ライフサイエンスコーパス: hydroxy group

1 anomeric hydroxy group is cis to an adjacent hydroxy group.

2 not as active as the compounds without the 1-hydroxy group.

3 s, accelerating the arylation of an adjacent hydroxy group.

4 f Arg9 forms an intra-hydrogen bond with the hydroxy group.

5 bly faster than O-acylation of the primary 6-hydroxy group.

6 s resulted in an in situ protection of the o-hydroxy group.

7 red spectroscopy confirmed the presence of a hydroxy group.

8 rescent PIP(2) derivatives modified at the 6-hydroxy group.

9 unable by easy modifications on the phenolic hydroxy group.

10 three-methylene unit, and an alkylamino or a hydroxy group.

11 with a predetermined stereochemistry of the hydroxy group.

12 here incorporate ribose mimics missing the 2-hydroxy group.

13 ses, C2 in ketoses), which has a more acidic hydroxy group.

14 an iCTC-like skeleton bearing two additional hydroxy groups.

15 differentiate between differently positioned hydroxy groups.

16 alkyl groups (e.g., propyl groups) onto the hydroxy groups.

17 me steps of protecting/deprotecting amino or hydroxy groups.

18 l depend upon the number and location of the hydroxy groups.

19 hydrogen bonds for the two binding sites via hydroxy groups 3-OH and 4-OH and hydrophobic contact by

20 l) derivatives, introduction of the 17 alpha-hydroxy group (4b) and 16 alpha,17 alpha-epoxide group (

21 le them to cross the cell membrane, the free hydroxy group also was esterified with a long hydrocarbo

22 Key H-bonding partners with the 17-hydroxy group and 3-keto group of testosterone are Asn70

23 a strong hydrogen bond between an ionized 2-hydroxy group and Ser195 of factor Xa.

24 validated the initial hypothesis that the C7 hydroxy group and the C14 and C16 methyl groups of (+)-d

25 tramolecular hydrogen bonding between the C8 hydroxy group and the C7 oxygen functionality in (aR,7R)

26 Oxidation of the hydroxy group and the reduction of a phenylnitro group p

27 wed by protection of the resulting secondary hydroxy group and treatment of the product with Boc anhy

28 re modified by the repositioning of phenolic hydroxy groups and by the addition of alkyl substituents

29 rol, including compounds that were devoid of hydroxy groups and were 100-fold more potent than resver

30 ing process, (2) flexible positioning of the hydroxy group, and (3) potential extension to other medi

31 Chlorophenylacetate, which lacks the ortho-hydroxy group, and hydroxyphenylacetate, lacking the chl

32 hat they interact electrostatically with the hydroxy group, and that the guanidinium group of Arg9 fo

33 rect protection methods targeting a specific hydroxy group are demanded.

34 side chain containing either a 3-oxo or a 3-hydroxy group are optimal structures for immune suppress

35 The phosphoramidite and the hydroxy group are reacted in step (i), thus leading to a

36 otected form of kaempferol in which all four hydroxy groups are differentiated and the first bis-glyc

37 Protection of the hydroxy group as a THP acetal and oxidative cleavage of

38 pyridine ring, implicating the oxazole alpha-hydroxy group as an active participant in the cycloadduc

39 exist in two alternative anomers (in which a hydroxy group at C-1 takes different orientations) and e

40 Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-

41 a hydroxy group (to give TDP-quinovose), the hydroxy group at C3 is oxidized to a ketone with no C4-d

42 Asymmetric introduction of hydroxy group at C7 is achieved by the enantioselective

43 mmins acetate aldol reaction to generate the hydroxy group at the C-13 position, Horner-Wadsworth-Emm

44 here demonstrate that the introduction of a hydroxy group at the C11beta position affords high selec

45 the 4-chromanone scaffold together with the hydroxy groups at 5- and 7-positions enhanced antibacter

46 The results showed that phenols having two hydroxy groups at meta positions of the aromatic ring we

47 nacene (TBTQ) derivatives bearing methoxy or hydroxy groups at the peripheral positions [(2,6-(OMe)2,

48 cis-diols, having an equatorial and an axial hydroxy group, benzoyl cyanide or acetyl cyanide as an a

49 These results indicate that the 6-hydroxy group can be modified to develop functional subs

50 utated 36 evolutionarily conserved basic and hydroxy group containing residues within RAG2.

51 However, although the 3-hydroxy group could be removed without significantly red

52 the side chain, the sterol nucleus, or the 3-hydroxy group did not.

53 se that catalyzes the dehydration of the C17 hydroxy group during iso-MGS biosynthesis.

54 ster cofactors in reductive ring opening and hydroxy-group elimination.

55 ted dienes in chains having also hydroperoxy/hydroxy groups, epoxides and aldehydes); the formation o

56 -norvitamin D analogue 4 possessing a 1alpha-hydroxy group fixed in the axial orientation (beta-chair

57 by contrast, recognizes few phosphate or 2'-hydroxy groups for aminoacylation.

58 nd stereochemistry of the C10-methyl and C11-hydroxy groups for potent PP2A inhibition.

59 d compounds (containing different numbers of hydroxy groups) for dansylation.

60 ly occurring analog of LPA in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phos

61 The primary hydroxy group from atROL is preserved in the metabolite.

62 receptor distinguishes estradiol's unique 3-hydroxy group from the 3-keto function of most other ste

63 proceeded by intramolecular transfer of the hydroxy group from the nitrogen to the C-2 position of t

64 he C-6 ester (H1 series), removal of the C-4 hydroxy group gave compounds with reduced potency, where

65 e N6-amino group with methylthio, chloro, or hydroxy groups greatly reduced the ability to interact w

66 The apparent specificity for the C(6)-hydroxy group in 1 suggests that an efficient hydrogen b

67 related analogues demonstrated that the C(6) hydroxy group in 1 was essential for activity.

68 We found that replacing the C(6)-hydroxy group in 1 with weaker hydrogen bond donors led

69 replacement of a single hydrogen atom with a hydroxy group in a Hp/Py pairing regulates affinity and

70 nol occurs with significant migration of the hydroxy group in cyclohexanol and the double bond in cyc

71 oth C-20 epimeric pairs containing the 24(R)-hydroxy group in the gemini and 19-norgemini series.

72 tionale in which proton abstraction from the hydroxy group in the initial cation radical does not cau

73 rent from the intermolecular transfer of the hydroxy group in the non-enzymatic Bamberger rearrangeme

74 Asp 145 in close proximity to the ligand's 4-hydroxy group in the structure of the product-enzyme com

75 directing groups because of the ubiquity of hydroxy groups in organic small molecules.

76 Site-selective functionalization of hydroxy groups in sugar derivatives is a major challenge

77 rifies the molecular conformation of the two hydroxy groups in terrein established by X-ray data.

78 ound I species that reacts with nucleophilic hydroxy groups in the 20R,22R-dihydroxycholesterol inter

79 Addition of a 14-hydroxy (the 4a-hydroxy) group in the enantiomeric isoquinolinones, (+)-

80 Reaction is completed only when the anomeric hydroxy group is cis to an adjacent hydroxy group.

81 of binding observed with the removal of the hydroxy group is decreased severalfold as compared to wh

82 ucture of an oxophlorin where the alpha-meso hydroxy group is deprotonated.

83 compound repository demonstrated that the 7-hydroxy group is essential for integrase inhibition.

84 introduced in which a stereocenter bearing a hydroxy group is given two different tags.

85 The 14-hydroxy group is known to increase the antagonist potenc

86 ply that the axial orientation of the 1alpha-hydroxy group is necessary for biological activity of vi

87 The product is unstable unless its 4-hydroxy group is protected, as it undergoes facile dimer

88 In the ferrous form, the alpha-hydroxy group is protonated and consequently the prosthe

89 itution at the C-2 position revealing that a hydroxy group is required for optimal activity.

90 Hydrogen-bonding via hydroxy groups is crucial for catalysis also.

91 nterion favors dual hydrogen bonding to both hydroxy groups leading to equatorial O-acylation.

92 nded to reduce the electron density on the N-hydroxy group, leading to higher redox potential and low

93 N-phenyl tended to increase the Km of the N-hydroxy group, leading to lower oxidation rate.

94 Subsequent optimization and removal of the 7-hydroxy group led to coumarin 59, which had increased po

95 array of representative reactions, including hydroxy group manipulation (acylation, protection/deprot

96 quine analogues and their Nomega-oxides with hydroxy group meta to the amino rather than in para posi

97 roup and that the nitrogen atom of the non-N-hydroxy group must contain at least a single hydrogen at

98 s the reduction of the carbonyl group to the hydroxy-group negates this difference to zero.

99 Replacement of the 4-hydroxy group of 1 with an ethyl group abolishes activit

100 Functionalization of the hydroxy group of 45 with a series of piperidinylalkyl gr

101 FosDH2 catalyzed the slow exchange of the 3-hydroxy group of 8 with [(18)O]-water.

102 tert-butyldimethylsilyl ether for the gamma-hydroxy group of Ahad.

103 involved in hydrogen bonding with a phenolic hydroxy group of cyperin.

104 ole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE).

105 catalyzes regiospecific methylation at the 7-hydroxy group of its native substrate, 2,7-dihydroxy-5-m

106 n atom or (ii) be attacked by a nucleophilic hydroxy group of its substrate, 20R,22R-dihydroxycholest

107 However, the role of the 6-hydroxy group of PIP(2) for interaction and hydrolysis b

108 the glycosyl donor but high affinity to the hydroxy group of the acceptor alcohol moiety, thus leadi

109 utyldimethylsilyl protecting group at the C3-hydroxy group of the beta-lactams provided optimum kinet

110 een catalytic aspartic acid residues and the hydroxy group of the bound clinical drug darunavir, loca

111 Replacement of the 4-hydroxy group of the high-affinity compound 2 with an am

112 the Gln217-Gly219 region caused by the ortho-hydroxy group of the inhibitor's aminobenzamidine moiety

113 The 7-hydroxy group of the isoquinoline skeleton of the aglyco

114 ue implicated in the binding of the phenolic hydroxy group of the keto and enol isomers of (p-hydroxy

115 xpected to occur upon the protonation of the hydroxy group of the N-hydroxysulfenamide intermediate.

116 the absolute configuration of the side chain hydroxy group of the natural product to be assigned as (

117 biosynthesis, the phosphorylation of the 3'-hydroxy group of the ribose sugar moiety.

118 equent hydrogen atom transfer (HAT) from the hydroxy group of the salicyl moiety to the vinyl radical

119 d O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids.

120 Ile12 forms the proline type I turn, and the hydroxy group of Tyr11 interacts with the two guanidiniu

121 and were covalently linked to the (omega-1)-hydroxy group of very long chain fatty acid in bradyrhiz

122 de the capsule and is hydrogen bonded to the hydroxy groups of 2a.

123 ioselectively differentiate the enantiotopic hydroxy groups of myo-inositol 1,3,5-orthoformate in the

124 al DHs that catalyze dehydration of the beta-hydroxy groups of the nascent polyketide intermediates,

125 tion; and (iv) the carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for

126 Some hydroxy groups of these fatty acids were further esterif

127 It is observed that the presence of a hydroxy group on the benzene ring of PEAs resulted in de

128 ytic site and forms a hydrogen bond with the hydroxy group on the farnesyl side chain of the heme.

129 vide convincing evidence for the presence of hydroxy groups on surface Ru sites in the HOR potential

130 Derivatives having hydroxy groups on the aryl moieties (2c, 2j-l) demonstra

131 = 1.2 microM) are reduced by incorporating a hydroxy group onto the 4-position of the piperidine ring

132 us PQS but not PQS derivatives lacking the 3-hydroxy group overcame the cell density but not growth p

133 ic activities of 7 and 9 suggest that the 14-hydroxy group plays an important role in determining the

134 lexation directed by proximal alpha- or beta-hydroxy groups present in the phosphine oxide structures

135 rivatives of N-hydroxyurea that contain an N-hydroxy group react with oxyhemoglobin to form methemogl

136 alogues were synthesized in which the 1alpha-hydroxy group, required for biological activity, is almo

137 proposed to proceed via transposition of the hydroxy group resulting from the initial annulation.

138 ese guanidinium groups are curled toward the hydroxy group so that they interact electrostatically wi

139 bonding of cyanide to the most acidic axial hydroxy group supported by hydrogen bonding of the equat

140 s a hydrogen-bonding network involving the 4-hydroxy group that anchors the aromatic ring and thereby

141 ubstrate bearing both aliphatic and aromatic hydroxy groups the enzyme preferentially silylates the l

142 may share a D1 pharmacophore made up of two hydroxy groups, the nitrogen atom (ca. 7 A from the oxyg

143 i-facial intramolecular hydrogen bond from a hydroxy group to an arene is favored by approximately 1.

144 Here, use of a proximal hydroxy group to control regioselection in the functiona

145 Introduction of a hydroxy group to increase the flexibility afforded B whi

146 ydrogen bond donor interaction from the C(6)-hydroxy group to rho or the C(6) hemiaminal bond cleavag

147 ported by hydrogen bonding of the equatorial hydroxy group to the axial oxygen.

148 ple, we demonstrate that the addition of two hydroxy groups to AQDS increases the open circuit potent

149 iperidine and subsequent deprotection of the hydroxy groups to give novel dicarboxylic acid 11 or dia

150 goes a very exothermic coupling of alkyl and hydroxy groups to give the alcohol complex VI of Fe(III)

151 eavage of the aromatic bond with two vicinal hydroxy groups to yield substituted cis,cis-muconic acid

152 er, if the C4 amino group is replaced with a hydroxy group (to give TDP-quinovose), the hydroxy group

153 alogues in which either the sn-1 or the sn-2 hydroxy group was replaced by fluorine, or the bridging

154 e E (6) to N-acyliminium ion 7, from which a hydroxy group was selectively introduced to the C6, C7,

155 ly assigned, while the position of the other hydroxy group was tentatively assigned.

156 eries of substituted trans-stilbenes without hydroxy groups were compared with resveratrol for their

157 is due to dual hydrogen bonding of the axial hydroxy group which enhances the nucleophilicity of the

158 eugenol, and methyl vanillate all contain a hydroxy group which is apparently important for the stro

159 " has been modified by replacement of the 4'-hydroxy group with a hydrogen, fluorine, or chlorine ato

160 ip study of 1 showed that replacing the C(6)-hydroxy group with alkoxy and thioalkoxy substituents le

161 highly directed interaction of the ligands' hydroxy group with an asparagine (N508(6.52)) prevents r

162 to having the required pharmacophore (the 4-hydroxy group with hydrogen-bonding interaction with the

163 r the 3alpha-isomer, yet replacing the 3beta-hydroxy group with larger polar groups in the same confi

164 trates that the noncovalent interaction of a hydroxy group with pi-deficient pyrazine and quinoxaline

165 -30 were prepared from 16a by protecting all hydroxy groups with esters with an aim to facilitate dru

166 After protection of the hydroxy groups with iodomethane, diiodide 6 is subjected

167 )CHNR2), where Ar(1) is substituted with a 2-hydroxy group, with arylboroxines (Ar(3)BO)3 in the pres