ライフサイエンスコーパス: hydrogen atom abstraction

1 l reactions, but the addition even more than hydrogen atom abstraction.

2 H bonding orbital in the best trajectory for hydrogen atom abstraction.

3 substrate radical intermediate is formed by hydrogen atom abstraction.

4 tivity of formation of a C4 radical by a 1,5-hydrogen atom abstraction.

5 h initiates opposite strand cleavage via C4'-hydrogen atom abstraction.

6 nitiates enzymatic transformations requiring hydrogen atom abstraction.

7 ps that include a solvent-dependent step and hydrogen atom abstraction.

8 allosteric effects were seen on diffusion or hydrogen atom abstraction.

9 xy radical, which is a selective reagent for hydrogen atom abstraction.

10 n rate, establishing that ABLM is capable of hydrogen-atom abstraction.

11 that an oxo-Mn(V) species is responsible for hydrogen-atom abstraction.

12 ransition-metal phosphinidene synthesized by hydrogen-atom abstraction.

13 ure-inspired pathway of high- and low-energy hydrogen atom abstractions.

14 Hydrogen-atom abstraction affords an achiral benzylic ra

15 complex, with the highest reactivity toward hydrogen-atom abstraction among the three, has the stron

16 ively), and with the nucleoside thymidine by hydrogen atom abstraction and addition at C5 in the base

17 te a copper-bound radical anion, followed by hydrogen atom abstraction and collapse to products, with

18 molecular dynamics confirmed that the 1beta-hydrogen atom abstraction and deformylation or decarbony

19 the thermodynamic unfavorability of both its hydrogen atom abstraction and oligomerization reactions

20 Finally, the hydrogen atom abstraction and proton coupled electron tr

21 substrates in a manner most consistent with hydrogen atom abstraction and provides chemical preceden

22 inglet oxygen scavenging, electron transfer, hydrogen atom abstraction and radical adduct formation.

23 elf-decay by rate-determining intramolecular hydrogen atom abstraction and subsequent formation of a

24 the reaction is not concerted but occurs via hydrogen atom abstraction and subsequent radical rebound

25 s in ((iPr)PDI)Mo(NH3)2(eta(2)-C2H4) enabled hydrogen atom abstraction and synthesis of a terminal ni

26 reacts with acetaldehyde and pivaldehyde by hydrogen atom abstraction and, in the presence of O(2),

27 Both the radical (hydrogen atom abstraction) and nonradical (NH(2) abstrac

28 Hence, the regioselectivity of hydrogen atom abstraction appears to be independent of t

29 nstants for reaction with organic compounds (hydrogen atom abstraction) approach the diffusion-contro

30 molecular isotope effects, that the rates of hydrogen atom abstraction are masked.

31 xperimental data seems to support the direct hydrogen atom abstraction as evidenced by the break in l

32 be expected if the mechanism of MMO involves hydrogen atom abstraction as indicated by many previous

33 The rate constant for hydrogen atom abstraction at 298 K by benzyl radical fro

34 Hydrogen atom abstraction at other sites of the deoxyrib

35 gma*z(2) excitation energy, which raises the hydrogen atom abstraction barrier above that found for t

36 We show that the hydrogen atom abstraction barrier of substrate hydroxyla

37 ever, that are associated with variations in hydrogen-atom abstraction barrier heights and tunneling

38 No evidence for internucleotidyl hydrogen atom abstraction by 1 was detected.

39 limination of the 3'-phosphate following C2'-hydrogen atom abstraction by 1.

40 occurs via beta-fragmentation following C2'-hydrogen atom abstraction by 1.

41 Rate constants for hydrogen atom abstraction by [Mn(2)(O)(2)](3+) and [Mn(2

42 This value is consistent with hydrogen atom abstraction by an electrophilic Fe(O) cent

43 adical clock is based on competition between hydrogen atom abstraction by an intermediate peroxyl rad

44 ed by determination of a rate expression for hydrogen atom abstraction by benzyl radical from 1 (log(

45 re-dependent rate data are also reported for hydrogen atom abstraction by benzyl radical from thiophe

46 idea that PFL-AE accesses Gly-734 for direct hydrogen atom abstraction by binding to the Gly-734 loop

47 ptides has been used to identify the site of hydrogen atom abstraction by hydroxyl radical.

48 lation sequence which are initiated by 1beta-hydrogen atom abstraction by P450 compound I are conside

49 A basis rate expression for hydrogen atom abstraction by sec-phenethyl alcohol, PhC*

50 This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and ad

51 ct is believed to result from intramolecular hydrogen atom abstraction by the C6-peroxyl radical (14)

52 onstants for the chain propagation reactions:hydrogen atom abstraction by the methoxy radical and ele

53 ), a hypothetical product resulting from C1'-hydrogen atom abstraction by the peroxyl radical, could

54 Hydrogen atom abstraction by the resulting methoxy radic

55 m, forming an alkoxy radical which undergoes hydrogen atom abstraction by the tyrosine-cysteine pheno

56 The percentage yield of hydrogen atom abstraction by these radicals was found to

57 te hexahydrate is described as a convenient, hydrogen atom abstraction catalyst that can mediate fluo

58 es suggest that thiolate coordination favors hydrogen-atom abstraction chemistry over oxygen-atom tra

59 photocatalysts for the requisite high-energy hydrogen atom abstraction event.

60 lytic step, which can be summarized by 1beta-hydrogen atom abstraction followed by gem-diol deprotona

61 Both results are consistent with 5'-hydrogen atom abstraction for initiation of the site-sel

62 omplished by measuring the rate constants of hydrogen atom abstraction for novel, charged dehydroquin

63 The data indicate a mechanism of initial hydrogen-atom abstraction forming radicals that dimerize

64 by computations, show that the position for hydrogen atom abstraction from 2,5-DAPn and 2,4-DAB by t

65 thyl groups in 3, followed by intermolecular hydrogen atom abstraction from 2-MeTHF solvent.

66 the adenosine nucleotide of the substrate by hydrogen atom abstraction from an amidine carbon, the 5'

67 an that of 1, possibly due to intramolecular hydrogen atom abstraction from benzylic methyl groups in

68 e that TPZ-mediated strand damage arises via hydrogen atom abstraction from both the most hindered (C

69 radical generator, which initiates repair by hydrogen atom abstraction from C-6 of SP.

70 Hydrogen atom abstraction from C2' in DNA under aerobic

71 lysed ring contraction reaction initiated by hydrogen atom abstraction from C2'.

72 rmal conditions, the benzyl radicals undergo hydrogen atom abstraction from dibenzyl ketone and para-

73 uces vinyl radical intermediates that affect hydrogen atom abstraction from DNA, leading to the forma

74 Transition states for 1beta-hydrogen atom abstraction from enolized substrates in th

75 These radicals can affect hydrogen atom abstraction from methanol and acetone.

76 n its chemistry than previously anticipated: hydrogen atom abstraction from Nalpha-cyclopropyltryptop

77 Hydrogen atom abstraction from NHC-BH(2)Ar groups produc

78 Moreover, a Hammett analysis of hydrogen atom abstraction from para-X-benzyl alcohol rev

79 hygromycin B consistent with metal-catalyzed hydrogen atom abstraction from substrate.

80 1beta-Hydrogen atom abstraction from substrates in the presenc

81 vity trends observed for these radicals upon hydrogen atom abstraction from tetrahydrofuran and 2-met

82 in this reaction was determined to occur by hydrogen atom abstraction from the 4'- and 5'-positions

83 xyuridin-6-yl involve pi-bond addition to or hydrogen atom abstraction from the adjacent nucleotides

84 sotopically labeled amino acids, we rule out hydrogen atom abstraction from the alpha-carbon as the i

85 The tandem lesion (17) resulting from hydrogen atom abstraction from the C1' position of the a

86 Hydrogen atom abstraction from the C5'-position of nucle

87 Hydrogen atom abstraction from the C5'-position of nucle

88 idence suggests DNA cleavage is initiated by hydrogen atom abstraction from the deoxyribose backbone.

89 directly cause DNA strand scission after C4' hydrogen atom abstraction from the deoxyribose moiety.

90 This paper provides support for 5'-hydrogen atom abstraction from the deoxyribose ring as t

91 hanisms as well as the proposal that initial hydrogen atom abstraction from the fatty acid is the fir

92 henyl radical and HO(*), but mainly react by hydrogen atom abstraction from the methyl group (some ad

93 ransfer from one SAM equivalent, followed by hydrogen atom abstraction from the methyl group by a 5'-

94 specific dehydrogenation of 3MI via initial hydrogen atom abstraction from the methyl group.

95 eration of the purine radical resulting from hydrogen atom abstraction from the N6-amine of 2'-deoxya

96 activated oxygen species thought to mediate hydrogen atom abstraction from the nearest substrate car

97 Formal hydrogen atom abstraction from the nitrogen-hydrogen bon

98 determining step is generally accepted to be hydrogen atom abstraction from the pentadiene subunit of

99 determining step is generally accepted to be hydrogen atom abstraction from the pentadiene subunit of

100 s favored by approximately 4-5-fold over C1'-hydrogen atom abstraction from the respective deoxyribos

101 orresponding tetraamine, suggesting that the hydrogen atom abstraction from the solvent is primarily

102 ggest that Co-C bond homolysis is coupled to hydrogen atom abstraction from the substrate and that th

103 active intermediate that results from formal hydrogen atom abstraction from the thymine methyl group.

104 Fe(IV), kH2O/kD2O = 2.8, is consistent with hydrogen atom abstraction from water.

105 In recent computational studies of hydrogen-atom abstraction from amino acid derivatives, t

106 Hydrogen-atom abstraction from M-E(H) to generate M hori

107 Hydrogen-atom abstraction from nickel(I) phosphide and a

108 iates play a major role and are generated by hydrogen-atom abstraction from substrate C-H bonds or in

109 ate detected prior to DNA cleavage following hydrogen-atom abstraction from the C-4' of a deoxyribose

110 gue show that DNA cleavage occurs through 4'-hydrogen-atom abstraction from the DNA backbone and oxid

111 Hydrogen atom abstraction (HAA) from 1,4-cyclohexadiene

112 ters that enables 1e(-) activation of O2 for hydrogen atom abstraction (HAA) of substrate C-H bonds a

113 Four different pathways were considered: (1) hydrogen atom abstraction (HAA) of the Pd-H bond by mole

114 e decomposition via intra- or intermolecular hydrogen-atom abstraction (HAA) from an imido aryl ortho

115 understanding the basis for the high rate of hydrogen atom abstraction (HAT) from dihydroanthracene (

116 ts on the thermodynamics and kinetics of its hydrogen-atom abstraction (HAT) reactions.

117 xperimental/theoretical study suggested that hydrogen atom abstraction in TAA by DPPH was located on

118 The reaction involves hydrogen atom abstraction in the transition state, and t

119 es of an apparent preference for alternative hydrogen-atom abstractions in which complexes 1 and 7/8

120 Hydrogen atom abstraction is another plausible pathway b

121 Internucleotidyl hydrogen atom abstraction is effected selectively by the

122 et up that explains how the rate constant of hydrogen atom abstraction is proportional to the differe

123 A new transition state model for hydrogen atom abstraction is proposed.

124 AA and LA as substrate, is large indicating hydrogen atom abstraction is the principle rate-determin

125 Hydrogen-atom abstraction is selective, preferentially p

126 retro-Bergman ring opening predominates over hydrogen atom abstraction (k-1 > k2) for 6,7-diethynylqu

127 energies, rather than pK(a)'s, suggesting a hydrogen atom abstraction mechanism.

128 ransfer step preceding deprotonation or to a hydrogen atom abstraction mechanism.

129 We probed their hydrogen atom abstraction mechanisms and regiochemical p

130 The fact that hydrogen atom abstraction occurs at C-3 also sheds light

131 ensity functional theory calculations on the hydrogen atom abstraction of propene by a range of diffe

132 of iron and oxygen mediate DNA damage by 4'-hydrogen atom abstraction of pyrimidines 3' to guanines.

133 be intercepted at the 5-exo stage via either hydrogen atom abstraction or C-S bond scission or allowe

134 The generated radicals undergo reduction via hydrogen atom abstraction or reductive cyclization.

135 oyl radicals, which can be formed via direct hydrogen atom abstraction or via an electron-transfer-pr

136 s the origin of the reactivity preference of hydrogen-atom abstraction over nucleophilic addition.

137 react with hydrocarbon substrates through a hydrogen atom abstraction pathway and raise the intrigui

138 )-superoxo species are capable of performing hydrogen atom abstraction processes.

139 ethoxypyridinium cations, in addition to the hydrogen atom abstraction product.

140 tent with the amination proceeding through a hydrogen atom abstraction, radical rebound type mechanis

141 )(hp)(4)Cl]-promoted C-H amination involving hydrogen-atom abstraction/radical recombination and the

142 The hydrogen atom abstraction rate constant (k(H)) was obser

143 10(3) M(-1) s(-1), respectively, both having hydrogen atom abstraction rate constants orders of magni

144 nism for the reaction that is initiated by a hydrogen atom abstraction reaction, which enables a keto

145 igh (D)k value is consistent with an initial hydrogen atom abstraction reaction.

146 rizability change and barrier height for the hydrogen atom abstraction reaction.

147 vealed a logarithmic correlation between the hydrogen-atom abstraction reaction efficiencies and the

148 No correlation was found between the hydrogen-atom abstraction reaction efficiencies and the

149 ogarithmic correlation was found between the hydrogen-atom abstraction reaction efficiencies and the

150 Hydrogen-atom abstraction reaction efficiencies for two

151 Thus, the hydrogen-atom abstraction reaction efficiency for an ary

152 onal potential energy surface for the direct hydrogen-atom abstraction reaction of the deoxyribose 4'

153 A time-resolved kinetic study of the hydrogen atom abstraction reactions from phenol by the c

154 ; however, the reverse trend is obtained for hydrogen atom abstraction reactions.

155 Manganese(III)-peroxo can react through hydrogen-atom abstraction reactions instead of the commo

156 Examination of the hydrogen-atom abstraction reactions of 29 different aryl

157 ) to other coordination complexes capable of hydrogen atom abstraction shows that, although a strong

158 llowing order of radical stabilities for the hydrogen atom abstractions: sp2 centers > heteroatom sp3

159 oes not proceed through the rate-determining hydrogen atom abstraction step that occurs in alcohol ox

160 nd anti isomers of adduct 7b showed that the hydrogen atom abstraction step was significantly more st

161 protein environment catalyzes the substrate hydrogen atom abstraction step with a remarkably low fre

162 results reveal that the enzyme catalyzes the hydrogen-atom abstraction step with a remarkably low fre

163 This intermediate reacts via an initial hydrogen-atom abstraction step, performing subsequent ha

164 for acetol formation reflects rate-limiting hydrogen atom abstraction; the lower isotope effect for

165 tone or an alkene changes the chemistry from hydrogen atom abstraction to double bond addition.

166 At higher energies, spin-allowed hydrogen atom abstraction to form FeOH(+) predominates.

167 een explored by determination of kinetics of hydrogen atom abstraction to form the radical Cp*Mo(mu-S

168 HmaS performs hydrogen-atom abstraction to yield benzylic hydroxylated

169 ent reactivities exhibited by these enzymes (hydrogen-atom abstraction vs. aromatic electrophilic att

170 Hydrogen atom abstraction was the only reaction observed

171 P450s to catalyze amine N-dealkylations via hydrogen atom abstraction when such a course is electron

172 beta-scission reactions are faster than 1,5-hydrogen atom abstractions when the incipient carbon rad

173 reactive radicals are most selective toward hydrogen atom abstraction, while the most reactive radic

174 theta = 2.303RT, was determined by competing hydrogen atom abstraction with radical self-termination.

175 lic radicals react with sugars via exclusive hydrogen atom abstraction, with adenine and uracil almos