ライフサイエンスコーパス: hundreds of thousands of

1 over the statistically significant range of hundreds of thousands of amino acid sequences that fold

2 ant growth over the past decade and now hold hundreds of thousands of arrays from multiple species.

3 By screening a library encoding hundreds of thousands of artificial transmembrane protei

4 large biomolecular systems, comprising e.g. hundreds of thousands of atoms or Mega-Dalton size elect

5 a debilitating genetic disease that affects hundreds of thousands of babies born each year worldwide

6 DNase I hypersensitivity assay can delineate hundreds of thousands of base-pair resolution in vivo fo

7 ata from multiple individuals across tens to hundreds of thousands of basepairs.

8 DNA methylation in genomic regions spanning hundreds of thousands of bases.

9 For high-throughput measurements, with hundreds of thousands of branches on each image, manual

10 tinal protozoan pathogens worldwide, causing hundreds of thousands of cases of diarrhoea each year.

11 and Central and South America, resulting in hundreds of thousands of cases.

12 By sampling hundreds of thousands of cells from individual zebrafish

13 ging data for thousands of islets containing hundreds of thousands of cells in human organ donor panc

14 cell measurement on 50 markers for more than hundreds of thousands of cells.

15 complexity of proteins, given that there are hundreds of thousands of chemically and physically disti

16 adverse kidney and urinary tract effects in hundreds of thousands of children and the reported death

17 Hundreds of thousands of children are annually infected

18 type (MMP) that leads to the accumulation of hundreds of thousands of clonal mutations in simple repe

19 identification of novel chemical leads among hundreds of thousands of commercially available compound

20 ed tissues or tissue compartments results in hundreds of thousands of complications annually.

21 P) Human Tumor Cell Line Screen has screened hundreds of thousands of compounds and extracts, for whi

22 Plant specialized metabolism produces hundreds of thousands of compounds, offering striking ex

23 ough for structure prediction, where tens or hundreds of thousands of conformations may be sampled du

24 ack two- and three-soliton bound states over hundreds of thousands of consecutive cavity roundtrips,

25 Hundreds of thousands of copies of this protein must pas

26 -electro-optical modulation can be driven to hundreds of thousands of cycles per second promising app

27 c device to date and has restored hearing in hundreds of thousands of deaf individuals worldwide.

28 ntion to the Syrian war that had resulted in hundreds of thousands of deaths and created millions of

29 ugh, a serious respiratory infection causing hundreds of thousands of deaths annually worldwide.

30 a serious hazard to human health that causes hundreds of thousands of deaths annually.

31 Influenza virus infection is responsible for hundreds of thousands of deaths annually.

32 n malignancy in women and is responsible for hundreds of thousands of deaths annually.

33 ubstantial morbidity and are responsible for hundreds of thousands of deaths each year.

34 military operations, and shigellosis causes hundreds of thousands of deaths per year in developing n

35 had more impact than statistical reports of hundreds of thousands of deaths.

36 ia these organisms have coevolved, producing hundreds of thousands of different chemicals that are us

37 atorial chemical synthesis and contain up to hundreds of thousands of different oligonucleotides on a

38 esized oligonucleotide libraries can contain hundreds of thousands of distinct sequences, however onl

39 The method revealed hundreds of thousands of DNA sequences, some present in

40 high-throughput technology that can sequence hundreds of thousands of DNA/RNA fragments in a single e

41 his technology, systematic identification of hundreds of thousands of DNase I hypersensitive sites (D

42 n has been limited by the high cost (tens to hundreds of thousands of dollars) and logistical challen

43 ened for the presence of A-to-G editing, and hundreds of thousands of editing sites identified.

44 rth's magnetosphere, electron energies reach hundreds of thousands of electron volts, whereas the typ

45 Mammalian genomes typically contain hundreds of thousands of endogenous retroviruses (ERVs),

46 is estimated that the human genome contains hundreds of thousands of enhancers, so understanding the

47 dicate that the human genome likely contains hundreds of thousands of enhancers, with a typical gene

48 ted in the deaths of thousands of humans and hundreds of thousands of equids during the past century.

49 rate progress, but sequencing the genomes of hundreds of thousands of eukaryotic species remains impr

50 ccounting for tens of millions of illnesses, hundreds of thousands of excess hospitalizations, and te

51 e population studies on the order of tens or hundreds of thousands of exomes.

52 mportant concern in Norway, where each year, hundreds of thousands of farm Atlantic salmon escape fro

53 ts, (2) our algorithm is capable of handling hundreds of thousands of features and thus, is particula

54 ar weight human genomic DNA samples in which hundreds of thousands of fragments need to be reannealed

55 About 40-99% of the hundreds of thousands of gapped segments were involved i

56 We next developed algorithms to search hundreds of thousands of Gene Expression Omnibus (GEO) d

57 e in the age of genomics and have discovered hundreds of thousands of genes of which we understand al

58 is the lack of an efficient way to genotype hundreds of thousands of genetic markers.

59 complex diseases typically requires testing hundreds of thousands of genetic polymorphisms.

60 mporary genetic association studies may test hundreds of thousands of genetic variants for associatio

61 ofluidic "mother machine" [21] and monitored hundreds of thousands of Gram-negative Escherichia coli

62 adult mouse already involve the analysis of hundreds of thousands of high resolution experimental im

63 e very large datasets consisting of tens and hundreds of thousands of high-coverage sequenced samples

64 duction to species in which colonies contain hundreds of thousands of highly specialized sterile work

65 SEECER efficiently learns hundreds of thousands of HMMs and uses these to correct

66 e of a year and has the potential to prevent hundreds of thousands of hospitalizations each year.

67 associated with millions of medical visits, hundreds of thousands of hospitalizations, and thousands

68 ined exclusively within host lineages across hundreds of thousands of host generations.

69 Outbreaks can involve tens to hundreds of thousands of human cases, and millions of li

70 Although hundreds of thousands of human embryos are cultured year

71 Hundreds of thousands of human genomes are now being seq

72 ridium tetani that causes paralytic death to hundreds of thousands of humans annually.

73 Worldwide, hundreds of thousands of humans have had their genomes o

74 the library size, which is typically in the hundreds of thousands of individual compounds.

75 We consider hundreds of thousands of individual economic transaction

76 onal approach which integrates evidence from hundreds of thousands of individual gene and protein int

77 approach of x-ray free-electron lasers from hundreds of thousands of individual microcrystals.

78 inst pathogenic arenaviruses that can infect hundreds of thousands of individuals and kill thousands

79 evel information while remaining scalable to hundreds of thousands of individuals and millions of SNP

80 effect sizes, large sample sizes of tens to hundreds of thousands of individuals are required for ad

81 tiatives are currently underway to phenotype hundreds of thousands of individuals for major human tra

82 advent of large genotyping studies involving hundreds of thousands of individuals, standard approache

83 pect to identify as sequencing cohorts reach hundreds of thousands of individuals.

84 scale up to very large samples, with tens or hundreds of thousands of individuals.

85 t feeding is generally not feasible or safe, hundreds of thousands of infants acquire HIV infection d

86 sed urolithiasis and other renal problems in hundreds of thousands of infants in the region, underlin

87 The arenavirus Lassa virus causes hundreds of thousands of infections each year, many of w

88 c Games, events that are expected to attract hundreds of thousands of international travelers.

89 Phylogenetic trees with hundreds of thousands of leaves are now being inferred f

90 ent of effective therapies result in tens to hundreds of thousands of life-years lost, whereas string

91 Hundreds of thousands of limb twitches are produced dail

92 ring 2 doses, may have the potential to save hundreds of thousands of lives in Africa.

93 tibiotic-resistant infections annually claim hundreds of thousands of lives worldwide.

94 omputationally feasible, even for studies of hundreds of thousands of loci, and second that even with

95 With PLINK, large data sets comprising hundreds of thousands of markers genotyped for thousands

96 Because of the high cost of genotyping hundreds of thousands of markers on thousands of subject

97 ets (e.g., thousands of individuals typed at hundreds of thousands of markers).

98 l interactions arising in models with, e.g., hundreds of thousands of markers, and that most of the a

99 an easily be applied to disease studies with hundreds of thousands of markers.

100 y comprises thousands of spectra and tens to hundreds of thousands of mass-to-charge (m/z) images and

101 in generating standards that can accept the hundreds-of-thousands of mass spectra produced per analy

102 We estimate that there exist hundreds of thousands of microinversions in genomes of m

103 r positive (RER(+)) and contain mutations at hundreds of thousands of microsatellite repeat sequences

104 The hundreds of thousands of minimotifs discovered thus far

105 Most of the hundreds of thousands of MITEs identified to date have b

106 ina next-generation sequencing (NGS) to test hundreds of thousands of MLV Env mutants for the ability

107 In this study, we tested hundreds of thousands of MLV Env mutants for the ability

108 potential role in human oncogenesis and the hundreds of thousands of mouse sequences available for u

109 ked list of peptide identifications based on hundreds of thousands of MS/MS spectra obtained in a mas

110 d simultaneous assessment of the function of hundreds of thousands of mutants that span the activity

111 rcuits within the brainstem [17, 18] trigger hundreds of thousands of myoclonic twitches each day [19

112 construct sustainable development indices in hundreds of thousands of neighborhoods and show that the

113 l organs of smell is the ability to identify hundreds of thousands of odours.

114 s into phylogenomic data matrices containing hundreds of thousands of orthologous nucleotides from hu

115 Hundreds of thousands of paired reads support random int

116 At this time, hundreds of thousands of patients have received these dr

117 Although hundreds of thousands of patients undergo chemotherapies

118 his preclinical model may be relevant to the hundreds of thousands of patients who require treatment

119 an transplantation is a curative therapy for hundreds of thousands of patients with end-stage organ f

120 ortant in choosing an anti-VEGF drug for the hundreds of thousands of patients with nAMD treated each

121 notyping projects producing genetic data for hundreds of thousands of patients, large-scale phenotypi

122 l enterotoxins A and B (SEA and SEB) affects hundreds of thousands of people annually.

123 single- or multi-organ pathologies, killing hundreds of thousands of people annually.

124 attributable to snake bite remains obscure, hundreds of thousands of people are known to be envenome

125 Hundreds of thousands of people die each year from liver

126 and is responsible for the annual deaths of hundreds of thousands of people worldwide.

127 Since nuclear disasters can affect hundreds of thousands of people, a substantial number of

128 proteomics enabling daily identifications of hundreds of thousands of peptides and proteins from tand

129 nbiased in vitro DNA binding microarray with hundreds of thousands of permutations of ERalpha-binding

130 kinases comprising the human kinome catalyze hundreds of thousands of phosphorylation events to regul

131 The contact angle was measured at hundreds of thousands of points for three samples after

132 Affymetrix GeneChip consists of an array of hundreds of thousands of probes (each a sequence of 25 b

133 The approach entails the display of hundreds of thousands of protein variants, moderate sele

134 We screened a retroviral library expressing hundreds of thousands of proteins consisting of hydropho

135 As it is easy to generate tens to hundreds of thousands of proviral transgenes in zebrafis

136 Mapping experiments have identified hundreds of thousands of putative enhancers whose functi

137 Many-body effects have been explored with hundreds of thousands of quantum-degenerate neutral atom

138 translocation sequencing (LAM-HTGTS) to map hundreds of thousands of RAG-initiated Tcrd D segment (T

139 development of genotyping arrays containing hundreds of thousands of rare variants across the genome

140 cale problems and is able to analyze several hundreds of thousands of reads within one day.

141 nment of each individual read out of tens to hundreds of thousands of reads.

142 We detect hundreds of thousands of recombination events, with sing

143 Since 2013, hundreds of thousands of refugees have migrated southwar

144 enting its chromosomes, and then unscrambles hundreds of thousands of remaining fragments by permutat

145 Hundreds of thousands of Rotary volunteers have provided

146 RGON) for the DTWF process that scales up to hundreds of thousands of samples and whole-chromosome le

147 ombination for chromosome-sized regions over hundreds of thousands of samples is possible, and substa

148 tool equipped to handle multi-omic data for hundreds of thousands of samples to explore complexity u

149 large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome seque

150 pplicability to data sets containing tens or hundreds of thousands of samples.

151 ome genotypes and frequencies across tens to hundreds of thousands of samples.

152 ip of chlorosomes each of which incorporates hundreds of thousands of self-assembled bacteriochloroph

153 e, are one of the best studied viral groups: hundreds of thousands of sequences are available togethe

154 e parallel measurements of the activities of hundreds of thousands of sequences from RNA device libra

155 We predict that hundreds of thousands of sequences will be necessary to

156 el evolutionary dynamics of populations with hundreds of thousands of sexual diploid individuals over

157 tudies (GWAS) generate relationships between hundreds of thousands of single nucleotide polymorphisms

158 By assaying hundreds of thousands of single nucleotide polymorphisms

159 ed GWA study will involve the measurement of hundreds of thousands of single nucleotide polymorphisms

160 r such an application by interrogating up to hundreds of thousands of single nucleotide polymorphisms

161 sands of expression variables when analyzing hundreds of thousands of single nucleotide polymorphisms

162 studies (GWAS) simultaneously investigating hundreds of thousands of single nucleotide polymorphisms

163 In genome-wide association (GWA) studies, hundreds of thousands of single-nucleotide polymorphisms

164 -throughput genotyping technologies to assay hundreds of thousands of single-nucleotide polymorphisms

165 ciation studies (GWAs) initially investigate hundreds of thousands of single-nucleotide polymorphisms

166 lution cryo-EM reconstruction often requires hundreds of thousands of single-particle images.

167 multaneous measurement of DNA copy number at hundreds of thousands of sites on a genome.

168 stem-generated spontaneous activity triggers hundreds of thousands of skeletal muscle twitches each d

169 fference in genome size can be attributed to hundreds of thousands of small deletions, mostly in nonc

170 Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of

171 Plants produce hundreds of thousands of small molecules known as specia

172 l advancement to enable the interrogation of hundreds of thousands of SNPs in one assay via microarra

173 Genome-wide association studies involving hundreds of thousands of SNPs in thousands of cases and

174 e it possible for the first time to genotype hundreds of thousands of SNPs simultaneously, enabling w

175 on mapping of inbred mouse strains involving hundreds of thousands of SNPs, in addition to Arabidopsi

176 for highly accurate genotype calling across hundreds of thousands of SNPs.

177 Hundreds of thousands of soldiers face exposure to comba

178 Plants collectively produce hundreds of thousands of specialized metabolites that ar

179 bility to synthesize small arrays containing hundreds of thousands of specifically chosen oligonucleo

180 They form blooms that can occupy hundreds of thousands of square kilometres and are disti

181 nstrates unexpected complexity of sRNAs with hundreds of thousands of sRNA species present.

182 origins of globular clusters, which contain hundreds of thousands of stars in a volume only a few li

183 equencing (HTS) has the potential to profile hundreds of thousands of STR loci.

184 Plants produce hundreds of thousands of structurally diverse specialize

185 Furthermore, this technique could replace hundreds of thousands of surgical biopsies on rodents an

186 genotyping or gene expression experiments on hundreds of thousands of test genes in parallel.

187 a virus infects millions of people and kills hundreds of thousands of them.

188 Hundreds of thousands of these nanocultures can be easil

189 Genomic approaches have predicted hundreds of thousands of tissue-specific cis-regulatory

190 for a single lab to rapidly generate tens to hundreds of thousands of transgenes.

191 AS regulation enables the production of the hundreds of thousands of types of proteins needed for th

192 et consisting of functional scores for up to hundreds of thousands of variants of a protein of intere

193 lly visualize large networks on the order of hundreds of thousands of vertices and millions of edges.

194 aspects of the behaviour of a sample of the hundreds of thousands of visitors who pass through the '

195 iagnosis that uses this new score could save hundreds of thousands of visits annually by identifying

196 lly, complications of unsafe abortion affect hundreds of thousands of women each year, and account fo

197 Hundreds of thousands of women now have enhanced survivo

198 nduce premature menopause and infertility in hundreds of thousands of women of reproductive age every

199 he eruption of components stored for tens to hundreds of thousands of years before eruption.

200 resence has been extended up to 1.8 Myr ago, hundreds of thousands of years earlier than previously e

201 pulation deep in the Middle Pleistocene, the hundreds of thousands of years of relative separation be

202 genic (last 200 yr) to glacial/interglacial (hundreds of thousands of years).

203 g evolved in this specific gastric niche for hundreds of thousands of years, this microbe has become

204 ature that can persist for many tens or even hundreds of thousands of years.

205 unication preceding behavioural modernity by hundreds of thousands of years.

206 Using this analysis, we have screened hundreds of thousands of zeolite and zeolitic imidazolat