ライフサイエンスコーパス: hundreds of

1 After screening hundreds of 2D materials, we identify candidates where s

2 blem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds to subtle en

3 c power from a low level to high levels, the hundreds of adherent cells can be ruptured from the fibr

4 t trematode parasite (Ribeiroia ondatrae) on hundreds of amphibian populations spanning four native s

5 ria, reveals exceptional 'genomic potential'-hundreds of ancient haplotypes bear insertion or deletio

6 the past decade, researchers have deposited hundreds of annotated and curated datasets on both norma

7 a canonical interferon-mediated response and hundreds of antiviral defense genes not observed followi

8 rons, which in turn induce the expression of hundreds of antiviral genes.

9 Hundreds of Arabidopsis NMD targets possess evident EJC

10 film evolution at pressures between one and hundreds of atmospheres.

11 ies of large (~30 aa) steps, each coupled to hundreds of ATP hydrolysis events.

12 The pathway is found in hundreds of bacteria, including the pathogens Pseudomona

13 The human gut microbiome harbors hundreds of bacterial species with diverse biochemical c

14 Supragingival plaque harbors hundreds of bacterial species, playing a significant rol

15 gned to screen thousands of molecules across hundreds of biological targets or pathways.

16 Since the birth of biotechnology, hundreds of biotherapeutics have been developed and appr

17 the program to estimate gametic variance for hundreds of bulls for lifetime net merit, productive lif

18 allowing for efficient chemical exchange for hundreds of C. elegans embryos simultaneously.

19 However, hundreds of cancer-associated PIK3CA mutations remain un

20 We identified hundreds of candidate domestication genes with drastical

21 ibrary CRISPR/Cas9 knockout screening across hundreds of cell lines has identified genes whose disrup

22 pan-epithelial smoking response networks and hundreds of cell-specific response genes, redefining the

23 pmental transition includes the formation of hundreds of cell-type-specific neuronal enhancers that a

24 microdevice design synchronizes analyses of hundreds of cells, compared to status quo serial analyse

25 With the simultaneous recording of hundreds of cells, we could reveal the existence of an e

26 AKI, including acute PD, have already saved hundreds of children.

27 od to sensitively quantify the expression of hundreds of chosen genes in single cells.

28 In addition, hundreds of circular DNA elements that do not encode any

29 Tens to hundreds of [Cl] exceedances observed annually at most o

30 Hundreds of clinical studies have been registered with t

31 ons of dollars and scientists have initiated hundreds of clinical trials in an expedited effort to un

32 riod length in thousands of single cells and hundreds of clonal cell lines and found that longer circ

33 Hundreds of common genetic variants acting through disti

34 We search across hundreds of complete GWAS summary datasets to systematic

35 ed state and reveals their organization into hundreds of complexes and complex variants observable in

36 ll poorly understood, in particular, how the hundreds of components are controlled.

37 Though the average human inhales hundreds of conidia daily, A. fumigatus invasive infecti

38 lygenic genetic architecture, and identified hundreds of contributing variants.

39 s identified previously, dRemp is present in hundreds of copies in all sequenced lines.

40 er, the oral microbiome is also comprised of hundreds of 'culture-difficult' or 'not-yet-culturable'

41 d features, with mz and rt differences up to hundreds of Daltons and seconds, display highly correlat

42 ns of glycan-binding proteins (GBPs) against hundreds of defined glycan structures, and have revoluti

43 free and permits interrogating an analyte by hundreds of different ligands immobilized in small spots

44 ed optoelectronic nose which can board up to hundreds of different sensing materials has shown promis

45 t active enhancers in PAH PAECs and identify hundreds of differentially active TFs, yet find very lit

46 2 human dermal fibroblast lines, identifying hundreds of differentially expressed genes between cells

47 (CHIKV) and influenza A virus and identified hundreds of direct RNA-protein interactions.

48 and a classic label propagation technique on hundreds of diverse prediction tasks and multiple networ

49 Legionnaires' disease, employs an arsenal of hundreds of Dot/Icm-translocated effector proteins to fa

50 s a monodisperse droplet population (tens to hundreds of droplets) and allows for the simultaneous si

51 canonical initiation and used divergently in hundreds of dual-initiation promoters during maternal to

52 We detected hundreds of dysregulated genes in Mef2c-Het cortex, incl

53 mass and resolves the internal structure of hundreds of Earth-mass haloes in as much detail as it do

54 trode arrays to record spontaneous LFPs from hundreds of electrode sites in a volume of brainstem tis

55 sis of the spatial configuration of a few to hundreds of enhancers or promoters in a single experimen

56 ic fetal cardiomyocytes in vitro to discover hundreds of ERV transcripts from the primate-specific ME

57 post-duplication, we systematically replaced hundreds of essential yeast genes with their human ortho

58 This review collects hundreds of examples, discusses the origins of stereosel

59 lected, harmonized and centralized data from hundreds of experiments for nearly two decades and is co

60 genetic background across individuals to map hundreds of expression quantitative trait loci that infl

61 In a database of hundreds of families of multimers, most show signatures

62 l allows for the transfection of shRNAs into hundreds of fertilized H. symbiolongicarpus eggs simulta

63 Hundreds of field experiments have demonstrated ecologic

64 ceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast

65 evealed by RNA sequencing (RNA-seq) at up to hundreds of folds reduction in conventionally used cover

66 r the temporal formation and dissociation of hundreds of functional protein complexes and the dynamic

67 B molecules nucleating at parS sites recruit hundreds of further ParB to spread is not fully understo

68 ng is required to maintain open chromatin at hundreds of gene regulatory elements, many of which cont

69 anscription factors are master regulators of hundreds of genes and proteins that maintain cellular ho

70 While hundreds of genes are induced by type I interferons, the

71 a common set of 1220 cancer cases, we report hundreds of genes for which the presence within 100 kb o

72 LRR-RLKs have diversified to hundreds of genes in many plant genomes.

73 factors cooperated to regulate expression of hundreds of genes in the basal-like gene expression sign

74 and observed that it affects mRNA levels of hundreds of genes that are significantly enriched in ost

75 everity may be modulated by oxygen and links hundreds of genes to oxygen homeostasis.

76 We identified hundreds of genes with intestinal expression undetected

77 tion factor CodY modulates the expression of hundreds of genes, including most virulence factors, in

78 g ovarian germ cells inappropriately express hundreds of genes, many of which are male germline genes

79 tetrameric transcription factor to regulate hundreds of genes-many in a tissue-specific manner.

80 e nucleus as a transcriptional activator for hundreds of genes.

81 w generations, leading to the duplication of hundreds of genes.

82 traits affect the evolutionary constraint on hundreds of genes.

83 fferences spanned all molecular features and hundreds of genes.

84 ed gene-expression profiles, each containing hundreds of genes.

85 f individual substitutions on specificity in hundreds of genetic backgrounds.

86 me-Wide Association Studies) have identified hundreds of genetic loci associated with atrial fibrilla

87 Whereas hundreds of genetic loci have been shown to be involved

88 genetic studies have successfully identified hundreds of genetic variants robustly associated with ri

89 t array for measuring the electrogenicity of hundreds of genetically engineered P. aeruginosa mutants

90 investigate the sensitivity of epi-drugs at hundreds of genomic locations by combining DNA barcoding

91 First we demonstrate multiplexed imaging of hundreds of genomic loci by sequential hybridization, wh

92 We identified hundreds of genotype-phenotype relationships ranging fro

93 and clustering, require days of runtime and hundreds of gigabytes of memory for today's largest data

94 col, thousands of O-GalNAcylation sites from hundreds of glycoproteins with information regarding sit

95 mber libraries can be synthesized for use in hundreds of healthcare target screens.

96 n learned from the successes and failures of hundreds of high-quality clinical trials.

97 ells and differentiated neurons and identify hundreds of highly expressed circRNAs.

98 We further show that hundreds of human and mouse NMD targets, especially RNA-

99 rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies (mAbs) against t

100 ionally that amines and acids can couple via hundreds of hypothetical yet plausible transformations,

101 g viral infections, induce the expression of hundreds of IFN-stimulated genes (ISGs).

102 rithm for D gene reconstruction, apply it to hundreds of immunosequencing datasets from multiple spec

103 roarray platform provides enzyme kinetics of hundreds of individual molecules at high throughput.

104 We quantified prey and predator traits from hundreds of individuals across their distributions, and

105 genome-wide datasets of epigenetic assays on hundreds of individuals.

106 ple tissues or organs sampled from dozens to hundreds of individuals.

107 ples because it allows the identification of hundreds of intact proteoforms from complex biological s

108 most of these crossover regions span tens to hundreds of kb, which is not sufficient resolution to ac

109 Sox17 and beta-catenin co-occupy hundreds of key enhancers.

110 nneae and P. punctatus/hespericus admix over hundreds of kilometers, suggesting that they have not ye

111 be isolated from their nearest neighbours by hundreds of kilometres of deep ocean and the Antarctic C

112 Each profile consists of hundreds of largely distinct proteins but also includes

113 physical and biogeochemical measurements of hundreds of living and dead conifers to reconstruct the

114 arkedly reduces the chromatin association of hundreds of lncRNAs and unstable transcripts, without al

115 ome-wide association studies have discovered hundreds of loci associated with complex brain disorders

116 e association studies (GWAS) have identified hundreds of loci associated with kidney-related traits s

117 Hundreds of loci gain ectopic CHG methylation, as well a

118 Hundreds of loci have been associated with blood pressur

119 y number variants (CNVs) of large effect and hundreds of loci of small effect.

120 Here, we report hundreds of loci underlying ecological adaptation to dif

121 embraneless organelles, comprising dozens to hundreds of macromolecular components, form heterogeneou

122 en distant genomic loci separated by tens to hundreds of megabases, even in the absence of transcript

123 hermore, chromatin interaction data identify hundreds of mencRNA promoters that loop to regions that

124 Transcriptome-wide mapping in ESCs reveals hundreds of messenger RNAs marked by 5hmC at sites chara

125 rongest predictive power, and each explained hundreds of metabolites-in some cases, explaining more t

126 nce extends for many kilometers radially and hundreds of meters in depth.

127 solution, while allowing them to freely move hundreds of meters in the vertical direction?

128 ccurring at relatively short spatial scales (hundreds of meters) due to fires, harvest, and climate-i

129 Seamounts, often rising hundreds of metres above surrounding seafloor, obstruct

130 ver length scales ranging from the atomic to hundreds of micrometers, and to originate from a wide ra

131 and clusters of thin sheets-each sheet up to hundreds of micrometres long and wide but only about fou

132 ve wound detection over distances of several hundreds of micrometres within a few minutes.

133 sely sized features in the ranges of tens or hundreds of microns.

134 ions, specific protein binding partners, and hundreds of microproteins that are presented by the huma

135 Although hundreds of microRNAs have been identified as differenti

136 ization of dG(N2-H)(.) to dG(N1-H)(.) within hundreds of microseconds.

137 m-forming foam (AFFF) has been documented at hundreds of military bases, airports, and firefighter tr

138 e and magnitude of the earliest transitions, hundreds of million years before photosynthesis evolved,

139 e tens of thousands of participants and cost hundreds of millions of dollars, which is prohibitively

140 cale datasets of millions of individuals and hundreds of millions of genetic variants.

141 ause of the vast numbers of animals involved-hundreds of millions of live animals are imported into t

142 nsmission of drug-resistant pathogens affect hundreds of millions of patients worldwide.

143 species are vectors of diseases that afflict hundreds of millions of people each year.

144 worms, such as Ascaris lumbricoides, affect hundreds of millions of people in all tropical and subtr

145 Every day, hundreds of millions of people worldwide take nonsteroid

146 1) and herpes simplex virus 2 (HSV-2) affect hundreds of millions of people worldwide.

147 s a debilitating parasitic disease infecting hundreds of millions of people.

148 cant improvements in air quality, benefiting hundreds of millions of people.

149 appeared, the atmosphere remained anoxic for hundreds of millions of years until the ~2.4 Ga Great Ox

150 ancient hydrophobic interface, conserved for hundreds of millions of years, is entrenched because exp

151 ed post-stimulatory activity that lasted for hundreds of milliseconds following the termination of th

152 s by tens of nanometers, followed by a slow (hundreds of milliseconds) elongation reaching hundreds o

153 On the order of hundreds of milliseconds, HFB responses peak fastest in

154 reases with the number of bonds from tens to hundreds of milliseconds.

155 lagged behind insular activations by several hundreds of milliseconds.

156 Hundreds of molecular tests and immunoassays were rapidl

157 sation mass spectrometry (DESI-MS) can image hundreds of molecules in a 2D tissue section, making it

158 alysis of single cells, capable of resolving hundreds of molecules in each mass spectrum.

159 The gut microbiota synthesize hundreds of molecules, many of which influence host phys

160 ibution, these results have implications for hundreds of monoderm species.

161 Hundreds of morphological, postural, and behavioral feat

162 d that most changes in ribosome occupancy on hundreds of mRNAs are largely driven by dysregulation in

163 low as tens of ng m(-3) with linearity up to hundreds of mug m(-3) at 0.2 Hz time resolution were obs

164 sults uncover the functional consequences of hundreds of mutations in a phenotype-associated enhancer

165 Skeletal muscle cells contain hundreds of myonuclei within a shared cytoplasm, present

166 al Si(2)Te(3) nanoplates with thicknesses of hundreds of nanometers and lateral sizes of tens of micr

167 nts decorating its surface, which can extend hundreds of nanometers from the virion.

168 omolecular complexes and organelles, tens to hundreds of nanometers in size, crowd the eukaryotic cyt

169 h leads to long-range exciton diffusion over hundreds of nanometers.

170 undreds of milliseconds) elongation reaching hundreds of nanometers.

171 polymerase inhibitor rifampicin, we identify hundreds of nascent transcripts that RsmA associates wit

172 calcium dynamics can capture the activity of hundreds of neurons across large fields of view at a low

173 We recorded the activity of hundreds of neurons in V4 and the inferior temporal cort

174 udy, 12 different genetic crosses were used, hundreds of neurons were electrophysiologically characte

175 We identify hundreds of new open reading frames (ORFs), including up

176 Plant genomes typically contain hundreds of NLR-encoding genes.

177 We identified hundreds of novel circRNAs and demonstrated that circRNA

178 We identified hundreds of novel sRNA base-pairing interactions, includ

179 The beam duration of hundreds of ns to tens of [Formula: see text] is evaluat

180 r simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples.

181 Despite the presence of hundreds of OSN subtypes in many animals, the overlappin

182 ution of those species highly coincides with hundreds of other endangered species, surviving in regio

183 prfA, but this site was weaker in vitro than hundreds of other sites.

184 In contrast, hundreds of papers describe polydopamine-based sensors.

185 Hundreds of parallel barbs branch from the sides of the

186 tography/mass spectrometry (GC/MS) data from hundreds of participants.

187 lify targeted regions for 48 DNA samples and hundreds of PCR primer pairs (producing up to 23,040 PCR

188 Every year, hundreds of people die at sea because of vessel and airp

189 Many hundreds of people have engaged with our collaborative s

190 uenced DNA from diverse ecosystems and found hundreds of phage genomes with lengths of more than 200

191 Bacterial polyphosphates are long chains of hundreds of phosphate units.

192 the tessellation and precise positioning of hundreds of picolitre-sized droplets within 3D-printed,

193 cial charge-transfer states that occurs over hundreds of picoseconds at room temperature, three order

194 orum, causal agent of white mold diseases on hundreds of plant species, triggers QDR in host populati

195 lium dahliae causes vascular wilt disease on hundreds of plant species.

196 t database to investigate the development of hundreds of polities, from multiple continents, over tho

197 receptors (GPCRs) must correctly select from hundreds of potential downstream signaling cascades and

198 response functions and host plant ranges for hundreds of potentially destructive plant-associated fun

199 nesis of mitochondria requires the import of hundreds of precursor proteins.

200 We identified hundreds of previously uncharacterized transcripts and t

201 network, we identify pathway communities and hundreds of previously unknown pathway contacts that rep

202 Satellite radar observations revealed hundreds of previously unmapped linear strain concentrat

203 Each NAc FSI innervates hundreds of principal neurons, and orchestrates populati

204 r FAT10, which gets covalently conjugated to hundreds of proteins and targets its conjugation substra

205 tandem mass tags-based sample multiplexing, hundreds of proteins can be quantified across 10 or more

206 Here we label hundreds of proteins constituting the mouse blood plasma

207 plexed quantitative proteomics(6,7) to track hundreds of proteins in the proximity of Ca(V)1.2.

208 Hundreds of proteins of interest from diverse biological

209 crocompartments that are self-assembled from hundreds of proteins within the bacterial cytosol.

210 CSF contains hundreds of proteins, with concentrations reflecting ong

211 1 domains, which are collectively present in hundreds of proteins.

212 rought about bioinspired soft robotics, with hundreds of publications on novel research each year.

213 f rodent or non-human primate stroke models, hundreds of putative neuroprotectants have been evaluate

214 erforming SEER in Escherichia coli to screen hundreds of putative SSAPs, we identify highly active va

215 tions, we measure the competitive fitness of hundreds of randomly selected clones from both mismatch-

216 In this manner, hundreds of reactions can be easily quantified in a few

217 arch is rapidly progressing, as shown by the hundreds of registered clinical trials on candidate drug

218 nal and translational changes and identified hundreds of regulated protein-coding and long noncoding

219 P. aeruginosa harbours hundreds of regulatory genes that play essential roles i

220 vealed unprecedented levels of ac(4)C across hundreds of residues in rRNA, tRNA, non-coding RNA and m

221 mass haloes in as much detail as it does for hundreds of rich galaxy clusters.

222 mical structure profiling, we determine that hundreds of RNA G-quadruplex structures are strongly fol

223 croscopy, and sediment analyses, we document hundreds of rodent coprolites found in association with

224 ts and data from NASA's GeneLab derived from hundreds of samples flown in space to determine transcri

225 lign scales to comparisons involving tens to hundreds of samples, enabling large-scale studies of nat

226 Here, we used a novel strategy to screen hundreds of sequences for tissue-specific silencer activ

227 For hundreds of sex- and age-specific diseases, we assessed

228 ch results in the accurate identification of hundreds of shared and tumor-specific non-canonical HLA

229 btained a phylogenomic dataset consisting of hundreds of single-copy nuclear loci.

230 -G and demonstrate that it dynamically binds hundreds of sites across the genome.

231 Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of

232 t in which subjects imagined and then viewed hundreds of spatially varying naturalistic stimuli.

233 f TIS has matured and resulted in studies of hundreds of species that include significant innovations

234 Often dozens or even hundreds of species with different degrees of specialisa

235 ted by representing tropical tree diversity (hundreds of species) with only five functional groups sp

236 tify orthologs of regulatory elements across hundreds of species, providing novel insights into the e

237 We have identified hundreds of splice junctions that exhibit distinct splic

238 Additionally, groundwater discharging at hundreds of spring locations in and near Grand Canyon su

239 Hundreds of sQTLs were identified in each brain region.

240 ntennas that are contained within an area of hundreds of square microns.

241 virulence plasmids and applied it to analyze hundreds of strains collected between 1927 and 2017, on

242 f sea turtles being satellite tracked across hundreds of studies [3], most are tracked to mainland co

243 However, in reviewing hundreds of studies, we find only six comprehensive exam

244 Hundreds of SV-gene pairs exhibit subtle and significant

245 are short, noncoding RNAs that can regulate hundreds of targets and thus shape the expression landsc

246 It is designed to be massively scalable to hundreds of taxa and thousands of samples, and can be ef

247 gratory species, which are still unknown for hundreds of taxa, especially Asian ones.

248 chromosome-length scaffolds, and we identify hundreds of TE insertions that were missed by Illumina-b

249 few terahertz for rotational transitions, to hundreds of terahertz for fundamental and overtone vibra

250 phase to any other optical frequency across hundreds of terahertz of bandwidth.

251 of XS(-) can also be characteristic of many hundreds of their structural analogues XM(YCH(2)CH(2))(3

252 Hundreds of thousands of candidate enhancers have been n

253 ression to annotate these data and cataloged hundreds of thousands of candidate regulatory elements t

254 of the COVID-19 epidemic in China, averting hundreds of thousands of cases by 19 February (day 50).

255 terial cells into "factories" for generating hundreds of thousands of crRNAs covering 95% of all targ

256 haeological sites globally, totaling perhaps hundreds of thousands of culturally and paleoenvironment

257 the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in

258 s responsible for millions of infections and hundreds of thousands of deaths globally.

259 bal pandemic with millions of infections and hundreds of thousands of deaths to date(1,2).

260 individuals in the United States and caused hundreds of thousands of deaths.

261 s of randomized promoter elements) to create hundreds of thousands of DPR (or TATA box) variants, eac

262 de chains in these contact pools to generate hundreds of thousands of energetically favorable binding

263 ful to predict biological pathways among the hundreds of thousands of eukaryotic species that will be

264 logenetic placement methods to contextualize hundreds of thousands of genomes must thus be efficientl

265 approaches to super-resolution, thousands to hundreds of thousands of individual cells can now be ana

266 of horizontal pleiotropy, and is scalable to hundreds of thousands of individuals.

267 ection of millions of people and has claimed hundreds of thousands of lives.

268 The plant kingdom produces hundreds of thousands of low molecular weight organic co

269 e generate multivariate feature profiles for hundreds of thousands of organoids to quantitatively des

270 particle images, which is much smaller than hundreds of thousands of particles required by the exist

271 izes, so previous pan-Caribbean estimates of hundreds of thousands of people are too large(5,6).

272 ARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting

273 Cochlear implants (CIs) have enabled hundreds of thousands of profoundly hearing-impaired peo

274 Hundreds of thousands of profoundly hearing-impaired peo

275 tochastic ("random") structure searches over hundreds of thousands of runs.

276 de and genome-wide region-based analysis for hundreds of thousands of samples and can account for unb

277 , existing region-based tests cannot analyze hundreds of thousands of samples while accounting for co

278 Plants produce several hundreds of thousands of secondary metabolites that are

279 wer predicted to be similar to bulk tests of hundreds of thousands of tumors.

280 eologic disposal, which extend to periods of hundreds of thousands of years.

281 usands of pairwise trait correlations across hundreds of thousands of yeast cells and reveals ample e

282 019 (COVID-19) has sickened millions, killed hundreds of thousands, and utterly disrupted the daily l

283 ty of microbiome data, often in the order of hundreds of thousands, yet low sample sizes, poses great

284 nd the globe, infecting millions and killing hundreds of thousands.

285 l models from the literature can run tens to hundreds of times faster than on CPU.

286 nd expensive rhodium-phosphine catalysts are hundreds of times more active and operate under consider

287 typing and data mining can capture dozens or hundreds of traits from the same individuals.

288 munoprecipitation (ChIP)-Seq datasets across hundreds of transcription factors (TFs) and cell lines p

289 Each ORN type expresses hundreds of transcription factors.

290 curate, predictions of the joint dynamics of hundreds of tree species.

291 extreme tails, with organoids generated from hundreds of tumors having power predicted to be similar

292 This interference includes suppression of hundreds of type I interferon-regulated genes due to low

293 protein and peptide microarrays representing hundreds of unique AMA1 variants.

294 alysis showed how cytotoxic agents introduce hundreds of unique mutations in each surviving cancer ce

295 We find hundreds of variants within known cancer-related genes d

296 plement at such voltages higher than several hundreds of volts.

297 n both United Nations policy discussions and hundreds of voluntary projects launched to earn carbon-o

298 to the evolution of herbicide resistance in hundreds of weed species.

299 Domestication has transformed hundreds of wild plant species into productive cultivars

300 , which enables the simultaneous analysis of hundreds of worms with respect to multiple behavioral pa