ライフサイエンスコーパス: hydrolyzable

1 the imido linkage usually regarded to be non-hydrolyzable.

2 (5)P, indicating that the replacement of the hydrolyzable 5-phosphate group does not compromise the b

3 Abscisic acid glucosyl ester (ABA-GE) is a hydrolyzable ABA conjugate that accumulates in the vacuo

4 The hydrolyzable agonist ADP (10 microM) produced 32% inhibi

5 oiety at the 1-position of PtdCho with a non-hydrolyzable alkyl moiety prevented degradation to GPC.

6 ithiocarbamate, carbamate, and pH responsive hydrolyzable amide analogues.

7 environmental stresses, we investigated the hydrolyzable amino acid distribution and concentration i

8 The high proportions of total hydrolyzable amino acids and presence of chemical specie

9 We extracted hydrolyzable amino acids from leaf litter and fine (< 2

10 cells, where it is processed releasing a non-hydrolyzable aminoacyl adenylate that inhibits an essent

11 the MccF clade can specifically detoxify non-hydrolyzable aminoacyl adenylates differing in their ami

12 on in real time, we found that AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5'-monophosphona

13 ADP, AMP and the non-hydrolyzable analog adenosine 5'-(beta, gamma-iminodipho

14 te when presented with either ATP or the non-hydrolyzable analog AMP-PNP, and these cycles of elongat

15 stranded DNA, in the presence of the ATP non-hydrolyzable analog AMP-PNP, have been performed, using

16 icrom) and is displaced by ATP or by its non-hydrolyzable analog AMPPNP (concentrations for half-maxi

17 the absence of ATP or presence of the poorly hydrolyzable analog ATP-gamma-S unexpectedly revealed th

18 When p21(cip1) is added, followed by the non-hydrolyzable analog ATPgammaS to block helicase function

19 inds to HSP90 also in the absence of the non-hydrolyzable analog ATPgammaS.

20 g ATP (K1/2, 1.3 +/- 0.7 mm) but not the non-hydrolyzable analog ATPgammaS.

21 the mechanisms by which substituting the non-hydrolyzable analog GDPCP for GTP or adding thiostrepton

22 g IF3, and/or (c) replacing GTP with the non-hydrolyzable analog GDPCP.

23 Both GTP and its non-hydrolyzable analog guanosine 5'-O-(thiotriphosphate) st

24 the eEF2-dependent dissociation, while a non-hydrolyzable analog of ATP was inactive in ribosome spli

25 n phosphorylation since 5 mM AMPPNP, the non-hydrolyzable analog of ATP, reversibly inhibited channel

26 only when the internal solution contained a hydrolyzable analog of ATP.

27 In this study, a novel non-hydrolyzable analog of cADPR, N1-cIDPR (N1-cyclic inosin

28 he production of NO were induced by a slowly hydrolyzable analog of cGMP, 8-bromo-cGMP, but not by no

29 In x-ray structures of hpol eta with a non-hydrolyzable analog of dATP or dGTP opposite an abasic s

30 polymer formed with GTP or GMPCPP (a slowly hydrolyzable analog of GTP) is moderate (micromolar rang

31 (alpha,beta-methylene)triphosphate, a slowly hydrolyzable analog of GTP, became larger and polydisper

32 ced by EF-G in the presence of GTP and a non-hydrolyzable analog of GTP, GDP*BeF3(-) are similar.

33 d without alpha-l-Glu-l-Glu dipeptide, a non-hydrolyzable analog of poly-gamma-d-glutamic acid, in th

34 omplex with the canonical tRNA2(Thr) and non-hydrolyzable analog of threonyl adenylate.

35 presence and absence of ATP, and of the non-hydrolyzable analog, adenosine 5'-O-(3-thiotriphosphate)

36 ATPgammaS, a slowly hydrolyzable analog, switches SUR1 conformations, albeit

37 Replacement of ATP with the poorly hydrolyzable analogs 5'-adenylyl methylenediphosphate, 5

38 nhydrolyzable analog GMP-PNP, and the slowly hydrolyzable analogs guanosine 5'-O-(2-thiodiphosphate)

39 anic phosphate rather than ATP, and that non-hydrolyzable analogs of ATP cannot support the enzymatic

40 f ATP was not specifically required, and non-hydrolyzable analogs of ATP that blocked 90% of the ATPa

41 icient DNA binding is only observed with non-hydrolyzable analogs of ATP, suggesting that ATP hydroly

42 hough substantial activity remained when non-hydrolyzable analogs were used instead.

43 In contrast, the addition of the non-hydrolyzable analogue ATPgammaS, did not reverse nuclear

44 creased by the addition of GTP or its slowly hydrolyzable analogue guanosine 5'-3-O-(thio)triphosphat

45 f the bound peptide in the presence of a non-hydrolyzable analogue of GTP, indicative of the alternat

46 oduction of IP(3), and adenophostin A, a non-hydrolyzable analogue of IP(3).

47 hate (O(3)P-NH-PO(2)-NH-PO(3); PNPNP), a non-hydrolyzable analogue of PPPi, is the most potent known

48 Here, we show that non-hydrolyzable analogues of PPi, bisphosphonates, are pote

49 Guanosine triphosphate (GTP) and its non-hydrolyzable analogues optimally enhance the phosphoryla

50 r elevation of cholesterol because (i) a non-hydrolyzable and a degradable SL analog elevated cellula

51 further enhanced upon the addition of a non-hydrolyzable ATP analog (adenylyl-imidophosphate), where

52 sed by vanadate (Vi), acetate, ATP, or a non-hydrolyzable ATP analog (AMP-PNP), with differential eff

53 Escherichia coli PhoQ complexed with the non-hydrolyzable ATP analog adenosine 5'-(beta,gamma-imino)t

54 both in the presence and absence of the non-hydrolyzable ATP analog ADP(BeF3).

55 the NtrC1 ATPase domain, bound with the non-hydrolyzable ATP analog ADP-beryllium fluoride, we studi

56 sults demonstrate that the presence of a non-hydrolyzable ATP analog allows Mtr4p to discriminate bet

57 tors or intracellular perfusion with the non-hydrolyzable ATP analog AMP-PNP dramatically reduce the

58 x structure of activated NTPDase3 with a non-hydrolyzable ATP analog and the cofactor Mg(2+) to a res

59 45 can also be interrupted by adding the non-hydrolyzable ATP analog ATP-gamma-S.

60 ls of closed clamps in the presence of a non-hydrolyzable ATP analog compared with the wild type enzy

61 ontrast, the presence of either ADP or a non-hydrolyzable ATP analog induces conversion to a monomeri

62 The protection from inhibition by a non-hydrolyzable ATP analog or acetylphosphate, in conjuncti

63 SynAPSK in complex with either APS and a non-hydrolyzable ATP analog or APS and sulfate revealed the

64 the wild-type enzyme is titrated with a non-hydrolyzable ATP analog or the enzyme is mutated such th

65 omplex of NS3 bound to labeled RNA and a non-hydrolyzable ATP analog provide a direct view of how lar

66 A non-hydrolyzable ATP analog was a competitive inhibitor.

67 ell as differences compared to AMPPNP (a non-hydrolyzable ATP analog) bound to PhoQcat and radicicol

68 ,gamma-methylene)triphosphate (AMP-PCP) (non-hydrolyzable ATP analog) bound were also solved at 1.9-A

69 he presence of ATP as well as AMP-PCP (a non-hydrolyzable ATP analog).

70 Using either ATP or the non-hydrolyzable ATP analog, adenosine 5'-O-(3-thiophosphate

71 y at high pH only in the presence of the non-hydrolyzable ATP analog, ADP(BeF3).

72 nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-beryllium fluoride, we obse

73 studies of this complex reveal that the non-hydrolyzable ATP analog, ATPgammaS, induces a high-affin

74 step in its functional cycle by use of a non-hydrolyzable ATP analog, ATPgammaS, to mimic the ATP-bou

75 ATP-gamma-S, a poorly hydrolyzable ATP analog, did not support endocytosis but

76 However, in the presence of a non-hydrolyzable ATP analog, DNA binding was only slightly c

77 ta,gamma-imido]triphosphate (AMP-PNP), a non-hydrolyzable ATP analog, has no effect on MGAD activity.

78 hen SecA associated with ATPgammaS, a poorly hydrolyzable ATP analog, or ADP plus AlF(4), which mimic

79 observed either with ATP-gamma-s, the slowly hydrolyzable ATP analog, or with ATP in the presence of

80 subunit poorly, whereas with AMP-PNP, a non-hydrolyzable ATP analog, the affinity was 11 nM.

81 e-5-maleimide-actin with bound AMPPNP, a non-hydrolyzable ATP analog, was determined to 1.85-A resolu

82 were suppressed by binding of a specific non-hydrolyzable ATP analog.

83 t in apo form as well as that bound to a non-hydrolyzable ATP analog.

84 Non-hydrolyzable ATP analogs (but not ATP or ADP) release P1

85 ither nonhydrolyzable (AMP-PNP, AMP-PCP) nor hydrolyzable ATP analogs (GTP, CTP, UTP, and ITP) activa

86 Non-hydrolyzable ATP analogs did not substitute for ATP in t

87 Nonhydrolyzable or poorly hydrolyzable ATP analogs inhibited MgATP-supported bindi

88 Finally, experiments with non-hydrolyzable ATP analogs suggest that SpoIIIE can operat

89 The finding that slowly hydrolyzable ATP analogs trigger slower nucleotide relea

90 challenged with neutral-backbone DNA and non-hydrolyzable ATP analogs.

91 DNA in a reaction promoted by ATP or the non-hydrolyzable ATP analogue AMP-PNP.

92 osine 5'-(gamma-thio)-triphosphate (a slowly hydrolyzable ATP analogue) differently from Hsp104.

93 ) In contrast, the hexokinase-treated poorly hydrolyzable ATP analogue, adenosine 5'-O-(thiotriphosph

94 The non-hydrolyzable ATP analogue, gamma-S-ATP, gave a similar p

95 Cl- channels were similarly affected by non-hydrolyzable ATP analogues and mutations in the CFTR R d

96 ration does not occur in the presence of non-hydrolyzable ATP analogues, nor when mutant rad54 protei

97 OS induction minimally require ssDNA and non-hydrolyzable ATP analogues.

98 ranscription by RNA polymerase II requires a hydrolyzable ATP cofactor for synthesis of the first pho

99 Strikingly, the presence of a non-hydrolyzable ATP derivative, ATPgammaS, not only increas

100 Inclusion of hydrolyzable ATP in binding reactions increased the appa

101 cordings and Ca(2+) imaging demonstrate that hydrolyzable ATP is essential to maintain synaptic Ca(2+

102 olar affinity to both Arp2 and Arp3 and that hydrolyzable ATP is required for actin nucleation activi

103 e-released factor(s) specifically required a hydrolyzable ATP substrate and was inhibited by procedur

104 Addition of hydrolyzable ATP to this complex results in the disrupti

105 titor substrate) began within 30 s, required hydrolyzable ATP, and plateaued after 60-70 s.

106 Consistently, non-hydrolyzable ATP, ATPgammaS, only inhibited but did not

107 y-purified and stabilized by addition of non-hydrolyzable ATP, which binds specifically to the ATPase

108 it compacts the DNA only in the presence of hydrolyzable ATP.

109 lex by displacement of E2 in the presence of hydrolyzable ATP.

110 addition of fractionated nuclear extract and hydrolyzable ATP.

111 lent metal, and adenosine nucleotides with a hydrolyzable beta,gamma-phosphate bond.

112 The presence of a hydrolyzable bond linking laccase to the cell wall was s

113 They usually contain ester and other hydrolyzable bonds, such as anhydride, acetal, ketal, or

114 , do not have peptidic features, and have no hydrolyzable bonds.

115 ly linked doxorubicin with a peptide that is hydrolyzable by prostate-specific antigen.

116 GaFK-Doxaz is hydrolyzable by the proteases plasmin and cathepsin B, b

117 s: (1) how the recognition properties of non-hydrolyzable C-glycoside analogues compare with those of

118 diesterase (PDE) inhibition, as well as by a hydrolyzable cAMP analog, but not by a nonhydrolyzable c

119 generation and hydrolysis; and exogenous PDE hydrolyzable cGMP analog induced iNOS and NO.

120 e synthase-derived and/or PDE type 5 (PDE-5)-hydrolyzable cGMP undetected at the sarcolemmal membrane

121 mediate over the less stable and more easily hydrolyzable cis-enamine and imine co-intermediates.

122 comprised of undecomposed plant material and hydrolyzable components associated with mineral surfaces

123 three Rho active sites are empty or bear non-hydrolyzable compounds.

124 wo insertion complexes revealed incoming non-hydrolyzable dATP or dGTP analogs not pairing with but i

125 Poorly hydrolyzable derivatives of ADP and ATP were effective c

126 ythrine prevented the PMA effects; and (3) a hydrolyzable diacylglycerol analogue, 1-oleoyl-2-acetyl-

127 ition of the lipolysis induced by the poorly hydrolyzable dibutyryl cAMP analog.

128 s oocytes that was able to transport the non-hydrolyzable dipeptide [3H]d-Phe-l-Gln, although unlike

129 ated with three-dimensional studies, the non-hydrolyzable donor analog UDP-phosphono-galactose (UDP-C

130 lysis of a single catalytic turnover using a hydrolyzable duplex oligodeoxyribonucleotide substrate c

131 er conjugation to octaarginine via a readily hydrolyzable ester linkage inhibits ENR activity, tachyz

132 tion of Ins(1,4,5,6)P4, a membrane-permeant, hydrolyzable ester was used to deliver it to the intrace

133 pCB can also be prepared in a hydrolyzable form as cationic pCB esters, which can kill

134 This required MgCl2 and a hydrolyzable form of ATP and was prevented by P1,P5-di-a

135 A hydrolyzable form of ATP is necessary to maintain the M

136 equired the presence of a DNA mismatch and a hydrolyzable form of ATP.

137 rtin with Nup153 could be disrupted by a non-hydrolyzable form of GTP or by a GTPase-deficient mutant

138 e triphosphate (ATP) or dATP whereas the non-hydrolyzable gamma-S-ATP does not support activity.

139 nding domain of Sec5 and RalA bound to a non-hydrolyzable GTP analog (GppNHp) at 2.1 A resolution, pr

140 etween microtubules stabilized with a slowly hydrolyzable GTP analog and microtubules stabilized with

141 -family GTPases in these extracts by the non-hydrolyzable GTP analog GTPgammaS stimulated barbed-end

142 actor 1 (ARF1) in the presence of the poorly hydrolyzable GTP analog guanosine 5'-O-(3-thiotriphospha

143 ures of (K180P)G alpha(i1) bound to a slowly hydrolyzable GTP analog, and the GDP.magnesium fluoroalu

144 ystals were obtained in complexes with a non-hydrolyzable GTP analog, GppNHp.

145 y, in two states: bound to GDP, and to a non-hydrolyzable GTP analog, guanosine-5'-(beta, gamma)-imid

146 lizes ternary complex in the presence of non-hydrolyzable GTP analogs.

147 G to the ribosome in the presence of the non-hydrolyzable GTP analogue GDPNP or GTP plus fusidic acid

148 ure in vitro, but were unaffected by the non-hydrolyzable GTP analogue GMP-PNP.

149 eabilized parasites was augmented by the non-hydrolyzable GTP analogue guanosine 5'-3-O-(thio)triphos

150 y(catastrophe) was obtained using the slowly hydrolyzable GTP analogue guanylyl-(a,b)-methylene-dipho

151 in in microtubules assembled with the slowly hydrolyzable GTP analogue guanylyl-(alpha, beta)-methyle

152 ent of agonist-occupied receptors with a non-hydrolyzable GTP analogue shifted the receptor into its

153 cyclase by receptors and GTP gamma S (a non-hydrolyzable GTP analogue) is reduced by up to 95%.

154 ules (MTs) polymerized with GMPCPP, a slowly hydrolyzable GTP analogue, are stable in buffer but are

155 duced by GTP and nearly abolished by the non-hydrolyzable GTP analogue, guanosine-5'-[thio]-triphosph

156 mutant fusion proteins using a fluorescent, hydrolyzable GTP analogue.

157 evertheless inhibited by the addition of non-hydrolyzable GTP analogues.

158 s, in contrast to smaller proteins, requires hydrolyzable GTP and the small GTPase Ran.

159 In the presence of non-hydrolyzable GTP, EF4 showed chemical protections simila

160 2 alone or with RF3 alone-RF3 bound to a non-hydrolyzable GTP-analog-have been reported.

161 S2 prevented stimulation of alpha1E with non-hydrolyzable guanosine 5'-0-(3-thiotriphosphate).

162 assays were performed in the presence of non-hydrolyzable guanosine 5'-triphosphate (GTP) analogue, 5

163 Using hydrolyzable H2B-Ub analogs, we show that Ubp10 activity

164 alpha-bromoacyl taxanes were synthesized as hydrolyzable hydrophobic prodrugs of paclitaxel.

165 involve the formation of bromophosgene as a hydrolyzable intermediate.

166 bicity from either the copolymerization of a hydrolyzable lactone ring or the hydrogel polymer conten

167 l of these duplexes are constructed with non-hydrolyzable lesion analogs that mimic the natural 8-oxo

168 can be rationalized by considering CFTR as a hydrolyzable-ligand-gated channel with cytoplasmic ATP a

169 All monomers contain hydrolyzable linkages to pendant functional groups, and

170 n, optimally linked through a differentially hydrolyzable linker unit, N-4-carboxymethylphenyl-methyl

171 he tissues either after hydrolysis or as non-hydrolyzable lipid esters.

172 Binding of non-hydrolyzable MgATP analogs or ATP in the absence of Mg i

173 studies suggest that MgAMP-PNP acts as a non hydrolyzable MgATP analogue for myosin.

174 e amide bond of anandamide (5, AN) to a less hydrolyzable moiety, analogues 1a-1l, 2a-2c, 3a-3c, and

175 and NBD2 as a site of fast turnover, the non-hydrolyzable N(3)AMP-PNP bound preferentially to NBD1.

176 nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic bond.

177 crystallized PEIII in the presence of a less hydrolyzable NAD analog, beta-methylene-thiazole-4-carbo

178 The activity required a hydrolyzable nucleoside triphosphate and both 5'- and 3'

179 ted nucleotide hydrolysis in the presence of hydrolyzable nucleoside triphosphates ATP, CTP, UTP, and

180 ure, complexes are also presented with a non-hydrolyzable nucleotide analog (adenosine 5'-(beta,gamma

181 imen crystallized in the presence of the non-hydrolyzable nucleotide analog, adenosine 5'-O-(thiotrip

182 ese studies utilized transition state or non-hydrolyzable nucleotide analogs, it is not clear at what

183 Further, using a combination of non-hydrolyzable nucleotide analogues and mutations that blo

184 Compared to those of the other hydrolyzable nucleotide triphosphates, the ATPase activi

185 The non-hydrolyzable nucleotides adenosine 5'-(beta,gamma-imino)

186 We conclude that poorly hydrolyzable nucleotides are less effective than ATP at

187 ein for Ypt7p:GTP), GTPgammaS or GppNHp (non-hydrolyzable nucleotides), and mutant forms of Ypt7p tha

188 - and time-dependent, and detected only with hydrolyzable nucleotides.

189 les was not sensitive to hydrolyzable or non-hydrolyzable nucleotides.

190 This study suggests that hydrolyzable O-alkyl soil OM components may block high a

191 Likewise, its affinity for the non-hydrolyzable oligonucleotide 6-FAM approximately d(CAA)

192 s with the microtubules was not sensitive to hydrolyzable or non-hydrolyzable nucleotides.

193 is into PGE2, were not observed with the non-hydrolyzable PGE2-serinol amide, and were completely pre

194 negatively charged substituents para to the hydrolyzable phosphate dramatically promote hydrolytic e

195 Hydrolyzable polymers are widely used materials that hav

196 Here, we report the first design of hydrolyzable polyureas bearing dynamic hindered urea bon

197 trategy, phenylsilanes were employed as acid-hydrolyzable precursors of the silanol group.

198 ct is reported as a new member of a class of hydrolyzable prodrugs of the duocarmycin and CC-1065 fam

199 roach that transforms a weak and general non-hydrolyzable pTyr mimetic (F(2)Pmp, phosphonodifluoromet

200 s been accomplished by replacing the rapidly hydrolyzable Schiff-base moiety of first-generation memb

201 even-amino acid peptide was documented to be hydrolyzable specifically by the serine protease prostat

202 on in complex with magnesium ion and the non-hydrolyzable substrate analog, alpha,beta-imido dUTP.

203 (DRV), a potent clinical inhibitor, or a non-hydrolyzable substrate analogue, Ac-Thr-Ile-Nle-r-Nle-Gl

204 ith alpha-maltose-C-phosphonate (MCP), a non-hydrolyzable substrate analogue, was solved to 1.9 A res

205 -MSA synthases with both nonhydrolyzable and hydrolyzable substrate mimics have provided additional i

206 in complex with NAD, deamido-NAD, and a non-hydrolyzable TAD analogue beta-CH(2)-TAD.

207 We experimentally induced hydrolyzable-tannin defenses in red oak, to show that in

208 Almost 200years ago, hydrolyzable tannins (HTs) were the first group of plant

209 d fatty acids and phenolic compounds (namely hydrolyzable tannins and anthocyanins) with antioxidant

210 one of the duplexes contains a central, non-hydrolyzable, tetrahydrofuran (THF) abasic site analog,

211 ther substitution of this residue with a non-hydrolyzable the phosphoserine/phosphothreonine mimetic

212 incorporated acetyl-lysine (AcK) and the non-hydrolyzable thioacetyl-lysine (ThioAcK) into full-lengt

213 ns of long chain fatty acyl-CoAs and the non-hydrolyzable thioether analog of palmitoyl-CoA markedly

214 s rapidly catabolized by V. furnissii, a non-hydrolyzable thioglycoside analogue was used: methyl bet

215 plasma was enriched in isoflavones that were hydrolyzable with a combined beta-glucuronidase and sulf