ライフサイエンスコーパス: hydrolytically

1 of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to p

2 mivir, a widely used anti-influenza drug, is hydrolytically activated by carboxylesterase 1 (CES1).

3 Herein, we designed and developed a hydrolytically activated oxygen-generating biomaterial i

4 Both hydrolytically active and inactive FlhF point mutants re

5 udohexamers containing different patterns of hydrolytically active and inactive subunits retain the a

6 eria-containing phagosome into an acidified, hydrolytically active compartment.

7 In the hydrolytically active complex, Met-peptide is coordinate

8 Because the increased acidity favors this hydrolytically active complex, the rate of cleavage guid

9 ATP binds to the hydrolytically active high-affinity site approximately 3

10 ents and restrict their differentiation into hydrolytically active vacuoles appears to correlate with

11 atic variation of active site location for a hydrolytically active ZnHis3O site contained within a de

12 ronin properties; it is structurally stable, hydrolytically active, and can bind both the co-chaperon

13 e derivatives 1 can be surprisingly unstable hydrolytically, affording, in solution, variable amounts

14 requires a free 3'-hydroxyl and degrades RNA hydrolytically and distributively, releasing nucleoside

15 tively resistant polytungstate ligands, is a hydrolytically and oxidatively stable homogeneous water

16 acid hydrolase opens the cyanuric acid ring hydrolytically and subsequent decarboxylation produces c

17 cytes exhibit ectoenzymatic activity able to hydrolytically cleave extracellular diadenosine polyphos

18 general acid/base mechanism used by BACE1 to hydrolytically cleave these substrates.

19 xygen to transform amines to imines that are hydrolytically cleaved to formaldehyde.

20 Valyl-tRNA synthetase is unable to hydrolytically deacylate misacylated tRNA(Val) terminati

21 Adenosine deaminases acting on RNA (ADARs) hydrolytically deaminate adenosines (A) in a wide variet

22 o1-E109K with that of wild type Exo1 and the hydrolytically defective active site mutant Exo1-D173A.

23 ow that a protein roadblock (EcoRI(E111Q), a hydrolytically defective form of EcoRI endonuclease) pla

24 ort that N-terminal His-tagged Exo1-E109K is hydrolytically defective.

25 nerally synthesized with either disulfide or hydrolytically degradable crosslinkers, is critical to t

26 ids by covalently bonding the drug through a hydrolytically degradable ester linkage to a common hydr

27 ified with hydroxyethyl methacrylate to form hydrolytically degradable hydrogels through free-radical

28 Comparative studies of bulk samples of hydrolytically degradable poly(lactic acid) (PLA) vs cor

29 3-dioxepane (BMDO), results in well-defined, hydrolytically degradable polymers, as confirmed by FTIR

30 We present the fabrication of conformal, hydrolytically degradable thin films capable of administ

31 s, because these mimetics have been shown to hydrolytically degrade urea.

32 Most of these mutations occur at hydrolytically disfavoured non-methylated cytosines thro

33 on repair pathway, DNA glycosylases find and hydrolytically excise damaged bases from DNA.

34 specially attractive for synthesis, as it is hydrolytically impaired but still able to catalyze N-gly

35 ally caused by beta-lactamases, enzymes that hydrolytically inactivate the antibiotics.

36 3OC12-HSL was previously shown to be hydrolytically inactivated by the paraoxonase (PON) fami

37 the E171Q mutant of the MJ0796 ABC, which is hydrolytically inactive due to mutation of the catalytic

38 of guanine, but the resulting conjugates are hydrolytically labile and thus are not suitable for stru

39 Addition of methyl groups adjacent to the hydrolytically labile ester linkage increased stability

40 BSA-bead linker was designed to incorporate hydrolytically labile fragment, which permits release of

41 rmits the formation of either a permanent or hydrolytically labile linkage.

42 al or chemical damage to these thermally and hydrolytically labile materials was observed.

43 2 O-glycan building block and replacement of hydrolytically labile tyrosine sulfates with isosteric s

44 Hydrolytically liberated endogenous cyanide from cyanoge

45 Transitory starch of leaves is broken down hydrolytically, making maltose the predominant form of c

46 breast cancer cells prompted the search for hydrolytically more stable anthracycline-formaldehyde co

47 Dyes 2-4 are hydrolytically more stable than other chalcogenopyrylium

48 probably the most common DNA damage produced hydrolytically or by glycosylase-mediated removal of mod

49 s loss to model the degradation of materials hydrolytically (PEG:dextran hydrogel) and enzymatically

50 The enzyme hydrolytically processes the lactyl amide bond of the 1,

51 ting that the final elongated product is not hydrolytically released by thioesterases as observed in

52 rmed "PolyMorphine", was designed to degrade hydrolytically releasing morphine in a controlled manner

53 n, Legionella provides the protein SidD that hydrolytically reverses the covalent modification, sugge

54 ridged lactams-a class of readily available, hydrolytically robust twisted amides-are ideally suited

55 silyl enol ether of cyclohexenone produced a hydrolytically sensitive [4 + 2] adduct in good yield.

56 s used in medicine, especially thermally and hydrolytically sensitive polymers by themselves and in c

57 e (thio)phosphodiester linkages to form less hydrolytically stable (thio)phosphotriesters, which then

58 Treatment of H508 cells with carbachol, a hydrolytically stable acetylcholine analog, promoted H50

59 Two hydrolytically stable adenylate analogues, 5'-O-[N-(sali

60 mational probe for selectin binding and as a hydrolytically stable analogue.

61 More hydrolytically stable anchors, such as silatranes and hy

62 d polyamide dendrimers are enzymatically and hydrolytically stable and also exhibit antimicrobial act

63 unknown family of peptidomimetics, which are hydrolytically stable and display very interesting confo

64 The anchoring group must be hydrolytically stable and oxidation resistant under a va

65 uted acenaphthene 3, affording thermally and hydrolytically stable arsanylidine-phosphorane 4 with a

66 6,6-tetramethylheptanedionate) ligand led to hydrolytically stable complex salts of type [(eta(6)-p-c

67 The discovery of potent (2-3 microM), hydrolytically stable dipeptide derivatives, bearing onl

68 The hydrolytically stable ether can be removed by the action

69 , we report the deliberate construction of a hydrolytically stable fluorinated metal-organic framewor

70 he design and synthesis of a novel family of hydrolytically stable glycoclusters bearing thiodigalact

71 oro-carbasugars are a particular subclass of hydrolytically stable glycomimetics that are expected to

72 ine with a similar vaccine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant

73 ADAM 4 was designed to be hydrolytically stable in blood plasma, and an investigat

74 rmed during the CuAAC reaction is robust and hydrolytically stable in both aqueous 1 M HClO(4) and 1

75 xylic acid 8a is thermally stable, and it is hydrolytically stable in water even at 40 degrees C and

76 -WO(3-x)/WO3xH2O nanowhiskers dispersed in a hydrolytically stable mesoporous polycarbosilane-siloxan

77 t of the relative humidity, positioning this hydrolytically stable MOF as a prospective adsorbent for

78 One of these thermally and hydrolytically stable new chemical entities (4c) complet

79 As a result, a number of hydrolytically stable NNRTIs were identified with anti-H

80 d ILs are significantly more hydrophobic and hydrolytically stable permitting them to be used in the

81 ously shown that a small peptide bearing the hydrolytically stable phosphotyrosyl (pTyr) mimetic, (di

82 therefore offers insight into the design of hydrolytically stable porous materials.

83 Addition of a hydrolytically stable PRPP analogue to the enzyme result

84 urated (C(10)-C(18)) FAP, headgroup-modified hydrolytically stable saturated (C(10)-C(18)) alkyl phos

85 indicate that these compounds can be used as hydrolytically stable structural and functional RNA mime

86 In this report, hydrolytically stable structural mimics of N7-guanine-co

87 the dimerization of an alpha-aminonitrile (a hydrolytically stable surrogate for its corresponding he

88 Recently, more hydrolytically stable systems incorporating the 4-aza-3-

89 ural trioxane artemisinin, the thermally and hydrolytically stable trioxane fluoroanilide 4b has been

90 st total synthesis of the membrane permeant, hydrolytically stable, cADPR receptor agonist 8-Br-N1-cI

91 ies of the existing ADAM lead compounds with hydrolytically stable, fused isoxazolone, isoxazole, oxa

92 anate reacts with the enzyme quickly to form hydrolytically stable, inactive forms of the enzyme that

93 an oxamic acid (compound 10) moiety leads to hydrolytically stable, monocharged ligands, with 83- and

94 hile to form an oxacarboline product that is hydrolytically stable.

95 ruction of MOFs provides a method to protect hydrolytically susceptible coordination backbones throug

96 In vitro RutB cleaves ureidoacrylate hydrolytically to release 2 mol of ammonium, malonic sem

97 The hydrolytically unstable aromatic lactone is important fo

98 he resulting diazaborolidine derivatives are hydrolytically unstable but can be isolated by recrystal

99 res by selectively disassembling preprepared hydrolytically unstable frameworks and then reassembling

100 us collagen web infiltrated primarily by the hydrolytically unstable HEMA.

101 mpounds is limited, however, as they contain hydrolytically unstable thioester linkages and have only

102 antage of their known reactivity to produce (hydrolytically unstable) anhydrides from carboxylic acid

103 ile complexes with monodentate NHCs only are hydrolytically unstable, complexes containing bidentate

104 affolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytic

105 reover, the lactone ring could not be opened hydrolytically without epimerization at C alpha.

106 sis (RCM) reaction, and the core was removed hydrolytically without significant fragmentation.

107 to trimethyluric acid stoichiometrically and hydrolytically, without producing hydrogen peroxide.