ライフサイエンスコーパス: hydroxy

1 rough a selective nucleophilic addition to a hydroxy 1,2-diketone.

2 ,N',N'-tetrakis(2-(1-ethylbenzimidazolyl))-2-hydroxy-1,3-diaminoprop ane) was synthesised in high yie

3 In this study, deuterated standards 2-hydroxy-1,4-benzoxazin-3-one (HBOA-d4) and 2-hydroxy-N-(

4 es, such as 9,10-phenanthrenequinone (PQ), 5-hydroxy-1,4-naphthoquinone (5H-1,4NQ), 1,2-naphthoquinon

5 Starting from 2-hydroxy-1,4-naphthoquinone (lawsone), we synthesized eig

6 gamma-hydroxy-1,N(2) -propanodeoxyguanosine (gamma-OHPdG) is a

7 sen-Schmidt base-catalyzed condensation of 6-hydroxy-1-indanone with substituted benzaldehydes and to

8 ), Mn(2+), Cu(2+), and Zn(2+) ions with 2-(3-hydroxy-1-phenyl-but-2-enylideneamino) pyridine-3-ol(HPE

9 The conformational equilibria of 1-hydroxy-1-phenylsilacyclohexane 2 and 3-hydroxy-3-phenyl

10 ted, allopregnanolone, (3alpha,5alpha,20E)-3-hydroxy-13,24-cyclo-18-norcholan-20-ene-21-carbonitrile,

11 racterized as (E)-12-(17-ethyl-tetrahydro-16-hydroxy-15-(methyl pentanoate)-14-oxo-2H-pyran-13-yl)-9-

12 xy-2-[[(3S,5R,8R,9R,10R,12R,13R,1 4R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8

13 hlearenine, paniculamine, and N-ethyl-1alpha-hydroxy-17-veratroyldictyzine) natural products from a c

14 ous heterocyclic compounds (e.g., 3-chloro-5-hydroxy-1H-pyrrole-2-one with dichloromethyl group, 3-ch

15 ly synthesized 4,5-substituted 3-amino- or 3-hydroxy 2-functionalized thiophenes.

16 -nonenal, 2,4-decadienal, 2,4-heptadienal, 4-hydroxy -2-hexenal, acrolein, 2-heptenal, 2-octenal, 4,5

17 f oxidatively and nitratively damaged DNA (8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-nitroguanine (8

18 otoxicity was shown as increased levels of 8-hydroxy-2'-deoxyguanosine and p53 protein.

19 8-hydroxy-2'-deoxyguanosine was only increased in mitochon

20 mutagenic MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) or halogenated pyrroles.

21 1-Hydroxy-2,2,6,6-tetramethylpiperidine (TEMPOH) was oxidi

22 well as the stable nitroxide free radical 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPOL).

23 nstrate that codelivery of paclitaxel and 2'-hydroxy-2,4,4',5,6'-pentamethoxychalcone (termed rubone)

24 tanedione; whereas, in oil roasted almonds 4-hydroxy-2,5-dimethyl-3(2H)-furanone, 2,3-pentanedione, m

25 last reductive step in the biosynthesis of 4-hydroxy-2,5-dimethyl-3(2H)-furanone, a major component i

26 a dozen, including the key compound HDMF [4-hydroxy-2,5-dimethyl-3(2H)-furanone] contribute to the f

27 l; 8-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-5-hydroxy-2,8-dimethyl-6-(3-methyl-2-bute n-1-yl)-2H-1-ben

28 vel synthetic flavonoid, Proxison (7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4-chromenone), using

29 ,trans-2,4-alkadienals, 4-hydroperoxy- and 4-hydroxy-2-alkenals, and several vitamin A derived metabo

30 Elaboration of the resulting substituted N-hydroxy-2-azetidinones allowed incorporation of function

31 hosts, 3-Methyl-2-buten-1-ol (prenol) and 3-Hydroxy-2-butanone (AMC) were selected for further behav

32 haviour, including 2- and 3-methylbutanal, 3-hydroxy-2-butanone, and 6-methyl-5-hepten-2-one.

33 HNE and HHE (4-hydroxy-2-hexenal) facilitated Mb-mediated lipid oxidati

34 pate in the cycloaddition, providing novel 5-hydroxy-2-isoxazolines in high chemical yield with high

35 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)amino]-3-methyl-benzonitril

36 A series of 7-hydroxy-2-methylidene-2,3-dihydro-1H-inden-1-ones with 2

37 nPM, the OE and OB had rapid increases of 4-hydroxy-2-nonenal (4-HNE) and 3-nitrotyrosine (3-NT) pro

38 The compound 4-hydroxy-2-nonenal (HNE) dissolved in water was examined

39 les of heated oil, the CCs identified were 4-hydroxy-2-nonenal, 2,4-decadienal, 2,4-heptadienal, 4-hy

40 -prostaglandin F2alpha (8-isoPF2alpha) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)).

41 Control experiments using enantioenriched 3-hydroxy-2-oxindole show that the reaction proceeds throu

42 t strategy for the allylation reactions of 3-hydroxy-2-oxindoles with allyltrimethylsilane has been d

43 Previously, we explored 1-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamid

44 loproteinase inhibitors that comprise rare N-hydroxy-2-pentyl-succinamic acid warheads.

45 lines, as aryl radical sources, a range of 3-hydroxy-2-phenylpyridines were obtained in moderate to g

46 amino acids, including a featured 3-amino-6-hydroxy-2-piperidone (Ahp) moiety and a (Z)-2-amino-2-bu

47 ic replacement or scaffold modification to 4-hydroxy-2-quinolone structure.

48 A few of the 4,5-substituted 3-amino/hydroxy-2-stryrylthiophenes (or 2-acrylates) displayed s

49 uantities in good yields from methyl 4(or 3)-hydroxy-3(or 4)-benzyloxybenzoate.

50 thesis and the first total synthesis of (2S)-hydroxy-3,4-dehydroneomajucin, these pursuits have resul

51 4-cyclopropyl-7-hydroxy-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxid

52 Among the active derivatives, compound 1-(4-hydroxy-3,5-dimethoxy) cinnamoyl-2-acyl-sn-glycero-3-pho

53 -2-acyl-sn-glycero-3-phosphocholine and 1-(4-hydroxy-3,5-dimethoxy) cinnamoyl-2-palmitoyl-sn-glycero-

54 were stimulated with IgE-ICs consisting of 4-hydroxy-3-iodo-5-nitrophenylacetyl (NIP)-specific IgE JW

55 ola with MIC of 15.6mug/mL and compound 1-(4-hydroxy-3-methoxy) benzoyl-2-acyl-sn-glycero-3-phosphoch

56 Compounds 1-(4-hydroxy-3-methoxy) cinnamoyl-2-acyl-sn-glycero-3-phospho

57 Compound 1-(4-hydroxy-3-methoxy) cinnamoyl-2-palmitoyl-sn-glycero-3-ph

58 ,4-dihydroxy-N-methylcathinone (HHMC), and 4-hydroxy-3-methoxy-N-methylcathinone (HMMC).

59 ized using a synthetic surrogate of FA, 3-(4-hydroxy-3-methoxyphenyl)propionic acid (HFA), as templat

60 ls consisting of new acentric core HMB (2-(4-hydroxy-3-methoxystyryl)-3-methylbenzo[d]thiazol-3-ium)

61 An analog of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) bound to

62 Small isoprenoid diphosphates, such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), are lig

63 sis induced by bis (pivaloyloxymethyl) (E)-4-hydroxy-3-methyl-but-2-enyl phosphonate.

64 dence that a specific parasite factor, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, may increase

65 onstrate that fluvastatin, an inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase and the N-

66 ranched hydroxylated esters, such as ethyl 2-hydroxy-3-methylbutanoate and ethyl 2-hydroxy-4-methylpe

67 Hitherto unknown cis- and trans-1-amino-3-hydroxy-3-methylcyclobutanecarboxylic acids were synthes

68 D1 to endoplasmic reticulum (ER)-localized 3-hydroxy-3-methylglutaryl (HMG) CoA reductase.

69 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

70 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

71 els in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is

72 i-signal recognition protein (SRP) or anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodie

73 ne and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene.

74 Of these 10 genes, the 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (HMGCS2) was the

75 Until recently, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase

76 Statins, or HMG CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitor

77 d aromatic arsenicals including roxarsone (4-hydroxy-3-nitrobenzenearsenate or Rox(V)) have been exte

78 ed a classic T cell-dependent response to (4-hydroxy-3-nitrophenyl)acetyl conjugated to chicken gamma

79 ady state and after oral immunization with 4-hydroxy-3-nitrophenylacetyl (NP)-Ficoll or cholera toxin

80 leens of mice that had been immunized with 4-hydroxy-3-nitrophenylacetyl-Ficoll, a T cell-independent

81 of 1-hydroxy-1-phenylsilacyclohexane 2 and 3-hydroxy-3-phenyl-3-silatetrahydropyran 3 could not be fr

82 thetic samples of (S)-N(1)-methyl-2-[2'-(3''-hydroxy-4''-methoxyphenyl)ethyl]-1,2,3,4-tetrahydroqui n

83 colonic microbiota-derived catabolite 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid are key biomar

84 tes of bacterial origin, most notably, 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid, did increase

85 A method for the synthesis of 3-hydroxy-4,4-difluoropyrrolidines from alpha,alpha-difluo

86 nsaldolase responsible for (2S,3R)-2-amino-3-hydroxy-4-(4-nitrophenyl)butanoate biosynthesis.

87 maintaining nanomolar inhibitory potency: N-hydroxy-4-[(N(2-hydroxyethyl)-2-phenylacetamido)methyl)-

88 hanges in serum total bile acids and 7 alpha hydroxy-4-cholesten-3-one (C4), and changes in the pharm

89 ipennis (Nv), employs additionally (4R,5R)-5-hydroxy-4-decanolide (RR).

90 e parasitic wasp genus Nasonia use (4R,5S)-5-hydroxy-4-decanolide (RS) as component of their sex pher

91 corresponding triketide substrates (3R,4E)-3-hydroxy-4-hexenoyl-FosACP2 (18) and (2Z,4E)-2,4-hexadien

92 roliferative compounds, including trans-4-(3-hydroxy-4-methoxyphenyl)-3-phenoxy-1-(3,4,5-trimethoxyph

93 thyl 2-hydroxy-3-methylbutanoate and ethyl 2-hydroxy-4-methylpentanoate were the only compounds to be

94 as converted to MCTR1 (13R-glutathionyl, 14S-hydroxy-4Z,7Z,9E,11E,13R,14S,16Z,19Z-docosahexaenoic aci

95 f MCTR1 to MCTR2 (13R-cysteinylglycinyl, 14S-hydroxy-4Z,7Z,9E,11E,13R,14S,16Z,19Z-docosahexaenoic aci

96 in two- to three-steps from the versatile 2-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-one core.

97 A facile, gram-scale preparation of 2-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-3-ones and 2-h

98 (68)Ga-PSMA-(N,N'-bis-[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diac

99 tors derived from the established N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diac

100 r changes in the ratio between alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N

101 t: dendritic spine morphology, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) to N-

102 he compositional plasticity of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and N-methyl

103 aspartate receptor (NMDAR) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AM

104 xone/naltrexone on hippocampal alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AM

105 oreover, these effects require alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor act

106 orporation of Ca(2+)-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (C

107 recruitment of synaptic AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors,

108 AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ion

109 In alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors

110 olves downstream activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) recept

111 mice, these compounds blocking alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) recept

112 rease in NAc spine density and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMP

113 (NAc) shell calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (CP-

114 In neurons, lysosomes regulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor leve

115 receptor 1, NMDA receptor 2A, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subu

116 l-D-aspartate (NMDA) and GluA2 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subu

117 R hypofunction is to stimulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AM

118 potential or co-activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AM

119 id (NMDA) receptors (NMDA-Rs), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, an

120 fication of postsynaptic AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor fun

121 d prevented NMDA-induced AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor int

122 cular targets (e.g., recycling alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, AMPA, recept

123 e receptor superfamily (namely alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, glycine, and

124 es is correlated with synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamat

125 with the potentially hexadentate ligand N-(2-hydroxy-5-methylbenzyl)-N,N',N'-tris(2-pyridinylmethyl)-

126 he ligand-binding domain of (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid (AMPA) rece

127 ts from the internalisation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AM

128 rs and decreased expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) recep

129 FES of unbinding of the antagonist N-(3alpha-hydroxy-5beta-cholan-24-oyl)-l-beta-homotryptophan (UniP

130 To validate this binding mode, new N-(3alpha-hydroxy-5beta-cholan-24-oyl)-l-beta-homotryptophan deriv

131 des the alpha-hydroxyketone (-)-(1R,3S,5R)-3-hydroxy-6,6-dimethylbicyclo[3.1.1]heptan-2-one in prepar

132 6,7,7a-tetrahydro-3H-pyrrolizin-3-ones and 2-hydroxy-6,7,8,8a-tetrahydroindolizin-3(5H)-ones from a c

133 vel compound mupirocin P, which contains a 7-hydroxy-6-keto-substituted THP, from a DeltamupP strain

134 mpounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran-2-one) is the most abu

135 Whereas beta-citronellol is well known, 2-hydroxy-6-methylacetophenone appears to be previously un

136 with previous work on insects showing that 2-hydroxy-6-methylacetophenone is derived from a polyketid

137 t, we report that (S)-beta-citronellol and 2-hydroxy-6-methylacetophenone, two biosynthetically disti

138 ,10R,12R,13R,1 4R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentame thyl

139 t (MCP) 4,11-dicarboxy-8-hydroxy-9-methoxy-2-hydroxy-6-oxo-6-phenyl-hexa-2,4-dienoate.

140 2-Hydroxy-8-(4-hydroxyphenyl)-1H-phenalen-1-one (1), the f

141 meta-cleavage product (MCP) 4,11-dicarboxy-8-hydroxy-9-methoxy-2-hydroxy-6-oxo-6-phenyl-hexa-2,4-dien

142 ased on the early application and success of hydroxy acid based polyesters as degradable sutures and

143 verned by a series of Mitsunobu reactions of hydroxy acid monomers.

144 trains that produce either chiral 2-methyl-3-hydroxy acids (1.1 +/- 0.2 g L(-1)) or branched enoic ac

145 and outdoors, including monoacids, diacids, hydroxy acids, carbonyl acids, and aromatic acids.

146 om naturally occurring alpha-amino- or alpha-hydroxy acids, was found to provide high levels of both

147 n experiments we are able to show that the N-hydroxy-alkyl-succinamic acid warhead is generated by an

148 and gold(I)-catalyzed cyclization of a beta-hydroxy allene to construct the dihydropyran ring.

149 They are commonly derived from beta-hydroxy-alpha-amino acids, which are themselves valuable

150 e useful for the preparation of L-threo-beta-hydroxy-alpha-amino acids.

151 site effect (as seen for 4-hydroxy AOH and 4-hydroxy AME).

152 ion of amides to alpha-keto amides and alpha-hydroxy amides is presented.

153 d 6'-deoxychalcone, yielding corresponding 5-hydroxy and 5-deoxyflavanones, resembling the typical ty

154 raised using hapten PC1 (a 1:1 mixture of 9-hydroxy- and 6-hydroxy-phenazine-2-carobxylic acids), de

155 an relative abundances of epoxy-, 7-keto-, 7-hydroxy- and triol-PS derived from sitosterol and campes

156 ation had the opposite effect (as seen for 4-hydroxy AOH and 4-hydroxy AME).

157 The alpha-(N-hydroxy/aryl)imino-beta-oxodithioesters are readily acce

158 sed by [4 + 1] heterocyclization of alpha-(N-hydroxy/aryl)imino-beta-oxodithioesters with in situ gen

159 the identification of positional isomers of hydroxy-atorvastatins, the primary metabolites of the dr

160 elate complexes of Al(III) and Cr(VI) with o-hydroxy azo dye, at pH 6.5, and then extraction of the h

161 This developed immunosensor was prepared on hydroxy-bearing ITO surface via an ester bond linkage of

162 ienyl)-12-propyl-cyclohex-10-en yl)-methyl-3-hydroxy benzoate (3).

163 le caffeic, sinapic, syringic, o-coumaric, p-hydroxy benzoic, vanillic, protocatechuic, gallic and ci

164 ration of these beta,gamma-diamino and alpha-hydroxy-beta,gamma-diamino esters gave the protected for

165 on, giving access to the corresponding alpha-hydroxy-beta,gamma-diamino esters.

166 xaziridine gave the corresponding anti-alpha-hydroxy-beta-amino ester.

167 n gave access to the corresponding syn-alpha-hydroxy-beta-amino ester.

168 electivity of NKA inhibition by native 3beta-hydroxy bufalin over the 3alpha-isomer, yet replacing th

169 onserved 3-hydroxy butyrate dehydrogenase, 3-hydroxy butyrate dehydrogenase 2 (Bdh2), catalyzes a rat

170 An evolutionarily conserved 3-hydroxy butyrate dehydrogenase, 3-hydroxy butyrate dehyd

171 arting materials such as hydroxamic acids, N-hydroxy carbamates, N-hydroxyureas, nitrile oxides, and

172 Gallionella-like ferrihydrite stalks to Fe (hydroxy)carbonates and Fe sulfides, as well as alteratio

173 ectrometry revealed elevations of ceramides, hydroxy-ceramides, dihydroceramides, sphingosine, dihexo

174 ed to an accumulation of nonesterified omega-hydroxy-ceramides.

175 The highest accumulation was in hydroxy-ceramides.

176 rol surrogate, PMHC (2,2,5,7,8-pentamethyl-6-hydroxy-chromanol, an alpha-tocopherol analogue lacking

177 esterase CA activity to the corresponding 2-hydroxy-cinnamic acid derivatives, the 2-thioxocoumarin

178 o chiral, nonracemic alpha-acyloxy and alpha-hydroxy cyclopentenones and their corresponding redox de

179 E)-9-hydroxydec-2-enoic acid (9-HDA), (E)-10-hydroxy-dec-2-enoic acid (10-HDA), 10-hydroxy-decanoic a

180 (E)-10-hydroxy-dec-2-enoic acid (10-HDA), 10-hydroxy-decanoic acid (10-HDAA), and methyl p-hydroxyben

181 8-Hydroxy-deoxy guanosine and malondialdehyde levels as ma

182 ls of Klotho, improved malondialdehyde and 8-hydroxy-deoxy guanosine levels, and also deteriorated re

183 eries incubated with DHA ex vivo produced 17-hydroxy DHA (17-HDHA) and D-series resolvins, as assesse

184 xidation products comprising hydroperoxides, hydroxy-dienes and other alcohols, epoxides, aldehydes a

185 sed expression of inflammatory cytokines, 12-hydroxy-eicosatetraenoic acid attenuated expression of l

186 irmed by chemical synthesis: ct-8,9-epoxy-11-hydroxy-eicosatrienoic acid (ct-8,9-E-11-HET) and ct-8,9

187 c acid (ct-8,9-E-11-HET) and ct-8,9-epoxy-15-hydroxy-eicosatrienoic acid (ct-8,9-E-15-HET).

188 pected Morita-Baylis-Hillman product, a beta-hydroxy enone, is observed.

189 biphenyl) catalyze the C-C coupling of alpha-hydroxy esters 1a-1i, alpha-ketols 1j-1o, or 1,2-diols d

190 bearing long alkyl chain, an alicyclic ring, hydroxy, ether, and ester functionality, which offer the

191 c intermediates (C4a-hydroperoxy-FAD and C4a-hydroxy-FAD) in the reaction, define rate constants and

192 rum levels of the novel fatty acid esters of hydroxy fatty acids (FAHFAs) were increased and transpla

193 The recent discovery of fatty acid esters of hydroxy fatty acids (FAHFAs), lipids with potent antidia

194 es, acylglucosylceramides and (O-acyl)-omega-hydroxy fatty acids are almost absent with reciprocal in

195 onesterified hydroxyl groups of glycerol and hydroxy fatty acids was performed within cutin.

196 robiological markers: bacterial endotoxin, 3-hydroxy fatty acids, and muramic acid.

197 upled receptor GPR84, which is activated by (hydroxy)fatty acids, is highly expressed on immune cells

198 ass of lipids, branched fatty acid esters of hydroxy-fatty acids (FAHFAs), which were elevated in AT

199 roach to a variety of optically active (poly)hydroxy furans and imidazoles containing multiple stereo

200 resulted in formation of the biomasses, beta-hydroxy-gamma-butyrolacetone and 3,4-dihydroxybutyrate,

201 rives from benzilic acid rearrangement of 19-hydroxy Gdm, and thereby provides a new synthetic deriva

202 The phosphoramidite and the hydroxy group are reacted in step (i), thus leading to a

203 exist in two alternative anomers (in which a hydroxy group at C-1 takes different orientations) and e

204 mmins acetate aldol reaction to generate the hydroxy group at the C-13 position, Horner-Wadsworth-Emm

205 here demonstrate that the introduction of a hydroxy group at the C11beta position affords high selec

206 se that catalyzes the dehydration of the C17 hydroxy group during iso-MGS biosynthesis.

207 FosDH2 catalyzed the slow exchange of the 3-hydroxy group of 8 with [(18)O]-water.

208 n atom or (ii) be attacked by a nucleophilic hydroxy group of its substrate, 20R,22R-dihydroxycholest

209 een catalytic aspartic acid residues and the hydroxy group of the bound clinical drug darunavir, loca

210 r the 3alpha-isomer, yet replacing the 3beta-hydroxy group with larger polar groups in the same confi

211 unable by easy modifications on the phenolic hydroxy group.

212 s, accelerating the arylation of an adjacent hydroxy group.

213 bly faster than O-acylation of the primary 6-hydroxy group.

214 ster cofactors in reductive ring opening and hydroxy-group elimination.

215 directing groups because of the ubiquity of hydroxy groups in organic small molecules.

216 Site-selective functionalization of hydroxy groups in sugar derivatives is a major challenge

217 ound I species that reacts with nucleophilic hydroxy groups in the 20R,22R-dihydroxycholesterol inter

218 nterion favors dual hydrogen bonding to both hydroxy groups leading to equatorial O-acylation.

219 ioselectively differentiate the enantiotopic hydroxy groups of myo-inositol 1,3,5-orthoformate in the

220 al DHs that catalyze dehydration of the beta-hydroxy groups of the nascent polyketide intermediates,

221 vide convincing evidence for the presence of hydroxy groups on surface Ru sites in the HOR potential

222 ubstrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the l

223 eavage of the aromatic bond with two vicinal hydroxy groups to yield substituted cis,cis-muconic acid

224 ted dienes in chains having also hydroperoxy/hydroxy groups, epoxides and aldehydes); the formation o

225 differentiate between differently positioned hydroxy groups.

226 nX Negishi cross-coupling affording an omega-hydroxy hemiacetal which was macrocyclized via a domino

227 chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts.

228 mediates were detected in the plant tissues: hydroxy-IBP, 1,2-dihydroxy-IBP, carboxy-IBP and glucopyr

229 droxy-IBP, carboxy-IBP and glucopyranosyloxy-hydroxy-IBP.

230 ibitors 4-methylthio-2-oxobutyric acid and 2-hydroxy-imino phenylpyruvic acid, both of which reduced

231 An efficient catalyst-free synthesis of 6-hydroxy indoles from carboxymethyl cyclohexadienones and

232 xadienones gave 6-amino indoles instead of 6-hydroxy indoles using the Re2O7 catalyst.

233 ore the synthetic utility of the synthesized hydroxy indoles.

234 se was involved in the production of the two hydroxy intermediates.

235 t of the peroxide to the corresponding alpha-hydroxy ketone.

236 excellent chemical and optical yields of (S)-hydroxy ketones.

237 (ii) The H2O2-mediated oxidation of N-hydroxy-L-arginine to L-citrulline by a series of hemin/

238 bes and human pathogens to dehydrate trans-4-hydroxy-l-proline, the product of the most abundant huma

239 o performed preincubation experiments with 5-hydroxy-L-tryptophan and serotonin.

240 5-hydroxy-l-tryptophan, but not 2-aminobicyclo-(2,2,1)-hep

241 oalkylation reaction involving various gamma-hydroxy lactams and C/O/S nucleophiles at room temperatu

242 ion analysis showed that five biomarkers (20-Hydroxy-leukotriene E4, Lysopc(20:4), 5-methoxytryptamin

243 5,20-tetra(p-tolyl)porphyrin) with two axial hydroxy ligands were studied in detail, demonstrating ca

244 Seven UV filters (UV-Fs), including 3 hydroxy-metabolites of oxybenzone (benzophenone 3, BP3)

245 ule methotrexate (MTX) and its metabolites 7-hydroxy methotrexate (7-OH MTX) and 2,4-diamino-N(10)-me

246 nolic compounds, carotenoids, organic acids, hydroxy methyl furfural (HMF) and other quality paramete

247 Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase i

248 was prepared via the (11)C-methylation of 4-hydroxy N-(2-diethylaminoethyl) benzamide (4-HBZA).

249 was prepared via the (11)C-methylation of 4-hydroxy N-(2-diethylaminoethyl) benzamide (4-HBZA).

250 Structural optimization of 3-hydroxy-N'-arylidenepropanehydrazonamides provided new a

251 reported the discovery of AT-076 (1), (R)-7-hydroxy-N-((S)-1-(4-(3-hydroxyphenyl)piperidin-1-yl)-3-m

252 ough rye breads were notably high in their 2-hydroxy-N-(2-hydroxyphenyl) acetamide (HHPAA) concentrat

253 hydroxy-1,4-benzoxazin-3-one (HBOA-d4) and 2-hydroxy-N-(2-hydroxyphenyl) acetamide (HHPAA-d4) were sy

254 Steady-state concentrations of endoxifen (4-hydroxy-N-desmethyltamoxifen), the most potent antiestro

255 e pyrazolo[1,5-a]pyridine appendage with a 5-hydroxy-N-propyl-2-aminotetraline unit led to balanced o

256 Photophysical studies revealed that 5-hydroxy-naphtho[2,1,8-def]coumarin has the most bathochr

257 The model 5-hydroxy-naphtho[2,1,8-def]coumarin was transformed into

258 o-mephedrone, 1-dihydro-normephedrone and 4'-hydroxy-normephedrone.

259 ydroxy-octadecenoic acid in comparison to 13-hydroxy-octadecenoic acid from oxidized CLs.

260 ted that iPLA2gamma selectively hydrolyzes 9-hydroxy-octadecenoic acid in comparison to 13-hydroxy-oc

261 d all-trans-retinol to 3,4-dehydroretinol, 4-hydroxy (OH) retinol, and 3-OH retinol in a 100:3:2 rati

262 nylalkanoic, alpha,omega-dicarboxylic, omega-hydroxy, omega-1-oxo, omega-1-methyl, 2-methyl, 2-methyl

263 ethyl-2-enolic and 2,3-dihydroxy acids, beta-hydroxy-omega-lactones, and omega-1-methyl alcohols.

264 molecule antagonists 1,1-bis(3-indolyl)-1-(p-hydroxy or p-carbomethoxyphenyl)methane (C-DIM) decrease

265 Starting from hydroxy- or methoxyisatin, the synthesis features a Noyo

266 In this regime, beta hydroxy peroxy radical isomers comprise approximately 95

267 lar 1,6 H-shift isomerization of the Z-delta hydroxy peroxy radical isomers produced from OH addition

268 In addition, the Z-delta hydroxy peroxy radical isomers undergo unimolecular 1,6

269 We find that the ratio of delta to beta hydroxy peroxy radicals depends on their bimolecular lif

270 lecular > 10 s, the distribution of isoprene hydroxy peroxy radicals will be controlled primarily by

271 ually reformed via decomposition of the beta hydroxy peroxy radicals.

272 Ten unidentified hydroxy PHE metabolites were measured in the derivatized

273 apten PC1 (a 1:1 mixture of 9-hydroxy- and 6-hydroxy-phenazine-2-carobxylic acids), designed to recog

274 e results demonstrated the presence of PLTX, hydroxy-PLTX and, at least, two additional compounds wit

275 tly transformed into vicinal diols and alpha-hydroxy propargylic esters without loss in enantiopurity

276 2-Hydroxy-propyl-beta-cyclodextrin (HPbetaCD), a cholester

277 (HDAC4) to the nucleus for repression of 15-hydroxy prostaglandin dehydrogenase (15-PGDH).

278 nosilyl enol ethers via ionization of alpha'-hydroxy silyl enol ethers to generate unsymmetrical sily

279 ightly more deeply inserted in 1-myristoyl-2-hydroxy-sn-glycero-3-phospho-1'-rac-glycerol (LMPG, anio

280 glycerol (LMPG, anionic) than in 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine (LLPC, zwitterionic)

281 es, such as branched palmitic acid esters of hydroxy stearic acids (PAHSAs); each family consists of

282 BMS-816336 (6n-2), a hydroxy-substituted adamantyl acetamide, has been identi

283 th supporting theoretical calculations, that hydroxy-substituted benzo[b]quinolizinium derivatives di

284 signed and synthesized a collection of novel hydroxy-substituted heteroarylpiperazines and heteroaryl

285 rmacological evaluation of novel C9- and C11-hydroxy-substituted hexahydrocannabinol (HHC) and tetrah

286 In this paper, hydroxy-telechelic isotactic PPO is synthesized from rac

287 eric chain shuttling agents are used to give hydroxy-telechelic isotactic PPO of varying functionalit

288 Currently there is no practical route to hydroxy-telechelic isotactic PPO using racemic propylene

289 Hydroxy-telechelic poly(propylene oxide) (PPO) is widely

290 Congruently, the addition of 4-hydroxy-TEMPO (TEMPOL), a superoxide dismutase mimic tha

291 nd cyclisation of acetol into 2,5-dimethyl-4-hydroxy-tetrahydrofuran-3-one was found to be catalysed

292 3-hydroxyphenyl pharmacophore, but not the 7-hydroxy Tic pharmacophore, are better tolerated at kappa

293 tricyclic undecose core decorated with a (5-hydroxy)tiglyl moiety.

294 sing organohypervalent iodine(III) reagent, [hydroxy(tosyloxy)iodo]benzene (Koser's reagent), has bee

295 [(11)C]5-hydroxy-tryptophan ([(11)C]5-HTP) positron emission tomo

296 The serum levels of 25-hydroxy VD, TGF-beta1, TIMP-1, MMP2 and MMP9 were measur

297 D) and neovascular AMD (nvAMD) with serum 25-hydroxy vitamin D (25(OH)D) and genetic variants in vita

298 may enhance erythropoiesis in settings of 25-hydroxy vitamin D (25(OH)D) deficiency.

299 IBD were also analyzed along with plasma 25-hydroxy vitamin D3 (25D) detection.

300 we showed that 1,25-vitamin D3-deficient 25-hydroxy-vitamin-D3-1alpha-hydroxylase knockout mice and