ライフサイエンスコーパス: hydrolase

1 -associated proteins, such as leukotriene A4 hydrolase.

2 anandamide catabolic enzyme fatty acid amide hydrolase.

3 damide-catabolizing enzyme, fatty acid amide hydrolase.

4 by overexpression of an endogenous cell wall hydrolase.

5 action specificity characteristic of epoxide hydrolase.

6 llular levels of MepS, a cross-link-specific hydrolase.

7 veals that the protein is an alpha/beta-fold hydrolase.

8 s encoding glyosyltransferases and bile salt hydrolases.

9 an uncharacterized lipase and/or of multiple hydrolases.

10 f which shares sequence homology to glycosyl hydrolases.

11 n is aided by digestion assays with glycosyl hydrolases.

12 ctable cross-reactivity against other serine hydrolases.

13 n by disrupting the trafficking of lysosomal hydrolases.

14 of expression of the WalRK TCS regulon of PG hydrolases.

15 nt of DPHP was produced from EHDPHP by serum hydrolases.

16 binding site and shares similarity to known hydrolases.

17 w-molecular-weight PBPs, which are typically hydrolases.

18 antimicrobial hydrolytic activities, termed hydrolases.

19 ges from what occurs in serine-dependent MCP hydrolases.

20 f targeting mycomembrane biosynthesis serine hydrolases.

21 e-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate canc

22 e annotated Rv2672 as mycobacterial secreted hydrolase 1 (Msh1).

23 des an ortholog of neutral cholesterol ester hydrolase 1 (NCEH-1), an IIS downstream protein that was

24 CsBGlu12 has a characteristic glucoside hydrolase 1 family (alpha/beta)8 triose-phosphate isomer

25 Glycoside hydrolase 12 (GH12) proteins act as virulence factors an

26 Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN suscept

27 Peptidyl-tRNA hydrolase 2 (PTRH2) regulates integrin-mediated pro-surv

28 pansins and xyloglucan endotransglucosylases/hydrolases, (2) down-regulation of chlorophyll biosynthe

29 activity towards UCHL5 (ubiquitin-C-terminal hydrolase-5).

30 per of human sperm via binding to the serine hydrolase ABHD2.

31 These hydrolases acquire a mannose 6-phosphate tag by the acti

32 ting membrane, and protect it from lysosomal hydrolase action.

33 entify which endocytic compartments are acid hydrolase active.

34 ke experiments, we have also shown that acid-hydrolase-active endolysosomes and acid-hydrolase-inacti

35 al endocytic compartment is composed of acid-hydrolase-active, acidic endolysosomes and acid hydrolas

36 functions are in nucleotide binding (20.9%), hydrolase activities (10.6%), kinase activities (7%), an

37 he two BioH proteins show remarkably similar hydrolase activities and substrate specificity.

38 ith PelA, an enzyme with PEL deacetylase and hydrolase activities.

39 Among known allergens, hydrolase activity and detectable IgE/IgG reactivity are

40 in yju3Delta mutants restored cellular FAEE hydrolase activity and FAEE catabolism.

41 sphate starvation response and implicate WTA hydrolase activity as a determinant of functional proper

42 xylase mRNA expression, implicates bile salt hydrolase activity as a potential mechanism of action.

43 acetylase activity of PelA increases and its hydrolase activity decreases when these proteins interac

44 protein extract possessed higher lipid acyl hydrolase activity emphasizing its preservation.

45 Therefore, nsP3 mono(ADP-ribosyl)hydrolase activity is critical for CHIKV replication in

46 The NlpC/p60 peptidoglycan hydrolase activity of SagA is required and generates mur

47 ndent tyrosyl-DNA phosphodiesterase 2 (TDP2) hydrolase activity on stalled TOP2cc.

48 MSI data set of a high-throughput glycoside hydrolase activity screen comprising 384 samples arrayed

49 tive site residue mutant reveal cyclopropane hydrolase activity that converts the electrophilic cyclo

50 for detecting exo- and endo-acting glycoside hydrolase activity using commercial enzymes, and demonst

51 Mutant viruses lacking hydrolase activity were unable to replicate in mammalian

52 This gene encodes an enzyme with lipid hydrolase activity, important for development and mainte

53 t S406 to decrease its triacylglycerol (TAG) hydrolase activity, lowering basal lipolysis in adipose

54 function most F-ATP synthases possess an ATP-hydrolase activity, which is coupled to proton-pumping a

55 urine liver largely reduced in vitro acid RE hydrolase activity.

56 onstrates that it possesses potent NAD(P)(+) hydrolase activity.

57 study, we found that murine LAL exhibits RE hydrolase activity.

58 y, we demonstrate that CES2 has triglyceride hydrolase activity.

59 secretory proteins revealed an enrichment of hydrolase activity.

60 e variant enzyme did not have any detectable hydrolase activity.

61 the ULD, resulting in loss of BAP1 ubiquitin hydrolase activity.

62 noncanonical Drosophila homologs of the SAH hydrolase Ahcy (S-adenosyl-L-homocysteine hydrolase [SAH

63 Human leukotriene (LT) A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional enzym

64 pendent proximity ligation (ADPL), to serine hydrolase and cysteine protease enzymes enables quantifi

65 ses: increased expression of the AtlA murein hydrolase and decreased expression of wall-teichoic acid

66 PCL is dependent upon the AtlA murein hydrolase and is regulated, in part, by the SrrAB two-co

67 antiallodynic effects with fatty acid amide hydrolase and monoacylglycerol lipase inhibitors in pacl

68 nabinoid-regulating enzymes fatty acid amide hydrolase and monoacylglycerol lipase produce reliable a

69 sults indicate that LAL is the major acid RE hydrolase and required for functional retinoid homeostas

70 evel view of the first reported cyclopropane hydrolase and support for a specific mechanistic role of

71 Globally, 9,003 sequences for glycoside hydrolases and lytic polysaccharide mono-oxygenases targ

72 ymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a co

73 gestive organ, whereas subsequent ones carry hydrolases and nutrient transporters, together with a gl

74 by a concerted action of peptidoglycan (PG) hydrolases and PG-synthesizing/modifying enzymes.

75 a directed fragment library targeting serine hydrolases and related enzymes.

76 ies including type-III polyketide synthases, hydrolases, and cytochrome P450s related to known fatty

77 Serine hydrolases are a diverse enzyme class that plays fundame

78 Such wall hydrolases are modular enzymes, composed of discrete dom

79 Cyanuric acid hydrolases are of industrial importance because of their

80 Organophosphate hydrolases are proficient catalysts of the breakdown of

81 Serine hydrolases are susceptible to potent reversible inhibiti

82 at pathogenic bacteria, given that cell wall hydrolases are ubiquitous in nature.

83 essing recombinant Aspergillus niger epoxide hydrolase as the model enzyme for various enantioselecti

84 lated probe identified Pks13 and Ag85 serine hydrolases as major targets.

85 xport of transmembrane cargoes and lysosomal hydrolases at the trans-Golgi network (TGN) are well und

86 uence a previously identified plastidial FMN hydrolase AtcpFHy1 (At1g79790), belonging to the haloaci

87 mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode

88 ies that match the most-efficient redesigned hydrolases based on natural protein scaffolds.

89 polyaniline nano-composite as transducer for hydrolase-based biosensors is proposed.

90 ss an armory of granule-localized toxins and hydrolases believed to contribute to pathology in inflam

91 PBPs that act as transpeptidases rather than hydrolases, but they do not cross-link peptidoglycan.

92 These findings suggest that glycoside hydrolases can exhibit activity against diverse microorg

93 Our results suggest that serum hydrolases can significantly contribute to the in vivo l

94 comprising an N-terminal family 81 glycoside hydrolase catalytic module, an internal family 6 carbohy

95 The lysosomal hydrolase cathepsin B (CTSB) is a known activator of try

96 studied CTSB regulation by another lysosomal hydrolase, cathepsin D (CTSD), using mice with a complet

97 these proteins as cyclopropanoid cyclopropyl hydrolases (CCHs) that can catalyze the hydrolysis of th

98 We show that cholesterol epoxide hydrolase (ChEH) metabolizes 5,6-EC into cholestane-3bet

99 A null mutant of 3-hydroxyisobutyryl-CoA hydrolase (CHY4, At4g31810) resulted in an embryo lethal

100 ological evidence that the bacterial epoxide hydrolase Cif disrupts resolution pathways during bacter

101 y of the desirable, highly efficient cocaine hydrolases (CocHs) that can efficiently detoxify and ina

102 These hydrolases comprise an array of lipases, glycosidases, a

103 capping domain insert within the alpha/beta hydrolase core.

104 therefore hypothesized that these glycoside hydrolases could exhibit antibiofilm activity and, furth

105 echanism in Salmonella wherein peptidyl-tRNA hydrolase counteracts TacT-dependent growth arrest, expl

106 e show that a secreted P. aeruginosa epoxide hydrolase, cystic fibrosis transmembrane conductance reg

107 we investigated whether fumarylacetoacetate hydrolase deficient (FAH(-/-)) pigs, a novel large-anima

108 4 synthase KO or mice transplanted with LTA4 hydrolase-deficient bone marrow.

109 nce of the restriction factor SAMHD1, a dNTP hydrolase (dNTPase) and RNase, on HBV replication.

110 Alpha/beta hydrolase domain (ABHD)-containing proteins are structur

111 the (ox)lipid-metabolizing enzyme alpha/beta-hydrolase domain 3 (ABHD3).

112 e inhibitory axon terminal, or by alpha-beta-hydrolase domain 6, which is co-localized presynapticall

113 Alpha-beta Hydrolase Domain Containing 5 (ABHD5) is a key regulator

114 that supports a periplasmic carbon-nitrogen hydrolase domain containing a Cys-Glu-Lys catalytic tria

115 may reflect the presence of a peptidoglycan hydrolase domain in the alpha-helical region (amino acid

116 Alpha-beta hydrolase domain-containing 5 (ABHD5), the defective gen

117 is conveyed by the orphan enzyme alpha/beta hydrolase domain-containing protein 2 (ABHD2).

118 pen beta-propeller appended to an alpha/beta hydrolase domain.

119 lix cap domain on top of a common alpha/beta hydrolase domain.

120 vates LPL by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 renders LP

121 Recombinant hydrolase domains from these proteins (Sph3h from A. fum

122 Proteins containing glycoside hydrolase domains have recently been identified within t

123 ECEPTOR KINASE 1 (CERK1) and alpha/beta-fold hydrolase DWARF14-LIKE (D14L) are involved in pre-symbio

124 g. Bowman-Birk inhibitors) or even different hydrolases (e.g. alpha-amylase/protease inhibitors preve

125 underpinnings of the enzyme's unique epoxide hydrolase (EH) activity, involving Zn(2+), Y383, E271, D

126 of elastin-like-polypeptide-organophosphate hydrolase (ELP-OPH), bovine serum albumin (BSA), titaniu

127 scheme of sequential action by the glycoside hydrolases encoded by the beta-mannan PUL and involved i

128 thesized that the genotype of leukotriene A4 hydrolase (encoded by LTA4H), which determines inflammat

129 degradation (by inhibiting fatty acid amide hydrolase) enhanced the effects of OEA and PEA.

130 The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required

131 utolysins and phage lysins are peptidoglycan hydrolases, enzymes that have evolved over a billion yea

132 cne-associated phylotypes and a cell surface hydrolase expressed in all phylotypes except those assoc

133 In Vibrio cholerae, VgrG3 has a hydrolase extension domain and degrades peptidoglycan in

134 A decrease in fatty acid amide hydrolase (FAAH) activity increases the levels of endoge

135 combined activity at human fatty acid amide hydrolase (FAAH) and dopamine receptor subtype D3 (D3R).

136 Fatty acid amide hydrolase (FAAH) degrades NAE into ethanolamine and free

137 recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the death

138 We found that both the fatty acid amide hydrolase (FAAH) inhibitor URB597 and the synthetic cann

139 ow here that mice devoid of fatty acid amide hydrolase (FAAH) with elevated levels ofN-arachidonyl et

140 Fatty acid amide hydrolase (FAAH), a gene in the minimal subcongenic inte

141 rachidonoylethanolamine via fatty acid amide hydrolase (FAAH), although it is unclear whether chronic

142 etabolic enzymes, including fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), N-acyl

143 to a common polymorphism in fatty acid amide hydrolase (FAAH), which alters endocannabinoid anandamid

144 s and their mobilization by LD-resident FAEE hydrolases facilitate a controlled metabolism of these p

145 the treatment generated fumarylacetoacetate hydrolase (Fah)-positive hepatocytes by correcting the c

146 nzymes from two previously unknown glycoside hydrolase families.

147 t bacterial phyla, which belong to glycoside hydrolase family 16 and cleave the beta-1,4 linkage of k

148 It encodes two glycoside hydrolase family 26 (GH26) beta-mannanases, BoMan26A and

149 cal roles of the four C. japonicus glycoside hydrolase family 3 (GH3) members on diverse beta-glucans

150 s thaliana) beta-glucosidases from glycoside hydrolase family 3.

151 somaltase) that both belong to the glycoside hydrolase family 31 (GH31) and differ in substrate speci

152 Multiple glycoside hydrolase family 47 (GH47) alpha-mannosidases, including

153 ate-Active Enzyme (CAZy) database, glycoside hydrolase family 5 (GH5) is a large family with more tha

154 The recent classification of glycoside hydrolase family 5 (GH5) members into subfamilies enhanc

155 n arabinose specific xylanase from glycoside hydrolase family 5 (GH5) was used to hydrolyse wheat and

156 aled three distinct subfamilies of glycoside hydrolase family 5 (GH5).

157 osylation on a model, multimodular glycoside hydrolase family 7 cellobiohydrolase (Cel7A), which exhi

158 a Cel7A, cellobiohydrolase I, from glycoside hydrolase family 7, is the workhorse enzyme of the proce

159 ydrate binding module (CBM32) of a glycoside hydrolase family 8 chitosanase from Paenibacillus elgii

160 o-alpha-1,2-mannanases, members of glycoside hydrolase family 99 (GH99), are interesting targets for

161 still needed, as is exemplified by glycoside hydrolase family-3 (GH3) proteins.

162 on step is catalyzed by members of the Nudix hydrolase family.

163 es that Chath_Est1 belongs to the alpha/beta-hydrolases family.

164 A comparison with closely related alpha/beta hydrolase fold enzyme structures shows that the AF-Est2

165 YbAnbu subunits have the Ntn-hydrolase fold, a putative S1 pocket and conserved candi

166 virus (HEV) serves as an ADP-ribose-protein hydrolase for mono-ADP-ribose (MAR) and poly(ADP-ribose)

167 CE clan proteases, specific hydrolases for ubiquitin-like modifications (SUMO and NE

168 the X-ray structure of TrzD, a cyanuric acid hydrolase from Acidovorax citrulli.

169 ptor-mediated targeting of newly synthesized hydrolases from Golgi to lysosomes, but the precise stru

170 Xyloglucan endotransglucosylase/ hydrolase gene (XET) up-regulated at different moisture

171 The complete genes included a novel hydrolase gene ddhA, which is responsible for the cleava

172 ngal endoxylanase belonging to the glycoside hydrolase gene family 11 (GH11) was obtained from the as

173 and its abilities to down-regulate cell wall hydrolase genes and disrupt the biofilm formation of MRS

174 le nucleotide polymorphisms in peptidoglycan hydrolase genes pgp1 or pgp2 or a reduction in curvature

175 which is the founding member of a glycoside hydrolase (GH) family, GH145.

176 Glycoside hydrolases (GH) are enzymes that mainly hydrolyze the gl

177 s a cohesin module and a family 25 glycoside hydrolase (GH25).

178 e identified that encode family 39 glycoside hydrolases (GH39s), and have conserved structural featur

179 These SLH proteins include five glycoside hydrolases (GHs) and one polysaccharide lyase, the genes

180 Glycoside hydrolases (GHs) have attracted considerable attention a

181 The conversion of glycoside hydrolases (GHs) into transglycosylases (TGs), i.e., fro

182 Salmonella contains 47 glycosyl hydrolases (GHs) that may degrade the glycan.

183 ene cluster containing multidomain glycoside hydrolases (GHs).

184 criptional regulator but also as a ubiquitin hydrolase has been proposed for this protein.

185 Here, we identified 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) as a possible toxicity-causing off-tar

186 sma MMA with SNPs in 3-hydroxyisobutyryl-CoA hydrolase (HIBCH, p = 8.42 x 10(-89)) and acyl-CoA synth

187 ethanolamine acid amidase (NAAA), a cysteine hydrolase highly expressed in macrophages and B lymphocy

188 ss of GlcNAc-1-phosphotransferase results in hydrolase hypersecretion and profound lysosomal storage.

189 that implicates participation of an epoxide hydrolase in converting epoxyalcohol to triol.

190 f irreversible inhibitors that target serine hydrolases in both cells and animal models.

191 h we could detect six of the documented PG-G hydrolases in neutrophils by quantitative PCR, only ABHD

192 l portrait of the cellular anatomy of serine hydrolases in the brain.

193 terminal storage lysosomes, which were acid hydrolase inactive and did not accumulate acidotropic pr

194 rolase-active, acidic endolysosomes and acid hydrolase-inactive, non-acidic, terminal storage lysosom

195 acid-hydrolase-active endolysosomes and acid-hydrolase-inactive, terminal storage lysosomes exist in

196 entiate the activity of a range of glycoside hydrolases including cellulases.

197 Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 t

198 _P contained higher proportions of glycoside hydrolases, indicating the ability of MGIIa_P to hydroly

199 suggested: 1) inhibition of fatty acid amide hydrolase-induced increases in anandamide or 2-arachidon

200 Treatment with soluble epoxide hydrolase inhibitor significantly reduces the activation

201 abolizing enzymes URB597 (a fatty acid amide hydrolase inhibitor) and JZL184 (a monoacylglycerol lipa

202 iazin-3-one 1,1-dioxides as candidate serine hydrolase inhibitors are disclosed, and represent the sy

203 Evaluated as glycoside hydrolase inhibitors, these quinolizidines revealed to b

204 n (PLF) results in the delivery of lysosomal hydrolases into phagosomes and in digestion of the cargo

205 putative mycolic acid mimics to block serine hydrolases involved in their biosynthesis.

206 ge of ester bonds by extracellular microbial hydrolases is considered a key step during the breakdown

207 A family of highly related alpha/beta hydrolases is involved in diverse processes in all domai

208 the 52-knotted protein ubiquitin C-terminal hydrolase isoenzyme L1 (UCH-L1) and have therefore been

209 e homology with the reported alpha/beta-fold hydrolases, it shows typical hydrolytic activity in vivo

210 Juvenile hormone epoxide hydrolase (JHEH) has attracted great interest because of

211 Two paralogous alpha/beta hydrolases, KAI2 and D14, are respectively karrikin and

212 evels of Abeta, Tau and Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in mouse cerebrospinal fluid (CSF)

213 idic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in a cohort of 45 children with cl

214 Here, we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1), which we previously identified as

215 re, we show that ubiquitin carboxyl-terminal hydrolase-L5 (UCHL5 or UCH37) de-ubiquitinates both Smad

216 Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abunda

217 Here we show that hydrolase levels between human ALF from healthy and CF p

218 nic acid, is removed from AGP by a glycoside hydrolase located in family GH105, producing the final p

219 The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the distal step in LTB4 synt

220 solated mutants that are resistant to the PG hydrolase lysozyme.

221 innate immune system, such as the cell wall hydrolase lysozyme.

222 cellular dynamics, defective proteolysis and hydrolase maturation, and impaired lysosomal acidificati

223 hway, which initiates secretion of an acidic hydrolase mixture to decompose the victim and acquire th

224 decapping protein (ASFV-DP) that has a Nudix hydrolase motif and decapping activity in vitro Here, we

225 Recently, the nucleoside diphosphate hydrolase NUDT15 has received attention on the basis of

226 n operons bioH is replaced by other alpha/ss hydrolases of diverse sequence.

227 ing modules (CBMs) of cell surface glycoside hydrolases often drive binding to the target substrate.

228 Cyanuric acid hydrolase opens the cyanuric acid ring hydrolytically an

229 nsors, based on stretchable organophosphorus hydrolase (OPH) enzyme electrodes, are coupled with a fu

230 Organophosphate hydrolase (OPH), encoded by the organophosphate degradat

231 sphorus compounds, based on organophosphorus hydrolase (OPH, EC 3.1.8.1), is produced in aqueous solu

232 Predictions indicated hydrolase or oxygenase enzymes catalyzed the initial rea

233 -responsive haloacid dehalogenase (HAD)-like hydrolase, OsHAD1 While OsHAD1 is a functional HAD prote

234 many microbes secrete mixtures of glycoside hydrolases, oxidoreductases, and accessory enzymes to de

235 ymes (EC 1.14.99.53-56) that, with glycoside hydrolases, participate in the degradation of recalcitra

236 vely) in the cytochrome P450/soluble epoxide hydrolase pathway.

237 inhibitor for a poorly characterized serine hydrolase (PNPLA4, patatin-like phospholipase domain-con

238 the heterotroph to cleave organic groups and hydrolase polymeric organic matter produced by the cyano

239 ide (Pheide) a, a metabolite of pheophorbide hydrolase (PPH).

240 didates capable of interacting with a serine hydrolase probe (with equilibrium binding constants rang

241 athway in the tunable regulation of glycosyl hydrolase production in response to changes in osmolarit

242 ucosamine transporter and an alpha/beta-fold hydrolase receptor at the earliest stages of AM symbiosi

243 findings that inhibition of soluble epoxide hydrolase reduces inflammation, oxidative stress, atrial

244 report the crystal structures of alpha/beta hydrolases representing two different clades of the fami

245 BioH is an alpha/beta-hydrolase required for synthesis of the pimelate moiety

246 ll surface for degradation by lysosomal acid hydrolases requires traffic through early endosomes to l

247 flavin reductase, ribokinase, and riboflavin hydrolase, respectively.

248 g acid stress MarP cleaves the peptidoglycan hydrolase RipA, a process required for RipA's activation

249 ating the activity of S-adenosylhomocysteine hydrolase (SAHH).

250 ion of ADK with S-adenosylhomocysteine (SAH) hydrolase (SAHH).

251 AH hydrolase Ahcy (S-adenosyl-L-homocysteine hydrolase [SAHH[), CG9977/dAhcyL1 and Ahcy89E/CG8956/dAh

252 l-target ligands that target soluble epoxide hydrolase (sEH) and the peroxisome proliferator-activate

253 Here we identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates pericyte

254 combined with inhibition of soluble epoxide hydrolase (sEH) as anti-inflammatory strategy promises s

255 blation or inhibition of the soluble epoxide hydrolase (sEH) enzyme led to increased levels of EDP an

256 study showed that inhibiting soluble epoxide hydrolase (sEH) increased EET concentration and mildly p

257 because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsa

258 biofilm was engineered to produce an epoxide hydrolase so that it efficiently removes the environment

259 s are the principal organelles in which acid hydrolase substrates are cleaved.

260 olinase A, pxpA) and homologs of allophanate hydrolase subunits (renamed pxpB and pxpC).

261 agy in Saccharomyces cerevisiae during which hydrolases such as prApe1 are transported into the vacuo

262 s premature degradation of primers by starch hydrolases, such as AMY3.

263 f which 38% are predicted to encode secreted hydrolases, suggesting a role in disassembly of the arbu

264 by an inherited deficiency of the lysosomal hydrolase sulfamidase.

265 e serine-dependent enzymes of the alpha/beta-hydrolase superfamily.

266 e carboxylesterase enzymes of the alpha/beta-hydrolase superfamily.

267 Across many environments microbial glycoside hydrolases support the enzymatic processing of carbohydr

268 Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into

269 he use of chitinosanase, a sequence-specific hydrolase that cleaves chitosan polymers into oligomeric

270 ion of monoacylglycerol lipase (MGL)-a lipid hydrolase that degrades 2-AG in presynaptic nerve termin

271 n is delayed by Doa4, which is the ubiquitin hydrolase that deubiquitinates transmembrane proteins so

272 By screening for the hydrolase that is responsible for the reversal of Ser-AD

273 We found that ASXL3 interacts with BAP1, a hydrolase that removes mono-ubiquitin from histone H2A l

274 al design of next-generation organophosphate hydrolases that are capable of selecting a specific reac

275 lyze the substrate specificities of chitosan hydrolases that can be used to produce paCOS.

276 ADP-Ribosylation is reversed by hydrolases that cleave the glycosidic bonds either betwe

277 essed and characterized all of the glycoside hydrolases that contain a dockerin module.

278 d guide the future design of organophosphate hydrolases that hydrolyze compounds with challenging lea

279 This system contains several glycoside hydrolases that trim the remnants of other pectin domain

280 caused by deficiency in fumarylacetoacetate hydrolase, the last enzyme in the tyrosine catabolic pat

281 ort its desorption after catalysis and allow hydrolases to access the cleavage site.

282 d to growth of a bacterial cell and requires hydrolases to cleave the cross-links for insertion of na

283 ikimotoi cells were expressing extracellular hydrolases to hydrolyse ATP.

284 of rab1a restored Golgi structure, improved hydrolase trafficking and activity, and reduced patholog

285 work suggests that enhancement of lysosomal hydrolase trafficking may prove beneficial in synucleino

286 dels of synucleinopathies through disrupting hydrolase trafficking.

287 serum concentrations of ubiquitin C-terminal hydrolase (UCH-L1) and glial fibrillary astrocytic prote

288 The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant neuronal deubiquitinas

289 ed to pooled plasma samples to enrich serine hydrolases using a fluorophosphonate (FP2) activity-base

290 Acid hydrolases utilize a carbohydrate-dependent mechanism fo

291 To elucidate interdependence among the NUDIX hydrolases, we pairwise deplete them generating an epist

292 Three of the most used hydrolases were assayed to catalyze the process, and bet

293 xpansins and xyloglucan endotransglucosylase/hydrolases were differentially expressed in growing stem

294 ATGL), a major hepatic triacylglycerol (TAG) hydrolase, were inversely regulated by fasting in mice,

295 ed triple-acting staphylolytic peptidoglycan hydrolases wherein three unique antimicrobial activities

296 ll-associated transglycosidases and glycosyl hydrolases, which are responsible for remodeling the de

297 rfamily, unlike previously characterized MCP hydrolases, which are serine-dependent enzymes of the al

298 SAMHD1 is a dNTP hydrolase, whose activity is required for maintaining lo

299 Here, we fabricate an artificial hydrolase with pH-switchable activity, achieved by intro

300 sible inhibition of a small subset of serine hydrolases without release of a leaving group, does not