ライフサイエンスコーパス: hydroxy acid

1 d) and 4-hydroxy-4-(3-pyridyl)butanoic acid (hydroxy acid).

2 lization by ester bond formation from a seco-hydroxy acid.

3 unsual nonproteinogenic amino acids and one hydroxy acid.

4 zation step of the activated linear trimeric hydroxy acid.

5 oxidation of L-lactate and other small alpha-hydroxy acids.

6 s for polyols, particularly, saccharides and hydroxy acids.

7 n enantiodiscrimination of chiral amines and hydroxy acids.

8 nt over other methods for the synthesis of 3-hydroxy acids.

9 reoselectively anti-gamma-(aryl,styryl)-beta-hydroxy acids.

10 ssential for reaction with water and d-alpha-hydroxy acids.

11 lavoenzymes that catalyze oxidation of alpha-hydroxy acids.

12 flavoproteins catalyzing oxidation of alpha-hydroxy acids.

13 flavoproteins catalyzing oxidation of alpha-hydroxy acids.

14 for amino acids and chiral HPLC analysis for hydroxy acids.

15 trains that produce either chiral 2-methyl-3-hydroxy acids (1.1 +/- 0.2 g L(-1)) or branched enoic ac

16 cascade biocatalysis to produce chiral alpha-hydroxy acids, 1,2-amino alcohols and alpha-amino acids,

17 A Mitsunobu macrolactonization of hydroxy acid 2 avoided isomerization of the sensitive 2,

18 mounts (1 to 3%) of 12:0 and 14:0; and eight hydroxy acids, 2-OH-12:0 (4%), 2-OH-14:0 (trace), 3-OH-1

19 , albeit 4-fold more potent than the acyclic hydroxy acid 25 (Ki = 1.5 mM as a mixture of epimers).

20 D-Alpha-hydroxy acids act as acyl acceptors for glycyl substrate

21 We interrogated A-domain 2-keto and 2-hydroxy acid activation and loading, and KR domain activ

22 t not for more specific d-alanyl substrates; hydroxy acids actually behave, more generally, as mixed

23 aminophenylboronic acid with saccharides and hydroxy acids also confirm that the observed resistance

24 ploys base-mediated esterification of a beta-hydroxy acid and a salicylate cyanomethyl ester.

25 Na(2)CO(3)-mediated esterification of a beta-hydroxy acid and a salicylate cyanomethyl ester.

26 sibility of enzymatic incorporation of alpha-hydroxy acid and acid analogues (lacking amino group) of

27 e studied direct acylation of tRNAs by alpha-hydroxy acid and acid analogues of amino acids and corre

28 Together, alpha-hydroxy acids and alpha-amino acids form depsipeptides-o

29 elective kinetic resolution to provide alpha-hydroxy acids and esters in high optical purity and good

30 ration of (i) alpha-hydroxyamides from alpha-hydroxy acids and of (ii) perfluoroalkylated amides.

31 -methylcyclopropyl)-glycine, a beta-branched-hydroxy acid, and 3-hydroxy glutamic acid, for which bio

32 s such as hydroxy amides, oxazolidinediones, hydroxy acids, and amino acids were included.

33 aterials such as amino acids, carbohydrates, hydroxy acids, and terpenes in the carbon framework of t

34 , which would ultimately yield keto acid and hydroxy acid as urinary metabolites.

35 ty can be detected with amino acids or alpha-hydroxy acids as substrates.

36 recognition of l-malate, but not other alpha-hydroxy acids, as the acceptor substrate.

37 bonds were generated by incorporating alpha-hydroxy acids at positions 39, 44, or 50, respectively,

38 ased on the early application and success of hydroxy acid based polyesters as degradable sutures and

39 Topical therapy including tretinoins, hydroxy acids, bleaching agents, and sunscreens are disc

40 ne, are converted to the corresponding alpha-hydroxy acids by the auxiliary enzyme.

41 oscopic discrimination of a series of chiral hydroxy acids by their coordination and self-assembly wi

42 and outdoors, including monoacids, diacids, hydroxy acids, carbonyl acids, and aromatic acids.

43 equired a highly discriminatory screen for 2-hydroxy acid dehydrogenase activity to select enzymes wh

44 binding core domain that is homologous to D2 hydroxy acid dehydrogenase enzymes, as well as an unstru

45 m Pseudomonas putida, an FMN-dependent alpha-hydroxy acid dehydrogenase, oxidizes (S)-mandelate to be

46 Pseudomonas putida is an FMN-dependent alpha-hydroxy acid dehydrogenase.

47 e/hydroxypyruvate reductase (GRHPR) is a D-2-hydroxy-acid dehydrogenase that plays a critical role in

48 The enzyme belongs to the family of D-hydroxy acid dehydrogenases (DHDHs).

49 ficant amino acid sequence similarity with D-hydroxy acid dehydrogenases (DHs), including strongly co

50 d dehydrogenases, in general, to function as hydroxy acid dehydrogenases.

51 The enzyme belongs to the family of D-hydroxy acid dehydrogenases.

52 cid dehydrogenases from functioning as alpha-hydroxy acid dehydrogenases.

53 Attempted cyclization of several C15 hydroxy acid derivatives to the 16-membered lactone bafi

54 pid access to enantioenriched tertiary alpha-hydroxy acid derivatives unavailable through Mo-catalyze

55 hesis of beta-methyl chiral amines and alpha-hydroxy acid derivatives, respectively.

56 l group tolerance is observed and amino- and hydroxy-acid derivatives can be functionalized.

57 ual nucleophilic displacement reaction and d-hydroxy acid DHs to oxidize alcohols to ketones.

58 e with the typical role of this residue in D-hydroxy acid DHs.

59 ination of lovastatin present in lactone and hydroxy acid forms and citrinin in red rice products pro

60 The stereochemistry of the hydroxy acids from the reduction of keto acids is depend

61 atic group of the fluorescent chromophore, a hydroxy acid group of beta-hydroxy aspartic acid, and a

62 A series of weak lipophilic hydroxy acids (HA) including fluorinated alcohols and ph

63 the amino acid immediately N-terminal of the hydroxy acid has a large effect on the hydrolysis rate.

64 d gamma-keto acids provide the corresponding hydroxy acids in 77-98% ee, and the alpha- and gamma- ke

65 er enable the incorporation of OEGs to alpha-hydroxy acids in a simple and efficient manner.

66 , were replaced with the corresponding alpha-hydroxy acids in the context of a chemoselectively ligat

67 The site-specific incorporation of alpha-hydroxy acids into proteins using nonsense suppression c

68 We describe here the incorporation of hydroxy acids into the precursor peptides in E. coli whi

69 general base accepting a proton as the beta-hydroxy acid is oxidized to the beta-keto acid, and this

70 lpha-hydroxy acids to optically active alpha-hydroxy acids is reported.

71 ctional enzyme CrpD-M2 that incorporates a 2-hydroxy acid moiety (unit D) into Crp analogues.

72 the asymmetric synthesis of the unique beta-hydroxy acid moiety (Z)-3-hydroxy-6,8-dimethylnon-4-enoi

73 ic steps leading to the incorporation of a 2-hydroxy acid moiety in the final chain elongation interm

74 chemical reactions are mediated by the alpha-hydroxy acid moiety, a group which has generally been fo

75 verned by a series of Mitsunobu reactions of hydroxy acid monomers.

76 t oxidize aliphatic or aromatic aldehydes or hydroxy acids, nor does it reduce keto acids.

77 ponsible for enabling GO to react with alpha-hydroxy acids of various chain lengths.

78 8-HPETE can be reduced to the corresponding hydroxy acid or be enzymatically converted to a newly id

79 is derived from the following: amino acids, hydroxy acids or peptides; a silicon alkoxide; and a met

80 Long chain hydroxy acid oxidase (LCHAO) is a member of an FMN-depen

81 genes are targeted to peroxisomes and have 2-hydroxy acid oxidase activities.

82 approaches identified three distinct human 2-hydroxy acid oxidase genes, HAOX1, HAOX2, and HAOX3, tha

83 to plant glycolate oxidase, a prototypical 2-hydroxy acid oxidase.

84 of the flavin mononucleotide-dependent alpha-hydroxy acid oxidase/dehydrogenase family, is a membrane

85 of the flavin mononucleotide-dependent alpha-hydroxy acid oxidase/dehydrogenase family, oxidizes (S)-

86 hese results indicate that all three human 2-hydroxy acid oxidases are involved in the oxidation of 2

87 In contrast to most alpha-hydroxy acid oxidases including spinach glycolate oxidas

88 rait of metal ion- and NAD(P)-dependent beta-hydroxy acid oxidative decarboxylases.

89 The amino and hydroxy acid partial structures of wewakpeptins A-D (1-4

90 ydroascorbic acid at biological pH to a C(4)-hydroxy acid plus a previously unreported ascorbate ozon

91 no acid residue with the corresponding alpha-hydroxy acid, preserving stereochemistry, and conformati

92 Incorporation of alpha-hydroxy acids (primary amino group is substituted with h

93 e uses encompass selective 1,2-diol or alpha-hydroxy acid protection, enantiotopic recognition and de

94 obic amino acids (Phe, two Leu, Val) and one hydroxy acid ((S)-2-hydroxy-4-methylpentanoic acid; O-Le

95 ymes that catalyze oxidation of various beta-hydroxy acid substrates to corresponding semialdehydes.

96 epresent an unusual arrangement of amino and hydroxy acid subunits relative to known cyanobacterial p

97 MN-dependent enzyme family that oxidizes L-2-hydroxy acids to ketoacids.

98 ve catalytic transformation of racemic alpha-hydroxy acids to optically active alpha-hydroxy acids is

99 dent, peroxisomal enzyme that oxidizes alpha-hydroxy acids to the corresponding alpha-keto acids, wit

100 library of propargylated and PEGylated alpha-hydroxy acids toward the preparation of "clickable" poly

101 in the extracts were phenolics and aliphatic hydroxy acids typical of royal jelly and unsaturated dic

102 The resulting 2-hydroxy acid was elongated with three synthetic Crp chai

103 om naturally occurring alpha-amino- or alpha-hydroxy acids, was found to provide high levels of both

104 of the channel, two imino acids and an alpha-hydroxy acid were incorporated at the proline position u

105 e methyl ester with an enantiomerically pure hydroxy acid, which in turn was synthesized by a highly

106 shown to catalyze hydroxylation to form beta-hydroxy acids, which upon decarboxylation led to hemiket

107 ide) bond formation that is enabled by alpha-hydroxy acids, which were likely present along with amin

108 by the enzyme paraoxonase to the respective hydroxy acids, which were very weak glucocorticoid agoni

109 eloped for the condensation of racemic alpha-hydroxy acids with trichloromethyl chloroformate (diphos