/18, by intercrossing B
48 n mRNA, in patient cells and in a completely
humanized mouse model of HD.
49 When introduced into a
humanized mouse model of HIV-1 infection, these corecept
50 but significant decrease in GAS fitness in a
humanized mouse model of impetigo; the DeltafbaA mutant
51 In our NOD/Scid IL-2Rgamma(null)
humanized mouse model of leukemia, control shRNA-transdu
52 Here, we describe the development of
humanized mouse model of MYC/BCL2-driven 'double-hit' ly
53 In a
humanized mouse model of pseudoxanthoma elasticum, we in
54 ere with the development of nephropathy in a
humanized mouse model of SCD.
55 We bred Kcc1(M935K) mutant mice with a
humanized mouse model of sickle cell disease to directly
56 In a
humanized mouse model of sickle cell disease, the captur
57 ation of nra leads to loss of virulence in a
humanized mouse model of superficial skin infection.
58 Using a
humanized mouse model of TSS and human cells, we herein
59 More important, in a preclinical
humanized mouse model of xenogeneic graft-versus-host di
60 ed protection by IFN-alpha-treated Treg in a
humanized mouse model of xenogeneic graft-versus-host di
61 This genetically
humanized mouse model opens new opportunities to dissect
62 Here, we use a
humanized mouse model overexpressing Tcf7l2, resulting i
63 This
humanized mouse model permits in vivo evaluation of immu
64 Thus, this
humanized mouse model permits preclinical testing of vac
65 Our establishment of this extensively
humanized mouse model phenotypically and functionally re
66 f Infectious Diseases summarizes work in the
humanized mouse model presented at an HIV Humanized Mous
67 The use of a
humanized mouse model provides a way of dissecting the r
68 This
humanized mouse model should be useful for studying immu
69 RT-PCR, lentiviral transduction, and in vivo
humanized mouse model studies demonstrated that malignan
70 s well, eliminating Ag-specific T cells in a
humanized mouse model system.
71 ll lymphomas in a newly developed cord blood-
humanized mouse model that allows EBV-infected B cells t
72 Here we report a genetically
humanized mouse model that incorporates a luciferase rep
73 Here we established a
humanized mouse model that reproduces features of acute
74 Halper-Stromberg et al. use a
humanized mouse model to demonstrate that broadly neutra
75 We developed a novel
humanized mouse model to evaluate in vivo human NK cell-
76 Here, we utilized a
humanized mouse model to recapitulate the low immunogeni
77 e recently used a newly developed cord blood-
humanized mouse model to show that EBV can cooperate wit
78 We generated a new
humanized mouse model to study HLA-restricted immune res
79 er immunotherapy and provide a translational
humanized mouse model to test the lifespan, safety, and
80 The hMB
humanized mouse model underscores the synergy of MYC and
81 ociated with systemic lupus erythematosus, a
humanized mouse model was examined.
82 A
humanized mouse model was used to demonstrate that this
83 a highly sensitive and ecologically relevant
humanized mouse model was used to measure superficial sk
84 Using a
humanized mouse model we demonstrate that this missense
85 r fibrosis, we utilized a recently developed
humanized mouse model with autologous human immune and l
86 We have developed a cytokine-enhanced
humanized mouse model with greatly improved reconstituti
87 ration and tubulogenesis, (b) in a PPARalpha-
humanized mouse model, activation of the receptor inhibi
88 In a genetically
humanized mouse model, active immunization with sE2 effi
89 to induce B cell lymphomas in the cord blood-
humanized mouse model, although the simultaneous loss of
90 Here, we have used a new
humanized mouse model, in which both human fetal CD34(+)
91 hibits all preeclampsia-like features in the
humanized mouse model, including new-onset proteinuria,
92 roved the immunogenicity of the H7 HA in the
humanized mouse model, leading to a greater than 4-fold
93 In a
humanized mouse model, NOTCH pathway disruption had stro
94 Ab513 mitigates thrombocytopenia in a
humanized mouse model, resolves vascular leakage, reduce
95 In the
humanized mouse model, T-cell infiltration into the sali
96 Using a novel
humanized mouse model, we demonstrated that LSEVh-LS-F r
97 Here, using a pregnane X receptor (PXR)-
humanized mouse model, we found that co-treatment with R
98 By using in vitro approaches and a
humanized mouse model, we provide evidence for a causal
99 is in a hematopoietic stem cell-transplanted
humanized mouse model.
100 nt receptor expression and localization in a
humanized mouse model.
101 habetaT cells both in vitro and in vivo in a
humanized mouse model.
102 orally acquired listeriosis in a gnotobiotic
humanized mouse model.
103 y mediated superior antitumor responses in a
humanized mouse model.
104 strains using immunoinformatics tools and a
humanized mouse model.
105 y image human immune responses in a relevant
humanized mouse model.
106 ction against HCV infection in a genetically
humanized mouse model.
107 a formation elicited by vascular injury in a
humanized mouse model.
108 ells undergo tolerance, we developed a novel
humanized mouse model.
109 at requires Fcgamma receptor engagement in a
humanized mouse model.
110 rapeutic option in allergic diseases using a
humanized mouse model.
111 ponse and celiac disease-like pathology in a
humanized mouse model.
112 e, we aimed to corroborate our findings in a
humanized mouse model.
113 than HSPCs with lower levels of ARID3a in a
humanized mouse model.
114 munopathogenesis during HIV-1 infection in a
humanized mouse model.
115 Additionally, we employed a chimeric "
humanized" mouse model of HCV infection to demonstrate f
116 The '
humanized' mouse model enables strict comparison of the
117 SPA70 inhibits hPXR in human hepatocytes and
humanized mouse models and enhances the chemosensitivity
118 important step forward in the development of
humanized mouse models and particularly for the analysis
119 These
humanized mouse models are becoming increasingly importa
120 Humanized mouse models are useful tools to understand pa
121 However, existing
humanized mouse models cannot support development of hum
122 ts associated with non-human primate models,
humanized mouse models containing chimeric human livers
123 Here, we describe the major
humanized mouse models currently in use, and some recent
124 Host & Microbe, McHugh et al. (2017) develop
humanized mouse models for EBV/KSHV co-infection and ide
125 arvard Center for AIDS Research symposium on
humanized mouse models for HIV vaccine design.
126 d Infectious Diseases convened a workshop on
humanized mouse models for immunity in Bethesda, MD, on
127 ults offer a proof of concept for the use of
humanized mouse models for surrogate efficacy and histol
128 Humanized mouse models have become increasingly importan
129 Various
humanized mouse models have been developed in efforts to
130 Improvements in
humanized mouse models have made them the preferred smal
131 Humanized mouse models have, over the past few years, se
132 nally, our findings highlight the utility of
humanized mouse models in interrogating therapeutic appr
133 The low efficiency of HCV replication in the
humanized mouse models is likely due to either the lack
134 In conclusion, both porcinized and
humanized mouse models of heterotopic subcutaneous bronc
135 This Review summarizes the contribution that
humanized mouse models of HIV infection have made to the
136 Thus
humanized mouse models of HIV vaginal infection will all
137 lly, the drug inhibited viral replication in
humanized mouse models of Rag2(-/-)gammac(-/-) with no t
138 ceptor pathway to facilitate construction of
humanized mouse models on non-NOD genetic backgrounds.
139 the basis for creating increasingly complex
humanized mouse models that could prove useful for study
140 The new
humanized mouse models with a transplanted human immune
141 The improvement of
humanized mouse models with robust human immune cell rec
142 Recent advances in
humanized mouse models, in particular the humanized bone
143 nonhuman primates (NHPs), and HIV-1-infected
humanized mouse models, passive transfer studies in infa
144 Of the two current leading
humanized mouse models, the hu-HSC model is created by h
145 Using several relevant
humanized mouse models, we demonstrate that TCR-transduc
146 Using both human and
humanized mouse models, we report that hyperglycemia-ind
147 ered insights into the development of future
humanized mouse models.
148 ected, we used 3 different but complementary
humanized mouse models.
149 wn can control rejection of human tissues in
humanized mouse models.
150 ve Abs when those cells were introduced into
humanized mouse models.
151 mes using a panel of knockout and transgenic
humanized mouse models.
152 uct NRG or NSG mutant mice to facilitate new
humanized mouse models.
153 now confirmed the findings from the cat and
humanized mouse models.
154 er of limitations in the currently available
humanized mouse models.
155 dy has not only provided direct evidence in "
humanized" mouse models that soluble and membrane-restri
156 issue in NOD hosts during the generation of "
humanized" mouse models.
157 Recently, several studies suggested that
humanized mouse or transgenic mouse expressing key HCV h
158 lls were assayed from both participants in a
humanized mouse outgrowth assay.
159 rum CSP inhibited liver-stage infection in a
humanized mouse/
P. falciparum challenge model.
160 Most significantly, when tested in
humanized mouse primary hepatocytes, TA inhibits hLRH-1
161 amma chain knockout-bone marrow-liver-thymus
humanized mouse provides a unique model for studying the
162 This "
humanized" mouse represents a potentially important mode
163 We have used a chimeric
humanized mouse system to model this arteriopathy in hum
164 Using a clinically relevant chimeric
humanized mouse system, we transplanted mice with human
165 osclerosis in a clinically relevant chimeric
humanized mouse system.
166 el small animal model of co-infection in the
humanized mouse to investigate how HIV infection disrupt
167 he humanized mouse model presented at an HIV
Humanized Mouse workshop in Boston, Massachusetts, in No