ライフサイエンスコーパス: hurdle

1 ics, poor systemic stability remains a major hurdle.

2 ne expression in vivo presents a significant hurdle.

3 ychological evaluation remains a significant hurdle.

4 okinetic and safety properties a significant hurdle.

5 tment systems remains as one major technical hurdle.

6 stranded RNA macromolecules, remains a major hurdle.

7 However, obtaining such crystals is a major hurdle.

8 r two-dimensional structure presents a major hurdle.

9 actionable mutations presents a significant hurdle.

10 into higher affinity binders remains a major hurdle.

11 articipants present significant experimental hurdles.

12 ory VLUs, but it faces additional regulatory hurdles.

13 linically actionable strategies remain major hurdles.

14 n complicated by logistic and interpretative hurdles.

15 nt delivery and gene expression remain major hurdles.

16 pment and primary operational and regulatory hurdles.

17 r components that can overcome some of these hurdles.

18 vivin is a central molecule involved in both hurdles.

19 scientific advances may help overcome these hurdles.

20 that are being considered to overcome these hurdles.

21 sidues has been unclear because of technical hurdles.

22 untable technical, financial, and logistical hurdles.

23 g stem cell-based transplantation faces many hurdles.

24 ong-term functional integration remain major hurdles.

25 t least two inherent and thus far unresolved hurdles: 1) provision of an unlimited source of function

26 In order to overcome this hurdle, a highly pH-sensitive histidine-glutamic acid (H

27 Overcoming this hurdle, a new study discovers a high incidence of non-ca

28 et al. describe methods for overcoming this hurdle and provide a new quantitative picture of the mit

29 This study has overcome this technical hurdle and provides new insights into this fundamental s

30 how early epidemiologists overcame research hurdles and advanced health through innovative strategie

31 view, we discuss possible ways to jump these hurdles and develop new gene therapies that may be used

32 ation, but there are technical and practical hurdles and difficulties in interpretation.

33 United States, likely because of logistical hurdles and oncology study design.

34 air pollution has been limited by logistical hurdles and resource constraints.

35 Addressing the hurdles and scaling successful health promotion, clinica

36 been some significant moves to easing these hurdles and, potentially, to bringing new drugs to the c

37 e competition from generics, high regulatory hurdles, and a tarnished image.

38 e competition from generics, high regulatory hurdles, and the industry's perceived tarnished image.

39 Two different architectures, channels and hurdles, are generated, and thin films of thermite are d

40 o functionally relevant groups is a critical hurdle as an increasing number of sequences are deposite

41 ls to the tumor microenvironment, overcoming hurdles associated with immunosuppression and aberrant v

42 Adressing the types is still a major hurdle because type-specific markers are lacking, and th

43 There are, however, at least three major hurdles before lithium metal anodes can become a viable

44 vercome many ecological and/or physiological hurdles before they become established and spread in the

45 mains technically challenging, with the main hurdle being the shortage of robust imaging processing a

46 e we demonstrate a strategy to overcome this hurdle by avoiding the gaseous or liquid phase, and dire

47 Here we overcome this fundamental hurdle by constructing a mutable and deformable array of

48 We overcame this hurdle by focusing on nascent full-length PrP(Sc) rather

49 all living systems; however, major technical hurdles challenge analyses of this class of proteins.

50 age mutant BRAF (V600E/K) melanomas, a major hurdle continues to be acquired resistance to BRAF inhib

51 In this study we hypothesized that this hurdle could be due to the presence of inhibitory factor

52 tructures as well as the potential technical hurdles DNA secondary structures may present to nanopore

53 Despite these hurdles, drugs that can kill slowly replicating or non-r

54 ysis of potent binders remains a significant hurdle due to limited sensitivity and accompanied deplet

55 overcome the increasing number of technical hurdles due to the complexity of manipulating large data

56 gh carbonate formation can be addressed as a hurdle during CO2 splitting, the problem can be avoided

57 This homology may explain hurdles encountered in the clinical development of IGF-t

58 Although we will need to overcome important hurdles, especially in terms of clinical trial design, w

59 from pluripotent stem cells and discuss the hurdles facing such strategies.

60 In this Commentary, we describe key hurdles facing the HIV-1 vaccine development field and o

61 expected, XR-NTX had a substantial induction hurdle: fewer participants successfully initiated XR-NTX

62 mmetry parameters has remained a significant hurdle for any structural technique and could thus far n

63 lack of a suitable draw solute is the major hurdle for commercial implementation of the FO desalinat

64 This presents a significant hurdle for data sharing, reanalysis, or meta-analysis of

65 genetic manipulation remains a translational hurdle for diabetes therapy.

66 A major hurdle for discovering treatments for the muscular dystr

67 in variable phenotypes, and remains a major hurdle for disease diagnosis and therapy.

68 It maintains brain homeostasis and is a hurdle for drug delivery to the CNS to treat neurodegene

69 iology of these pests presents a significant hurdle for either protein- or nucleotide-based managemen

70 A major hurdle for functional recovery after both spinal cord in

71 teady-state kinase bias imposes an energetic hurdle for inappropriate ligands to elicit signal transd

72 late in free flight has been a long-standing hurdle for insect flight studies.

73 ryonic age and, thus, presents a significant hurdle for modeling late-onset disorders.

74 A major hurdle for molecular mechanistic studies of many protein

75 r, its low oral bioavailability is the major hurdle for moving this drug to clinical trial.

76 t pre-existing resistance may not be a major hurdle for novel-target antimalarial candidates, and foc

77 fluorophore functionality, which is a major hurdle for systematic characterization.

78 Despite their therapeutic promise, a crucial hurdle for the clinical implementation of human PSCs is

79 stemic drug therapies, has presented a major hurdle for the development of successful immunotherapies

80 A major clinical hurdle for the management of advanced prostate cancer (P

81 ations in brain tumors remains a significant hurdle for treating patients successfully.

82 hat are enabling the field to overcome these hurdles for clinical impact.

83 e, the PEGylation of ConA can overcome major hurdles for ConA-based glucose sensing assays to be used

84 sly for hundreds of samples create technical hurdles for data analysis.

85 Since biofouling is one of the main hurdles for efficient operation of membrane-based techno

86 Though hurdles for efficient treatment remain, these trials hol

87 reases in complexity of data make formidable hurdles for exploring, analyzing and presenting results.

88 ts, and we describe the remaining issues and hurdles for genomic footprinting.

89 We also discuss current technical hurdles for recreating the cell-type complexity and spat

90 concentration in plasma created significant hurdles for scientists working to reveal its identity.

91 One of the main hurdles for the development of an effective and broadly

92 laucoma, as well as anticipated barriers and hurdles for the future adoption of teleophthalmology.

93 activation in virus-infected cells to create hurdles for the manufacture of viral proteins.

94 hese molecules imposes significant synthetic hurdles for their selective functionalization and deriva

95 Two major hurdles for therapeutic use of Hsp90 inhibitors are syst

96 aterials and electrolytes present regulatory hurdles for use in temporary medical devices.

97 ntibodies have not been identified, creating hurdles for vaccine development.

98 A key technical hurdle has been a lack of optimized protocols for the is

99 A major hurdle has been dissecting macrophage-specific functions

100 gn of artificial riboswitches, a significant hurdle has been to couple the two domains enabling their

101 Overcoming this hurdle has required the development of new coherent imag

102 This technical hurdle has stymied progress toward understanding persist

103 However, one of the hurdles has been understanding and quantifying the effec

104 Major hurdles have been overcome to reach this point and almos

105 ntified zones in the striatum, yet technical hurdles have hampered the study of the functions of thes

106 These hurdles have motivated the engineering of smaller antibo

107 mutation in neurons; however, methodological hurdles have prevented testing this hypothesis directly.

108 and analysis tools will soon become a major hurdle, hindering the analysis phase.

109 Overcoming this technical hurdle, however, provides a unique opportunity to probe

110 on of CsA has the potential to overcome this hurdle; however, its use is limited by poor water solubi

111 n the targets sites of both agents, a higher hurdle, if the virus is to retain the ability to replica

112 Chemoresistance is a major hurdle in cancer treatment.

113 oligodeoxyribonucleotides overcome the major hurdle in cell-specific siRNA delivery.

114 whole blood ex vivo represents a logistical hurdle in clinical and research settings.

115 However, a key hurdle in considering ApiCCT1 as a potential treatment i

116 oxidized organic species, and a fundamental hurdle in determining its composition is the lack of aut

117 A central hurdle in developing small interfering RNAs (siRNAs) as

118 ong PIM family members imposes a substantial hurdle in formulating a compelling patient stratificatio

119 elopment of drug resistance has been a major hurdle in gemcitabine therapy leading to unsatisfactory

120 The delivery of nucleic acids is a major hurdle in gene therapy or therapeutic gene knockdown, an

121 kinase inhibitors (RTKi) represents a major hurdle in improving the management of clear cell renal c

122 etic intervention in disease states, a major hurdle in its broad application to unpredictable brain s

123 Drug resistance is a major hurdle in oncology.

124 ing current therapies, thus creating a major hurdle in radiotherapy/chemotherapy.

125 of robust functional assays has been a major hurdle in RAS pathway-targeted drug development.

126 A major hurdle in studying glycans through functional glycomics

127 A major hurdle in the application of these techniques is the lab

128 Toxicity assessment is thus a major hurdle in the compound discovery pipeline, currently inv

129 ite, which represents a possible biochemical hurdle in the development of potent RNase H inhibitors.

130 hat promote remyelination represents a major hurdle in the development of rational therapeutics for m

131 A major hurdle in the development of the strategy has been to el

132 A major hurdle in the effective management of the disease by cel

133 HOXB4 variant to overcome a major technical hurdle in the ex vivo expansion of adult HSCs and early

134 is a major cause of mortality and remains a hurdle in the search for a cure for cancer.

135 therapeutic resistance remains a significant hurdle in the treatment of multiple myeloma (MM) and is

136 A major hurdle in this field is the lack of reliable and conveni

137 A major hurdle in this process is the bias in amplifying the gen

138 NP and the clinical outcome is a significant hurdle in translating associations into biological insig

139 chronic allograft rejection remains a major hurdle in transplantation medicine.

140 ion remain to be elucidated and pose a major hurdle in treating or preventing chronic HCV-induced adv

141 ering with optogenetics to overcome critical hurdles in cancer immunotherapy.

142 duties of sirtuins in tackling the metabolic hurdles in cancer.

143 s with detailed phenotypes and technological hurdles in characterizing the state of chromatin, these

144 fungal infections, which creates significant hurdles in conducting clinical trials in a timely and ec

145 dendrimers could be useful to overcome these hurdles in order to develop adenoviral vectors for combi

146 poor biological understanding of aging, and hurdles in performing clinical trials for aging.

147 However, technological hurdles in producing defined protein sialylation due to

148 The hurdles in realizing successful cancer immunotherapy ste

149 nd their control has become one of the major hurdles in successfully adapting these biological machin

150 Among many hurdles in synthesizing proteoglycan glycopeptides, one

151 Overall this strategy helps to address major hurdles in the design of antivirulence vaccines, enablin

152 ing variable regions of the HIV proteome are hurdles in the development of an effective AIDS vaccine.

153 To overcome these hurdles, in this study peptide-Dox conjugates were prepa

154 These hurdles include a lack of awareness of the benefits, a l

155 Major hurdles include the increasing need for powerful new too

156 al application of ADC remains elusive; major hurdles include the instability of antibody-chemotherapy

157 egenerative medicine currently faces several hurdles, including immune rejection of transplanted cell

158 current approaches face major translational hurdles, including limited cell sources and the need for

159 Regulatory hurdles involved in validating quantitative assays and t

160 This hurdle is largely due to the differentiation of long-ter

161 A major hurdle is that inflammatory products of cerebral disease

162 A significant hurdle is the availability of antivirals to treat the in

163 A significant hurdle is the extraction of the functional protein from

164 A severe hurdle is the hypervariability of its major antigen, the

165 -efficient chemical separations, but a major hurdle is the lack of a scalable and inexpensive membran

166 A fundamental hurdle is the signal response time.

167 Overcoming these hurdles is paramount to realizing the exceptional oncoly

168 A major hurdle limiting the ability to improve the quality of re

169 To gain insights into the main hurdles linked to HE treatment, we conducted a multipara

170 lignocellulosic lipid production, technical hurdles, lipid recovery, and technoeconomics.

171 Despite these hurdles, macrocyclic natural products, including FK506,

172 nal levels where these infants can encounter hurdles may assist caregivers in identifying a potential

173 Instead, greater adaptive hurdles may have prevented the successful colonization o

174 -inflated negative binomial regression and a hurdle model, respectively.

175 strated by various theoretical and technical hurdles, mostly stemming from the dramatic heterogeneity

176 However, a number of hurdles must be overcome in the coming years before non-

177 Two main hurdles must be overcome.

178 HiC-DC uses hurdle negative binomial regression account for systemat

179 by resistant weeds and increased regulatory hurdles, new screening tools promise to provide an upsur

180 The major hurdle, now that effective vaccines are available, is to

181 ing this labeling strategy are possible, the hurdle of assigning the NMR peaks to the corresponding r

182 This uncertainty is largely due to the hurdle of forging links between theory and brain [7-9].

183 umination microscopy, fairSIM takes away the hurdle of generating yet another implementation of the r

184 nd chemotherapy in order to tackle the major hurdle of increased cancer cell growth and proliferation

185 By overcoming the technical hurdle of nonspecific Cre-loxP-mediated recombination, t

186 romise to solve the feasibility and efficacy hurdles of adoptive T-cell therapy for cancer.

187 cterial infections circumventing some of the hurdles of protein IgG delivery.

188 astases seen in patients and to overcome the hurdles of systemic delivery of OV, we developed melanom

189 potential benefits, research, and potential hurdles of this approach through discussion; and reached

190 disease-causing mutations and circumvent the hurdles of traditional gene- and cell-based therapies.

191 rly promise and exciting potential, critical hurdles often involving delivery of miRNA-targeting agen

192 success of hPSC therapies and the remaining hurdles on the road towards developing hPSC-based cell t

193 Major hurdles overcome by the ancestor of these lineages were

194 One major hurdle preventing these therapies from reaching the mark

195 This is partly a consequence of specific hurdles related to the large size of these organisms and

196 f an indivisible resource is an evolutionary hurdle relatively few species have overcome.

197 This is a proof of principle, and major hurdles remain before optimization and scale-up could be

198 Considerable hurdles remain for inducing neutralizing antibodies to a

199 However, many hurdles remain in making them a robust and reliable tool

200 However, some hurdles remain prior to commercialization of these mater

201 However, major hurdles remain to be addressed to acquire an ultraclean,

202 n genomics and bioinformatics, technological hurdles remain to examine host-microbe transcriptomics.

203 Difficult hurdles remain, however, and these too are reviewed.

204 Although substantial hurdles remain, opportunities are now rich for the ratio

205 clinical outcomes after transplantation, but hurdles remain.

206 d regeneration, perhaps the most significant hurdle remains the establishment of non-destructive mean

207 (RSV) can be partly attributed to regulatory hurdles resulting from vaccine enhanced respiratory dise

208 However, several technical hurdles severely limit the definition of an effective vi

209 As a way to avoid this hurdle, sticholysin (St) II, a pore-forming protein from

210 dinitrogen with protons and electrons major hurdles still have to be overcome.

211 tive protein modification and consider which hurdles still need to be overcome for more widespread us

212 We describe which hurdles still need to be taken to make SRM a robust and

213 ging issues of ADC construction, significant hurdles still remain.

214 ated exon skipping for DMD still faces major hurdles such as extremely low efficacy in the cardiac mu

215 Results presented in this study show that hurdle technology (heating plus refrigeration) may help

216 ear-infrared (NIR) region has been the major hurdle that has hindered further development and clinica

217 We also address controversies and hurdles that challenge the field.

218 history of antibody conjugates is marked by hurdles that have been identified and overcome.

219 sic properdin biology, emphasizing the major hurdles that have complicated the interpretation of resu

220 however, remains incomplete due to technical hurdles that have prevented the removal of astrocytes fr

221 y in a nonpathogenic context, as well as the hurdles that have to be overcome in Gram-negative envelo

222 , our results highlight the complex array of hurdles that HCMV must overcome in order to infect primi

223 However, there are substantial technologic hurdles that must be addressed before clinical efficacy

224 isorders using iPS cells, and illustrate the hurdles that must be overcome before iPS cell therapies

225 scussed, with an eye toward anticipating the hurdles that must be overcome for a network-based framew

226 influence on solid electrolytes and are key hurdles that must be overcome for their successful appli

227 es (MPTs), and the scientific and regulatory hurdles that must be overcome to make combination preven

228 These findings reveal hurdles that must be overcome to successfully analyze fu

229 for regenerative medicine, while pointing to hurdles that must be overcome to translate this technolo

230 inary studies have shown that there are many hurdles that need to be overcome as we explore pharmacog

231 r the survival of cell transplants are major hurdles that need to be overcome in dental pulp regenera

232 er patients requires better understanding of hurdles that prevent the generation of effective antitum

233 ill faces important financial and regulatory hurdles that should be addressed to optimise clinical ad

234 ey current questions in cell biology and the hurdles that we have encountered along the way.

235 Research hurdles that were overcome included considering that fac

236 Although there are technical hurdles, the integrated use of these approaches can eluc

237 apy-induced resistance remains a significant hurdle to achieve long-lasting responses and cures in ca

238 ade the immune response, and present a major hurdle to adoptive CTL therapies.

239 Such learned dependence is likely a hurdle to autonomy to be overcome for many robot locomot

240 ain barrier (BBB) poses the most significant hurdle to brain tumor treatment.

241 current study, we analyze the causes of one hurdle to clinical development, off-target reactivity, o

242 A major hurdle to clinical translation of brain-machine interfac

243 H) fosters drug resistance and is a critical hurdle to clinical treatment.

244 The discrepancies between assays are a hurdle to clinical trials that aim to measure the effica

245 A major hurdle to control PRRSV is the ineffectiveness of the cu

246 erapeutic molecules, presenting a formidable hurdle to drug development in brain diseases.

247 Latent HIV reservoirs are the primary hurdle to eradication of infection.

248 A major hurdle to evolutionary engineering approaches for multig

249 hat underlie neural activity is the greatest hurdle to faster advances.

250 ating broad, protective antibodies remains a hurdle to HIV vaccine design.

251 One hurdle to implementation of DESI-MS intraoperatively is

252 A major hurdle to killing Epstein-Barr virus (EBV)-infected tumo

253 nd addition of arginine did not constitute a hurdle to lactic and probiotic bacteria survival, with p

254 his approach lowers a longstanding technical hurdle to manipulating large proteins in cardiomyocytes.

255 ations of their backbone amides is the major hurdle to overcome for the construction of discrete fold

256 Delivery of siRNA is a key hurdle to realizing the therapeutic promise of RNAi.

257 A major hurdle to study the distribution of TBPVs is the lack of

258 herin confers Nef resistance, representing a hurdle to successful zoonotic transmission.

259 Such memory requirements are a significant hurdle to the computation of minimal absent words in lar

260 A major hurdle to the development of effective therapeutics has

261 Antiviral immune responses present a major hurdle to the efficacious use of oncolytic adenoviruses

262 A major hurdle to the implementation and optimization of this tr

263 However, a critical hurdle to the latter is how to safely and densely store

264 ithin an array remains however a significant hurdle to the practical realization of a quantum compute

265 in cell function has presented a significant hurdle to the successful clinical translation of many ce

266 of most drugs into the brain and is a major hurdle to the use of drugs for brain tumors and other ce

267 regression but their rareness poses a major hurdle to their clinical application.

268 One hurdle to treating tuberculosis could be that it is so d

269 The main hurdle to using lipoplexes in gene therapy lies in their

270 However, bacterial recombination poses hurdles to a sequential Markov approximation, as it lead

271 ted cycles of charge and discharge are major hurdles to commercialization of energy-storage devices b

272 development of NTD vaccines and some of the hurdles to ensuring their availability to the world's po

273 enomics, discuss the scientific and clinical hurdles to furthering our knowledge of the variability i

274 n practice context, there were few perceived hurdles to future curriculum adoption.

275 have detailed strategies that overcome prior hurdles to generate functional beta-like cells from huma

276 w area of medicine in which the conventional hurdles to implementing chemicals to effect human health

277 munodeficiency virus type 1 (HIV-1) has many hurdles to overcome.

278 lped clarify these relationships, overcoming hurdles to provide a range of potential models for ESCRT

279 reactions, and huge volume effect are major hurdles to the commercial application of Li-metal anodes

280 The hurdles to the development of commercial MFC technology

281 nanoparticle at any feeding ratios are major hurdles to their widespread applications.

282 Significant hurdles to vaccine development include host range specif

283 e of drug resistance continues to be a major hurdle towards improving patient outcomes for the treatm

284 tion of engineered dental pulp poses a major hurdle towards successful implementation of pulp regener

285 Currently, despite large regulatory hurdles, UAVs are being deployed by researchers and cons

286 cal practice will depend on overcoming major hurdles, ultimately including evidence that the detectio

287 To address this hurdle, we developed a vaccine based-approach comprised

288 To overcome this hurdle, we generated a SCID-hu lung mouse model that clo

289 To overcome this hurdle, we utilized non-canonical amino acids and bio-or

290 To overcome these hurdles, we have developed a switchable CAR-T cell platf

291 By overcoming biochemical and image analysis hurdles, we obtained accurate EM structures of yeast and

292 To overcome these hurdles, we successfully used minicircle (MC) naked-DNA

293 a condition which is essential and is a key hurdle when operating at short wavelength due to the str

294 anied by significant economic and regulatory hurdles which compound the costs of screening for promis

295 g and technical expertise and the regulatory hurdles, which might prevent vendors from marketing card

296 However, researchers still face hurdles, which slow progress and need to be resolved to

297 Strategies are presented to overcome these hurdles, which will ultimately improve cancer survivorsh

298 Overcoming these hurdles will require a new approach.

299 intravenous delivery is the greatest single hurdle, with synthetic vectors frequently found to be un

300 One of the biggest hurdles yet to be overcome for the continued improvement