ライフサイエンスコーパス: hydrophobic pocket

1 g increased complementarity with the primary hydrophobic pocket.

2 e dihydroisoquinoline to bind in an adjacent hydrophobic pocket.

3 in but with distinct interactions within the hydrophobic pocket.

4 inal chemical investigation of the conserved hydrophobic pocket.

5 conformation, allowing access to an extended hydrophobic pocket.

6 ospholipid-cycling into and out of the Sfh1* hydrophobic pocket.

7 teraction site was identified in a conserved hydrophobic pocket.

8 of the penetration protein and embedded in a hydrophobic pocket.

9 ormation of the ferric protein with a closed hydrophobic pocket.

10 1, spanned from the active site pocket to a hydrophobic pocket.

11 l vicinal disulfide bond that is buried in a hydrophobic pocket.

12 were changed to match those of CatM in this hydrophobic pocket.

13 cacy of anticancer drugs directed toward its hydrophobic pocket.

14 isting of a shallow groove linked to a small hydrophobic pocket.

15 d, ordered beta1-alpha1 loop and an adjacent hydrophobic pocket.

16 D630N on an increased affinity of O2 for its hydrophobic pocket.

17 ense quite different environments within the hydrophobic pocket.

18 teraction between the N-terminal helix and a hydrophobic pocket.

19 smembrane receptor that contains a conserved hydrophobic pocket.

20 protein and the methyl group inserted into a hydrophobic pocket.

21 her with Trp(803) and Phe(804), form a large hydrophobic pocket.

22 ciation of the RS20 domain from calmodulin's hydrophobic pocket.

23 istinct nonpolar side chains that fill three hydrophobic pockets.

24 nd-gated ion channels, and ligand binding to hydrophobic pockets.

25 through a complex network of interconnected hydrophobic pockets.

26 Spa15 where labels are seen to be buried in hydrophobic pockets.

27 th scales that accompany exposure of protein hydrophobic pockets.

28 Importantly, we have identified a hydrophobic pocket accessory to the S1 site that can be

29 human cells, and I2 acts as a "flap" on the hydrophobic pocket accommodating template G.

30 active, so-called DFG-out state, occupying a hydrophobic pocket adjacent to the ATP binding site.

31 ng decreases the size and accessibility of a hydrophobic pocket, adjacent to the ATP site, to inhibit

32 troduction of a single substitution into the hydrophobic pocket affected entry through both nectin-4

33 A conserved hydrophobic pocket allows the hugely diverse PfEMP1 prot

34 erated tyrosine then collapses into a nearby hydrophobic pocket, anchoring a modified conformational

35 We hypothesize that compound 7 binds to this hydrophobic pocket and as a consequence inhibits EBOV in

36 LPS binds to the MD-2 hydrophobic pocket and bridges the dimerization of two T

37 d a novel binding mode with occupancy of the hydrophobic pocket and channel of ATX but no interaction

38 The alphaTSR domain possesses a hydrophobic pocket and core, missing in TSR domains.

39 atalytic chamber pointing toward an extended hydrophobic pocket and is critical for the inactivation.

40 The D ring of the chromophore sits within a hydrophobic pocket and is tilted by approximately 80 deg

41 nd that the myristoyl group inserts into the hydrophobic pocket and leads to a tighter packing of the

42 d on the surface of MDM2 and will "open" the hydrophobic pocket and stabilize the MDM2-p53 complex, w

43 te determinant NUMB with both the N-terminal hydrophobic pocket and the acidic domain of MDM2 also in

44 , involving interactions with the N-terminal hydrophobic pocket and the acidic domain of MDM2.

45 Molecular oxygen is bound in a small hydrophobic pocket and the substrate provides the reduci

46 x to the CP where it enters and exits the CP hydrophobic pocket and then folds back to contact the vi

47 The hydrophobic pockets and adaptability seen in the availab

48 nalyses suggest that these mutations distort hydrophobic pockets and affect residues in the NA active

49 Cooperativity was also observed between hydrophobic pockets and positions with intermediate solv

50 evel scale rationalizes the hydration of two hydrophobic pockets and the presence of a void in a thir

51 rings bind into distinct relatively narrow, hydrophobic pockets, and both are required for biochemic

52 ocated in the alpha5-beta3 loop, buried in a hydrophobic pocket approximately 16 A from the SAM-bindi

53 ed to sequence differences in a known distal hydrophobic pocket are also described.

54 gs with modifications that interact with the hydrophobic pocket are potential specific inhibitors of

55 P binding pocket not only contributes to the hydrophobic pocket, as previously thought, but also recr

56 ive-helix bundle; Tyr-377 of F3 docks into a hydrophobic pocket at one end of the bundle, whereas a b

57 h their omega-end distant from the iron in a hydrophobic pocket at one side of the active site.

58 e in its prefusion conformation, suggested a hydrophobic pocket at or near the GP1 and GP2 interface

59 the long hypothesized binding of CO(2) in a hydrophobic pocket at the active site and demonstrate th

60 bl tyrosine kinase, myristate binds within a hydrophobic pocket at the base of the kinase domain and

61 on-induced dimerization that features a deep hydrophobic pocket at the center of the receiver domain

62 The existence of a hydrophobic pocket at the elbow region of the Fc appears

63 ral model, showed that Tyr(981) may lie in a hydrophobic pocket at the end of the S6 transmembrane se

64 and marine toxins target this cleft and the hydrophobic pocket at the front end of the cleft (viewin

65 HEG1 binds in a hydrophobic pocket at the KRIT1 F1 and F3 interface, and

66 pamine complex, dopamine was orientated in a hydrophobic pocket at the midpoint of the membrane.

67 The domain structure includes: (i) a hydrophobic pocket at the N terminus of MDM2 that is inv

68 e molecule is characterized by two prominent hydrophobic pockets at either end of the peptide binding

69 could spontaneously release from its initial hydrophobic pocket before MA protein interacts with the

70 The N(7)-benzyl groups pack into a hydrophobic pocket behind the two tryptophan side-chains

71 The active site is located in a hydrophobic pocket between an N-terminal dinucleotide bi

72 is located in the extracellular domain in a hydrophobic pocket between the beta7-beta10 strands.

73 I relative to TM-III by sliding into a tight hydrophobic pocket between TM-III and TM-V and that the

74 ubstitution of the residues constituting the hydrophobic pocket between TM-III and TM-V in the ghreli

75 channel-drug complex revealed six equivalent hydrophobic pockets between the peripheral and pore-form

76 and that are vital for the enzymatic or the hydrophobic pocket binding activity of CypA.

77 binds in a channel-specific orientation to a hydrophobic pocket bounded by the S5/pore helix/S6 of on

78 nding kinetics of a ligand to a prototypical hydrophobic pocket by explicit-water molecular dynamics

79 residue is located immediately adjacent to a hydrophobic pocket, called the switch 3 loop.

80 e we show that the binding affinity of MDM2s hydrophobic pocket can be regulated through the RING fin

81 ent of the C-terminal cap region, creating a hydrophobic pocket centered around residue Trp197.

82 ide chain of alanine binds in a well defined hydrophobic pocket characterized by conserved residues I

83 structure allows the definition of conserved hydrophobic pockets comparable with those of ClpS or Bam

84 the ATG3 binding surface on ATG12 contains a hydrophobic pocket corresponding to the binding pocket o

85 eptides and small molecules that bind in the hydrophobic pocket could be selectively detected, provid

86 acids in the G domain demonstrated that the hydrophobic pocket created by these amino acids is neces

87 dies suggest that the 4'-ethynyl fits into a hydrophobic pocket defined by RT residues Ala-114, Tyr-1

88 erged adjacent to a computationally designed hydrophobic pocket during directed evolution.

89 A single mutation of murine MD-2 at the hydrophobic pocket entrance, E122K, substantially reduce

90 igopyridines potentially targeting the Mcl-1 hydrophobic pocket, evaluated their capacity to inhibit

91 ling structure shows that ZAA binds the MD-2 hydrophobic pocket exclusively via specific molecular re

92 The binding mode of BPTES on the hydrophobic pocket explains its specificity to KGA.

93 s(naphthalene)-8,8'-disulfonate (bis-ANS) to hydrophobic pockets exposed in the sheared protein.

94 gages the receptor by binding to an extended hydrophobic pocket facilitated by the large outward move

95 Tyr residue that provides the bottom of the hydrophobic pocket for ATP yielded a PI4KIIIbeta enzyme

96 structures reveal that PylRS utilizes a deep hydrophobic pocket for recognition of the Pyl side chain

97 erring substrate oxidation, and a C-terminal hydrophobic pocket for substrate binding.

98 This is critical both for creating a hydrophobic pocket for the catalytic base and for mainta

99 The structures identify a common hydrophobic pocket for the indole ring but exhibit unusu

100 nding pockets at the BSSalpha active site: a hydrophobic pocket for toluene binding and a polar pocke

101 Moreover, the unusual hydrophobic pocket for Y(0) explains the distinctive abi

102 rm, three hydrophobic helical grooves, and a hydrophobic pocket for Y(0)).

103 (TBHQ), shows that the inhibitor binds in a hydrophobic pocket formed at an interface between HA mon

104 of paAzoR1 was shown to be a well-conserved hydrophobic pocket formed between two monomers.

105 be rotated away from the metal center, to a hydrophobic pocket formed by Ala212, Val293 and Phe295.

106 modeling indicates that PD-118057 binds to a hydrophobic pocket formed by L646 of one hERG1 subunit a

107 M3 loops where Phe135 is stabilized within a hydrophobic pocket formed by Leu270 and Ile271.

108 The K4me3 occupies a deep hydrophobic pocket formed by the conserved Y212 and W235

109 XLF Leu-115 ("Leu-lock") inserts into a hydrophobic pocket formed by XRCC4 Met-59, Met-61, Lys-6

110 gatively charged glutamate residues within a hydrophobic pocket formed from six of the alpha-helices,

111 This hydrophobic pocket, formed by the alphaF-alphaG loop and

112 rm IgE-Fc structures and that it retains the hydrophobic pocket found in the hinge region of the clos

113 that mutation of a highly conserved FAK-like hydrophobic pocket (HP1) abrogates CCM3-CCM2 interaction

114 receptor, including the highly sought after hydrophobic pocket important for the binding of the C3 a

115 ined that the binding site for Taxol is in a hydrophobic pocket in beta-tubulin, little was known abo

116 These changes create a hydrophobic pocket in COX-2, with Arg-513 located at the

117 Furthermore, the hydrophobic pocket in HCAII that stabilizes the apolar m

118 f some of the residues in the GAF domain and hydrophobic pocket in interaction with isoleucine and GT

119 eling studies demonstrate the existence of a hydrophobic pocket in pol eta that participates in the i

120 dium lack side chains that typically block a hydrophobic pocket in protein kinases.

121 kinase phosphorylation, which defines a new hydrophobic pocket in S1P(1).

122 A hydrophobic pocket in the active site chamber is positio

123 yl or even cyclododecyl groups, fit into the hydrophobic pocket in the active site of CA IX but not C

124 y inhibited by zanamivir owing to an altered hydrophobic pocket in the active site of the enzyme requ

125 henylalanine side-chain inserts into a major hydrophobic pocket in the apple 2 domain and the isoleuc

126 lecules reveals that the compounds bind in a hydrophobic pocket in the CDC25 domain of SOS adjacent t

127 f ADAMTS13 that appears to interact with the hydrophobic pocket in the central A2 domain of von Wille

128 s are mediated by the binding of cdE2 into a hydrophobic pocket in the CP.

129 is issue of Blood, de Groot et al identify a hydrophobic pocket in the Cys-rich domain of ADAMTS13 th

130 e burial of Ubc12's N-acetyl-methionine in a hydrophobic pocket in the E3, Dcn1, promotes cullin nedd

131 Mutations to alanine identified a hydrophobic pocket in the extracellular cavity of NET, c

132 re indicates that SMARCA3 peptide binds to a hydrophobic pocket in the heterotetramer.

133 idated by the docking simulation: one at the hydrophobic pocket in the ICAM-1 binding domain (the alp

134 d a high-affinity propofol binding site in a hydrophobic pocket in the middle of a triangular cleft l

135 are noncompetitive inhibitors that bind in a hydrophobic pocket in the p66 subunit of reverse transcr

136 e complementarity of the 5-substituent for a hydrophobic pocket in the protein.

137 A novel hydrophobic pocket in the rear of the RT dNTP binding si

138 tors are designed to effectively fill in the hydrophobic pocket in the S1'-S2' subsites and retain al

139 EX5 structures reported here reveal a unique hydrophobic pocket in the subdomain interface that might

140 psid-binding antiviral compounds because the hydrophobic pocket in VP1 is filled with multiple bulky

141 n a catalytic pocket, (ii) the creation of a hydrophobic pocket in water, (iii) self-replication prop

142 tains six antiapoptotic members, each with a hydrophobic pocket in which Bcl-2 homology region 3 (BH3

143 r CO2 binding site for CAIR and N5-CAIR in a hydrophobic pocket in which the carboxylate or CO2 inter

144 rounding residues, and (2) the presence of a hydrophobic pocket in which the chloride resides.

145 The receptor features a hydrophobic pocket in which the substrate is bound and p

146 their phenolic moieties occupying equivalent hydrophobic pockets in each protomer and their CoA moiet

147 gh affinity for the target by utilizing four hydrophobic pockets in its binding groove.

148 turing of transient substrates and revealing hydrophobic pockets in proteins.

149 binding mode of this molecule in two similar hydrophobic pockets in the Aurora A kinase.

150 binaphthyl-5,5'-disulfonic acid (bis-ANS) to hydrophobic pockets in the blood protein von Willebrand

151 a ligand side chain that binds in a shallow hydrophobic pocket, in the presence and absence of a nei

152 through a local conformational change and a hydrophobic pocket interaction, whereas the S443 destabi

153 ive and positive cooperative effects between hydrophobic pocket interactions.

154 omplementary surface on Rae1 displays a deep hydrophobic pocket, into which Met51 fastens like a bolt

155 orresponding regions in ADAMTS1 identified a hydrophobic pocket involving residues Gly471-Val474 as b

156 pite the small size of the protein domain, a hydrophobic pocket is formed by the side chains of nonpo

157 An allosteric model for regulation of the hydrophobic pocket is supported by differences in protei

158 on at this, or any other positions in BRAF's hydrophobic pocket, is predominant.

159 ing to a 156 +/- 18 microM Kd interaction: a hydrophobic pocket lined by 4 critical residues (L173, N

160 RPR binds to a hydrophobic pocket located between two adjacent hERG1 su

161 binding site for RPR, previously mapped to a hydrophobic pocket located between two adjacent subunits

162 A resolution revealed a flavivirus-conserved hydrophobic pocket located next to the AdoMet-binding si

163 The docking of the farnesyl group to the hydrophobic pockets located at both CaM lobes further en

164 three structural elements contributing to a hydrophobic pocket, namely, the hydrophobic loop, the DN

165 ent-copalyl diphosphate substrate binds to a hydrophobic pocket near a cluster of Asp and Arg residue

166 actions of the amino acid side chains with a hydrophobic pocket near R47, as revealed by our crystal

167 etwork of interactions in a fairly conserved hydrophobic pocket near the active site.

168 that serves as the gatekeeper to the buried hydrophobic pocket occupied by 2,4-difluorophenyl of PH-

169 Using antibodies (Abs) that bind near the hydrophobic pocket of AMA1 and AMA1 mutated in the pocke

170 results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plas

171 2), which is thought to insert itself into a hydrophobic pocket of another cadherin molecule (thereby

172 esults identify the molecular surface of the hydrophobic pocket of ATX as a target-binding site for i

173 compete with one another for binding at the hydrophobic pocket of BTD using overlapping but specific

174 broadening effects occur for residues in the hydrophobic pocket of Ca2+-S100A4.

175 (76) of Orai1-CMBD, which interacts with the hydrophobic pocket of CaM-C.

176 Ten residues lining the hydrophobic pocket of COMPcc were mutated into alanine;

177 We then mutated residues that reside in the hydrophobic pocket of CypA where proline-containing pept

178 h this mechanism, where 4EGI-1 attaches to a hydrophobic pocket of eIF4E between beta-sheet2 (L60-T68

179 to flip out of the bilayer directly into the hydrophobic pocket of GM2AP.

180 information on small molecules bound in the hydrophobic pocket of gp41, using a paramagnetic probe p

181 of Glu37, a glutamate residue embedded in a hydrophobic pocket of HdeA, is important in controlling

182 , these results indicate that the C-terminal hydrophobic pocket of MA, which encompasses both residue

183 protrusion of that fatty acyl chain from the hydrophobic pocket of MD-2, independent of association w

184 -3 binds as an asymmetrical dimer within the hydrophobic pocket of MD-2, inducing an active receptor

185 in interaction occurs between the N-terminal hydrophobic pocket of MDM2 and the transactivation motif

186 g transient structures that bind to the same hydrophobic pocket of MDM2 as TAD1.

187 The N-terminal hydrophobic pocket of Mdm2 binds to p53 and thereby inhi

188 ubstrate or "lid" adjacent to the N-terminal hydrophobic pocket of MDM2 has a phosphorylation site, a

189 results demonstrate the crucial roles of the hydrophobic pocket of Munc18 in mast cell degranulation,

190 (D3R, L8A) that perturb interaction with the hydrophobic pocket of Munc18-1 rescues impaired secretio

191 e 5 has identified the E132A mutation in the hydrophobic pocket of Munc18-2, prompting us to examine

192 tants (F115E, E132A, and F115E/E132A) in the hydrophobic pocket of Munc18.

193 The cyclohexyl group of Ches binds in the hydrophobic pocket of NanB occupied by the acetamidometh

194 E6A Pisoform 1 (Ki22M) reported to bind the hydrophobic pocket of other Hect ligases, presumably blo

195 SSB-Ct binds the hydrophobic pocket of RecO in a conformation similar to

196 The PLD2-GEF catalytic site is formed by a hydrophobic pocket of residues Phe-107, Phe-129, Leu-166

197 this peptide binds within the Ca2+-dependent hydrophobic pocket of S100A1.

198 d in the packing of Phe(50) in PrxI within a hydrophobic pocket of Srx.

199 ecule, termed deep water, Dw, and bound in a hydrophobic pocket of the active site forms a short, str

200 at the leucine side chain protrudes into the hydrophobic pocket of the active site that accommodates

201 oplasmic domain of alphaIIb is buried in the hydrophobic pocket of the C-lobe of Ca(2+)-CIB1.

202 models places the P-CR connector loop into a hydrophobic pocket of the catalytic core, with the coile

203 r fitting of the 6-benzylthio group into the hydrophobic pocket of the enzyme at the 6-position.

204 petitive binding of the co-salt anion to the hydrophobic pocket of the host and counterion binding to

205 (NTA) is held in the helix alpha1 and loop 5 hydrophobic pocket of the human eIF3b RNA recognition mo

206 The lipid chain of the cysLT binds in a hydrophobic pocket of the N-terminal domain, whereas bin

207 structure, and points its side chain into a hydrophobic pocket of the neighboring subunit.

208 nes of TrxR perfectly fit into the conserved hydrophobic pocket of the NrdH-redoxin.

209 We identified a hydrophobic pocket of the P-protein C-terminal domain as

210 the peptide (F263) anchors into a transient hydrophobic pocket of the receptor to facilitate the for

211 ial to inhibit HIV-1 fusion by targeting the hydrophobic pocket of transmembrane glycoprotein gp41.

212 hat overexpressed spartin binds to the Ile44 hydrophobic pocket of ubiquitin, suggesting spartin migh

213 tyl)-cognitin presumably interacted with the hydrophobic pockets of Abeta, which confers stabilizing

214 anism of binding between the hydrophilic and hydrophobic pockets of CA IX versus CA II.

215 D)-helix with its anchors buried in the main hydrophobic pockets of the two CaM lobes establishes tha

216 er and the (2)beta(2)85 Phe-(2)beta(2)88 Leu hydrophobic pocket on a different tetramer is observed b

217 Upon binding Ca(II), native CaM opens a hydrophobic pocket on each of its domains.

218 easing when Pro-139 (IC-2 loop) anchors in a hydrophobic pocket on Galphai1 (Val-34, Leu-194, Phe-196

219 teracting region (RIR) motifs that bind in a hydrophobic pocket on the C-terminal domain of Rev1.

220 an unexpected binding mode identifying a new hydrophobic pocket on the enzyme.

221 eracting protein (PIP) motifs that bind in a hydrophobic pocket on the front side of PCNA as well as

222 -27) directing the binding of Phe(22) into a hydrophobic pocket on the GLP-1R.

223 Da) and could occupy more space in the deep hydrophobic pocket on the gp41 NHR trimer.

224 the PIP motif of polymerase eta binds in the hydrophobic pocket on the Rev1 C-terminal domain.

225 YPX(n)L late domains bind in a conserved hydrophobic pocket on the second arm near the apex of th

226 a mutagenesis approach, we have identified a hydrophobic pocket on the Spt5 NGN domain as binding sit

227 orms a striking hook that binds to a shallow hydrophobic pocket on the surface of each She2p subunit

228 insertion (residues 98-151) forming a unique hydrophobic pocket on the surface that likely accommodat

229 that a loop from TBC1d5 binds to a conserved hydrophobic pocket on VPS29 opposite the VPS29-VPS35 int

230 ementarity of the molecules that include two hydrophobic pockets on IL-13 that accommodate Phe32 [com

231 ents are the two leucine residues binding in hydrophobic pockets on sigma2.

232 region, which is anchored to one of the two hydrophobic pockets on the GABARAP molecule.

233 Finally, we found two hydrophobic pockets on the HUS1 outer surface that were

234 hor of MT-WQ-IDL also binds with the shallow hydrophobic pocket outside the groove of the NHR trimer,

235 of KRAS4b that binds tightly in the central hydrophobic pocket present in PDEdelta.

236 conserved interaction between Phe(727) and a hydrophobic pocket present on the adjacent subunit is cr

237 e 3-phenoxyphenyl side chain is located in a hydrophobic pocket previously reported to bind farnesyl

238 A tight hydrophobic pocket provides p-hydroquinones access to th

239 s a putative NPM SMI that disrupts a defined hydrophobic pocket required for oligomerization.

240 tructural event - a closure of the A/B helix hydrophobic pocket results from the integrated effect of

241 ClpAP, demonstrate that modification of the hydrophobic pocket results in altered N-end rule specifi

242 cture of apoNPC2, the sterol binds in a deep hydrophobic pocket sandwiched between the two beta-sheet

243 to levels of full efficacy in vivo through a hydrophobic pocket separate from the orthosteric site of

244 ers identified previously, which occupy both hydrophobic pockets simultaneously.

245 roduct to 5hmC, probably because the reduced hydrophobic pocket size restricts the binding of 5hmC as

246 ester the Trp residue of the ULM ligand in a hydrophobic pocket, Snu17p and Bud13p utilize a large in

247 site with concomitant formation of a highly hydrophobic pocket spatially suited to accommodate SL010

248 f the Ile(181) (P1') main chain, whereas the hydrophobic pockets stabilize the side chains of Ile(181

249 section of the gp41 coiled coil containing a hydrophobic pocket suitable for small molecule binding.

250 e four leucine residues in Ca(V)beta3 form a hydrophobic pocket surrounding key residues in the alpha

251 site of human and Drosophila Notum, a large hydrophobic pocket that accommodates palmitoleate.

252 y-Pro analog revealed that ARM1 binds in the hydrophobic pocket that accommodates the omega-end of LT

253 recognition centre connected to an interior hydrophobic pocket that adaptively expands to ensheath d

254 dicate that loop 2 constitutes the predicted hydrophobic pocket that binds the AIP thiolactone ring w

255 e crystal structure of SIRT6 reveals a large hydrophobic pocket that can accommodate long-chain fatty

256 peptide reveals that SIRT2 possesses a large hydrophobic pocket that can accommodate the myristoyl gr

257 of the passenger, at the entrance of a large hydrophobic pocket that contains a bound detergent molec

258 2.4 A from the isopeptide bond in the partly hydrophobic pocket that contains the cross-link.

259 receiver domain, promoting the opening of a hydrophobic pocket that is essential for homodimer forma

260 The MIF molecule contains a hydrophobic pocket that is important for many of its pro

261 he chlorine substituent is accommodated by a hydrophobic pocket that is larger than the homologous si

262 rtially buries protoporphyrin within a large hydrophobic pocket that is located at the end of its bet

263 odes of these hits and revealed an auxiliary hydrophobic pocket that is positioned adjacent to the ph

264 ter of 10'-demethoxystreptonigrin binds in a hydrophobic pocket that mainly consists of cap domain re

265 The second is a hydrophobic pocket that makes contact with residues on t

266 ase protein family and contains a novel core hydrophobic pocket that may be responsible for binding a

267 The Arc N-terminal lobe evolved a unique hydrophobic pocket that mediates intermolecular binding

268 re, with the acyl chain deeply buried into a hydrophobic pocket that runs perpendicular to a long gro

269 s is due, in part, to a phenylalanine in the hydrophobic pocket that selects for the alternative ster

270 ATP-binding site of Grp94 possesses a unique hydrophobic pocket that was used to design isoform-selec

271 e body of the Tim8-Tim13 complex contain six hydrophobic pockets that likely interact with specific s

272 n formed a stable dimer, which contained two hydrophobic pockets that provide a molecular interface f

273 tures, including a central basic patch and a hydrophobic pocket, that are important for dsRNA binding

274 In crystal structures, AurkinA binds to a hydrophobic pocket (the 'Y pocket') that normally accomm

275 uilibrium between the destabilization of the hydrophobic pocket, the overall folding energy, the acti

276 Within this hydrophobic pocket, there is a significant reduction in

277 suggested that compounds 1 and 2 target the hydrophobic pocket, thereby blocking access to the activ

278 action site on MAPKs, the common docking and hydrophobic pocket, they use distinct kinase interaction

279 95.5-8 is able to use a reactive lysine in a hydrophobic pocket to accelerate promiscuous Knoevenagel

280 to the formation of a previously undisclosed hydrophobic pocket to accommodate the alpha-phenyl ring

281 s is necessary to complete a solvent-exposed hydrophobic pocket to form the catalytically competent a

282 at these type II inhibitors utilize the same hydrophobic pocket to gain strong inhibitory potency (13

283 agates conformational energy from within the hydrophobic pocket to the helical unit that gates pocket

284 s that Phe19 and Leu53 of IGF-II lock into a hydrophobic pocket unique to domain 11 of mammalian IGF2

285 hain of PS, PE, and PC lipids is buried in a hydrophobic pocket whereas the 1'-acyl chain is exposed.

286 ety of 2 which is favorably located within a hydrophobic pocket, whereas in NTPDase1 it is exposed to

287 ed end of the fatty acid chain buried in the hydrophobic pocket, whereas the carboxylate end of the l

288 The function of the Munc18-1 protein hydrophobic pocket, which interacts with the syntaxin-1

289 small central volume surrounded by four deep hydrophobic pockets, which may explain hERG's unusual se

290 the tetramer, the "inner" beta-sheet forms a hydrophobic pocket while the helix and loop are solvent-

291 iphatic tail of the fatty acid is bound in a hydrophobic pocket with two potential entrances.

292 Small molecule inhibitors binding into a hydrophobic pocket within capsid viral protein 1 were pr

293 ir structural configurations relative to the hydrophobic pocket within tens of picoseconds.

294 The hydrophobic pocket within the coiled coil domain of HIV-

295 otinic, and 5-HT3A receptors suggests that a hydrophobic pocket within the Cys-loop and the M4 segmen

296 system, we selected mimetics of a conserved hydrophobic pocket within the N-heptad repeat region of

297 y to be nonspecific and does not involve the hydrophobic pocket within the PER2 PAS domains that in o

298 r) of [FeFe]-hydrogenases is embedded into a hydrophobic pocket within the protein.

299 rotein includes a GAF domain that contains a hydrophobic pocket within which isoleucine and valine bi

300 Phe105 and Met109 insert into hydrophobic pockets within the catalytic domain of the s