1 We demonstrate that the
hydrogenosomal AAC can be targeted to the inner membrane
2 The
hydrogenosomal AAC contains a cleavable, N-terminal pres
3 te that the membrane-targeting signal(s) for
hydrogenosomal AAC is internal, similar to that found fo
4 Interestingly, a comparison of
hydrogenosomal and mitochondrial protein presequences re
5 While both
hydrogenosomal and mitochondrial succinyl-CoA synthetase
6 rodimer for accurate cleavage, while shorter
hydrogenosomal and mitosomal presequences did not.
7 TvFd, a member of the
hydrogenosomal class of ferredoxins, possesses a unique
8 Phylogenetic analyses of
hydrogenosomal complex I-like proteins Ndh51 and Ndh24 r
9 0 in a clade that includes mitochondrial and
hydrogenosomal cpn60 proteins.
10 irmed the mitochondrial affiliation of these
hydrogenosomal enzymes, in contrast to previous results.
11 of hydrogenosomes, and decreased amounts of
hydrogenosomal enzymes.
12 ory complex I that is coupled to the central
hydrogenosomal fermentative pathway to form a hydrogenos
13 It is the first
hydrogenosomal ferredoxin to have its structure determin
14 Biochemical analysis of
hydrogenosomal Hsp60 shows that the mature protein isola
15 Moreover, phylogenetic analyses of
hydrogenosomal Hsp70, Hsp60, and Hsp10 show that these p
16 As is the case for experimentally verified
hydrogenosomal matrix enzymes from N. frontalis, the [Fe
17 ydrogenosomal fermentative pathway to form a
hydrogenosomal oxidoreductase complex that seems to func
18 ing purified hydrogenosomes and radiolabeled
hydrogenosomal precursor ferredoxin (pFd), we demonstrat
19 ng peptidase (HPP), is capable of cleaving a
hydrogenosomal presequence in vitro, in contrast to MPP
20 The purified recombinant protein, named
hydrogenosomal processing peptidase (HPP), is capable of
21 tochondrial AAC- deficient yeast strain, the
hydrogenosomal protein was correctly targeted to the yea
22 Analyses of the activity of
hydrogenosomal proteins in Fd KO cells show a fourfold i
23 imilar to presequences found on all examined
hydrogenosomal proteins.
24 nsion reminiscent of known mitochondrial and
hydrogenosomal targeting signals.
25 features of this enzyme, including predicted
hydrogenosomal targeting signals.
26 TC-driven ATP synthesis, but also possessing
hydrogenosomal-
type pyruvate metabolism and substrate-le