ライフサイエンスコーパス: hydrophobic group

1 lly disordered solvent shells around exposed hydrophobic groups.

2 y involving the burying of otherwise-exposed hydrophobic groups.

3 ductive substrate containing hydrophilic and hydrophobic groups.

4 t-range interactions among the polar and the hydrophobic groups.

5 basic nitrogen center flanked by aromatic or hydrophobic groups.

6 igned to template positions randomly, within hydrophobic groups.

7 rophobic effect and encouraging solvation of hydrophobic groups.

8 two hydrogen bond acceptors (HBAs) and three hydrophobic groups.

9 and interactions as well as by burial of its hydrophobic groups.

10 onic acid, a fluorescent probe that binds to hydrophobic groups.

11 cial about the ability of urea to solubilize hydrophobic groups.

12 icative of a substantial solvent exposure of hydrophobic groups.

13 f collapsed states with local clusterings of hydrophobic groups.

14 by the molecules used in this study, are two hydrophobic groups 16.5 A apart and two hydrogen-bond-ac

15 d are better catalysts than those with small hydrophobic groups (1a is 43.5 times faster than 1f).

16 Using a ligand bearing a bulky hydrophobic group, a "shish kabob" of nanocages, has bee

17 ed ensembles in water despite the absence of hydrophobic groups--a result that holds for polypeptide

18 /L2302C) and a second variant with a bulkier hydrophobic group (A108I) to better occupy a cavity betw

19 onnecting 4,4'-dimethylbipyridine to a bulky hydrophobic group (adamantane, 1), a heme ligand (imidaz

20 etween molecules containing both charged and hydrophobic groups and are shown to provide valuable new

21 the 2-substituted moieties and prefers small hydrophobic groups and hydrogen bonding functionalities.

22 Results strongly suggest that, while hydrophobic groups and presumably an intact helix B are

23 positions in (R)-1 can accommodate nonbulky, hydrophobic groups and still retain pronounced anticonvu

24 arly differentiates between structure-making hydrophobic groups and structure-breaking hydrophilic gr

25 correlates with interactions between ligand hydrophobic groups and the C-terminal lid region that is

26 no acid, and O is an amino acid with a bulky hydrophobic group), and to the di-leucine (or LL) motif.

27 ite and projects an aminopyridine, a central hydrophobic group, and an aryl group, into the S1, S2, a

28 ometre striations of alternating anionic and hydrophobic groups, and the other coated with the same m

29 ble pharmacophore features (carboxylate, two hydrophobic groups, and three NH groups) and wrote a com

30 nucleotides that contain pi-electron and/or hydrophobic groups are incorporated opposite the non-nat

31 tive potency against stromelysin when larger hydrophobic groups are used.

32 4-CmC analogs containing a single hydrophobic group at either the 3- or 4-position as well

33 contribute a large favorable enthalpy, (2) a hydrophobic group at P2' can contribute a favorable entr

34 (3) The potential importance of the hydrophobic group at position R3 as illustrated by its a

35 is required for activation of RyR1 and that hydrophobic groups at the 3,4- and 5-positions are prefe

36 Substitution of hydrophobic groups at the 3-position enhanced bioactivit

37 ure drug design in terms of extending planar hydrophobic groups at the C2 position of PBDs to maximiz

38 that while calpain I tolerates a variety of hydrophobic groups at the P1 site, Leu at P2 is preferre

39 emonstrated that introduction of appropriate hydrophobic groups at the phenyl ring and a gem-dimethyl

40 butions of specific cationic side chains and hydrophobic groups at the rim of the alpha beta-barrel t

41 FIV PR exhibited strong preference for small hydrophobic groups at the S3 and S3' subsites.

42 aromatic portion of the molecule as well as hydrophobic groups at the vicinity of this aromatic regi

43 that isatins (indole-2,3-diones), containing hydrophobic groups attached at a variety of positions wi

44 t water cage formation and breakage near the hydrophobic groups control the fusion dynamics and aggre

45 he orientational entropy of waters hydrating hydrophobic groups decreases during pulling of the molec

46 An examination of solvent density near hydrophobic groups during folding suggests that in the c

47 designed within collagen peptides, including hydrophobic groups, electrostatic interactions, and meta

48 n state for dimerization has a high level of hydrophobic group exposure, indicating that gross confor

49 s is largely set by the balance of polar and hydrophobic groups flanking a conserved carboxylic side

50 mportance of a long side chain capped with a hydrophobic group for optimal potency, consistent with a

51 established that the cationic center and the hydrophobic group found in JN430 and MLA are important f

52 Replacing the 5'-methyl group with other hydrophobic groups gave 17 transition state analogue inh

53 been made by either deleting or substituting hydrophobic groups, hydrophilic groups, aromatic amino a

54 e COOH-terminal half of the core recognize a hydrophobic group in glibenclamide, adjacent to the sulf

55 e presence of a conformationally constrained hydrophobic group in position 6 in complementary topolog

56 etic compounds, containing aromatic or other hydrophobic groups in combination with two carboxylate g

57 In addition, the hydrophobic groups in ILV form "specific" hydrophobic in

58 ting substituents in the salicyloyl ring and hydrophobic groups in the anilide moiety for optimal act

59 sulfoxide suggest that interactions between hydrophobic groups in the distal regions may play a sign

60 demonstration of the involvement of the same hydrophobic groups in the high affinity binding of CaM t

61 tween the dry region in the receptor and the hydrophobic groups in the ligands.

62 2-Anilino groups with small hydrophobic groups in the meta or para position enhanced

63 Bulky hydrophobic groups in the side chain of residue 3 turned

64 idence for an increase in solvent accessible hydrophobic groups in the transition state.

65 tify interactions between ions and molecular hydrophobic groups in water.

66 s of pressure on the pairwise interaction of hydrophobic groups in water.

67 vatives of 4-hydroxyproline with a series of hydrophobic groups in well-defined orientations have bee

68 The presence of a hydrophobic group interacting with multiple receptor res

69 Addition of phenyl or butyl hydrophobic groups into guanidine-oxanorbornene polymers

70 The nature of the hydrophobic group is likely a discriminator for super- v

71 Layer packing of hydrophobic groups is compared for possible combinations

72 nts: one involving replacement of the highly hydrophobic groups, Leu404, Phe408, and Phe412, all with

73 Substitution of long-chain or bulky hydrophobic groups (leucines or phenylalanines) for isol

74 that direct the distribution of the leading hydrophobic groups (LHG).

75 An aryl ring at position 7 or a hydrophobic group linked to the 8-position through an am

76 taLg native conformation causing exposure of hydrophobic groups, lower thermal stability and also, sh

77 isomerization from trans to cis exposes more hydrophobic groups, making the cis bilayers more hydroph

78 This work suggests that the bulky hydrophobic groups may locally influence the formation o

79 However, when a large hydrophobic group occupies position -1, Arg47 adopts a n

80 en a GSH conjugate with a sufficiently large hydrophobic group occupies the H-site, Tyr-9 is fully pr

81 ced by a polar group of similar size or by a hydrophobic group of smaller size.

82 The replacement by hydrophobic groups of the homologous residues of the bra

83 complexes, accommodating the diverse, rigid hydrophobic groups of the inhibitors.

84 ved inhibitor potency by introducing a small hydrophobic group on the adenine ring.

85 rogen on the quinoline group, and (iii) of a hydrophobic group on the quinazoline.

86 Modifications of the hydrophobic group on the terminal urea produced substant

87 P1 substrate preference including basic and hydrophobic groups on either side of the scissile bond.

88 unds 1 and 3, was conceived to allow the new hydrophobic groups on the lactone to engage in specific

89 The effect of introducing hydrophobic groups onto the disaccharide portion of the

90 ative refinement of the CSP model identified hydrophobic groups other than the traditional phenylalan

91 ensin-induced unfolding promoted exposure of hydrophobic groups otherwise confined to the core of the

92 vity based on the addition of multiple small hydrophobic groups positioned away from the cationic cen

93 Likewise, 4-CmC analogs with hydrophobic groups substituted into the 4-position enhan

94 A hydrophobic group such as isobutyl or isopropoxyl was fo

95 crystallization of molecules with polar and hydrophobic groups, such as ionic amphiphiles and protei

96 with the modification; the bulkier and more hydrophobic groups (tert-butyl and phenyl) exhibited low

97 ese data indicate that Cys-168 contributes a hydrophobic group that influences the structure and ulti

98 hat would allow a number of both charged and hydrophobic groups to be presented to fibronectin for hi

99 ar groups from and near-complete exposure of hydrophobic groups to solvent, in a manner resembling a

100 The addition of specific bulky hydrophobic groups to the insulin molecule provides it w

101 e structure which favors the partitioning of hydrophobic groups to the surface of ice.

102 five-point pharmacophores (carboxylate + two hydrophobic groups + two NH groups) for the three compou

103 atured state while increasing the density of hydrophobic groups, two effects that also contribute to

104 rs at mildly acidic pH following loss of the hydrophobic groups upon acetal hydrolysis.

105 One compound with a bulky hydrophobic group (VPC12249) was a dual LPA1/LPA3 compet

106 Those data demonstrated that a C-terminal hydrophobic group was an important determinant for elici

107 This hydrophobic group was designed to mimic the hydrophobic

108 ysine or polyester dendron were prepared and hydrophobic groups were attached to the dendrimer periph

109 0P) derived from thalidomide by insertion of hydrophobic groups were evaluated for anti-inflammatory

110 eous urea solution unfolds a chain of purely hydrophobic groups which otherwise adopts a compact stru

111 modifying hydrophilic PSs with a variety of hydrophobic groups, which allow the constructs to self-a

112 Spherical hydrophobic groups, which assemble via shape complementa

113 nd interior volume available for packing the hydrophobic groups, which is reflected in different aggr

114 ent to the surface or a strongly interacting hydrophobic group with the surface; and (3) lockdown of

115 lidinedione-based peptide hybrids containing hydrophobic groups with Ki values between 1.5 and 1.8 mu

116 Hydrophobic groups within Nt17 become sequestered in int