ライフサイエンスコーパス: hydrazide

1 osis antibiotic isoniazid (isonicotinic acid hydrazide).

2 ding template composed of 5-aminoanisic acid hydrazide.

3 3,5-dibromo-2,4-dihydr oxyphenyl) methylene] hydrazide.

4 examined after derivatization by L-tyrosine hydrazide.

5 C-biotin, sulfo-NHS-LC-biotin, and biotin-LC-hydrazide.

6 s proved to be Gly-l-Pro-l-Ser anthraquinone hydrazide.

7 t by the peroxidase inhibitor 4-aminobenzoic hydrazide.

8 of radicals was produced from nicotinic acid hydrazide.

9 entary reactive functional group such as the hydrazide.

10 inylated in a one-step reaction using biotin-hydrazide.

11 ith sodium cyanoborohydride to form a stable hydrazide.

12 nyl products with 3-hydroxy-2-naphthoic acid hydrazide.

13 hydrazone formation with an acridone-labeled hydrazide.

14 mples of this type of reaction for any metal hydrazide.

15 queous solutions, such as hydrazines to form hydrazides.

16 a sequential addition--dehydration with acyl hydrazides.

17 is using amidites with preformed, protected hydrazides.

18 or the modification of oligonucleotides with hydrazides.

19 ese earlier observations and tested 45 novel hydrazides.

20 een the aldehyde residue and alkoxyamines or hydrazides.

21 rior study identified phenyl benzenesulfonyl hydrazide 2 as a potent in vitro (though not in vivo) in

22 lactam derivative 18 and helioxanthin cyclic hydrazide 28 exhibited significant in vitro antiviral ac

23 on, co-administration of 4-aminobenzoic acid hydrazide (4-ABAH), an irreversible inhibitor of MPO, si

24 enyl)-2-oxo-2,3-dihydro-1H-indole-5-sulfonyl hydrazide 40, which demonstrated 59% oral bioavailabilit

25 -2-yl)-N'-[(4-ethoxyphenyl)methylidene]benzo hydrazide 6P was identified as a promising anti-inflamma

26 onditions (50 equiv of TFA), combinations of hydrazide A-B monomers self-assemble into octameric [2]-

27 ved from inexpensive, commercially available hydrazides A and methyl coumalate B.

28 hesis of Gly-l-Pro-l-Ala-chloroanthraquinone hydrazide, a compound that had been reported to serve as

29 ic acid (3-methyl-3H-benzothiazol-2-ylidine) hydrazide, a potent KCNQ2/Q3 agonist.

30 were treated with either 4-aminobenzoic acid hydrazide (ABAH), 40 mg/kg injected intraperitoneally, a

31 Histidine-derived hydrazide acetal monomers (3-dimethoxymethylbenzoyl)-L-h

32 ylic acid 4'-benzyloxy-3'-methoxybenzylidene-hydrazide) activated neutrophils at nanomolar concentrat

33 rbohydrate chains in AGP for attachment to a hydrazide-activated support.

34 described for the entrapment of proteins in hydrazide-activated supports using oxidized glycogen as

35 of the subsequent ring closure of the N-acyl hydrazide adduct.

36 pture of the aldehyde-modified protein using hydrazide-agarose.

37 We demonstrate that Alexa Fluor 633 hydrazide (Alexa Fluor 633) selectively labels neocortic

38 cid 3'-bromo-5'-ethoxy-4'-hydroxybenzylidene-hydrazide), an analog of compound 14.

39 The binding of INH and a series of hydrazide analogues to resting KatG was examined using o

40 otinylation of oxidized proteins with biotin hydrazide and (2) affinity enrichment using monomeric av

41 ex (25, for N-acetamido) of the deprotonated hydrazide and a Pt-alkyl complex of the cyclized pyrroli

42 The hydrazide and aldehyde precursors take a total of 5 d to

43 ipeptides derived from 5-chloroanthraquinone hydrazide and anthraquinone hydrazide have been prepared

44 r immunosensors based on mixed monolayers of hydrazide and hydroxyl diothiolated linkers (15 pfu/mL).

45 at the released material in our assay is VSG hydrazide and strengthen the proof that GPI anchoring pr

46 es of bis(cyclopentadienyl) titanium amides, hydrazides and imides by proton coupled electron transfe

47 AcCoA to primary arylamines, hydrazines, and hydrazides and play a very important role in the metabol

48 Br-ANT (2-amino-benzoic acid, 2-(bromoacetyl)hydrazide) and Br-MANT (N-[2-[(bromoacetyl)amino]ethyl]-

49 , (c) glycan purification on solid-supported hydrazide, and (d) glycan quantification by ultra perfor

50 rface active' polymeric carriers for biotin, hydrazide, and azide moieties, which selectively capture

51 during coupling reactions with anthraquinone hydrazide, and several tripeptide derivatives of this co

52 tics of the reactions of amines, hydrazines, hydrazides, and hydroxylamines with benzhydrylium ions a

53 Glyco-TMTs bearing hydrazide- and aminooxy-functionalized groups were compa

54 cluding the epi-amine and epi-4-azidobenzoyl hydrazide as a candidate affinity probe.

55 occus triatomea, selective glycan capture on hydrazide beads on a robotics platform, 2AB-fluorescent

56 It is based on the conjugation of glycans to hydrazide beads through the formation of reversible hydr

57 development of a novel technique, which uses hydrazide beads to capture glycans.

58 isolated from concatenate peptides by using hydrazide beads.

59 to block the C terminus of the released VSG hydrazide because the released material, unlike a trunca

60 Moreover, the hydrazide bond was also unstable in buffer.

61 uenched by addition of isoniazid and benzoic hydrazide, but not by iproniazid, which binds poorly to

62 monstrated that hyperconjugation operates in hydrazides by analyzing the N-H stretching mode in gas p

63 cocrystal structure of the related oxindole hydrazide c-MET inhibitor 10 with a nonphosphorylated c-

64 ate of N-acetyl-gamma-calicheamicin dimethyl hydrazide [CalichDMH], a potent DNA-binding cytotoxic an

65 -phase extraction (SPE) of glycopeptides via hydrazide capture chemistry as well as hydrophilic inter

66 By employing biotin hydrazide capture, it was confirmed that 4-HNE treatment

67 ozide chelates the active site metal via its hydrazide carbonyl and dimethylamino groups.

68 We previously identified glycine hydrazide CFTR blockers that by electrophysiological stu

69 nd release strategy that utilizes reversible hydrazide chemistry to enrich HNE-modified peptides.

70 on of glycoproteins to a solid support using hydrazide chemistry, stable isotope labeling of glycopep

71 inhibitors of the thiazolidinone and glycine hydrazide classes slow cyst expansion in in vitro and in

72 tion of four-coordinate tetramanganese-amide-hydrazide clusters is described.

73 ic acid [5-(3-bromophenyl)-2-furyl]methylene-hydrazide; compound 2, 4-fluoro-benzoic acid [5-(3-trifl

74 rbohydrates with periodate and labeling with hydrazide-conjugated digoxigenin.

75 The hydrazide-containing analogue 17 was identified as the m

76 bohydrazide is accompanied by formation of a hydrazide-containing product and a carbamyl-enzyme inter

77 solid-phase enrichment of glycopeptides via hydrazide-coupled magnetic beads, in conjunction with (1

78 o at the carboxyl terminus by trypsin during hydrazide coupling and the third at the N-glycosylation

79 appropriately modified desacetylvinblastine hydrazide (DAVLBH) resulted in a conjugate (25) with an

80 and the vinca alkaloid desacetylvinblastine hydrazide (DAVLBH), is a ligand for the folate receptor

81 The cyclic hydrazide derivative of helioxanthin 28 and its brominat

82 The resultant adipic acid hydrazide derivatives (AH-proteins), containing 2.3 to 3

83 10-epi-methoxyamino, and 10-epi-azidobenzoyl hydrazide derivatives and 10-deoxydehydroryanodine.

84 screened a series of 71 arylcarboxylic acid hydrazide derivatives for their ability to induce macrop

85 to obtain insight on the hyperconjugation in hydrazide derivatives from solution IR spectroscopy.

86 henylalanine can be selectively labeled with hydrazide derivatives not only in vitro but also in livi

87 ne for specific labeling of the protein with hydrazide derivatives of fluorophores.

88 The approach is based on the creation of a hydrazide-derivatized, self-assembled monolayer on a gol

89 Using biotin hydrazide detection, it was established that the incubat

90 The product Cbz-leu-hydrazide does not appear enzyme-bound after cleavage in

91 were patch-clamped and filled with Alexa 568 hydrazide dye to visualize their morphological relations

92 2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide (Dynasore), a dynamin guanosine 5'-triphosphat

93 m adult leeches with dye-filled (Alexa Fluor hydrazide) electrodes.

94 When the solid-phase hydrazide enrichment strategy was applied to a yeast lys

95 st cell cultures with a complementary biotin hydrazide enrichment strategy.

96 a mechanism involving N-H activation of the hydrazide, followed by insertion of the alkene into the

97 oteins was indicated by labeling with biotin hydrazide following periodate oxidation, a specific and

98 entional protein stains, and reactivity with hydrazide following periodate oxidation.

99 The hydrazide-forming reaction shows identical amino acid re

100 odologies reported for direct preparation of hydrazides from acids are inefficient.

101 cile incorporation of aryl aldehyde and acyl hydrazide functionalities into peptide oligomers via sol

102 of this approach is the installation of acyl hydrazide functionality at the C-terminus of the proxima

103 tely novel approach is the generation of the hydrazide functionality during the oligonucleotide cleav

104 These SWCNTs were hydrazide functionalized by electrochemical grafting of

105 ere then reacted with synthetic aminooxy and hydrazide-functionalized carbohydrates.

106 for site-specific labeling with aminooxy- or hydrazide-functionalized probes.

107 The novel aldehyde-reactive, hydrazide-functionalized, isotope-coded affinity tag (HI

108 A biotin-hydrazide glycosylation assay was performed on the flage

109 previously discovered low- affinity glycine hydrazide (GlyH) CFTR inhibitors that block CFTR at its

110 ibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide (GlyH-101), which is thought to act by enterin

111 ith a bifunctional reagent containing both a hydrazide group for hydrazone formation with carbonyl-co

112 Those hydrazide groups are introduced by electrografting of di

113 oieties of periodate-oxidized antibodies and hydrazide groups on functionalized gold electrodes.

114 s of superparamagnetic silica particles with hydrazide groups on the surface and further evaluate the

115 -decorated SWCNTs to functionalize them with hydrazide groups that facilitate site-directed immobiliz

116 Hydrazide groups were introduced into proteins (bovine s

117 mbled monolayer between the gold surface and hydrazide groups, followed by detection involving three

118 plementary nucleophiles such as aminooxy and hydrazide groups.

119 ary amines, propiolic acid, isocyanides, and hydrazides has been developed in order to access polyfun

120 oroanthraquinone hydrazide and anthraquinone hydrazide have been prepared as potential reagents to pr

121 osis antibiotic isoniazid (isonicotinic acid hydrazide), have confirmed that the heme iron in the res

122 An oxindole hydrazide hit 6 was identified during a c-MET HTS campai

123 og/10(7) cells) and reacted with fluorescein hydrazide in vitro to produce fluorescently labeled rhod

124 This process gives the desired hydrazides in excellent yield and purity under mild cond

125 ases gives N'-(het)aryl-N'-[2-nitro(het)aryl]hydrazides in good yields.

126 ction with hydrazine, for the preparation of hydrazides including those of alpha,beta-unsaturated aci

127 eloperoxidase inhibitor 4-amino-benzoic acid hydrazide, indicating peroxidase catalytic activity is e

128 of the antitubercular drug isonicotinic acid hydrazide (INH) and is important for survival of M. tube

129 ine antituberculosis agent isonicotinic acid hydrazide (INH) compared with the parental furA+ strain.

130 irst-line antituberculosis drug isonicotinic hydrazide (INH) is a prodrug whose bactericidal function

131 obacterium tuberculosis to isonicotinic acid hydrazide (INH) lacks satisfactory definition.

132 vity of M. tuberculosis to isonicotinic acid hydrazide (INH).

133 osis drug isoniazid [i.e., isonicotinic acid hydrazide (INH)].

134 Although isoniazid (isonicotinic acid hydrazide, INH) is widely used for the treatment of tube

135 Acid-promoted hydrolysis of each acetal hydrazide initially produced a library of cyclic oligome

136 The binding of hydrazides is associated with a large enthalpy loss (>10

137 tandard method for preparing carboxylic acid hydrazides is hydrazinolysis of esters in alcoholic solu

138 One method to introduce hydrazides is using amidites with preformed, protected h

139 id gamma-methyl ester, L-glutamic acid gamma-hydrazide, L-glutamic acid gamma-hydroxamate, L-glutamic

140 This procedure identified a hydrazide-labeled peptide, which has the sequence XKEGR.

141 e blue-NP41-bound nerves, followed by biotin hydrazide labeling and purification, resulted in light-i

142 wing intramolecular chelation of NPh2 of the hydrazide ligand.

143 cycloaddition to the Ti=N(alpha) bond of the hydrazide ligand.

144 retro-inverso, retro, and inverso isomers of hydrazide linked bifunctional peptides were designed, sy

145 A series of hydrazide-linked bifunctional peptides designed to act a

146 The stability of hydrazide-linked oligogalacturonides was confirmed using

147 This unusual natural product contains a hydrazide linker between a carboxylic acid and a phospho

148 icing elements called inteins, a novel thiol-hydrazide linker was designed and used to orient immobil

149 or by self assembly of mono- and dithiolated hydrazide linkers, resulting in films with tailored func

150 GlyH analogs (malonic hydrazides, MalH) were chemically conjugated to various

151 chemical inhibitor of MPO (aminobenzoic acid hydrazide) mimicked the effects of hLF1-11 on the inflam

152 anoparticles were dispersed in aldehyde- and hydrazide-modified hyaluronic acids (HA), then combined

153 tached without prior derivatization onto the hydrazide-modified, self-assembled monolayer on gold-coa

154 t a model in which amino acid binding to the hydrazide moiety of the luminol-derived probes provides

155 ved with INH, which shares the isonicotinoyl hydrazide moiety with PCIH.

156 as both the right and left components of the hydrazide moiety.

157 boxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride (1, SC-51089) is a function

158 nd selective class I HDAC inhibitors using a hydrazide motif.

159 were reacted with 3-hydroxy-2-naphthoic acid hydrazide (NAH), and NAH-carbonyl compounds were detecte

160 ydroamination of allenes occurs readily with hydrazide nucleophiles, in the presence of 3-12% Ph(3)PA

161 oamination/cyclization reactions of zinc(II) hydrazides obtained through reaction of diethylzinc with

162 ished by reacting protein carbonyls with the hydrazide of GRP.

163 pochlorite (OCl(-)), a novel rhodamine-based hydrazide of the chiral acid ((S)-(-)-2-pyrrolidone-5-ca

164 The efficiency of branched hydrazide oligonucleotides compared with standard amino

165 The reaction of these hydrazide oligonucleotides with active esters and aldehy

166 de monomers were independently conjugated to hydrazide or aldehyde-containing cross-linkers using thi

167 s were affinity-tagged with either biotin-LC-hydrazide or biocytin hydrazide, which are known to labe

168 A1 receptors than the corresponding carboxyl hydrazide or carboxylic acid derivatives.

169 he GPI pathway produced large amounts of the hydrazide or hydroxamate of miniPLAP.

170 In contrast, native HPRG bound to hydrazide or nickel chelate surfaces strongly stimulated

171 elemer did not affect the potency of glycine hydrazide or thiazolidinone CFTR inhibitors.

172 Methimazole, 4-aminobenzoic acid hydrazide, or azide inhibits the reaction, suggesting th

173 emically modified by selective reaction with hydrazide- or aminooxy-functionalized reagents.

174 ne probe and then specifically conjugated to hydrazide- or hydroxylamine-functionalized molecules.

175 We developed a poly(acryloyl hydrazide) (PAH) scaffold to which we conjugated a varie

176 The rates of reduction of KatG Compound I by hydrazides parallel the on rates for association with th

177 de lysates revealed para-hydroxybenzoic acid hydrazide (pHBH) to be best suited for application in a

178 e structurally characterized manganese-amide-hydrazide pinned butterfly complex, Mn4(mu3-PhN-NPh-kapp

179 The hydrazide pipet tips have great potential in achieving a

180 Briefly, a heterobifunctional linker, hydrazide-polyethylene glycol-dithiol, is used to direct

181 ing blocks for the introduction of esters as hydrazide precursors are described.

182 The requisite allylic hydrazide precursors are readily prepared and undergo sm

183 s potent antitubercular agent nicotinic acid hydrazide produced the corresponding nicotinyl radicals.

184 ansfer efficiency, with unlinked QDs and Cy5 hydrazide producing nearly zero background signal in cap

185 perature, gradually converting to the Fe(II) hydrazide product [kappa(2)-((t)Bu2CN)C(eta(6)-NAr*)(N-N

186 Most significantly, the hydrazide product can be enriched by affinity chromatogr

187 The stable hydrazide products can be analyzed by standard proteomic

188 fies already known warheads but also reveals hydrazide, pyrazole, or carboxylic acid fragments as nov

189 reaction and an electrochemically reductive hydrazide reaction.

190 also shown that both the O-GlcNAc and biotin hydrazide-reactive carbohydrate moieties are located on

191 rst amino acid, X, which is labeled with the hydrazide reagent, is a modified form of aspartic acid.

192 pment of stable-isotope labeled hydrophobic, hydrazide reagents for the relative quantification of N-

193 Aminooxy TMTs outperform the hydrazide reagents in terms of labeling efficiency (>95%

194 onality can be chemoselectively ligated with hydrazide reagents under mild conditions.

195 The MPO inhibitor 4-aminobenzoic acid hydrazide reduced peroxidase activity of neutrophils and

196 Selective capture of glycopeptides by hydrazide resin followed by mass spectrometric identific

197 size these compounds from acid chlorides and hydrazides, respectively.

198 The chemically labile oxindole hydrazide scaffold was replaced with a chemically and me

199 he chemical functionality of a poly(acryloyl hydrazide) scaffold was activated under aqueous conditio

200 ing end-labeling with the fluorophore BODIPY hydrazide, separation by HPLC, and subsequent fluorescen

201 established amino modified oligonucleotides, hydrazides show enhanced reactivity at neutral and acidi

202 oborates to generate a transient propargylic hydrazide species.

203 ubstrates but become rate-limiting when poor hydrazide substrates are used.

204 s increased sensitivity to isonicotinic acid hydrazide, suggesting that the natural loss of oxyR in t

205 lity normalization when labeling with glycan hydrazide tags (INLIGHT) for analysis of plasma.

206 thod and then derivatized their surface with hydrazide-terminated silane.

207 ycopeptide isolation, in this study, a novel hydrazide tip was devised and an integrated workflow of

208 low of N-linked glycopeptide isolation using hydrazide tips was presented.

209 ations of glycopeptides were performed using hydrazide tips with a liquid handling robotic system.

210 We demonstrated that, with the hydrazide tips, the processing time was significantly de

211 n of the resulting cyclized alkyl complex by hydrazide to release the hydrohydrazination product and

212 ovirus receptor by covalently binding biotin hydrazide to the ketone.

213 ponding amide analogues were compared to the hydrazides to determine the effect of the second nitroge

214 yst system for the conversion of substituted hydrazides to five- and six-membered N-amino lactams (N-

215 rinsic reactivity of reducing glycans toward hydrazides to form stable cyclic N-glycosides.

216 system, terminal alkynes react with sulfonyl hydrazides to produce branched allylic sulfones with goo

217 Decomposition of this unstable hydrazide via an intermediate monoalkyldiazine produces

218 e [2,3]-sigmatropic rearrangement of allylic hydrazides, via singlet N-nitrene intermediates, is repo

219 In the first reaction biotin-x-hydrazide was coupled to the anomeric carbon of the redu

220 N'-aryl acyl hydrazides were identified as P2X7 receptor antagonists.

221 3-trifluoromethyl-phenyl)-2-furyl]-methylene-hydrazide] were selected for further analysis.

222 enzylidenesorbitol (DBS), modified with acyl hydrazides which extracts gold/silver salts from model w

223 ated with methimazole or 4-aminobenzoic acid hydrazide, which are inhibitors of myeloperoxidase, they

224 with either biotin-LC-hydrazide or biocytin hydrazide, which are known to label carbonyl groups.

225 ute to the N'-(het)aryl-N'-[2-nitro(het)aryl]hydrazides, which works well with benzo- and picolinohyd

226 l is used to selectively derivatize the free hydrazide with an N-hydroxysuccinimide ester, while the

227 eactions of diamide-amine supported titanium hydrazides with alkynes is presented.

228 e, and Ph-GlyH-101, a phenyl-derived glycine hydrazide, without an effect on cell proliferation.