ライフサイエンスコーパス: hydrophobic core

1 eract with the protein before disrupting the hydrophobic core.

2 ype of flanking residues at both ends of the hydrophobic core.

3 d T39 by a hydrogen-bond linkage through the hydrophobic core.

4 for internalization, is fully buried in the hydrophobic core.

5 ed on both faces and the lack of a canonical hydrophobic core.

6 ng of five helices held together by a strong hydrophobic core.

7 fluorophenylalanine (F(5)Phe) residue in the hydrophobic core.

8 s organized in a highly ordered bilayer-like hydrophobic core.

9 ability to increase the order of the bilayer hydrophobic core.

10 which one Asp side chain faces the membrane hydrophobic core.

11 rged with nonpolar residues, stabilizing the hydrophobic core.

12 1 even without its proper insertion into the hydrophobic core.

13 away from the solvent to form a central dry hydrophobic core.

14 by hydrophobic interactions into a spherical hydrophobic core.

15 t an evolutionarily invariant residue in its hydrophobic core.

16 nt of the first helix and instability of the hydrophobic core.

17 and compaction of others, most notably, the hydrophobic core.

18 s governed by the formation of a well-packed hydrophobic core.

19 ying the polar Ser side chain in the bilayer hydrophobic core.

20 es and a pair of histidines, and by an inner hydrophobic core.

21 s required for destruction of the receptor's hydrophobic core.

22 signal transfer mechanism in the membrane's hydrophobic core.

23 closure of the lateral access pathway to the hydrophobic core.

24 aqueous phase to the center of the designed hydrophobic core.

25 s-66 Nzeta group is completely buried in the hydrophobic core.

26 partially, protonation of H41 buried in the hydrophobic core.

27 f secondary structure and dissolution of the hydrophobic core.

28 essing pathway from the aqueous phase to the hydrophobic core.

29 GCN4 leucine zipper nomenclature, which form hydrophobic core.

30 is likely mediated by the flexibility in the hydrophobic core.

31 otein size and the flexibility of the native hydrophobic core.

32 alpha-helical segments packed around a small hydrophobic core.

33 eir cargo covalently encapsulated within the hydrophobic core.

34 ively charged head groups at each end of the hydrophobic core.

35 d residues of the protein are trapped in the hydrophobic core.

36 gregation and in organization of the protein hydrophobic core.

37 self-assembly does not entail formation of a hydrophobic core.

38 trimer subunits further associate to form a hydrophobic core.

39 mic cost of exposing charged residues to the hydrophobic core.

40 ative state stabilizing interaction with the hydrophobic core.

41 of ion pairs ( approximately 60,000) in each hydrophobic core.

42 unzips due to the loss of contacts with the hydrophobic core.

43 lobular domain and increased exposure of its hydrophobic core.

44 ubility, and tailored binding sites in their hydrophobic cores.

45 Greek key beta-sheet folds with well packed hydrophobic cores.

46 drophobic residues into strikingly different hydrophobic cores.

47 onomers to the solvent, while maintaining a "hydrophobic" core.

48 ilizing interactions are located outside the hydrophobic core a and d positions that have been shown

49 med two "cationic donuts" that protected the hydrophobic core against aggregation in water.

50 This results in a new hydrophobic core, an intraprotein hydrogen bond and a qu

51 regions: a positively charged N-terminus, a hydrophobic core and a more polar C-terminal region that

52 o the main fibril axis, where they produce a hydrophobic core and are surrounded by the structurally

53 e partially unfolded structure, exposing the hydrophobic core and backbone hydrogen bond donors and a

54 ring stacking of F12 and W15 along the long hydrophobic core and by a nearly perfect stretch of hydr

55 B), which are held together by an extensive hydrophobic core and disulphide bonds.

56 lymer nanoparticles with lightly-crosslinked hydrophobic core and hydrophilic surface groups are synt

57 s to form a single bilayer structure, with a hydrophobic core and hydrophilic surfaces, and the resul

58 s-ms time-scale dynamics of the intra-strand hydrophobic core and interfaces of the fibrils composed

59 drophobic core mutants as it is close to the hydrophobic core and known to cause instability.

60 results in increased flexibility within the hydrophobic core and loop regions that orient the DNA bi

61 We explored the contribution of the hydrophobic core and of the extended C terminus by exami

62 mNramp1 and a fusion chimera of the PmNramp3 hydrophobic core and PmNramp1 N- and C-termini.

63 amma-zein family are arranged in the central hydrophobic core and the cross-linked protein body perip

64 ferent alkyl linker lengths separating their hydrophobic core and the hydrophilic carboxylate headgro

65 lay between the conformational states of the hydrophobic core and the N terminus.

66 g from the interaction between the channels' hydrophobic cores and that of the lipid bilayer.

67 particles with a narrow size distribution, a hydrophobic core, and an ionic shell.

68 s driven by the lipid-facing residues in its hydrophobic core, and its NC-IN topology is determined b

69 rtain glycan mutants, mutations in the gp120 hydrophobic core, and mutations in residues involved in

70 ted by interactions arising from the central hydrophobic core, and precipitated by those arising from

71 at is, the extracellular domain, the central hydrophobic core, and the transmembrane domain.

72 is buried in the beta4-strand in the central hydrophobic core, and the Tyr structurally links to the

73 bility and cooperativity can occur without a hydrophobic core, and without alpha-helices or beta-shee

74 E and G5 domains lack a compact hydrophobic core, and yet G5 domain and multidomain cons

75 cycles lack regular secondary structures and hydrophobic cores, and can contain local structures not

76 Many mutations in the hydrophobic core are also associated with drug resistanc

77 g residence urea molecules placed around the hydrophobic core are crucial to stabilize partially open

78 results reveal that dynamics in the extended hydrophobic core are important for binding site selectio

79 volved in intermolecular interactions in the hydrophobic core are only partially folded in I(2).

80 R measures, the aliphatic side chains in the hydrophobic core are slightly more dynamic in the free p

81 light the calcium-binding loop (R1597W), the hydrophobic core around the vicinal disulfide (M1528V),

82 ining proteins, including a long loop region hydrophobic core associated with calcium-dependent glyca

83 f-life of yeast CD (yCD) by repacking of its hydrophobic core at several positions distant from the a

84 The loop possesses a hydrophobic core at the center of the region with an unu

85 Thus, with increasing temperature, first the hydrophobic core awakens, followed by the hydrophilic su

86 ins much to be learnt about how and when the hydrophobic core becomes desolvated and tightly packed d

87 on of the protein, with urea penetrating the hydrophobic core before water, forming a "dry globule."

88 the cyclohexane ring buried within the gp120 hydrophobic core but able to assume multiple orientation

89 es sequesters elongating products within its hydrophobic core, but this dynamic mechanism remains poo

90 Moreover, the shielding of the hydrophobic core by the charged exterior shell decreases

91 nesulfonate monitored the involvement of the hydrophobic core/calyx of beta-lactoglobulin in the aggr

92 Here we report that this hydrophobic core can be re-engineered to contain a fluor

93 Thus, altered flexibility within the hydrophobic core can modulate HIV-1 protease activity, s

94 The peptoid nanotubes form without a central hydrophobic core, chirality, a hydrogen bond network, an

95 0'), I84 (I84'), and V82 (V82') which create hydrophobic core clusters to further stabilize the close

96 ric helix-bundle quaternary structure with a hydrophobic core composed solely of beta-amino acids.

97 The domain has a well-packed hydrophobic core comprised in part of an unusual set of

98 The Rnt1p dsRBD has an extended hydrophobic core comprising helix alpha1, the alpha1-bet

99 ic reveals that the left arm forms a concise hydrophobic core comprising tryptophans Trp(21) and Trp(

100 barstar forms a partially solvent-accessible hydrophobic core consisting of several residues that hav

101 r the synthesis of hybrid micelles with PPhe hydrophobic core, cross-linked ionic PGlu intermediate s

102 ein, including the side-chain packing in the hydrophobic core, denatures in a single cooperative proc

103 nd that polar interactions buried within the hydrophobic core determine the specificity of heterodime

104 GAA hairpin reveals that dynamics within the hydrophobic core differentiate between specific and nons

105 lices, and the side-chain packing within the hydrophobic core differs fundamentally from the knobs-in

106 shells of the cationic nanoparticles and the hydrophobic core domain of the anionic central cylindric

107 Development of a tightly packed hydrophobic core drives the folding of water-soluble glo

108 L1M/L38M)(2), was designed to contain a long hydrophobic core, enclosed by four amphipathic alpha-hel

109 In view of the high hydrophobic core exposure, hydration, and curvature pres

110 ds to form the native three-strand sheet and hydrophobic core features.

111 he voltage sensor domain translates across a hydrophobic core forming a barrier for the gating charge

112 Overall, mutations in the hydrophobic core have a significant effect on the dynami

113 ity of the amphipathic helices TH1-3 and the hydrophobic core helix TH8 at pH 6.5.

114 uM) and K162 (EC(50) = 0.080 muM), stabilize hydrophobic core I of Abeta(42) peptide (residues 17-21)

115 e importance, this phenomenon indicates that hydrophobic core I of the Abeta(42) peptide plays a majo

116 a unique spatial arrangement that caught the hydrophobic core in a cage, thereby protecting it fully

117 f which are compromised to maintain a stable hydrophobic core in the DEP domain.

118 hydrophobic cluster and another delocalized hydrophobic core in the folding kinetics, are discussed.

119 The mutation M16I loosens the hydrophobic core in the G domain and affects domain I to

120 P14 residue retains an interaction with the hydrophobic core in the intermediate state but is releas

121 viously, it is attenuated in Pol lambda by a hydrophobic core including Leu431, Ile492, and the Tyr50

122 at the slower structural fluctuations in the hydrophobic core, indicating a more tightly structured c

123 aggered by only 4 amino acids and displaying hydrophobic core interactions similar to those of the pa

124 ular hydrophilic patterning of its otherwise hydrophobic core is a prerequisite for the TolA-induced

125 determinants of DNA binding, whereas the RHH hydrophobic core is assembled from amino acids in both t

126 Here, we report that the hydrophobic core is crucial for biological activity of p

127 ate with the fourth arginine in S4 above the hydrophobic core is destabilized by approximately 17 kJ/

128 -coil are stabilized by Leu-110, whereas the hydrophobic core is destabilized in the SCR by Ala resid

129 namics suggest that the rearrangement of the hydrophobic core is essential for enzyme activity.

130 lix bundle protein, alpha 4F 6, in which the hydrophobic core is packed entirely with the extensively

131 mall, de novo-designed proteins in which the hydrophobic core is packed with various combinations of

132 hermal unfolding experiments indicate that a hydrophobic core is present in the tetramer.

133 Loose packing of hydrophobic cores is not infrequent in proteins, as the

134 on of E9, which has sparse contacts with the hydrophobic core, is linked to an allosteric activator r

135 s of two leucine residues that belong to the hydrophobic core (L17 and L34) as well as M35 residues b

136 e investigate methyl group dynamics of a key hydrophobic core leucine residue in chicken villin headp

137 ively stabilize each other by completing the hydrophobic core lining the central part of HP35.

138 hin all substructures of the WW domain fold (hydrophobic core, loop 1, loop 2, beta-sheet).

139 on the surface of the protein as well as the hydrophobic core maintaining the structural integrity ar

140 A BDTA hydrophobic core micelle coupled with a positive electri

141 The T183A mutation is related to the hydrophobic core mutants as it is close to the hydrophob

142 s of chymotrypsin inhibitor 2 (CI2) and five hydrophobic core mutants, some of which are members of t

143 structure that can be perturbed by discrete hydrophobic core mutations.

144 cine (hFLeu) at various positions within the hydrophobic core of a de novo-designed four-alpha-helix

145 Our findings imply that the hydrophobic core of a micelle is surrounded by a highly

146 onation of a lysine side chain buried in the hydrophobic core of a protein, demonstrating heteronucle

147 for sensing oxidative stress centred on the hydrophobic core of a sensor protein.

148 Of note, crenezumab also sequesters the hydrophobic core of Abeta and breaks an essential salt-b

149 (494-515) region and aligns with the central hydrophobic core of Abeta.

150 own (1)O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and

151 CK-0993548 inserts into the hydrophobic core of Arp3 and alters its conformation.

152 In contrast, Met10 is buried in the hydrophobic core of Atox1, and its removal results in a

153 from the native residue tryptophan-48 in the hydrophobic core of azurin.

154 ained by a cysteine bridge buried within the hydrophobic core of beta4.

155 m infrared results reveal an ordering of the hydrophobic core of bilayers when leakage is noted, i.e.

156 ical unfolding begins with disruption of the hydrophobic core of Bn near the Ub insertion site.

157 Carotenoids can accommodate into the hydrophobic core of cyclodextrins and therefore, they ar

158 N-terminus of the peptide backbone near the hydrophobic core of cylindrical nanofibers leads to stro

159 binding; and 4), VBS inserts itself into the hydrophobic core of D1.

160 active chromanol moiety residing deep in the hydrophobic core of di-14:0PC bilayers, a location that

161 rmally present in wild type that weakens the hydrophobic core of Domain II.

162 Mutations in the hydrophobic core of frataxin affected stability whereas

163 itors are 12-amino-acids-long and target the hydrophobic core of gp41.

164 issense mutations disrupt the folding of the hydrophobic core of hCDC73-NTD, while others such as the

165 show here that the P2204L mutation impairs a hydrophobic core of Ig20, generating a conformationally

166 s not affect methyl group motions within the hydrophobic core of individual cross-beta subunits but h

167 ne-conjugated acyl-group of ACP occupies the hydrophobic core of ISD11, explaining the basis of ACP s

168 rved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is

169 ile procedure is used for reconstituting the hydrophobic core of LDLs with a binary fatty acid mixtur

170 The localization of dendrimers in the hydrophobic core of lipid bilayers restricts the motion

171 ts the side chain of a lysine residue in the hydrophobic core of lobe 2 by a salt bridge.

172 e flexible peptide flip domain and the rigid hydrophobic core of lobe 2.

173 lipids allowing direct interaction with the hydrophobic core of membranes.

174 (NCBD), we have compared the dynamics of the hydrophobic core of NCBD in the ligand-free state and in

175 Their hydrophobic core of neutral lipids stores metabolic ener

176 Positions in the hydrophobic core of peptide-membrane complex show the gr

177 arily occurs by solvent penetration into the hydrophobic core of proteins in a sequence-independent m

178 ged side chains can be buried readily in the hydrophobic core of stable proteins without the need for

179 An artificial charge pair buried in the hydrophobic core of staphylococcal nuclease was engineer

180 in Su(H) by interacting with residues in the hydrophobic core of Su(H), illustrating the structural p

181 small and nonpolar-to-polar mutations in the hydrophobic core of T4 lysozyme cause significant loss i

182 ino acids in place of a phenylalanine in the hydrophobic core of T4 lysozyme was well tolerated by th

183 lalanine (pENPhe) were incorporated into the hydrophobic core of the 171-residue protein, T4 lysozyme

184 However, whether flip-flop through the hydrophobic core of the bilayer or desorption from the m

185 n the NP surface interact favorably with the hydrophobic core of the bilayer structure and guide the

186 largely encoded polar insertions within the hydrophobic core of the coiled-coil interface.

187 could penetrate the amide layer to reach the hydrophobic core of the cross-linked micelles.

188 t after the rapid dimerization reaction, the hydrophobic core of the dimer interface has few fully na

189 tate and N(2); however, only residues in the hydrophobic core of the dimer interface perturbed the I(

190 gn of the N-terminus were used to expand the hydrophobic core of the domain, and in the third case, t

191 of this enzyme and likely interacts with the hydrophobic core of the endoplasmic reticulum membrane.

192 loop, and Met42, which is located within the hydrophobic core of the enzyme.

193 hrough JMJD6 interactions with the conserved hydrophobic core of the ET domain, and reinforced by ele

194 s reveals dynamical perturbations within the hydrophobic core of the folded domain, which are attribu

195 The two [4Fe-4S] clusters are located in the hydrophobic core of the helical bundle as characterized

196 gate" opens, and guests can freely enter the hydrophobic core of the hemicarcerand.

197 single alanine mutation at Tyr507 within the hydrophobic core of the isolated colicin E3 rRNase domai

198 Our results support the idea that the hydrophobic core of the isolated monomer of Pfk-2 is sol

199 insertion of the two key tyrosines into the hydrophobic core of the lipid bilayer.

200 rane surface and penetrates further into the hydrophobic core of the lipid bilayer.

201 (1) allow the sodium ion to pass through the hydrophobic core of the membrane and (2) provide cation

202 of an organic solvent layer to represent the hydrophobic core of the membrane and short-tailed phosph

203 Delta5 isoform was more integrated into the hydrophobic core of the membrane than the FL isoform.

204 the 7-transmembrane (TM) bundle towards the hydrophobic core of the membrane, one between TM1/TM7 an

205 disaccharide-pentapeptide as it crosses the hydrophobic core of the membrane.

206 another phospholipid by penetrating into the hydrophobic core of the membrane.

207 s were encapsulated noncovalently inside the hydrophobic core of the micelle, which was composed of l

208 via even redistribution of stress along the hydrophobic core of the molecule.

209 alpha-Syn100 variant in which we removed the hydrophobic core of the non-amyloid component (NAC) doma

210 ed (NIR) emissive probes embedded within the hydrophobic core of the polymersome membrane.

211 ) did equalize rates without eliminating the hydrophobic core of the protein (i.e., without unfolding

212 The VP40 SDP Q245P affects the structure and hydrophobic core of the protein and consequently protein

213 is a more conservative substitution into the hydrophobic core of the protein compared to pCNPhe.

214 The urea-induced disruption of the hydrophobic core of the protein was probed by the change

215 minal leucine residues that form part of the hydrophobic core of the protein.

216 de bridge between the two beta-sheets in the hydrophobic core of the protein.

217 sence of distinct residues buried within the hydrophobic core of the RelB dimerization domain appears

218 The hydrophobic core of the signal sequence forms a helix th

219 Thus, the hydrophobic core of the signal sequence is primarily res

220 eals that a majority of mutations affect the hydrophobic core of the structure, indicating that most

221 s by disulphide-bonded caps that protect the hydrophobic core of the terminal repeats.

222 bability of observing water molecules in the hydrophobic core of these lipid membranes and their prot

223 residues were clustered together within the hydrophobic core of this enzyme.

224 (V619 and L623) then gradually penetrate the hydrophobic core of Vh1, thus further separating helix 1

225 asing the probability of contact between the hydrophobic cores of adjacent membranes.

226 complex, but have mobility comparable to the hydrophobic cores of average folded proteins.

227 goal of investigating dynamical features of hydrophobic cores of proteins over a wide range of tempe

228 solvent excluded voids that are found in the hydrophobic cores of the respective native states.

229 ty protein Im7 to examine the specificity of hydrophobic core packing during folding.

230 on of the UBL results from rearrangements to hydrophobic core packing that modify its structure.

231 These observations show that the hydrophobic core per se does not fully account for the a

232 f a stabilizing Leu residue in a coiled-coil hydrophobic core position d that causes this dramatic ef

233 y approximately 3.5-fold, is not part of the hydrophobic core presumably involved in the anesthetic b

234 ne-386 at the center of ER46's transmembrane hydrophobic core prevents membrane spanning, obscures th

235 aring hydrogen bonds (H bonds) buried in the hydrophobic core protected from water attacks.

236 acking of the fluorous amino acid within the hydrophobic core provides a more important contribution

237 site and turns the side chain of M513 into a hydrophobic core, providing a basis to understand how Ca

238 th a short alpha-helix formed at the central hydrophobic core region (L17-D23).

239 ) indicates that the domain contains limited hydrophobic core regions.

240 nding residues are sequestered back into its hydrophobic core, releasing sigma(R) to activate transcr

241 The hydrophobic core residues are a mix of an 11-mer repeat

242 Although the interfacial hydrophobic core residues Leu(12) and Tyr(84) play impor

243 e chain shifts the structure and dynamics of hydrophobic core residues of the protein so that these r

244 ervation analysis confirms the importance of hydrophobic core residues that stabilize the beta-trefoi

245 We also mutated hydrophobic core residues to destabilize III3 and found

246 Substituting the hydrophobic core residues, Leu-331, Val-338, and Ile-345

247 In contrast, the N-terminal hydrophobic core showed extremely slow solvent exchange,

248 /F77A-AT(1) receptor, designed to weaken the hydrophobic core, showed significant agonist-induced sig

249 ese structures reveal a solvent-sequestered, hydrophobic core stabilized by a unique arrangement of l

250 catalytic activity through interactions with hydrophobic core structures (beta1, beta3, alpha5, and a

251 ty shows high flexibility inside the bilayer hydrophobic core, suggesting its potential role as a ten

252 by a specific group of residues which form a hydrophobic core surrounding the oxyferryl heme center.

253 een two molecular moieties, for the micellar hydrophobic core, tends to expose a reacting fragment di

254 ing force for assembly is the formation of a hydrophobic core that excludes water, whereas the hydrop

255 concerted structural changes in the extended hydrophobic core that govern binding of helix alpha1 to

256 an independent domain but forms part of the hydrophobic core that joins the two beta-propellers.

257 t the requirement for a conserved Glu in the hydrophobic core that mediates interactions between othe

258 del in which the regulatory sequences form a hydrophobic core that reciprocally inhibits DNA binding

259 nosorbent assay (ELISA) results identified a hydrophobic core that stabilizes the V2 region for optim

260 and arranged in a manner that generates two hydrophobic cores that are capped at the end of the chai

261 ray structures for three small proteins with hydrophobic cores that are packed with either fluorocarb

262 nds are often found to depend on well-packed hydrophobic cores that influence the distance between th

263 y, although the amine group is buried in the hydrophobic core, the hydrogen exchange between water an

264 ved along the peptide backbone away from the hydrophobic core, the interactions with dodecanoic acid

265 s that Ala-40 contributes to an intrasubunit hydrophobic core, the principal effect of the A40V mutat

266 espite the large thickness mismatch in their hydrophobic cores, the hybrid membranes do not exhibit m

267 a" positions or all the "d" positions of the hydrophobic core, thereby creating an alternating packin

268 By localizing the sensor components in a hydrophobic core, these nanosensors are able to monitor

269 This protein is assumed to bind the membrane hydrophobic core through a transmembrane domain (TMD) as

270 beta(9-40) fibril suggest formation of tight hydrophobic core through M35 interactions across the fib

271 of DeltaN6 reveals a major repacking of the hydrophobic core to accommodate the nonnative peptidyl-p

272 mperatures demonstrate the distortion of the hydrophobic core to be a crucial step.

273 We show that RsrA utilizes its hydrophobic core to bind the sigma factor sigma(R) preve

274 incoming peptide and can penetrate into the hydrophobic core to disrupt the Asp23-Lys28 salt bridges

275 example, we instruct the computer "to form a hydrophobic core," "to form good secondary structures,"

276 se in exchange are all located either in the hydrophobic core underneath the lid region or near the l

277 semble and does not dock onto the developing hydrophobic core until after the rate-limiting transitio

278 sistent with the MSI-78 solvent-inaccessible hydrophobic core upon binding bicelles.

279 nors with Trp to probe the disruption of the hydrophobic core upon protein unfolding.

280 binding site has been incorporated into the hydrophobic core using natural amino acids, restricting

281 ssociated missense mutants of PrP are in the hydrophobic core: V180I, F198S, V203I and V210I.

282 of protegrin-1 in which key residues in the hydrophobic core, valine-14 and -16, are changed to leuc

283 naturation for a series of four-helix bundle hydrophobic core variants.

284 l, polar groups were introduced into the Im7 hydrophobic core via Val-->Thr or Phe-->Tyr substitution

285 alue, less dense hydrophilic corona and more hydrophobic core volume are efficient in solubilising an

286 This hydrophobic core was well conserved throughout the m02 f

287 To further investigate the effect of this hydrophobic core, we disrupted it in Galphai1 by inserti

288 rtion of cysteine residues or changes in the hydrophobic core were associated with greater difference

289 any MHR residues that are not in the protein hydrophobic core were nevertheless found to be critical

290 cyanophenylalanine residues inserted in the hydrophobic core were used as a vibrational probe.

291 d NA activities map predominantly to the 4HB hydrophobic core, whereas mutations that affect only F-p

292 tral Pro contacts Val(A3) at the edge of the hydrophobic core, whereas the final Arg extends the A1-A

293 leaving the Asp side chain shielded from the hydrophobic core, which is also consistent with availabl

294 eed, in Az48W the radical is embedded in the hydrophobic core while, in ReAz108W it is solvent-expose

295 d reference dyes are encapsulated inside the hydrophobic core, while a pH-sensitive probe is covalent

296 lyzed hydration of an alkyne proceeds in the hydrophobic core, while the Rh-catalyzed asymmetric tran

297 toward downhill folding by a loosely packed hydrophobic core with low aromatic content, large stabil

298 he protein displays a well organized compact hydrophobic core with structural changes confined to the

299 tal results revealed that, through forming a hydrophobic core with the conserved SAT motif of the N-t

300 W15 side chains at the center of the dimeric hydrophobic core, with the possibility of two additional