ライフサイエンスコーパス: hyaluronan synthase

1 syltransferases (e.g. cellulose, chitin, and hyaluronan synthases).

2 that the recombinant protein is an authentic hyaluronan synthase.

3 a novel mouse gene which encodes a putative hyaluronan synthase.

4 human homolog of a recently described murine hyaluronan synthase.

5 ding frame, A98R, with similarity to several hyaluronan synthases.

6 TGF-beta also strongly induced hyaluronan synthase 1 (HAS1) and HAS2 mRNA levels, which

7 rs contained a c-Maf binding site, including hyaluronan synthase 1 (HAS1).

8 brane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfe

9 1 and UGDH with specific siRNAs also lowered hyaluronan synthase-1 (HAS-1) and HAS-2 levels and reduc

10 Soluble hyaluronan levels and expression of hyaluronan synthase-1 were increased in TNFDeltaARE mice

11 creased HA secretion resulted from increased hyaluronan synthase 2 (HAS2) activity localized to sphin

12 STAT3 pathway, which regulates expression of hyaluronan synthase 2 (HAS2) and subsequent hyaluronan s

13 We identified hyaluronan synthase 2 (Has2) as another novel downstream

14 Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in

15 Here, we report that upregulation of hyaluronan synthase 2 (HAS2) occurs in highly metastatic

16 In addition, we found that expression of hyaluronan synthase 2 (Has2) was elevated by a loss of S

17 tures induced a specific, rapid induction of hyaluronan synthase 2 (HAS2), and an increase of hyaluro

18 ntricular canal marker genes, such as tbx2b, hyaluronan synthase 2 (has2), notch1b and bmp4, are chan

19 A-degrading enzymes and a unique sequence of hyaluronan synthase 2 (HAS2).

20 enhanced thrombin-induced HA synthesis, and hyaluronan synthase 2 expression in VSMC.

21 ynovial cells, and condyles displayed higher Hyaluronan synthase 2 expression.

22 ytes demonstrated overexpression of SAA3 and hyaluronan synthase 2 in vitro and in vivo in diet-induc

23 g hyaluronan production by overexpression of hyaluronan synthase 2 or emmprin causes elevated ErbB2 p

24 Furthermore, TBX4 regulated hyaluronan synthase 2 production to enable fibroblast in

25 dentification of a natural antisense mRNA of hyaluronan synthase 2 that we have chosen to designate a

26 Both Irinotecan/HAS2 (Hyaluronan synthase 2) and Bevacizumab/PGAM1 (Phosphogly

27 d-glucosaminyl 3-O-sulfotransferase 3A1, and hyaluronan synthase 2) that have direct or indirect role

28 expression of CD44 exon 19 and CD44 exon 20, hyaluronan synthase 2, aggrecan, and GAPDH messenger RNA

29 d-glucosaminyl 3-O-sulfotransferase 3A1 and hyaluronan synthase 2, are also potentially important me

30 This group included hyaluronan synthase 2, nephroblastoma-overexpressed gene

31 actor signaling, including cyclooxygenase 2, hyaluronan synthase 2, tumor necrosis factor-stimulated

32 ression of hyaluronan (HA) and activation of hyaluronan synthase-2 (Has2) are also enhanced upon PN/I

33 We identified hyaluronan synthase-2 (Has2) as a likely source of hyalu

34 Targeted deletion of the hyaluronan synthase-2 (Has2) gene in mice results in an

35 The aim of this study was to characterize hyaluronan synthase-2 (HAS2)-driven HA synthesis and det

36 Cells infected with hyaluronan synthase-2 adenovirus also acquired mesenchym

37 , we have shown that increased expression of hyaluronan synthase-2 induces malignant cell properties,

38 oblasts revealed induction of IL8, SERPINB2, hyaluronan synthase-2, and other genes associated with t

39 Using recombinant adenoviral expression of hyaluronan synthase-2, we show that increased hyaluronan

40 e identified a common SNP, rs2232228, in the hyaluronan synthase 3 (HAS3) gene that exerts a modifyin

41 Hyaluronan synthase 3 (HAS3) is responsible for the prod

42 on is dependent on de novo synthesis through hyaluronan synthase 3, and plays a role in the inflammat

43 aluronan induced by high VT was dependent on hyaluronan synthase 3, and was associated with ventilato

44 hereas adenoviral-mediated overexpression of hyaluronan synthase 3, which stimulated endogenous hyalu

45 high VT ventilation in C57BL/6 wild-type and hyaluronan synthase-3 knockout mice were compared.

46 hese reactions were significantly reduced in hyaluronan synthase-3 knockout mice, except the capillar

47 nthase-3 mRNA, neither of which was found in hyaluronan synthase-3 knockout mice.

48 sues and concomitant increased expression of hyaluronan synthase-3 mRNA, neither of which was found i

49 s, and was accompanied by an upregulation of hyaluronan synthase-3 mRNA.

50 In analogy to known hyaluronan synthases, a single polypeptide species, pmCS

51 hree homologous genes encoding proteins with hyaluronan synthase activity (Has1-3), all producing an

52 revious reports indicate that hasA, encoding hyaluronan synthase, and hasB, encoding UDP-glucose 6-de

53 gest that there are three putative mammalian hyaluronan synthases encoded by three separate but relat

54 mRNA for hyaluronan synthase enzymes HAS1 and HAS2 increased >10-

55 ion, but the depletion of versican decreased hyaluronan synthase expression and decreased the retenti

56 ereas CD44 is expressed in tumor epithelium, hyaluronan synthase expression is restricted to stromal-

57 ant cDNAs included S10-40-H5, members of the Hyaluronan synthase family, Xvent-2 and XFD2/FoxI1.

58 for a virus, e.g., ornithine decarboxylase, hyaluronan synthase, GDP-D-mannose 4,6 dehydratase, and

59 nt was studied using knock-out mice of three hyaluronan synthase genes (Has1, Has2, and Has3).

60 ization studies, in combination with a novel hyaluronan synthase-GFP transgenic mouse, show a restric

61 Collagen I (COL1A1), collagen III (COL3A1), hyaluronan synthase (HAS) 2, and fibronectin expression

62 wn products UDP and UMP act as mediators for hyaluronan synthase (HAS) activation in human epidermal

63 ERK) signaling, and their role in regulating hyaluronan synthase (HAS) activity in human ovarian tumo

64 Subcutaneous injection of SCID mice with hyaluronan synthase (HAS) antisense-transfected cells pr

65 a functional glycosaminoglycan synthase, the hyaluronan synthase (HAS) from Group A Streptococcus pyo

66 the role of HA in this disease, we examined hyaluronan synthase (Has) gene expression and HA product

67 but related genes which comprise a mammalian hyaluronan synthase (HAS) gene family.

68 The three mammalian hyaluronan synthase (HAS) genes and the related Xenopus

69 Hyaluronan synthase (HAS) utilizes UDP-GlcUA and UDP-Glc

70 f the cell membrane by the membrane-embedded hyaluronan synthase (HAS).

71 To dissect the roles of hyaluronan synthases (HAS) and Hyal1 in tumorigenesis an

72 In monolayer cultures, UVB increased hyaluronan synthase Has1 mRNA already 4 h postexposure,

73 egulated HAS2 expression, although the other hyaluronan synthases (HAS1, HAS3) and hyaluronidases (HY

74 Hyaluronan synthases (HAS1-3) are unique in that they ar

75 ice isoform CD44s promoted expression of the hyaluronan synthase HAS2 by activating the Akt signaling

76 r cells express 20-fold higher levels of the hyaluronan synthase HAS3, but the mechanistic relevance

77 lation of a cDNA encoding the third putative hyaluronan synthase, HAS3.

78 an cDNA that is related to the Streptococcus hyaluronan synthase (HasA) and the Xenopus developmental

79 Hyaluronan synthases (HASs) are glycosyltransferases tha

80 be a sensitive assay for detection of active hyaluronan synthases (HASs) capable of synthesizing hyal

81 different conclusions about whether class I hyaluronan synthases (HASs) elongate hyaluronic acid (HA

82 The two hyaluronan synthases (HASs) from Streptococcus pyogenes

83 he functional sizes of the two streptococcal hyaluronan synthases (HASs) were determined by radiation

84 A human hyaluronan synthase (HuHAS1) cDNA was isolated by a func

85 Cps1p also shares similarity with hyaluronan synthase of higher eukaryotes.

86 lusively attributed to the ubiquitous hasABC hyaluronan synthase operon, which is highly conserved ac

87 The Pasteurella multocida hyaluronan synthase (PmHAS) catalyzes the polymerization

88 e nucleotide and the amino acid level to the hyaluronan synthase, pmHAS, from P. multocida Type A.

89 with the mouse HAS protein, another putative hyaluronan synthase recently reported by Itano and Kimat

90 mbranes expressing Streptococcus equisimilis hyaluronan synthase (seHAS) demonstrated an inherent art

91 onstrated that the Streptococcus equisimilis hyaluronan synthase (seHAS) is phospholipid-dependent an

92 ne domains (MD) of Streptococcus equisimilis hyaluronan synthase (seHAS), Lys48 in MD2 and Glu327 in

93 protein is a crucial component of the human hyaluronan synthase system.

94 the Pasteurella multocida Type A PmHAS, the hyaluronan synthase that makes the alternating (-beta3-G

95 llular UDP-glucuronic acid and inhibition of hyaluronan synthase transcription.

96 ion is only partially PKC dependent; and (3) hyaluronan synthase turnover time is >6 h in vivo, which

97 To identify the putative mammalian hyaluronan synthase, we cloned a human cDNA that is rela

98 The prototypical vertebrate hyaluronan synthase, xlHAS1 (or DG42) from Xenopus laevi