ライフサイエンスコーパス: hydrazone

1 itithine) and MGBG [methylgloxal-bis (guanyl hydrazone)].

2 ts: synthetic RNA oligonucleotides and DMNPE-hydrazone.

3 omewhat by preferential stabilization of the hydrazone.

4 o form a highly conjugated, immobilized FmPH-hydrazone.

5 than the benzoyl group to conjugate with the hydrazone.

6 , provides the corresponding "twisted" amino hydrazone.

7 olished with Carbonyl cyanide m-chlorophenyl hydrazone.

8 -amino-2-methoxymethylpyrrolidine (SAMP/RAMP)hydrazones.

9 ysts leads to formation of the corresponding hydrazones.

10 bonyls, and diazo compounds as well as tosyl hydrazones.

11 oylhydrazone (1)(4)C-pyridoxal isonicotinoyl hydrazone ((1)(4)C-PIH) and the thiosemicarbazone ((1)(4

12 The set of hydrazones [(1)A(1)B, (1)A(2)B, (2)A(1)B, (2)A(2)B] unde

13 Hydrazone 12z that carried a 2',4'-dichlorobiphenyl resi

14 iodides to propionaldehyde and benzaldehyde hydrazones (3 and 7) under tin hydride radical chain con

15 r 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311), and the iron chelator deferasirox (ICL6

16 Fluorescein hydrazones (3a-3l) were synthesized in three steps with

17 Constitutional dynamic libraries of hydrazones (a)A(b)B and acylhydrazones (a)A(c)C undergo

18 The pyridyl-acyl E-hydrazone acts as a hydrogen bonding template that direc

19 Constitutional dynamic libraries (CDLs) of hydrazones, acylhydrazones, and imines undergo reorganiz

20 The hydrazone adduct appears to be stabilized by two key hyd

21 cilitated the 1,3-dipolar cycloaddition with hydrazones, affording optically active 4-nitropyrazolidi

22 The derivatized hydrazones (aldehyde- and ketone-DNPH derivatives) were

23 e additions of the N-H bonds of benzophenone hydrazone and 1-aminopiperidine to iridium(I) complexes

24 ation with 2-diphenylacetyl-1,3-indandione-1-hydrazone and 1-ethyl-3-(3-(dimethylamino)propyl)carbodi

25 he transition-metal-free coupling of a tosyl hydrazone and a boronic acid to the preparation of a com

26 tinoyl hydrazone and pyridoxal isonicotinoyl hydrazone and demonstrate that the intracellular LIP and

27 protonophore carbonyl cyanide m-chlorophenyl hydrazone and is approximately 10-fold higher in the str

28 l ionophore, carbonyl cyanide m-chlorophenyl hydrazone and other respiratory inhibitors, which pertur

29 obenzoic acids act as superior catalysts for hydrazone and oxime formation, speeding the reaction con

30 While formation of hydrazone and oxime has been traditionally regarded as b

31 conjugate formation included an acid-labile hydrazone and protease-sensitive dipeptides, leading to

32 s derived from salicylaldehyde isonicotinoyl hydrazone and pyridoxal isonicotinoyl hydrazone and demo

33 carbonyl cyanide 4-(trifluoromethoxy)phenyl-hydrazone and regulated by [Ca2+]mito.

34 n molecular shuttles containing pyridyl-acyl hydrazone and succinic amide ester binding sites, the ch

35 catalyzed (3(+) + 2) cycloadditions between hydrazones and alkenes provide a general approach to pyr

36 gurationally labile molecules (for instance, hydrazones and imines), which exhibit isomerization, and

37 The formation of hydrazones and oximes of FTCRI was accomplished by a deh

38 ted hydrazines and alkoxyamines, to generate hydrazones and oximes, respectively.

39 promotes the reaction between ketone-derived hydrazones and silyl ketene acetals, providing the beta,

40 its anticancer activities: diphenylmethane, hydrazone, and dinitrophenyl.

41 weak phosphoric acid does not protonate the hydrazone, and only a hydrogen-bonded complex is formed.

42 erivatives, thiazolidindiones, (thiazol-2-yl)hydrazones, and analogues of marketed drugs.

43 osen because they highlight the diversity of hydrazones, and emphasize their uniqueness vis-a-vis the

44 i) chemical and light activated switching of hydrazones, and how this can be used in controlling the

45 The resulting TSH-hydrazones are separated by ultrahigh-performance liquid

46 N-dimethylaminobenzoyl)-2-hydroxy-1-naphthyl hydrazone as specific inhibitors of RT DNA polymerase or

47 g 1,3-dibenzoylpropane bis-p-toluenesulfonyl hydrazone as the addend precursor.

48 ounds with neighboring acid/base groups form hydrazones at accelerated rates.

49 echanism in these hydrogen-bonded systems is hydrazone-azo tautomerization followed by rotation aroun

50 been chemically conjugated through bis-aryl hydrazone (BAH) moieties.

51 this method to control the diversity of acyl hydrazone based dynamic combinatorial libraries.

52 A hydrazone-based carbene/alkyne cascade produced a variet

53 om a promising lead, a small series of novel hydrazone-based compounds were synthesized and evaluated

54 ic combinatorial library composed of racemic hydrazone-based dipeptides becomes deracemized on bindin

55 d the emission properties of a series of BF2-hydrazone-based dyes as a function of solvent viscosity.

56 Described is a new hydrazone-based exo-directing group (DG) strategy develo

57 By altering the rate of formation of the hydrazone-based gelator from two water-soluble compounds

58 Because the structure of the hydrazone-based inhibitors mimics the redox features of

59 accelerating the acid-catalyzed formation of hydrazone-based supramolecular gelators near the membran

60 This hydrazone-based, pH-controlled, molecular switch is the

61 ert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone (BBNH) inhibits both the DNA polymerase and ri

62 ied (4-t-butylbenzoyl)-2-hydroxy-1-salicylyl hydrazone (BBSH) and (4,N,N-dimethylaminobenzoyl)-2-hydr

63 A series of hydrazones bearing different substituents on the oxazoli

64 -linking process exploits the formation of a hydrazone between a non-natural N(4) -amino-2'-deoxycyti

65 in the chemical links (amide, thioether, and hydrazone) between spacer arm and the various functional

66 s TATp moieties after the degradation of the hydrazone bond and removal of the long PEG chains.

67 A degradable pH-sensitive hydrazone bond between a long shielding PEG chains and P

68 try is based on UV/vis-quantifiable bis-aryl hydrazone bond formation that allows direct quantificati

69 n of antibodies was then carried out through hydrazone bond formation.

70 proposed pathway for the dissociation of the hydrazone bond involves transfer of the electron directl

71 o the doxorubicin moiety of the linker via a hydrazone bond that is stable at pH 7 but hydrolyzes rap

72 step necessary for the transformation of the hydrazone bond to the chemically more stable hydrazine b

73 The resulting hydrazone bond was reduced by sodium cyanoborohydride to

74 Dissociation of the N12-N13 hydrazone bond yielded the two constituent peptides, one

75 eptides through preferential cleavage of the hydrazone bond.

76 ons due to selective cleavage of the N12-N13 hydrazone bond.

77 oth strategies are based on the formation of hydrazone bonds between aldehyde groups on the Fc moieti

78 he organic building units are linked through hydrazone bonds to form extended two-dimensional porous

79 gen bonding, metal coordination, and dynamic hydrazone bonds, allows the reversible recognition of lo

80 ) via reducible disulfide and acid-sensitive hydrazone bonds, respectively.

81 lled through electrophilic chlorination of a hydrazone, but only after adjustment of reactivity to ci

82 lpha-keto esters and formaldehyde tert-butyl hydrazone by BINAM-derived bis-ureas is the key to achie

83 Protonation of hydrazones by N-triflylphosphoramide produces hydrazoniu

84 indazoles were formed selectively from alkyl hydrazones by ring closure with Vilsmeier reagent.

85 zation takes place via a rotation around the hydrazone C=N bond.

86 in the switch induces a rotation around the hydrazone C=N double bond, leading to isomerization.

87 bsequent covalent bond formation between the hydrazone carbon and an oxygen atom is rate controlling.

88 an asymmetric boronate addition to sulfonyl hydrazones catalyzed by chiral biphenols to access enant

89 of ionophore carbonyl cyanide m-chlorophenil hydrazone (CCCP) causes decreased growth in yeast lackin

90 Herein, carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-induced mitochondrial depolarization de

91 nophore) and carbonyl cyanide m-chlorophenyl hydrazone (CCCP; a mitochondrial uncoupler) alter [Ca2+]

92 /breakage of a disulfide bond, while dynamic hydrazone chemistry controls the cargo binding to the pl

93 Using alpha,beta-unsaturated hydrazones, chiral sulfide 7 gave epoxides with high dia

94 -functionalized QDs, which produces a stable hydrazone chromophore with a well-defined optical signat

95 These results suggest that nonpeptidyl, hydrazone class Mpl agonists may be clinically useful an

96 cterization of SB-559457 (SB), a nonpeptidyl hydrazone class of thrombopoietin receptor (Mpl) agonist

97 he basis of existing knowledge, a library of hydrazone compounds was generated for screening by coupl

98 The ligand was generated in situ by hydrazone condensation in water, thereby bypassing the n

99 vatized FodU with Girard reagent T to form a hydrazone conjugate harboring a precharged quaternary am

100 nd lower in vivo toxicity than corresponding hydrazone conjugates.

101 s drug isoniazid can form one, two, or three hydrazone connectivity products, meaning kinetic gelatio

102 y for metal ion binding compared to its keto-hydrazone counterpart.

103 te-directed immobilization of antibodies via hydrazone coupling.

104 Manganese dioxide oxidation of the hydrazone derivative of tert-butyldimethylsilyl acetophe

105 s and verified by X-ray crystallography of a hydrazone derivative.

106 The hydrazone derivatives are generally reliable precursors

107 lyst-controlled reaction with Enders' chiral hydrazone derivatives followed by diastereoselective nuc

108 solid-state organizations of three discotic hydrazone derivatives with dendritic groups attached to

109 formation of both the carbinolamine and the hydrazone derivatives.

110 The combination of a simple hydrazone derivatization step with multistage MS greatly

111 rs with good enantioselectivity even for the hydrazone derived from 2-butanone (methyl vs ethyl, 91%

112 Phosphino hydrazones derived from C(2)-symmetric hydrazines exhibi

113 Moreover, the hydrazone DG can be readily removed, and a one-pot C-H a

114 nthesized from protected primary amines, the hydrazone DGs are shown to site-selectively promote the

115 arization by carbonyl cyanide m-chlorophenyl hydrazone did not induce Parkin translocation to mitocho

116 Metalations of arenes, epoxides, ketones, hydrazones, dienes, and alkyl and vinyl halides are repr

117 Grignard reagents to alpha-epoxy N-sulfonyl hydrazones-directed by the alkoxide of the 1-azo-3-alkox

118 columnar (Colh) organization with nontilted hydrazone discs for all three compounds.

119 We have interfaced these hydrazone dynamic combinatorial libraries with two isozy

120 The set of acyl hydrazones [E-(1)A(1)C, (1)A(3)C, (2)A(1)C, (2)A(3)C] un

121 yde adducts react further to form protonated hydrazones, e.g., CH(3)CH(2)CH[double bond]HNNH(2)(+) fr

122 incorporated into a rotary switch based on a hydrazone enables a switching cascade that involves prot

123 rgo simultaneous dynamic exchange processes: hydrazone exchange and photoisomerization.

124 ial, pure, or mixed-were added by orthogonal hydrazone exchange.

125 chondrial uncoupler p-trifluoromethoxyphenyl hydrazone (FCCP).

126 carbonyl cyanide p-(trifluoromethoxy) phenyl hydrazone (FCCP).

127 where each protein selects the best-fitting hydrazone for the hydrophobic region of its active site.

128 pable of activating different N-arylsulfonyl hydrazones for asymmetric radical cyclopropanation of a

129 and D383N is a tautomeric mixture where the hydrazone form is favored.

130 uilibrium is further shifted in favor of the hydrazone form.

131 ample, TiCl(4) was an efficient catalyst for hydrazone formation and cycloelimination with methylhydr

132 n progress of up to six reactions, including hydrazone formation and Katritzky transamination, can be

133 The developed method includes hydrazone formation and selective beta-halogenation (bro

134 rein, it is shown that, through an efficient hydrazone formation derivatization of N-linked glycans (

135 rface Staudinger ligation is compatible with hydrazone formation from metabolically introduced ketone

136 base-catalyzed Claisen-Schmidt condensation, hydrazone formation from precharged and neutral ketones,

137 Also, a procedure for glycan hydrazone formation is optimized and outlined where a la

138 Following adduct formation, the process of hydrazone formation may be rate limiting at thermal ener

139 he alternative process of C-H insertion with hydrazone formation occurs through the triplet T1 state.

140 Hydrazone formation provided bi-specific MHC heterodimer

141 ions affected the reaction efficiency of the hydrazone formation reaction.

142 Immobilization via hydrazone formation was also shown to be reversible via

143 Oxime or hydrazone formation was then employed to immobilize, flu

144 eagent containing both a hydrazide group for hydrazone formation with carbonyl-containing PLs and a t

145 ramolecular proton transfer during imine and hydrazone formation.

146 or PFTase and as reactants in both oxime and hydrazone formation.

147 The hydrazone functional group has been extensively studied

148 r of the electron directly to the protonated hydrazone functionality and subsequent rearrangement to

149 s the addition of homoenolate equivalents to hydrazones, generating highly substituted gamma-lactams

150 ed a fortuitous kinetic preference for the E-hydrazone geometry during the hydrazonation reaction, as

151 This compound contains an acyl hydrazone group and exhibits higher inhibitory activitie

152 ce-inhibitor carbonyl cyanide m-chlorophenyl hydrazone had no effect.

153 h succinimidyl 6-hydrazinonicotinate acetone hydrazone (HYNIC) and labeled with 99mTc using a coordin

154 duce N-monoalkyl or N,N-dialkyl benzaldehyde hydrazones in 44-87% yield.

155 The switching properties of the hydrazones in both toluene and DMSO were assessed offeri

156 esponsive metallogrids, and (iii) the use of hydrazones in detecting metal cations (Zn(2+), Cu(2+), H

157 ly stable alpha,alpha-disubstituted aldehyde hydrazones in high enantiomeric excess and yield.

158 s of self-assembled systems, (ii) the use of hydrazones in the formation of dynamic and stimuli respo

159 zo reagents, generated in situ from sulfonyl hydrazones in the presence of base, can serve as suitabl

160 Photolysis (300 nm) of alkyl halides and hydrazones in the presence of Mn2(CO)10 and InCl(3) as a

161 Pd-catalyzed selective coupling reaction of hydrazones in the presence of t-BuOLi and benzoquinone t

162 w provides an overview of the utilization of hydrazones in three supramolecular chemistry related are

163 cts serve as superior alternatives to simple hydrazones in Wolff-Kishner-type reduction reactions, in

164 ith NH4Cl or carbonyl cyanide m-chlorophenyl hydrazone, indicating that SWEET17 functions as an energ

165 tophagy upon carbonyl cyanide m-chlorophenyl hydrazone-induced mitochondrial depolarization.

166 Both foscarnet and the hydrazone inhibit RNase H cleavage and DNA polymerizatio

167 he uncoupler carbonyl cyanide m-chlorophenyl hydrazone inhibited AGT(P11LG170R) import into mitochond

168 Negatively charged TSH-hydrazone ions furthermore show a simple and predictable

169 Acyl hydrazone is an important functional group for the disco

170 inetic resolution of racemic alpha-arylamino hydrazones is also described.

171 ediated radical nitration of bisarylsulfonyl hydrazones is described.

172 The formation of oximes and hydrazones is employed in numerous scientific fields as

173 alloradical activation of o-cinnamyl N-tosyl hydrazones is presented, taking advantage of the intrins

174 ol for the reductive coupling of ketones and hydrazones is reported.

175 The formation of oximes and hydrazones is widely used in chemistry and biology as a

176 lpha,beta-unsaturated ester, oxime ether, or hydrazone) is appropriately placed.

177 zed by trace copper salts and that a Z- to E-hydrazone isomerization occurs through an enehydrazine i

178 y screening of biphenyl focused pseudostatic hydrazone libraries formed from hydrazine 10 and 36 biph

179 Screening of small hydrazone libraries targeting gamma-aminobutyric acid tr

180 A family of glyoxal bis-hydrazone ligands containing various 2,5-diarylpyrrolidi

181 1-naphthyldimethylsilanolates and chiral bis-hydrazone ligands has been developed.

182 These results suggest that aniline catalyzed hydrazone ligation has the potential to provide a genera

183 We applied the highly efficient hydrazone ligation to couple 2-hydrozinopyridine (2-HP)

184 t (QD) surfaces that use click chemistry and hydrazone ligation under catalyst-free conditions.

185 ally fast rates of nucleophilic catalysis of hydrazone ligation were observed when polyvalent anthran

186 ation through the formation of an oxime or a hydrazone linkage.

187 cess that relies on the formation of dynamic hydrazone linkages in an acidic aqueous medium.

188 In addition, the labile hydrazone linkages of the individual [2]catenane compone

189 drug release through the use of pH-sensitive hydrazone linkages.

190 l)alanine], which reversibly combine through hydrazone linkages.

191 Here we exfoliate a hydrazone-linked covalent organic framework (COF) to yie

192 njugated with doxorubicin via an acid-labile hydrazone linker as a function of local pH and time with

193 icine prodrug by cancer cells, whereupon the hydrazone linker undergoes hydrolysis in the lysosome to

194 lamin (vitamin B(12)) through an acid-labile hydrazone linker.

195 h glyoxylate- and aliphatic aldehyde-derived hydrazones may be employed, as may variously substituted

196 tituted alpha-keto-1,5-diesters by using the hydrazone moiety as a masked carbonyl group.

197 report on rotaxanes featuring a pyridyl-acyl hydrazone moiety on the axle as a photo/thermal-switchab

198 e] revealed a strong n-pi conjugation in the hydrazone moiety, identified by a high planarity degree

199 nyl)guanidine) followed by hydrolysis of the hydrazone moiety.

200 Discotic hydrazone molecules are of particular interest as they f

201 In this regard, only the binding of hydrazone molecules in the DNA polymerase domain activit

202 fferent tilt/pitch angles between successive hydrazone molecules.

203 The use of hemilabile pyridine-hydrazone N,N-ligands allows the highly selective Ir-cat

204 ered electron-rich primary anilines, primary hydrazones, N,N-dialkylhydrazines, and cyclic primary al

205 ecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), using virtual screening, binding affin

206 relative populations of two rotamers in the hydrazone of 2H-perfluoro-2-methyl-3-pentanone can be al

207 Treatment of the hydrazone of 2H-perfluoro-2-methyl-3-pentanone with trie

208 nd plasma than the conjugates of mAb and the hydrazone of 5-benzoylvaleric acid-AE ester (AEVB).

209 olopyridinium compounds was synthesized from hydrazones of 2-hydrazinylpyridine (HPY) and evaluated a

210 en developed starting from readily available hydrazones of aldehydes and o-(trimethylsilyl)aryl trifl

211 ing diazo compounds that are formed from the hydrazones of benzaldehydes and aryl ketones.

212 re involving the metalation of the SAMP/RAMP hydrazones of N-Boc-azetidin-3-one, reaction with a wide

213 o 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a

214 d compounds belonging to a class of acylated hydrazones of salicylaldehydes, can inhibit the growth o

215 orm of wild type (WT-ECAO) was assigned as a hydrazone on the basis of the X-ray crystal structure.

216 fore the rate-determining cyclization of the hydrazone onto the alkyne group.

217 s not affect carbonyl cyanide m-chlorophenyl hydrazone or apoptosis-induced cleavage.

218 The hydrazone or enehydrazino side chain at the 5-position o

219 nosa exotoxin A, and ovalbumin, using amide, hydrazone, or thioether linkages.

220 In this work, known protocols for hydrazone oxidation were adapted to permit facile access

221 Assisted by the advent of new protocols for hydrazone oxidation, we also provide full details on han

222 ated, in addition to methods reported by us, hydrazone, oxime, and thioether linkages between gammaDP

223 g catalyst-imine intermediates, allows rapid hydrazone/oxime formation even with relatively low conce

224 Donor-acceptor monosubstituted hydrazones participate as suitable reagents able to unde

225 amely, 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH), exhibited nanomolar in vitro activity

226 his approach is generally more applicable to hydrazone perfluoroalkylation using perfluoroalkyl iodid

227 ron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class can restrict the growth of clinica

228 Presumably, the glycosyl-hydrazines/hydrazones present in the mixture did not interfere with

229 In addition to hydrolysis, the hydrazone products are poised to undergo numerous differ

230 stereoselective nucleophilic addition to the hydrazone products constitutes a two-step stereodivergen

231 nt hydrolysis of the beta-hydroxy N-sulfonyl hydrazone products produces the corresponding beta-hydro

232 e neurotransmitter to solutions of dipeptide hydrazones [proline-phenylalanine or proline-(cyclohexyl

233 nd carbonyl cyanide p-trifluoromethoxyphenyl hydrazone rapidly activated the fuel sensor AMP-activate

234 ar core, which is best described as the tris(hydrazone) [rather than tris(azo)] tautomer stabilized b

235 Tosyl hydrazones reacted cleanly with primary and secondary al

236 Boc-hydrazones required electron-withdrawing substituents to

237 iron chelator, salicylaldehyde isonicotinoyl hydrazone, revealed that depletion of cellular iron was

238 d(P/N)Cl(2)] precatalysts [(P/N) = phosphino hydrazone] revealed a strong n-pi conjugation in the hyd

239 d configurational changes within an embedded hydrazone rotary switch that steers the robotic arm.

240 The hydrazone scaffold was active in all of the different as

241 Several compounds based on the diaryl hydrazone scaffold were designed.

242 ith orthogonal dynamic bonds, disulfides and hydrazones, self-organizing surface-initiated polymeriza

243 We describe a family of sulfonyl-hydrazone (Shz) small molecules that can trigger cardiac

244 trong chelator salicylaldehyde isonicotinoyl hydrazone (SIH) in rapidly releasing iron from the iron-

245 l as flash vacuum pyrolysis (FVP) of a tosyl hydrazone sodium salt precursor, to give a number of rea

246 yl motif are accessed from simple alkene and hydrazone starting materials.

247 , but, also in some cases, the rate at which hydrazone stereoisomers interconvert under the reaction

248 are tunable through variation of pyridyl or hydrazone substituents, and they offer favorable photoph

249 coupling with a hindered diortho substituted hydrazone substrate.

250 upling agent carbonyl cyanide m-chlorophenyl hydrazone, suggesting an essential role for TRAF2 in hom

251 TEG functionalization of the hydrazone switch allows for the process to be carried wi

252 oordination-coupled deprotonation (CCD) of a hydrazone switch has been developed.

253 t, efficient, and reversible modulation of a hydrazone switch in methanol using a visible-light activ

254 acing the rotor pyridyl group of our typical hydrazone switch with a phenyl one leads to the long-liv

255 e sequesters the excess of zinc(II) from the hydrazone switch, hence lowering the effective amount of

256 on of a non-coordinating pyridine-containing hydrazone switch.

257 family of easily accessible light-activated hydrazone switches has been developed having thermal hal

258 In our new procedure for silyl hydrazone synthesis, aliphatic and aromatic ketones and

259 , that initiates an E/Z isomerization in the hydrazone system through a coordination-coupled proton t

260 t I is protonated at pH 7 and stabilizes the hydrazone tautomer by a short hydrogen-bonding interacti

261 onstrates that the substrate is present in a hydrazone tautomer conformation.

262 at higher temperatures with no traces of the hydrazone tautomer.

263 veal that SHQ exists predominantly in a keto-hydrazone tautomeric form at applied potentials that are

264 ts with 2,4-dinitrophenylhydrazine forming a hydrazone that is separated from interfering substances

265 densed with hydrazine derivatives to provide hydrazones that underwent cycloelimination.

266 ord the corresponding ionic liquid-supported hydrazones that were converted to 1,2,3-thiadiazoles in

267 imycin A1 or carbonyl cyanide m-chlorophenyl-hydrazone, the stimulation-induced increase in cytosolic

268 anes in up to 85% yield; the corresponding Z-hydrazone thread affords no rotaxane under similar condi

269 ent is exothermic electron transfer from the hydrazone to (1)O(2) leading to an ion-radical caged pai

270 sed to demonstrate that slow addition of the hydrazone to a mixture of oxidant and carboxylic acid av

271 ds and carbenes, although cyclization of the hydrazone to afford a pyrazole can be a complicating fac

272 rable due to the endergonic isomerization of hydrazone to azomethine imine.

273 aOSiMe3 is a superior base for conversion of hydrazones to diazoalkanes.

274 ated ligand can be achieved by hydrolysis of hydrazones to disrupt the sandwich complex structure.

275 r the enantioselective conjugate addition of hydrazones to enals under metal-free conditions and lead

276 ition of alpha-alkoxy-alpha,beta-unsaturated hydrazones to provide E-alkenes with high 1,4-stereocont

277 Using carbonyl cyanide m-chlorophenyl hydrazone treatment, we found that the non-specific accu

278 er carbonyl cyanide p-trifluoromethoxyphenyl hydrazone, tyrphostins AG10 and AG18 increased the rate

279 al trifluoromethylation of aryl N,N-dimethyl hydrazones using TBAI as an initiator and Togni's reagen

280 erization of C horizontal lineN bond in acyl hydrazones, using aromatic thiols as nucleophilic cataly

281 iazomethane generated from the corresponding hydrazone via manganese dioxide oxidation and that forme

282 The alpha-alkylation of N-sulfonyl hydrazones via in situ-derived azoalkenes provides an um

283 de beads through the formation of reversible hydrazone, washing out unbound nonglycans, then releasin

284 hanced up to two hours and the structures of hydrazones were confirmed by LC-MS for the first time.

285 Tosyl- and Boc-hydrazones were found to be effective nucleophiles in th

286 The resulting alpha-arylamino hydrazones were obtained in good yields and excellent en

287 A series of phenolic hydrazones were synthesized and evaluated for their inhi

288 hen stable carba analogues of representative hydrazones were synthesized and evaluated, the best bind

289 ed with 2,4-dinitrophenylhydrazine to obtain hydrazone, which was further treated with potassium hydr

290 ized with Girard P (GP) hydrazine to give GP hydrazones, which are charged species and readily analyz

291 Next, mild treatment of the hydrazone with an excess of piperidine-N,N-dimethylforma

292 ples a chelation-controlled reduction of the hydrazone with an in situ allylic strain controlled retr

293 ess involves the reaction of a ketone trityl hydrazone with tBuOCl to give a diazene which readily co

294 phenylhydrazine (DNPH) to form protein-bound hydrazones with absorbance at 370 nm.

295 ction of alpha-alkyl-beta-hydroxy N-sulfonyl hydrazones with alpha-quaternary centres.

296 Hydrolysis of the resultant hydrazones with aqueous oxalic acid provides the 2-subst

297 lladium catalyzed cross-coupling reaction of hydrazones with aryl halides in the absence of external

298 ect, route to these salts by the reaction of hydrazones with dimethylsulfonium ditriflate is also des

299 rbene transfer reactions, in the reaction of hydrazones with Pd(II) under oxidative conditions, we en

300 The reaction of ionic liquid-supported hydrazones with selenium dioxide in acetonitrile afforde