ライフサイエンスコーパス: humoral immunity

1 endosomal toll-like receptors and antiviral humoral immunity.

2 ction or vaccination to assess durability of humoral immunity.

3 es are superior at generating stalk-specific humoral immunity.

4 L-21 and IFN-gamma, with IL-21 being key for humoral immunity.

5 ress GC B cell responses and anti-Plasmodium humoral immunity.

6 evels of viral replication and dysregulating humoral immunity.

7 mechanisms collaborate to provide protective humoral immunity.

8 als, ART does not fully restore cellular and humoral immunity.

9 for optimal GC-Tfh cell differentiation and humoral immunity.

10 h cells, germinal centers, and Tfh-dependent humoral immunity.

11 e is known about functional abnormalities in humoral immunity.

12 ng, which is known to facilitate T-dependent humoral immunity.

13 ells in CD4(+) T-cell responses that support humoral immunity.

14 cells) regulate the quantity and quality of humoral immunity.

15 tion in the germinal center is a hallmark of humoral immunity.

16 Tfr, and Treg cells, which together control humoral immunity.

17 in the generation of protective cellular and humoral immunity.

18 r certain conditions PEGylated lipids induce humoral immunity.

19 bers of circulating B cells suggest impaired humoral immunity.

20 ection is thought to be conferred in part by humoral immunity.

21 ions in LPA levels likely influence adaptive humoral immunity.

22 mulatory receptor that enhances cellular and humoral immunity.

23 f strategies that elicit effective antiviral humoral immunity.

24 regulation of CD1d in normal B cells and in humoral immunity.

25 stand the outcome of vaccine trials based on humoral immunity.

26 d bone marrow-resident plasma cells maintain humoral immunity.

27 or CD20 in B cell activation and T-dependent humoral immunity.

28 f GC responses, memory B cell formation, and humoral immunity.

29 s provide new insight into the regulation of humoral immunity.

30 cies surrounding the role of this pathway in humoral immunity.

31 or (Cr)2 are important for the generation of humoral immunity.

32 n Ag receptor-mediated B cell activation and humoral immunity.

33 ntigen and are the cellular basis of durable humoral immunity.

34 ent for strong adjuvants to elicit effective humoral immunity.

35 adjuvant properties to initiate and enhance humoral immunity.

36 lymphocytes but with deficient cellular and humoral immunity.

37 eed IL-21 signaling for generating long-term humoral immunity.

38 that IL-10 is essential for anti-Plasmodium humoral immunity.

39 he fetus and newborn with passive protective humoral immunity.

40 tunes the strength of B cell activation and humoral immunity.

41 nt manner, without compromising cellular and humoral immunity.

42 ical role in limiting both cell-mediated and humoral immunity.

43 ma cells, which are essential for long-lived humoral immunity.

44 rate cross-strain specific cell mediated and humoral immunity.

45 ently, mediate the development of long-lived humoral immunity.

46 ultiple Ags and generate robust cellular and humoral immunity.

47 maintain homeostasis by inducing protective humoral immunity.

48 ion, which are critical steps for initiating humoral immunity.

49 b-forming cells and the functions of CD80 in humoral immunity.

50 hocyte response at the expense of Th2-driven humoral immunity.

51 hallenges, but spares previously established humoral immunity.

52 T helper cells (T(FH)) are key regulators of humoral immunity.

53 a demonstrate that PfEMP1 is a key target of humoral immunity.

54 vival of ASCs and plays an important role in humoral immunity.

55 ory that differs markedly from canonical B-2 humoral immunity.

56 gainst disease, suggesting a limited role of humoral immunity.

57 uced inflammation is important for eliciting humoral immunity.

58 proteins that allow evasion from preexisting humoral immunity.

59 elper T (Tfh) cells, which are essential for humoral immunity.

60 served peptide sequences from recognition by humoral immunity.

61 activation and the development of long-lived humoral immunity.

62 ibody/effector cell interaction in mediating humoral immunity.

63 of soluble BAFF, which in turn up-regulated humoral immunity.

64 then tested as adults for cell-mediated and humoral immunity.

65 barrier to their participation in protective humoral immunity.

66 of immune cell subsets involved in antiviral humoral immunity.

67 s and is a key component of HIV evasion from humoral immunity.

68 Cs in humans that contribute to long-lasting humoral immunity.

69 ered in pathophysiological states, modulates humoral immunity.

70 y, especially for protection against EBV and humoral immunity.

71 on and sustained expansion of GC B cells for humoral immunity.

72 r understanding disease mechanisms involving humoral immunity.

73 lymphocytes that promote the development of humoral immunity.

74 CD4(+) T cell subset critical for long-lived humoral immunity.

75 act with B cells, and foster tumor-promoting humoral immunity.

76 ration and as such are vitally important for humoral immunity.

77 ay contribute to long-term cell-mediated and humoral immunity.

78 riment to assess the nature and longevity of humoral immunity after a single primary influenza infect

79 The longevity of protective humoral immunity after influenza infection has important

80 lity and immune determinants of induction of humoral immunity after primary influenza infection remai

81 r signaling molecule, in inducing protective humoral immunity after vaccination with influenza virus-

82 nt role in the induction of antigen-specific humoral immunity after vaccination with MF59-adjuvanted

83 ed RABV vaccines expressing ZEBOV GP induced humoral immunity against each virus and conferred protec

84 ugh prophylactic vaccines provide protective humoral immunity against infectious agents, vaccines tha

85 The COBRA clade 2 HA H5N1 VLP elicits broad humoral immunity against multiple H5N1 isolates from dif

86 B cells mediate humoral immunity against pathogens but also direct CD4(+

87 ated in the pathogenesis of SLE by promoting humoral immunity against self-antigen.

88 4 costimulation are essential for productive humoral immunity against T-dependent Ags.

89 XmAb5871 suppressed humoral immunity against tetanus toxoid and reduced seru

90 ter B cell responses, which provide lifelong humoral immunity against the homotypic virus strain.

91 ses for long-lived cellular and neutralizing humoral immunity against the viral hemagglutinin.

92 ses for long-lived cellular and neutralizing humoral immunity against the viral hemagglutinin.

93 Specific serum antibodies mediating humoral immunity and autoimmunity are provided by mature

94 However, the role of A2aR in humoral immunity and B cell differentiation is unknown.

95 it does not sustain long-lasting anti-donor humoral immunity and B cell memory responses.

96 oncogenic repressor is a master regulator of humoral immunity and B-cell lymphoma survival.

97 nces lymph flow needed for fluid regulation, humoral immunity and cancer metastasis.

98 en CD4(+) T cells and B cells are needed for humoral immunity and CD4(+) T cell memory.

99 Since both humoral immunity and cell-mediated immunity are essentia

100 tly limits helper T cell-mediated support of humoral immunity and decreases parasite control.

101 Humoral immunity and donor B-cell engraftment was achiev

102 The duration and quality of humoral immunity and generation of immunological memory

103 glucosphingolipid-mediated dysregulation of humoral immunity and increased risk of B-cell malignancy

104 ent with the VSL#3 probiotic on cellular and humoral immunity and inflammation in healthy macaques.

105 e mechanisms through which iNKT cells impact humoral immunity and may inform design of vaccines that

106 ght impair the TFH cell-dependent control of humoral immunity and might lead to the development of ab

107 age plays more important roles in regulating humoral immunity and peripheral tolerance than in effect

108 B cells promoted restoration of cellular and humoral immunity and protection against opportunistic in

109 ted genetically attenuated S. aureus induces humoral immunity and provides a vaccine strategy for pat

110 Humoral immunity and resident-memory T cells notwithstan

111 s that may be targeted to promote long-lived humoral immunity and resistance to malaria.

112 nct commensal bacteria by multiple layers of humoral immunity and reveal a specialized function of th

113 y target cells of rapamycin for the impaired humoral immunity and that reduced Tfh formation in rapam

114 ious variable major proteins (VMPs) to evade humoral immunity and that VMPs are antigenic in humans.

115 ghts into the interplay between cellular and humoral immunity and the immunomodulatory capacity of Ig

116 e formation of the cells that provide stable humoral immunity and therefore have implications for aut

117 ycoproteins C (gC2) and D (gD2) to stimulate humoral immunity and UL19 (capsid protein VP5) and UL47

118 e is critical for the rescue of host natural humoral immunity and vaccine development.

119 Germinal centres (GCs) promote humoral immunity and vaccine efficacy.

120 for the generation of antibody diversity in humoral immunity and, when deregulated, also has severe

121 atio, limited removal of delivery vectors by humoral immunity, and avid binding between enzyme and it

122 methods were used to evaluate kidney damage, humoral immunity, and cellular immunity.

123 reveal connections with nonlytic exocytosis, humoral immunity, and cytokine signaling.

124 of intestinal immunity, induction of durable humoral immunity, and low cost.

125 Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in

126 gnaling enhances helper CD4 T cell activity, humoral immunity, and parasite clearance in rodents.

127 (LLPC) are essential for durable protective humoral immunity, and, conversely, in disease are a majo

128 magnitude, and kinetics to control mice and humoral immunity appeared intact.

129 haematopoiesis, although their functions in humoral immunity are difficult to decipher as a result o

130 However, whether and how mTOR regulates humoral immunity are not well understood.

131 s underlying the maintenance of long-lasting humoral immunity are not well understood.

132 However, mechanisms that regulate TI humoral immunity are poorly defined.

133 lasma cells (PCs), the terminal effectors of humoral immunity, are short-lived unless supported by ni

134 Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective anti

135 ed with defective CTL functions and impaired humoral immunity as indicated by reduced germinal center

136 Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen

137 This was not due to a defect in humoral immunity, as Cd22(-/-) mice had normal WNV-speci

138 The elderly have reduced humoral immunity, as manifested by increased susceptibil

139 in-depth understanding of both cellular and humoral immunity, as well as the intrinsic balances of t

140 Beyond their critical role in humoral immunity, B lymphocytes can employ a variety of

141 Antibodies confer humoral immunity but can also be harmful when they targe

142 These receptors link cellular and humoral immunity by bridging the antibody specificity to

143 fh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper s

144 ance the durability, breadth, and potency of humoral immunity by enhancing key elements of the B-cell

145 GCs provide an important source of humoral immunity by generating high affinity antibodies

146 ontribute to the development of long-lasting humoral immunity by germinal center formation.

147 We found that CXCL13 expression promoted humoral immunity by recruiting Tfh and GC B cells, facil

148 entify a mechanism by which IL-21 reinforces humoral immunity by restricting Tfr cell proliferation.

149 IL-10 also indirectly supports humoral immunity by suppressing excessive IFN-gamma, whi

150 er function for IgG production and long-term humoral immunity can also be restored by OSGE treatment

151 Recent studies in mice show that humoral immunity can alter M. tuberculosis infection out

152 ts our hypothesis that effective antimalaria humoral immunity can develop in low-transmission regions

153 ice have shown that components of B cell and humoral immunity can modulate the immune responses again

154 us vaccines that stimulate both cellular and humoral immunity can protect older individuals against s

155 tation, and highlights relationships between humoral immunity, cellular immunity and nonadherence.

156 irie dogs resulted in a significant boost in humoral immunity characterized by a shift in reactivity

157 Humoral immunity consists of pre-existing antibodies exp

158 Both cellular and humoral immunity contribute to this complication, with i

159 Long-lived humoral immunity depends on help provided by Tfh cells,

160 Immunization induced humoral immunity depends on rapid B cell proliferation a

161 We now report that long-term humoral immunity depends on the PC-intrinsic function of

162 ot affect the development of anti-Bordetella humoral immunity, did not contribute to disease severity

163 strategies that focus on the development of humoral immunity directed against the stalk domains of t

164 Unexpectedly, loss of FRCs also attenuated humoral immunity due to impaired B cell viability and fo

165 ever, the effect of antioxidant treatment on humoral immunity during a viral infection was unknown.

166 ytokine interleukin-21 (IL-21) in regulating humoral immunity during acute viral infections.

167 understanding the effects of antioxidants on humoral immunity during infection and immunization.

168 s are essential for generation of protective humoral immunity during influenza infection.

169 1 regulatory (Tr1) cells, and restriction of humoral immunity during malaria blood stage infection.

170 uating combined allele-specific cellular and humoral immunity elicited by malaria provides a more inf

171 in mice and nonhuman primates induces strong humoral immunity even in the absence of adjuvant, a proc

172 To better understand humoral immunity following ebolavirus infection, a serol

173 immunodeficiencies characterized by impaired humoral immunity following infection or vaccination.

174 ls are necessary for promotion of protective humoral immunity following pathogen challenge, but when

175 hylaxis (PEP) requires rapid vaccine-induced humoral immunity for protection.

176 However, adaptive cellular and humoral immunity frequently remain impaired posttranspla

177 moniae infections, and underscore the effect humoral immunity has on evolving drug resistance.

178 ecent attempts to target these components of humoral immunity have failed.

179 g T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL

180 eature has been associated with avoidance of humoral immunity, i.e., B cell activation and antibody n

181 bda light chain, thus potentially minimizing humoral immunity impairment.

182 add to the understanding of anti-ebolavirus humoral immunity.IMPORTANCE This study describes the gen

183 its established role in B cells, to promote humoral immunity in a variety of contexts.

184 ith correlation of CMV-specific cellular and humoral immunity in all subjects.

185 both reduced neutralization activity against humoral immunity in antisera of patients and healthy adu

186 ry of contradictory evidence for the role of humoral immunity in defense against tuberculosis.

187 Our study thus suggests that defective humoral immunity in early life is associated with limite

188 esearchers to gain a better understanding of humoral immunity in HCV infection.

189 In this study, we assess the induction of humoral immunity in humans and prairie dogs receiving Dr

190 To explore PC longevity and humoral immunity in humans, we investigated the fate of

191 s a significant threat due to the absence of humoral immunity in individuals under the age of 50.

192 Here, we studied the evolution of humoral immunity in low-risk pediatric patients during t

193 n ER-negative disease, suggesting a role for humoral immunity in mediating response to cytotoxic ther

194 BAFF) is critical for B cell development and humoral immunity in mice and humans.

195 ccessful induction of pulmonary cellular and humoral immunity in mice requires pulmonary replication

196 immunization with Lu AF20513 induced strong humoral immunity in mice with preexisting memory T-helpe

197 cicept suggests that the role of B cells and humoral immunity in multiple sclerosis is complex.

198 on to understand decline in T cell-dependent humoral immunity in older age.

199 is in Rb1(+/-) mice and corrected decline in humoral immunity in older mice following immunization wi

200 nical course of disease suggesting a role of humoral immunity in S. aureus clearance.

201 ent understanding of how TRIM21 orchestrates humoral immunity in the cytosolic environment.

202 ell immunity plays a more critical role than humoral immunity in the prevention of VZV reactivation a

203 Although the contributory role of humoral immunity in the protection against Mtb infection

204 o manipulate these cells to not only improve humoral immunity in the setting of primary immunodeficie

205 ell differentiation in the regulation of gut humoral immunity in vivo has never been directly shown.

206 To date, the contribution of humoral immunity, including antibodies and specific func

207 torically have not been good models of human humoral immunity induced by either infection or immuniza

208 ile malaria but did not increase with age as humoral immunity is acquired or correlate with protectio

209 Impaired humoral immunity is also common.

210 Humoral immunity is also dysregulated, as demonstrated b

211 Humoral immunity is an essential correlate of protection

212 Development of long-lived humoral immunity is dependent on CXCR5-expressing T foll

213 from malaria in animal models but protective humoral immunity is difficult to induce in humans.

214 Humoral immunity is essential for protection against WNV

215 Humoral immunity is generated and maintained by antigen-

216 elative importance of mucosal, cellular, and humoral immunity is important in developing vaccine stra

217 ng of how persistent viral infection impacts humoral immunity is incomplete.

218 our current knowledge on the role of ILCs in humoral immunity is limited.

219 results show that induction of antibacterial humoral immunity is only partially effective in protecti

220 gainst severe respiratory viral disease when humoral immunity is overcome.

221 The cornerstone of humoral immunity is the differentiation of B cells into

222 roles in cardiovascular disease, the role of humoral immunity is unknown.

223 ligand superfamily with an important role in humoral immunity, is also implicated in several cancers

224 f innate immunity is important in regulating humoral immunity largely through the complement receptor

225 of cattle to colonization generally focus on humoral immunity, leaving the role of cellular immunity

226 creased interest in the role of Tfr cells in humoral immunity, many fundamental aspects of their biol

227 indicate that the escape of HIV-1 from host humoral immunity may play a direct role in TF in long-te

228 lar regulatory T cells (T(FR) cells) inhibit humoral immunity mediated by CD4(+)CXCR5(+)Foxp3(-) foll

229 reg cells play a critical role in regulating humoral immunity mediated by CD4(+)CXCR5(+)PD-1(+) folli

230 esting that targeting both cell-mediated and humoral immunity might optimally protect against seconda

231 one, as assessed by the primary endpoints of humoral immunity (neutralising antibodies-ie, seroconver

232 aft survival in adults, but the influence of humoral immunity on transplant outcomes in children is n

233 n the critical contribution of complement to humoral immunity, our observations provide new mechanist

234 dentify mechanisms underlying persistent IgE humoral immunity over almost the entire lifespan of the

235 considered, mostly due to the paradigm that humoral immunity plays little role in the protection aga

236 own whether these changes continue to affect humoral immunity postpartum or how quickly they resolve.

237 al fatty acid status is a factor influencing humoral immunity, potentially through an SPM-mediated me

238 Plasma cells (PCs) as effectors of humoral immunity produce Igs to match pathogenic insult.

239 During infection, humoral immunity produces a polyclonal response with var

240 ion, a discriminatory or protective role for humoral immunity remains unclear.

241 Humoral immunity requires B cells to respond to multiple

242 Humoral immunity requires cross-talk between T follicula

243 immune effectors, representing cellular and humoral immunity, respectively, remain largely unexplore

244 Unfortunately, humoral immunity restricts patient treatment and in addi

245 protein SAP (Sh2d1a) have a major defect in humoral immunity, resulting from a lack of T cell help f

246 that SAP-deficient NKT cells can facilitate humoral immunity, SAP was deleted after development in S

247 While humoral immunity seems to be central for protection agai

248 lts establish PTIP as a licensing factor for humoral immunity that acts at several junctures of B lin

249 mmunological insights into the complexity of humoral immunity that are likely to apply to other patho

250 most critically, to identify the features of humoral immunity that distinguish protective from non-pr

251 ls has shed new light on pathways regulating humoral immunity that enable potent and specific respons

252 l-intrinsic, role for IDO1 as a regulator of humoral immunity that has implications for both vaccine

253 onse in combination with IgG1/IgG3-dominated humoral immunity that increase with age.

254 HA) effectively induces rapid and sustained humoral immunity that is protective against lethal chall

255 though TFH cells are important in anti-viral humoral immunity, the contribution of TH1 cells to a pro

256 To better understand how injury inhibits humoral immunity, the effects of chronic thoracic SCI on

257 IgA are poorly characterized and the type of humoral immunity they elicit remains elusive.

258 allele was also associated with up-regulated humoral immunity through increased levels of soluble BAF

259 support that mTORi is a potent inhibitor of humoral immunity through suppression of alloprimed B cel

260 brane targets are simultaneously targeted by humoral immunity, thus forming recognizable immunoglobul

261 Remarkably, rVSV(GP) escapes humoral immunity, thus, for the first time, allowing rep

262 step toward understanding the importance of humoral immunity to control of M. tuberculosis infection

263 3BNC117-mediated immunotherapy enhances host humoral immunity to HIV-1.

264 Improving humoral immunity to influenza is the target of current c

265 Tfh cell generation and prevented protective humoral immunity to intestinal helminth infection.

266 Natural infection-induced humoral immunity to matrix protein 2 (M2) of influenza A

267 -O(-/-) mice exhibit a delayed generation of humoral immunity to model Ags (OVA and keyhole limpet he

268 fection and gastric inflammation may enhance humoral immunity to oral attenuated S. Typhi vaccine.

269 Elderly humans show decreased humoral immunity to pathogens and vaccines, yet the effe

270 gen presenting cells to improve cellular and humoral immunity to plasmid-coded antigen.

271 Humoral immunity to Plasmodium falciparum circumsporozoi

272 didates suggests that both cell-mediated and humoral immunity to pre-erythrocytic parasite stages can

273 ong-lived plasma cells (LLPCs) that maintain humoral immunity to previously encountered Ags occupy a

274 sociated with interindividual differences in humoral immunity to rubella virus.

275 fects of acute malaria on the development of humoral immunity to secondary Ags.

276 yte trafficking was accompanied by defective humoral immunity to T-cell-dependent antigens.

277 -restricted invariant NKT (iNKT) cells boost humoral immunity to T-dependent Ags that are coadministe

278 SS provides the potential to elicit humoral immunity to target Plasmodium at multiple stages

279 s to examine the contribution of B cells and humoral immunity to the control of TB in nonhuman primat

280 e relative contribution of cell-mediated and humoral immunity to the vaccine-induced protection in a

281 dies demonstrate a clear association between humoral immunity to these toxins and protection against

282 results highlight the importance of IL-21 in humoral immunity to viruses.

283 ile progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little

284 e in vivo, B cell responses to model Ags and humoral immunity upon influenza infection were enhanced.

285 es a novel role for Eos in the regulation of humoral immunity via their impact on B cell homeostasis

286 Humoral immunity was associated with viral load at prese

287 Humoral immunity was critically important for vaccine-in

288 Humoral immunity was dominated by IgG1 and IgG3, whereas

289 Similar systemic cellular and humoral immunity was elicited by all immunization routes

290 Humoral immunity was identified as the correlate of prot

291 We found that impairment of humoral immunity was most outspoken in the first year af

292 In contrast, renal humoral immunity was unaffected in BL5923-treated mice,

293 Many of the principles of humoral immunity were discovered in chickens, yet the la

294 2 months of the HSCT, and both cellular and humoral immunity were re-established within a year of th

295 A total of 26 mutations that impair humoral immunity were recovered, and 19 of these mutatio

296 ole of GS protein-coupled A2aR in regulating humoral immunity, which may be pharmacologically targete

297 ess vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig,

298 MVs retain the ability to induce MV-specific humoral immunity while also eliciting HCV neutralizing a

299 IV vaccine design has been that cellular and humoral immunity work together to provide the strongest

300 rofound impact on CD4(+) T cell function and humoral immunity, yet the impact of aging on antigen spe