ライフサイエンスコーパス: hydrogenolysis

1 onverted to the alkaloid australine (3) upon hydrogenolysis.

2 subsequently be removed in a single step by hydrogenolysis.

3 osphorylated hexasaccharide by hydrogenation/hydrogenolysis.

4 ng inhibition by H2, also observed in alkane hydrogenolysis.

5 es that suffer alpha-ketol mediated transfer hydrogenolysis.

6 d by one-step catalytic (Pd/C) hydrogenation/hydrogenolysis.

7 roup and organometallic addition followed by hydrogenolysis.

8 tituent, which could be removed by catalytic hydrogenolysis.

9 sters, by further esterification followed by hydrogenolysis.

10 orary blocking groups removable by catalytic hydrogenolysis.

11 ion of the aryl iodide followed by catalytic hydrogenolysis.

12 at near theoretical yields during subsequent hydrogenolysis (47 mole % of Klason lignin for beech and

13 ubstituted isoxazoles by SN Ar reactions and hydrogenolysis allows access to useful products.

14 depolymerization can be accomplished through hydrogenolysis, although the development of catalysts ba

15 ination by reductive elimination rather than hydrogenolysis and (ii) sequestration of metals as sulfi

16 the protective groups in (-)-29 followed by hydrogenolysis and decarboxylation afforded the cross-li

17 yield and provided a substrate suitable for hydrogenolysis and deprotection.

18 of the 4-O-5 linkage is cleaved via parallel hydrogenolysis and hydrolysis.

19 tely functionalized benzylamine, followed by hydrogenolysis and lactam formation.

20 use of the ligand lability, 2 also undergoes hydrogenolysis and rapid exchange with labeled NH(3).

21 s, namely selective oxidation, hydrogenation/hydrogenolysis and reforming of biomass derived molecule

22 aldehyde, olefination, tandem hydrogenation/hydrogenolysis, and cyclization upon reaction with 4-bro

23 shed some light on the mechanism of epoxide hydrogenolysis, and further, deuterium labeling studies

24 es (ca. 5 s) were observed in Pd/C-catalyzed hydrogenolysis, and several intermediates were seen in N

25 at the picolinyl ether is readily removed by hydrogenolysis at atmospheric pressure and room temperat

26 C-O hydrogenolysis becomes the preferred deoxygenation route

27 The rate difference of the hydrogenolysis between two diastereomeric epoxide interm

28 map out a plausible mechanism of aryl ether hydrogenolysis catalyzed by nickel.

29 debenzylated aminoindolizidines by selective hydrogenolysis catalyzed by Pt/C or Pd/C, respectively,

30 ies with final deprotection by hydrogenation/hydrogenolysis caused by the presence of galacturonic ac

31 up that is conveniently removed via benzylic hydrogenolysis concomitantly with the catalytic hydrogen

32 The group is stable to mild acid, base, hydrogenolysis conditions, and lithium/halogen exchange

33 corresponding DTPA analogues under very mild hydrogenolysis conditions.

34 onverted into ortho-alkylated alcohols under hydrogenolysis conditions.

35 vity outcome (inversion vs retention) of the hydrogenolysis depends on the tertiary benzylic alcohol

36 pplications in olefin polymerization, alkane hydrogenolysis, depolymerization of branched polymers, r

37 Ethane hydrogenolysis displayed significant structure sensitivi

38 ce of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted

39 numerous catalytic processes (hydrogenation, hydrogenolysis, etc.).

40 ) to a cyanohydrin (3) which is subjected to hydrogenolysis followed by lactamization and reduction t

41 agent; (2) deprotection of the "top" unit by hydrogenolysis, followed by exhaustive aryl triflate for

42 epoxidation of the Delta(6)-double bond, and hydrogenolysis/hydrogenation of the 5,6-epoxy enone syst

43 e hydrogenation of the C=N bond, followed by hydrogenolysis-hydrolysis.

44 nanoribbons could remarkably prohibited the hydrogenolysis in chemoselective hydrogenation of C=C bo

45 erent selectivity of acyl formation and acyl hydrogenolysis in hydroformylation reactions.

46 The catalytic C-O hydrogenolysis is shown to have significant scope, and t

47 n is selective for the iodomethyl group over hydrogenolysis-labile protecting groups, such as benzylo

48 of these diastereoisomeric lactones through hydrogenolysis, N-Boc protection, reduction, methanolysi

49 1 is alternatively synthesized upon hydrogenolysis of (BDI)Nb(N(t)Bu)Me2 in the presence of

50 The Hammett plot of the hydrogenolysis of 4-methoxyacetophenone displayed two op

51 e empirical rate law was determined from the hydrogenolysis of 4-methoxyacetophenone: rate = kobsd[Ru

52 Hydrogenolysis of [Cp(PMe(3))Rh(Me)(CH(2)Cl(2))](+)BAr'(

53 Hydrogenolysis of a p-nitrobenzyl ester is effected usin

54 y not being fully determined until the final hydrogenolysis of a platinum acyl intermediate.

55 gous Mukaiyama reaction and a stereospecific hydrogenolysis of a tertiary benzylic center using Pd/C

56 ct, noncatalytic quantitative observation of hydrogenolysis of acyl dicarbonyls.

57 lead to a mixture of products from competing hydrogenolysis of aliphatic C-O bonds and hydrogenation

58 Currently, the hydrogenolysis of aromatic C-O bonds requires heterogene

59 synthesized and employed as catalyst for the hydrogenolysis of aryl ethers as models for lignin.

60 Mechanistic studies of the hydrogenolysis of aryl ethers by nickel were undertaken

61 erogeneous nickel catalyst for the selective hydrogenolysis of aryl ethers to arenes and alcohols gen

62 eld by coupling of two monomers, followed by hydrogenolysis of benzyl ether protecting groups.

63 esis, microwave-assisted palladium-catalyzed hydrogenolysis of benzyl ethers was used to reduce react

64 yromellitate (27b) was obtained by catalytic hydrogenolysis of benzyl tri-l-menthyl pyromellitate (31

65 2) to produce the hydrogen necessary for the hydrogenolysis of C-S bonds and the removal of sulfur.

66 d to exhibit high catalytic activity for the hydrogenolysis of carbonyl compounds to yield the corres

67 Selective hydrogenolysis of cyclic and linear ether C-O bonds is a

68 report detailed mechanistic analysis of the hydrogenolysis of diaryl ethers catalyzed by the combina

69 oduct (2-methyl furan) in catalytic transfer hydrogenolysis of furfural at low temperatures.

70 ts and provide a general description for the hydrogenolysis of hydrocarbons.

71 Hydrogenolysis of lignin model compounds highlights the

72 Hydrogenolysis of n-butane catalyzed by these hydrides w

73 ne derivatives underwent palladium-catalyzed hydrogenolysis of one C-F bond at atmospheric pressure,

74 Selective hydrogenolysis of the aromatic carbon-oxygen (C-O) bonds

75 Dihydroxylation of the alkene followed by hydrogenolysis of the benzyl protecting groups results i

76 We report the chemo- and regioselective hydrogenolysis of the C-O bonds in di-ortho-substituted

77 Hydrogenolysis of the cyclometalated rhodium dichloride

78 d to the methyl-substituted enye 20, through hydrogenolysis of the derived bromide 19.

79 he Ir-H bond of (Phebox)Ir(OAc)(H), and (ii) hydrogenolysis of the Ir-alkyl bond of (Phebox)Ir(OAc)(n

80 e for key sigma-complex intermediates in the hydrogenolysis of the iridium-methyl bond of (PONOP)Ir(H

81 rbon cleavage, while under basic conditions, hydrogenolysis of the metal-carbon bond was predominant.

82 Hydrogenolysis of the resultant polymers affords the pol

83 on with subsequent Bronsted acid cocatalyzed hydrogenolysis of the resulting oxa- or azarhodacyclohep

84 Transfer hydrogenolysis of the resulting ruthenium(II) diolate me

85 The catalytic hydrogenolysis of the titanium-amide bond in (eta(5)-C5M

86 The hydrogenolysis of titanium-nitrogen bonds in a series of

87 the C-O of fatty acid esters, leading to the hydrogenolysis of triglycerides.

88 ecarbonylation (C-C cleavage) instead of C-O hydrogenolysis on Ir, Pt, and Ru, leading to strong inhi

89 pha-O-4 and beta-O-4 linkages are cleaved by hydrogenolysis on Ni, while the C-O bond of the 4-O-5 li

90 as esterification, Suzuki-Miyaura coupling, hydrogenolysis, or Petasis borono-Mannich.

91 r easily reduced functionality by controlled hydrogenolysis over Lindlar catalyst.

92 f the acetyl protected aglycons, followed by hydrogenolysis over Pearlman's catalyst.

93 eactions favored on terrace sites, while C-C hydrogenolysis prefers sites with lower coordination, be

94 ther analysis reveals that hydrogenation and hydrogenolysis products are generated by parallel ECH pa

95 Methyl substituents at C-C bonds influence hydrogenolysis rates and selectivities of acyclic and cy

96 C-O hydrogenolysis rates are independent of H2 pressure and

97 n-alkyl R-groups exerted opposite effects on hydrogenolysis rates in homogeneous versus heterogeneous

98 Branched alkyl R-groups decreased hydrogenolysis rates relative to their straight-chain ho

99 euterium isotope effect was observed for the hydrogenolysis reaction catalyzed by 1/p-X-C6H4OH with a

100 d atomic charge distributions and calculated hydrogenolysis reaction energies.

101 y the structural changes were evaluated by a hydrogenolysis reaction of strained species resulting in

102 t mechanistic pathways are presented for the hydrogenolysis reaction on the basis of these kinetic an

103 cross metathesis followed by a hydrogenation/hydrogenolysis reaction stereoselectively formed the pip

104 Some C-C bond hydrogenolysis reactions also have been examined includi

105 d from 0.7 to 7 nm; these trends reflect C-O hydrogenolysis reactions favored on terrace sites, while

106 Hydrogenolysis reactions of palladium(II) hydroxide and

107 ontinued utility of such approaches even for hydrogenolysis reactions, with complexity seemingly beyo

108 s indicate each safener can undergo stepwise hydrogenolysis (replacement of chlorine by hydrogen) in

109 zyl phosphite phosphorylation and subsequent hydrogenolysis sequence (3b --> 3c --> 3d).

110 The first hydrogenolysis step generates compounds similar (in one

111 n that they incorporate an alkylation in the hydrogenolysis step to close the second ring of the azab

112 A final hydrogenolysis step to remove the protective groups prod

113 novel heterogeneous catalytic hydrogenation-hydrogenolysis strategy has been developed for the alpha

114 rrangement and a regioselective cyclopropane hydrogenolysis, the total synthesis of 9-epi-pentalenic

115 d identify Bronsted acid cocatalyst assisted hydrogenolysis to be the most difficult step.

116 The ratio of C-O hydrogenolysis to decarbonylation rates increased almost

117 ed N-benzyl tetrazoles can be deprotected by hydrogenolysis to form the corresponding NH tetrazoles i

118 mono- and dicarbonyl intermediates and their hydrogenolysis to give aldehydes.

119 N) in benzene at reflux for 36 h resulted in hydrogenolysis to give ethyl hexanoate (60%), whereas no

120 eprotected by catalytic (Pd/C) hydrogenation/hydrogenolysis to give the desired, amino-functionalized

121 -phosphorylation, followed by desilation and hydrogenolysis to the free mono- and diphosphates, and,

122 In the final synthetic step, hydrogenolysis was applied to remove the thiol handle fr

123 The use of bicarbonate in the hydrogenolysis was key in providing protection of the py

124 -4 and beta-O-4 linkages can undergo further hydrogenolysis, while phenol (produced by hydrolysis of

125 zylamide and lactams which are refractory to hydrogenolysis with hydrogen and a catalyst.

126 -ylsulfonyl)hexanoate underwent quantitative hydrogenolysis within 1 h under these conditions.

127 otection by ester saponification followed by hydrogenolysis yielded the free procyanidins, which were