ライフサイエンスコーパス: humoral immune response

1 the two main players of the T cell-dependent humoral immune response.

2 lutinin is the major antigenic target of the humoral immune response.

3 Abs to remove the pathogen that induces the humoral immune response.

4 gical effects of omega-3-derived SPMs on the humoral immune response.

5 immunization induced a robust and long-lived humoral immune response.

6 rotection and forms an important part of the humoral immune response.

7 ndent on neither cytotoxic T lymphocytes nor humoral immune response.

8 ost cells and are the primary targets of the humoral immune response.

9 e virus may subvert the early HIV-1-specific humoral immune response.

10 al and participates in the regulation of the humoral immune response.

11 antibody production, signifying an increased humoral immune response.

12 gM is the first antibody produced during the humoral immune response.

13 urther elucidated the role of mPGES-1 in the humoral immune response.

14 ance mechanism to limit accessibility to the humoral immune response.

15 for 3 weeks, allowing sufficient time for a humoral immune response.

16 in the follicle early in the genesis of the humoral immune response.

17 impact the initiation and maturation of the humoral immune response.

18 HSH2 expression have profound effects on the humoral immune response.

19 stem (CNS), intrinsic neuroinflammation, and humoral immune response.

20 es, which increases the effectiveness of the humoral immune response.

21 virus spread, which is resistant to the host humoral immune response.

22 cell formation, directly linking EG with the humoral immune response.

23 hether and to what extent 9cRA modulates the humoral immune response.

24 elucidate the effect of the adjuvant on the humoral immune response.

25 nstruct and help B cells launch an effective humoral immune response.

26 Tfh cells, resulting in marked impairment of humoral immune responses.

27 and maintenance of germinal center (GC) and humoral immune responses.

28 primary and secondary adaptive cellular and humoral immune responses.

29 iggered cellular immunity and cross-reactive humoral immune responses.

30 ce and are transforming our understanding of humoral immune responses.

31 zation strategies induce strong cellular and humoral immune responses.

32 egimen for both vaccine-induced cellular and humoral immune responses.

33 cells has complementary functions to promote humoral immune responses.

34 nity, in addition to potent and high-avidity humoral immune responses.

35 lls) provide critical help to B cells during humoral immune responses.

36 pendent primarily on generation of effective humoral immune responses.

37 l responses and the development of effective humoral immune responses.

38 e polyreactive and/or Ag-specific Abs during humoral immune responses.

39 nt role in IgM homeostasis and regulation of humoral immune responses.

40 of the murine CR2 locus results in impaired humoral immune responses.

41 y clearance of infection and by promotion of humoral immune responses.

42 boost elicited robust CD4 and CD8 T-cell and humoral immune responses.

43 HV68 reactivation requires both cellular and humoral immune responses.

44 development, proliferation, homeostasis, and humoral immune responses.

45 capable of eliciting both cell mediated and humoral immune responses.

46 se, pre-existing B cell memory, or secondary humoral immune responses.

47 on lymphocyte activation limits cellular and humoral immune responses.

48 enic DC subsets for B cell activation during humoral immune responses.

49 host cell was sufficient to induce antivirus humoral immune responses.

50 hly effective adjuvant for CD4(+) T cell and humoral immune responses.

51 tion needles, or F1 capsule generated robust humoral immune responses.

52 velopment and regulation of T cell-dependent humoral immune responses.

53 (Tfh) cells have a central role in mediating humoral immune responses.

54 he GC reaction and is required for secondary humoral immune responses.

55 ial for induction of potent and long-lasting humoral immune responses.

56 he surface of particles to directly initiate humoral immune responses.

57 from the lymph and for initiating antiviral humoral immune responses.

58 ccines continue to fail to induce these rare humoral immune responses.

59 ted roles of LCs in type 17, regulatory, and humoral immune responses.

60 an immune system to induce both cellular and humoral immune responses.

61 c portion of IgG and important regulators of humoral immune responses.

62 arding the optimal approach for induction of humoral immune responses.

63 ins, most of which constitute key targets of humoral immune responses.

64 complex interplay between mucosal and serum humoral immune responses.

65 nfection and induced both systemic and local humoral immune responses.

66 in induction of germinal center B cells and humoral immune responses.

67 e primary objective of noninferiority of the humoral immune response 1 month post-dose 2 was consider

68 ersistent, broad, and effective cellular and humoral immune responses able to delay heterologous SIVs

69 mAb), which does not affect CD4(+) T cell or humoral immune responses, abrogated protection in four o

70 The humoral immune response after acute infection with HIV-1

71 We investigated the role of CD47 in inducing humoral immune responses after intranasal infection with

72 To examine the humoral immune response against B. miyamotoi, we infecte

73 lenge depended largely on the quality of the humoral immune response against EBOV GP.Here we present

74 ly to enhance the breadth and potency of the humoral immune response against HCV.

75 d are capable of contributing to the ongoing humoral immune response against Plasmodium infection.

76 avirus infection, a serological study of the humoral immune response against the individual viral pro

77 otein, resulting in an enhanced cellular and humoral immune response against the vaccine antigen.

78 d play important roles in T cell-independent humoral immune responses against blood-borne pathogens.

79 s in an attempt to induce broad cellular and humoral immune responses against blood-stage malaria Ags

80 Germinal center formation and humoral immune responses against C. rodentium were sever

81 o the coat protein or as adjuvant to enhance humoral immune responses against coadministered Ags or v

82 Humoral immune responses against donor antigens are impo

83 te robust antigen-specific cell-mediated and humoral immune responses against EBOV GP and that Ad5 im

84 are more potent to provoke both cellular and humoral immune responses against hepatitis C virus (HCV)

85 ts/cells that are responsible for sustaining humoral immune responses against HIV.

86 EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis throu

87 ew networks that have important functions as humoral immune response and organismal injury/abnormalit

88 neutralizes viral variants that escaped the humoral immune response and reinfected the liver graft o

89 a susceptible hamster model in terms of the humoral immune response and survival from leptospiral ch

90 t assay to define the characteristics of the humoral immune response and to determine seroprevalence.

91 MN vaccine induced superior humoral immune responses and conferred protective immuni

92 ed novel knowledge about the role of TL1A in humoral immune responses and its mechanism of action in

93 alled IL-40, that plays an important role in humoral immune responses and may also play a role in B c

94 ength HA antigens at inducing cross-reactive humoral immune responses and that VSV-cHA vaccine-induce

95 , we tested the immunogenicity (cellular and humoral immune responses) and efficacy (AD-like patholog

96 into host cells and is a key target for the humoral immune response, and yet many structural details

97 on and efficacy of HIV-specific cellular and humoral immune responses, and the preclinical modeling o

98 The BuV-specific humoral immune responses appeared to be strong and long-

99 cal tolerance that control both cellular and humoral immune responses are desirable.

100 that the suppressive effects on Ag-specific humoral immune responses are entirely B cell intrinsic.

101 ous other diseases where strong cellular and humoral immune responses are required for protection.

102 Humoral immune responses are thought to play a major rol

103 tical role in determining the outcome of the humoral immune response as demonstrated using HSH2 trans

104 e variants was not due to suppression by the humoral immune response as virus neutralising antibodies

105 acking HS V display marked defects in type 2 humoral immune responses, as evidenced by abrogated IgE

106 Furthermore, T2D mice had an impaired humoral immune response at day 14 with reduced total IgG

107 During the humoral immune response, B cells undergo a dramatic chan

108 During the activation of humoral immune responses, B cells acquire antigen for su

109 oses immense immunological challenges to the humoral immune response because of its ability to shield

110 or vaccination strategies aimed at improving humoral immune responses, because of their natural abili

111 ymphocyte subsets representing stages of the humoral immune response before and after antigen exposur

112 induces persistent SIV-specific cellular and humoral immune responses both systemically and at the or

113 Mice immunized with LANACs mounted a strong humoral immune response but did not produce neutralizing

114 tic leukemia (CLL), lenalidomide can promote humoral immune responses but also induces a distinct dis

115 vants capable of promoting both cellular and humoral immune responses, but in most cases the mechanis

116 Both forms of iNKT-cell help induce primary humoral immune responses, but only noncognate iNKT-cell

117 helper (Tfh) cells play a prominent role in humoral immune responses, but the mechanisms of their ac

118 s play an essential role in antigen-specific humoral immune responses by differentially regulating B

119 emonstrate that the absence or diminution of humoral immune responses by itself is insufficient to dr

120 ly on the induction of long-lived protective humoral immune responses by memory B cells and plasma ce

121 cells are necessary to generate and maintain humoral immune responses by providing help to antigen-sp

122 helper (Tfh) cells promote T cell-dependent humoral immune responses by providing T cell help to B c

123 However, CPS-specific adaptive humoral immune responses can only be achieved by the cov

124 ation regimens that elicit both cellular and humoral immune responses can prevent HIV infection in hu

125 prehensive approach to systematically survey humoral immune responses, capturing the array of functio

126 In addition to eliciting humoral immune responses, CD4(+) and CD8(+) T cells char

127 o raise significant and durable cellular and humoral immune responses comparable to those seen in RMs

128 mulation showed more robust and long-lasting humoral immune response compared to a single bolus injec

129 burden, resistant mice exhibited an elevated humoral immune response compared with susceptible mice.

130 dose, inducing a significantly more durable humoral immune response compared with three doses of a l

131 trated a strong, efficient, and safe in vivo humoral immune response compared with traditional forms

132 that can induce strong and broad T cell and humoral immune responses correlating with HIV-1 protecti

133 e absence or weakening of the virus-specific humoral immune response could be an environmental factor

134 Long-lived humoral immune responses depend upon the generation of m

135 The efficiency of humoral immune responses depends on the selective outgro

136 V-positive C cases did not elicit long-lived humoral immune responses, despite viremia levels of up t

137 -4 (IL-4) in secondary lymphoid organs where humoral immune responses develop.

138 humanized mice to support the study of human humoral immune responses, discussing the current and fut

139 B cells ensure humoral immune responses due to the production of Ag-spe

140 rane fusion and is the primary target of the humoral immune response during infection.

141 Dysregulation of cellular and humoral immune response elements, along with organ-defin

142 e report strong class-switched, high avidity humoral immune responses elicited by a vaccine system ba

143 We compared the HIV-1-specific cellular and humoral immune responses elicited in rhesus macaques imm

144 c cells (DCs) can result in antigen-specific humoral immune responses even in CD4(+) T-cell-depleted

145 Common VH gene usage indicates common humoral immune responses, even among unrelated patients.

146 mas arise in the germinal center (GC), where humoral immune responses evolve from potentially oncogen

147 insic manner to mount an effective long-term humoral immune response following immunization.

148 hemagglutinin (HA) is a major target of the humoral immune response following infection and/or seaso

149 The significance of humoral immune response for allograft survival after liv

150 pointed to the potential for harnessing the humoral immune response for early cancer detection.

151 a correlation between disease protection and humoral immune responses for the deduction of vaccine an

152 This study shows the evolution of the humoral immune response from IgM to IgG DSA posttranspla

153 Although the humoral immune response generates the primary correlate

154 Humoral immune responses have the potential to maintain

155 immunity, but whether and how mTOR modulates humoral immune responses have yet to be fully understood

156 rences in their induction of CD4+ T-cell and humoral immune responses; however, differences in the re

157 rked by potent antigen-specific cellular and humoral immune responses; however, the immune mechanism

158 ecent findings related to B cells and to the humoral immune response in cancer and their translationa

159 odified Ad vectors boosted the OprF-specific humoral immune response in contrast to immunization with

160 activity, and neutralization capacity of the humoral immune response in ebolavirus survivors.

161 d individuals is likely due to a more intact humoral immune response in ECs and/or distinct responses

162 al targets on CHIKV that elicit a protective humoral immune response in humans are poorly defined.

163 In the current study, we evaluated the humoral immune response in humans vaccinated with H5N1 A

164 replication was a consistent feature of the humoral immune response in immunized mice.

165 d a strong capacity to induce a long-lasting humoral immune response in mice.

166 and retained the ability to induce a strong humoral immune response in monkeys.

167 in alteration is associated with a decreased humoral immune response in Rictor KO mice.

168 ynthetic DNA adjuvant, eliciting an enhanced humoral immune response in vaccinated mice.

169 tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellular immune

170 ospheres significantly enhanced both Th1 and humoral immune responses in a mouse model of genital gon

171 erations in the disease-related cellular and humoral immune responses in AIA.

172 with this localization, LipC elicits strong humoral immune responses in both HIV-negative (HIV-) and

173 ied Env proteins elicited potent and durable humoral immune responses in colorectal mucosa in rhesus

174 used to analyze the established cellular and humoral immune responses in healthy adults and asthmatic

175 Advax(CpG) induced the highest cellular and humoral immune responses in mice.

176 d the magnitude of CMV-specific cellular and humoral immune responses in milk of 30 seropositive moth

177 potent and durable Gag-specific cellular and humoral immune responses in neonatal rhesus monkeys, inc

178 HIV may each enhance mucosal HIV-1-specific humoral immune responses in sexually exposed but HIV-1-u

179 Adaptive humoral immune responses in the airways are mediated by

180 nts in cervical lymph nodes (CLN) to driving humoral immune responses in the infected CNS is poorly d

181 The patterns of humoral immune responses in the natural host are therefo

182 The protective role of B cells and humoral immune responses in tuberculosis infection has b

183 of PNSN(OVA + CpG) to stimulate cellular and humoral immune responses in vivo was compared with other

184 enchymal stromal cells play a key role in TD humoral immune responses in vivo.

185 ings that form a framework for examining the humoral immune response induced by systemic orthopoxviru

186 Anti-Id antibody responses (humoral immune responses [IRs]) were measured before eac

187 rotein antigens are conjugated with DNA, the humoral immune response is blunted and acquires features

188 fect on the induction and progression of the humoral immune response is not fully understood.

189 re the functional defect of the cellular and humoral immune response is often not recognized until th

190 ses, but their control of TFH cell-dependent humoral immune responses is unknown.

191 arly stages of infection when a delayed host humoral immune response likely affects virus systemic di

192 but HIV-induced dysfunction in the anti-HCV humoral immune response may play a role.

193 se of the peripheral nervous system in which humoral immune responses mediate tissue damage, inductio

194 , we sought to determine whether and how the humoral immune response might vary among controllers.

195 We therefore analyzed the humoral immune response of mice chronically treated with

196 (NS1), we are able to stimulate cellular and humoral immune responses of aged mice comparable to leve

197 The humoral immune response over time was measured by ELISA.

198 HIV employs multiple means to evade the humoral immune response, particularly the elicitation of

199 Humoral immune responses, particularly immunoglobulin A

200 es are significant human pathogens, with the humoral immune response playing an essential role in res

201 vement, cell-cell signaling and interaction, humoral immune response, protein synthesis, cell death a

202 tly augmented and prolonged the cellular and humoral immune responses provoked by H5N1 and 2009 H1N1

203 mic repertoire of antigens associated with a humoral immune response reflecting disease pathogenesis

204 lls play roles in both normal and pathogenic humoral immune responses regardless of host age.

205 -viral vector boosts to enhance cellular and humoral immune responses remains poorly understood.

206 The generation of robust T-cell-dependent humoral immune responses requires the formation and expa

207 p24CE DNA vaccination induced humoral immune responses similar in magnitude to those i

208 tive virulence attributes for S. aureus, and humoral immune responses specific for these polypeptides

209 ine produced a more robust cell-mediated and humoral immune response than the systemic replicon vacci

210 nd toward higher HIV-1-specific cellular and humoral immune responses than did ALVAC-C, indicating th

211 ion leads to the development of adaptive and humoral immune responses that are among the largest for

212 the PC that could be an important target of humoral immune responses that are involved in protection

213 that a live-attenuated HSV-1 vaccine elicits humoral immune responses that are unparalleled by a glyc

214 onses induced by nasal allergen exposure and humoral immune responses that included IgE-dependent bas

215 boost in an attempt to generate cellular and humoral immune responses that might be desirable in a pr

216 hen used as an immunogen in mice, stimulates humoral immune responses that neutralize the Fcgamma and

217 ating strains but can also stimulate broader humoral immune responses that potentially attenuate infe

218 skin DCs is their promotion of TFH cells and humoral immune responses that potentially represent an e

219 e podocyte, and both induce IgG4-predominant humoral immune responses that produce circulating autoan

220 ino acids 36 to 1334 is sufficient to elicit humoral immune responses that protect animals against le

221 head-to-head comparisons of the cellular and humoral immune responses that were elicited by these vec

222 iated activation of MZ B is known to trigger humoral immune response, the signal cascade directing th

223 onses were modest in frequency compared with humoral immune responses, the CD4(+) T cell response was

224 lls (B(mem)) are essential for the secondary humoral immune responses, the chemokine response pattern

225 re of infectious HIV-1 correlated with other humoral immune responses, the extent of variation betwee

226 een proposed to mediate viral evasion of the humoral immune response, though the mechanisms are poorl

227 racteristics of antibodies that underlie the humoral immune response to a given antigen.

228 Moreover, the humoral immune response to a second antigen is also hamp

229 sponse but that IL-33 was needed to induce a humoral immune response to a single inhalational challen

230 genesis, we screened mice for defects in the humoral immune response to a type II T-independent immun

231 We investigated the humoral immune response to Abeta42 fibrils and produced

232 ng the way to defining the repertoire of the humoral immune response to cancer.

233 of CHIKV E2/E1 is the primary target for the humoral immune response to CHIKV, and antibodies targeti

234 new avenues to a better understanding of the humoral immune response to CMV and development of more e

235 otype 2 strain (R36A)] markedly inhibits the humoral immune response to coimmunized heterologous prot

236 The humoral immune response to decellularized scaffolds has

237 differences in the associations between the humoral immune response to EBV and disease risk across c

238 te of a virion modulates the efficacy of the humoral immune response to flavivirus infection.

239 underlie the best available examples of the humoral immune response to HIV are providing important i

240 uppression and viral breakthrough impact the humoral immune response to HIV infection.

241 In 430 participants, humoral immune response to HZ/su was noninferior in HZ-P

242 S/CpG and BCG vaccine generated a comparable humoral immune response to ID injection.

243 understanding of how pregnancy modifies the humoral immune response to influenza vaccination will ai

244 The humoral immune response to most respiratory virus infect

245 A better understanding of the humoral immune response to natural dengue virus infectio

246 posures to PFCs were associated with reduced humoral immune response to routine childhood immunizatio

247 18R1 genes as plausible genes regulating the humoral immune response to smallpox vaccine in both Cauc

248 Taken together, these data suggest that the humoral immune response to the HgbA vaccine is protectiv

249 ents receiving the active treatment showed a humoral immune response to the MAGE-A3 antigen, although

250 o investigated a possible role of GrB on the humoral immune response to the model Ag 4-hydroxy-3-nitr

251 kers able to monitor or predict a protective humoral immune response to the vaccine.

252 r of viral entry and the principal target of humoral immune response to the virus.

253 pp Deltapla mutant-immunized mice elicited a humoral immune response to the WT bacterium, as well as

254 Our findings indicate that a humoral immune response to this protein is not associate

255 hip between gene expression patterns and the humoral immune response to vaccination.

256 on are transforming our understanding of the humoral immune response to viral infection.

257 Humoral immune responses to alloantigens are a growing c

258 Clearance was proposed to be mediated by humoral immune responses to amyloid.

259 ficantly less likely to develop long-lasting humoral immune responses to DENV, as measured in healthy

260 ozoans, and fungi, their potential impact on humoral immune responses to extracellular bacteria are u

261 Pregnant women do not have impaired humoral immune responses to IIV and may have increased c

262 erall, Spns2(tm1a/tm1a) resulted in impaired humoral immune responses to immunization.

263 Most humoral immune responses to influenza virus target the h

264 7 plays an important role in vaccine-induced humoral immune responses to influenza virus through the

265 an IL-17 T-helper response and activation of humoral immune responses to liver-associated self-antige

266 ion is associated with decreased mucosal and humoral immune responses to OPV but not the prolonged vi

267 fh) cells are critical for the generation of humoral immune responses to pathogenic infections, provi

268 The contribution of humoral immune responses to spontaneous control of hepat

269 t required for the generation of Ag-specific humoral immune responses to T-dependent or T-independent

270 synthetic oligosaccharide epitopes revealed humoral immune responses to the PS-I related glycan epit

271 To obtain an overview of humoral immune responses to these viruses, we generated

272 to marked amplification of both cellular and humoral immune responses to vaccination.

273 emulsion (GLA-SE) augments both cellular and humoral immune responses to vaccine Ags.

274 Humoral immune responses to varicella vaccine are best a

275 ntal understanding of coordinated aspects of humoral immune responses, to more globally differentiate

276 a model Ag, we investigated the evolution of humoral immune responses toward its immunodominant seque

277 post-RABV immunization.IMPORTANCE Extending humoral immune responses using adjuvants is an important

278 egion as being significantly associated with humoral immune response variations after rubella vaccina

279 and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms.

280 -binding cytokine interleukin (IL)-21 drives humoral immune responses via STAT3-dependent induction o

281 Concurrent induction of potent cellular and humoral immune responses was also achieved by combining

282 Cell-mediated and humoral immune responses were assessed at baseline and f

283 t clinical symptoms, although DTMUV-specific humoral immune responses were detected.

284 Cellular and humoral immune responses were equivalent in wild-type an

285 CD4(+) T-cell and humoral immune responses were much higher with HZ/su tha

286 nd ability to induce skin abscesses and host humoral immune responses were significantly attenuated i

287 milk CMV load and CMV-specific cellular and humoral immune responses were similar in mothers of VLBW

288 This is best exemplified during humoral immune response when an expanding B cell clone a

289 We investigated cellular and humoral immune responses when allogeneic hepatocytes are

290 , respectively, and induced balanced Th1/Th2 humoral immune responses, whereas mice immunized with th

291 ll subsets beyond the T1 stage and disrupted humoral immune responses, which can be recovered by addi

292 r signal-regulated protein kinase to inhibit humoral immune responses, while stimulating cell 'spread

293 This led to a balanced Env-specific humoral immune response with a more inflammatory Fc glyc

294 co-loaded with F1-V and MPLA induced potent humoral immune responses with 11-, 23-, and 15-fold incr

295 Previous efforts focused on priming humoral immune responses with recombinant HCV envelope E

296 Most subunit vaccines primarily generate humoral immune responses, with a weaker than desired CD8

297 ck of MOZ affected the functional outcome of humoral immune responses, with an increase in secondary

298 ent gp120 elicited high levels of T cell and humoral immune responses, with the vector containing a d

299 Suppressing unwanted humoral immune responses without compromising the host's

300 ine that could induce both cell-mediated and humoral immune responses would enable important proof-of