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1 rface area of the K1-K10 structure is 20-25% hydrophobic.
2 of BslA is required to render the community hydrophobic.
3 y which the oxidized form of the ECP becomes hydrophobic.
4 lustrated the importance of ASO backbone and hydrophobic 2' sugar modifications and revealed that the
7 s integrate water-soluble phenylethanoid and hydrophobic alkyl into one molecule thus are endowed wit
13 lysis to export many structurally dissimilar hydrophobic and amphipathic compounds, including antican
14 iral moieties, resulting in a combination of hydrophobic and auxiliary pocket effects that yielded hi
15 dy shows that increasing segregation between hydrophobic and cationic moieties in these polymeric mim
16 coiled-coil dimer pairing is mainly based on hydrophobic and electrostatic interactions between resid
18 gned and synthesized by interconnecting both hydrophobic and hydrophilic molecular nanoparticles in p
19 potential of a novel formulation for coating hydrophobic and hydrophilic peptides onto MN devices and
22 which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, includi
23 block copolymers made of sequence-controlled hydrophobic and ionizable monomers on the inner surface
25 e at the second position of the peptide, and hydrophobic and polar amino acids at the C-terminal end.
26 ility of --CH3- or -C-C-PO4- species through hydrophobic and/or cation-pi associations between green
27 ding van der Waals', ionic, carbonyl, metal, hydrophobic, and halogen bond contacts, and hydrogen bon
28 mpounds tend to be smaller, more rigid, more hydrophobic, and more drug-like than non-allosteric comp
30 h also depended on their ability to transfer hydrophobic antimicrobial constituents to the separated
31 virucidal activity of a region that combines hydrophobic-at-interface membrane-proximal external regi
33 rmulation that is suitable for MN coating of hydrophobic auto-antigen peptides currently being invest
34 n of paper-based microfluidics by patterning hydrophobic barriers using a desktop pen plotter integra
36 antially increased intrahepatic retention of hydrophobic BAs and decreased hepatic expression of tumo
37 of BH3-only proteins with both the canonical hydrophobic binding groove (alpha2-5) and alpha6 at the
38 the signal sequence is extending beyond its hydrophobic binding groove of the SRP M domain towards t
40 ngly, in all three structures, the bulky and hydrophobic BP pyrenyl residue is entirely solvent-expos
41 (alpha-olefinate)s (xPAOs) as a new class of hydrophobic building block for amphiphilic materials, an
42 ng factors that compensate for the dearth of hydrophobic burial include shorter and stronger H-bonds,
43 simply distinguishes between hydrophilic and hydrophobic, but fine-tuning of the microenvironment is
45 ncreasing carbonization was explained by the hydrophobic carbonaceous matrix acting like a filter fav
49 ability of burying their lipid chains in the hydrophobic cavity of TLR2 and, in some cases, TLR1, at
50 d helix S6 of a neighbouring subunit, form a hydrophobic cavity to house the agonist, suggesting a di
51 lipopolysaccharide and traffic it along the hydrophobic cavity toward the transporter's periplasmic
52 lycolipids identified to date consist of two hydrophobic chains and an alpha-glycoside in which the 2
53 ure revealed that HO-2 binds myristate via a hydrophobic channel adjacent to the heme-binding pocket.
54 esults using structural data, which show the hydrophobic channel is interrupted by a highly charged r
55 enter of the PD-L1 homodimer, filling a deep hydrophobic channel-like pocket between two PD-L1 molecu
56 m membrane to membrane, our findings support hydrophobic channeling within membranes as a means of ce
58 Asn-110 and Asn-137 form a highly conserved hydrophobic cleft interacting with the core trisaccharid
59 In contrast, NH2-K(Boc)LVFF-CONH2 undergoes hydrophobic collapse at a low concentration, followed by
60 e cotranslational folding sites initiated by hydrophobic collapse for an unstructured and two globula
61 (II) in aqueous samples was converted into a hydrophobic complex of copper(II) diethyldithiocarbamate
62 ature of the hydrophilic PSs and that of the hydrophobic components, of linkers, targeting groups and
65 tioning of polar constituents, proteins, and hydrophobic constituents in three phases comprising of w
66 espread biological role is providing a rigid hydrophobic contact surface under the undecorated side o
67 om a variety of conformations with different hydrophobic contact surfaces that interconvert on the mi
68 ons involving 11 hydrogen bonds and numerous hydrophobic contacts account for stable complex formatio
69 H-1-PGC1alpha complex, which depicts several hydrophobic contacts and a strong charge clamp at the in
70 t, anchoring the CTD in place and permitting hydrophobic contacts between FtsZ residues Ile-374, Pro-
71 own (1)O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and
73 N-terminus of the peptide backbone near the hydrophobic core of cylindrical nanofibers leads to stro
74 issense mutations disrupt the folding of the hydrophobic core of hCDC73-NTD, while others such as the
75 ne-conjugated acyl-group of ACP occupies the hydrophobic core of ISD11, explaining the basis of ACP s
76 ile procedure is used for reconstituting the hydrophobic core of LDLs with a binary fatty acid mixtur
77 hrough JMJD6 interactions with the conserved hydrophobic core of the ET domain, and reinforced by ele
79 ved along the peptide backbone away from the hydrophobic core, the interactions with dodecanoic acid
82 cycles lack regular secondary structures and hydrophobic cores, and can contain local structures not
83 tabilizes a mobile C-terminal helix inside a hydrophobic crevice of NCS-1 to impede Ric8a interaction
85 ue to the monodispersity and symmetry of the hydrophobic dendritic block, which significantly simplif
87 ith electrodes utilizing PEDOT-C14, a highly hydrophobic derivative of poly(3,4-ethylenedioxythiophen
88 mbly displays the typical characteristics of hydrophobic desolvation processes, and detailed analysis
89 the as-formed Ag-NW thin film with a dense, hydrophobic dodecanethiol layer, the stability of the Ag
90 anchored (TA) proteins, bearing a C-terminal hydrophobic domain that is essential for their membrane
93 ifferences between charged nucleic acids and hydrophobic drugs have hindered entrapment of both compo
95 self-assembles to form long fibrils with the hydrophobic edge and histidine residues extending in an
98 <F127<P123, indicating the importance of the hydrophobic environment for the colorimetric transition
99 ructural and genetic analyses, that a unique hydrophobic environment in the catalytic space of gp17-a
103 ling and molecular simulations reveal unique hydrophobic environments near the arginine CDR mutations
104 y charged RNA-binding tunnel with a separate hydrophobic extension that unexpectedly engages the cap
105 nd cellular mutational analysis revealed the hydrophobic face of two alpha-helices to be critical for
106 trate that PgP/pDNA polyplexes loaded with a hydrophobic fluorescent dye are retained in local neural
108 le surface model describes how curvature and hydrophobic forces lead to the emergence of new protein
109 e folding and binding of random sequences of hydrophobic ([Formula: see text]) and polar ([Formula: s
110 s to release smaller, soluble but relatively hydrophobic fragments of protein (plasmin-generated prot
112 ated Na(+), and these results also support a hydrophobic gating mechanism for control of ion permeati
114 uate the potential role of these residues in hydrophobic gating, Leu267 and Leu270 in human Slo2.1 we
120 r achieving effective encapsulation of large hydrophobic guests, including fullerenes, polycyclic aro
121 d alphaS variant added hydrophobicity to the hydrophobic half of alphaS helices, thereby stabilizing
122 ng charged for uncharged residues within the hydrophobic half of the stabilized helix not only revers
125 hilic material can macroscopically behave as hydrophobic if a surface has proper microstructured feat
126 negligible when a hydrophilic (Ser-109) or a hydrophobic (Ile-305) amino acid is mutated instead.
127 s radicals in both environments, aqueous and hydrophobic, indicating the importance of phenolic compo
128 NTH), previously thought to drive fission by hydrophobic insertion, our results show that membrane co
129 In addition to characterizing heterogeneity, Hydrophobic Interaction Chromatography (HIC) is an assay
130 In this study, a storage- and pH-sensitive hydrophobic interaction chromatography (HIC) profile cha
131 on, monitoring of foulants during multimodal hydrophobic interaction chromatography of recombinant hu
132 imary amide group (Q side chain) weakens the hydrophobic interaction generated by the six cyclohexyl
133 inly through hydrogen bonding, although some hydrophobic interaction may also have been involved.
135 eet contents and more chemical bonds such as hydrophobic interactions and disulfide bonds than those
138 e main driving forces of these interactions, hydrophobic interactions and hydrogen bonds, respectivel
140 onic polar groups have pronounced effects on hydrophobic interactions generated by a neighboring nonp
141 trate the importance of hydrogen bonding and hydrophobic interactions in the oligomerization of IAPP-
142 signal-anchored MAM proteins can make use of hydrophobic interactions independently of conventional E
143 ized by either electrostatic interactions or hydrophobic interactions involving the I36 hydrophobic p
144 (primary amine and primary amide) influence hydrophobic interactions of neighboring nonpolar domains
145 ersus methanol allowed quantification of the hydrophobic interactions of the beta-peptide with the no
146 to better overall shape complementarity and hydrophobic interactions with S372 and M368 on KCa3.1 an
149 sidues at V3 positions 306 and 308 to create hydrophobic interactions with the tryptophan residue at
150 one hand, such aggregates can disrupt native hydrophobic interactions, and on the other hand, they ca
151 electrostatic interactions, hydrogen bonds, hydrophobic interactions, and van der Waals interactions
152 pramolecular motifs in water are directed by hydrophobic interactions, cooperative delivery strategie
159 hole-transport-layer covered substrates by a hydrophobic interface confined lateral crystal growth me
161 ing form along with providing a sufficiently hydrophobic interface to counteract the aqueous layer fo
162 lical portions of M2 contribute to extensive hydrophobic interfaces between AMPA receptor subunits in
163 coiled-coil heterodimer with a predominantly hydrophobic intermolecular interface; this heterodimer f
164 ailable cyclodextrins (CDs) with an inherent hydrophobic internal cavity and hydrophilic external sur
167 ation or long-term storage and relies on the hydrophobic ligand-binding pocket of AHR, with identical
168 zone in the paper is delimited by drawing a hydrophobic line with an inexpensive permanent marker.
171 e concave plots originate from AOs in a more hydrophobic location in the micro-heterogeneous system.
172 of the protein-a cationic patch and a unique hydrophobic loop-that are essential for accessing SM in
173 w type of magnetoliposomes (MLs), containing hydrophobic magnetic-gold nanoparticles and the long wav
175 Commercial superglue mostly for binding hydrophobic materials is used to strongly immobilize the
177 In order for many proteins to move across hydrophobic membrane bilayers, they must be unfolded and
178 g constricting rings, helical scaffolds, and hydrophobic membrane insertions are thought to be the pr
179 entin matrix create tight biointerfaces with hydrophobic methacrylate adhesives on wet surfaces.
180 t-off curves yield information regarding the hydrophobic microenvironment surrounding the reactive AO
181 ressure forced intrusion studies of water in hydrophobic microporous materials such as zeolites and M
182 ns them, and causes the greatest increase in hydrophobic mismatch between liquid-ordered (Lo) and Ld
183 lower the energetically unfavorable residual hydrophobic mismatch between TM4 and the membrane, reduc
186 of surfactant was particularly notable for a hydrophobic monomer glycidyl methacrylate combined with
189 f Wnts, Frizzleds, and SFRPs, as well as the hydrophobic nature of Wnt, poses challenges to laborator
191 Moreover, regarding a liquid droplet on hydrophobic or superhydrophobic surfaces, an approximate
192 en these surfaces are micro/nanotextured and hydrophobic, or superhydrophobic, an impacting drop can
193 philic perovskite precursor solutions on the hydrophobic organic charge-transport layers (CTLs).
195 ngulfing of a hygroscopic particle core by a hydrophobic organic-rich phase, can explain the lack of
196 ansmembrane region of FtsLB is stabilized by hydrophobic packing and by a complex network of hydrogen
197 ding of natural proteins typically relies on hydrophobic packing, metal binding, or disulfide bond fo
198 h dimer is stabilized by interactions of one hydrophobic palmitoleic acid tail with two CRD palmitole
199 Our molecular modeling suggested that a hydrophobic patch created after TCRalpha-TCRbeta pairing
201 a single point-site mutation at the docking hydrophobic patch of a Cu-azurin causes minor structural
203 he helix is ejected and unravels, exposing a hydrophobic patch, which then serves as a degradation si
205 Porewater concentrations of the strongly hydrophobic PCB congeners were overestimated by up to an
210 ion to this paradox by implementing a highly hydrophobic perfluorinated anion (perfluorooctanesulfona
212 omplex controls the passage of molecules via hydrophobic phenylalanine-glycine (FG) domains on nucleo
214 gages the receptor by binding to an extended hydrophobic pocket facilitated by the large outward move
215 of Glu37, a glutamate residue embedded in a hydrophobic pocket of HdeA, is important in controlling
216 models places the P-CR connector loop into a hydrophobic pocket of the catalytic core, with the coile
217 The docking of the farnesyl group to the hydrophobic pockets located at both CaM lobes further en
219 bicity, in situ passive sampling of strongly hydrophobic polychlorinated biphenyls (PCBs) is still ch
222 the substrate proteins they translocate via hydrophobic pore loops and cleft structures called clamp
224 ion by bringing together a hydrophilic and a hydrophobic precursor, which leads to repeated droplet d
225 ved effect was an increased affinity towards hydrophobic probes in the presence of all co-solutes but
226 Here we report an investigation into the hydrophobic properties of the exopolysaccharide produced
228 spectroscopy applying stable hydrophilic and hydrophobic radicals is advantageous, especially for cha
231 ar protein homeostasis by binding to exposed hydrophobic regions of incompletely folded or aggregated
232 mational change that lead to the exposure of hydrophobic regions responsible for target protein recog
233 rface charges and increased accessibility of hydrophobic residues (including the nuclear export seque
234 the first two residue sidechains complement hydrophobic residues around the active site, while the t
235 receptors containing each of four different hydrophobic residues at position 195 served as input dat
236 data support a model in which small neutral hydrophobic residues facilitate the post-translational c
239 diates, each with a nonnative arrangement of hydrophobic residues in the MDM2 binding cleft, control
240 eed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.
243 -directed mutagenesis on the surface-exposed hydrophobic residues of pvLAAD INS, and we found that th
244 rane-proximal external region aromatics with hydrophobic residues of the transmembrane domain, and co
245 econfiguration rate is slow enough to expose hydrophobic residues on the same time scale that bimolec
246 Residues P193 and W222 comprise a series of hydrophobic residues surrounding the cofactor binding si
247 s simultaneous substitution of four aromatic/hydrophobic residues with Ala dramatically impairs both
248 ulations, here we identified single aromatic/hydrophobic residues within the amyloid core IAPP region
249 site-directed mutagenesis of outward-facing hydrophobic residues within the transmembrane region of
250 nus side of the HA PCS (P2 position) avoided hydrophobic residues, whereas the P3 position avoided hy
255 hydration state of the deep, well-accessible hydrophobic S1' specificity pocket of the metalloproteas
256 ructure of most potent sweeteners combines a hydrophobic scaffold functionalized by a limited number
258 rease in polar side chains and a decrease in hydrophobic side chains lining the vestibule, and this w
259 ruitment site that normally accommodates the hydrophobic sidechains of a canonical D-site, retaining
260 ynthesis the nanocapsules can be loaded with hydrophobic small molecules and post self-assembly under
262 nanoporphyrin micelles (NPM), the extremely hydrophobic SN-38 was successfully encapsulated into NPM
264 obic hydration is that, in the presence of a hydrophobic solute, water forms transient microscopic "i
267 retching mode of HDO water near small purely hydrophobic solutes (methane, ethane, krypton, and xenon
268 Sarcoma Virus (RSV), CA carries a short and hydrophobic spacer peptide (SP) at its C-terminus early
269 viously shown that this is in part because a hydrophobic statin with a long half-life is necessary.
270 nism underlying this effect is unclear, i.e. hydrophobic/steric effects versus electrostatic effects.
271 e, degenerate, interchangeable, linear or 3D hydrophobic stretches that become available because of t
272 strongly compromises the water-repellency of hydrophobic structures, this failure can be minimized by
273 ibitors; PJ34 inserts a flexible moiety into hydrophobic subpockets in various ADP-ribosyltransferase
274 water droplet surface suggests that strongly hydrophobic substituents determine the reactivity of Cri
275 Combinatorial mutagenesis demonstrated that hydrophobic substitutions were tolerated but polar or ch
276 e transporters that transport amphipathic or hydrophobic substrates in a detergent-free native or art
279 th nanogold-conjugated CBM3, which binds the hydrophobic surface of crystalline cellulose, was infreq
280 er-layer shedding depend on interaction of a hydrophobic surface on VP5* with the membrane bilayer an
281 ed by the cohesion-tension theory by coating hydrophobic surfaces and nanobubbles, thereby keeping th
282 show that angiosperm xylem contains abundant hydrophobic surfaces as well as insoluble lipid surfacta
284 cular kinetic analyses of water spreading on hydrophobic surfaces via molecular dynamics simulation.
285 ic energy from the motions of water drops on hydrophobic surfaces, and thus, the resulting schemes in
288 o dye, at pH 6.5, and then extraction of the hydrophobic ternary complexes formed in presence of cety
289 ted from electrically conductive, insulated, hydrophobic textiles, but the concept can be extended to
290 is lamellar and determined that its average hydrophobic thickness is 24.3 +/- 0.9 Angstroms (A).
293 ted mainly Abeta dimer and trimer formation, hydrophobic toluene mainly affected formation of larger
295 Prp40 homolog A (HsPrp40A), which contains a hydrophobic triad W1L4L8 that is known to be important i
296 ike a lid, opening and closing access to the hydrophobic tunnel, which accommodates the aliphatic tal
299 , the bulk polymer itself is elastomeric and hydrophobic while its superhydrophilic surface propertie
300 rpret drop movements on both hydrophilic and hydrophobic wires, with the support of experimental resu
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