ライフサイエンスコーパス: hydroxyethyl

1 rdination between A20 and coralyne in a 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) bu

2 strong copper binding was observed for 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 4

3 l enhancement at 48 mT, is demonstrated on 2-hydroxyethyl-1-(13)C-propionate-d(2,3,3) using a double-

4 8S)-tert-butyl 8- inverted question mark(1R)-hydroxyethyl-1-aza-9-oxobicyclo inverted question mark5.

5 attached to the SWNT by esterification of 2-hydroxyethyl 2'-bromopropionate with carboxylic acid gro

6 S-benzyl phenylmethanethiosulfinate and S-(2-hydroxyethyl) 2-hydroxyethanethiosulfinate, respectively

7 K(i) = 389 +/- 72 nM), and (S)-N-(1-methyl-2-hydroxyethyl)-2-(R)-methyl-arachidonamide (K(i) = 233 +/

8 ethyl anandamide analogues (R)-N-(1-methyl-2-hydroxyethyl)-2-(R)-methyl-arachidonamide (K(i) = 7.42 +

9 (K(i) = 7.42 +/- 0.86 nM), (R)-N-(1-methyl-2-hydroxyethyl)-2-(S)-methyl-arachidonamide (K(i) = 185 +/

10 de (K(i) = 185 +/- 12 nM), (S)-N-(1-methyl-2-hydroxyethyl)-2-(S)-methyl-arachidonamide (K(i) = 389 +/

11 lecule inhibitor of tau fibrillization, 3-(2-hydroxyethyl)-2-[2-[[3-(2-hydroxyethyl)-5-methoxy-2-benz

12 omolar inhibitory potency: N-hydroxy-4-[(N(2-hydroxyethyl)-2-phenylacetamido)methyl)-benzamide)] (HPB

13 amycin (17AAG), and (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl

14 a-2'-deoxyguanosine as the analogues of N(7)-hydroxyethyl-2'-deoxyguanosine and N(7)-oxoethyl-2'-deox

15 pared by deamination of 3',5'-protected O(6)-hydroxyethyl-2'-deoxyguanosine followed by cyclization t

16 ng studies show that an amide analogue, N-(2-hydroxyethyl-2,2-(3)H)nodulisporamide ([(3)H]NAmide), bi

17 utative structure for diplopyrone {6-[(1S)-1-hydroxyethyl]-2,4a(S),6(R),8a(S)-tetrahydropyran[3,2-b]p

18 -N'-[2-ethanesulfonic acid]), Bes (N,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid), Tes (N-tris[h

19 4, ethyl 16 and 35, hydroxymethyl 20 and 41, hydroxyethyl 22, fluoroethyl 23, hydroxypropyl 27, and f

20 revealed it to be 2-amino-4-(2-hydroxy-3-(2-hydroxyethyl)-2H-benzo[b][1,4]oxazin-5-yl)-4-oxobutanoi

21 ovel photoactivable general anesthetic, 3-(2-hydroxyethyl)-3-n-pentyldiazirine (3-diazirinyloctanol),

22 1R,4S,5R,7S)-4- inverted question mark(1R)-1-hydroxyethyl-3,9, 11-trioxo-10-phenyl-2,8,10,12-tetraaza

23 rocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl) -4-methoxybenzenesulfonamide) also suppres

24 s with the paraquat derivative N,N'-bis(beta-hydroxyethyl)-4,4'-bipyridinium bis(hexafluorophosphate)

25 N-Boc syn-7-(2-hydroxyethyl)-4-(alkyl or aryl)sulfonyl-2-azabicyclo[2.2

26 hexen-1-yl)-1E,3E,5E,7E-octatet raenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexe

27 rocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-meth oxybenzenesulfonamide phosphate sal

28 des with N-(4-hydroxy-2-methylenebutyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide has been develo

29 hyl)-2-methylpyrimidine pyrophosphate and 5-(hydroxyethyl)-4-methylthiazole phosphate.

30 been characterized as the ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid.

31 of benzaldehyde, catalyzed by 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide in methanol buf

32 The synthesis of a series of 3-beta-hydroxyethyl-4-arylquinolin-2-ones is described.

33 In particular, the 3-hydroxyethyl-4-ethyl congener 29 is a potent inhibitor o

34 ethylpyrimidine pyrophosphate (HMP-PP) and 5-hydroxyethyl-4-methylthiazole phosphate (THZ-P) moieties

35 d by the addition of the thiamin precursor 5-hydroxyethyl-4-methylthiazole, indicating that iscS is r

36 ocinnamyl)-N:-methylaminomethyl)phenyl]-N-[2-hydroxyethyl]- 4-methoxybenzenesulfonamide).

37 R)-2-((1R,2R)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothi azolone), which displays

38 no]carbonyl]-3-pyrrolidinyl ]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-e

39 le-1-yl)heptane phosphonate) and YM 50201 (3-hydroxyethyl 5,3'-thiophenyl pyridine) strongly inhibite

40 brillization, 3-(2-hydroxyethyl)-2-[2-[[3-(2-hydroxyethyl)-5-methoxy-2-benzothiazolylide ne]methyl]-1

41 hibitor of tau fibrillization, 3,3'-bis(beta-hydroxyethyl)-9-ethyl-5,5'-dimethoxythiacarbocyanine iod

42 We report the design and synthesis of N(7)-hydroxyethyl-9-deaza-2'-deoxyguanosine and N(7)-oxoethyl

43 M6P and mannose 6-phosphate-poly[N-(2-hydroxyethyl)-acrylamide] (M6P-PAA) inhibited the infect

44 crylamide, poly(ethylene glycol) acrylate, 2-hydroxyethyl acrylate (HEA), and an acrylamido glyco mon

45 he formation of hydroxyethyl propionate from hydroxyethyl acrylate and ethyl acetate from vinyl aceta

46 ns of poly(tert-butyl acrylate)-block-poly(2-hydroxyethyl acrylate), yielding poly(tert-butyl acrylat

47 Rigid poly[hydroxyethyl acrylate-co-poly(ethylene glycol) diacrylat

48 AdaGb(3) (but not hydroxyethyl adaGb(3)) incorporation into Gb(3)-positive

49 CarboxyadaGb(3), urea-adaGb(3), and hydroxyethyl adaGb(3), preferentially bound by VT2, also

50 A 2-hydroxyethyl adduct was found by mass spectrometry to be

51 A series of potent hydroxyethyl amine (HEA) derived inhibitors of beta-site

52 NA to produce N-[2-(N7-guaninyl) ethyl]-N-[2-hydroxyethyl]-amine (G-NOR-OH) monoadducts and N,N-bis[2

53 monoamine analogues, which features a bis(2-hydroxyethyl)amino group in the side chain, proved to be

54 derivatives, MJ-III-65 (NSC 706744; 6-[3-(2-hydroxyethyl)amino-1-propyl]-5,6-dihydro-2,3-dimethoxy-8

55 ternating pi-electron layers of 4-[[4-[bis(2-hydroxyethyl)amino]phenyl]diazenyl]-1-[4-(diethoxyphosph

56 ((+/-)-(R*,R*)-[4-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy] acetic acid sodium hy

57 3 [disodium (RR)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodiox azole-2,2-dica

58 city maximized in a single compound, 6-[3-(2-hydroxyethyl)aminopropyl]-5,6-dihydro-2,3-dimethoxy-8, 9

59 oisoquinoline MJ-III-65 (NSC 706744, 6-[3-(2-hydroxyethyl)aminopropyl]-5,6-dihydro-5,11-diketo-2,3-di

60 phate), and two protic ionic liquids, (bis(2-hydroxyethyl)ammonium acetate and triethylammonium aceta

61 he potential of (18)F-fluoromethyldimethyl-2-hydroxyethyl-ammonium (FCH) PET/CT in the detection of r

62 o-carrier-added [18F]fluoromethyl-dimethyl-2-hydroxyethyl-ammonium (FCH), was synthesized through the

63 X-ray structures of a C-2 hydroxyethyl analogue in complex with both JAK1 and JAK2

64 der reactions of chiral 9-methoxyethyl and 9-hydroxyethyl anthracene have been investigated both expe

65 N, N-Bis(2-hydroxyethyl)arachidonamide (3) was not hydrolyzed, sugg

66 ive formation of chiral 2-(2,2,2-trifluoro-1-hydroxyethyl)azetidines via trifluoromethylation through

67 orophyllide a hydratase (BchF) followed by 3-hydroxyethyl bacteriochlorophyllide a dehydrogenase (Bch

68 rovided the corresponding free-base 10(3)-(2-hydroxyethyl)benzochlorin, which upon a sequence of reac

69 converted to a mixture of predominantly 4-(1-hydroxyethyl)-benzoic acid and 4-vinylbenzoic acid, the

70 ibes the effect of urea on the properties of hydroxyethyl cellulose (HEC) polymer solutions used for

71 illary electrophoresis in buffers containing hydroxyethyl cellulose (HEC) was used to separate double

72 The two networks interact through hydroxyethyl cellulose adsorption to the nanofibrillated

73 hydrogel consists of naphthyl-functionalized hydroxyethyl cellulose and a cationic polystyrene deriva

74 fted silica nanoparticles, a semicrystalline hydroxyethyl cellulose derivative, and cucurbit[8]uril u

75 Ethyl(hydroxyethyl)cellulose was functionalized with Brooker's

76 s broadened in vitro activity, the chlorin 3-hydroxyethyl chlorophyllide a was newly identified as a

77 The primary alcohol 2-hydroxyethyl-CoM was a substrate for both R-HPCDH and S-

78 abolite identified by mass spectrometry as 2-hydroxyethyl-CoM was produced from epoxyethane.

79 prepared from key trioxane alcohol 10beta-(2-hydroxyethyl)deoxoartemisinin (9b).

80 were diluted with sample buffer containing 2-hydroxyethyl disulfide (2-HED) (1:3) or were cup-loaded

81 d is described for measuring bioreduction of hydroxyethyl disulfide (HEDS) or alpha-lipoate by human

82 tivities that are typical for glutaredoxins, hydroxyethyl disulfide reduction and electron donation t

83 ivity was assayed with a synthetic substrate hydroxyethyl disulfide.

84 iple by-product is the organic sulphide 5-(2-hydroxyethyl)dithiazine.

85 ries out the condensation of pyruvate as a 2-hydroxyethyl donor with d-glyceraldehyde-3-phosphate (d-

86 otection against inactivation provided by S-(hydroxyethyl)ethacrynic acid indicates that MOI reacts i

87 tions of N-(2-hydroxyethyl) glycine (HeGly), hydroxyethyl-ethylenediamine (HEEDA), and DEA, secondary

88 -1,2-cyclohexanediaminetetracetic acid, N-(2-hydroxyethyl)ethylenediaminetriacetic acid, trimethylene

89 The hydroxyethyl flip results in both the decreased basicity

90 An orthogonally protected 2'-hydroxyethyl GlcN derivative was immobilized on a trityl

91 was blended with low concentrations of N-(2-hydroxyethyl) glycine (HeGly), hydroxyethyl-ethylenediam

92 itrosodiethanolamine (NDELA), and nitroso-(2-hydroxyethyl) glycine (NHeGly) were measured over a rang

93 3-fold relative to the acyclic analogue N-(2-hydroxyethyl)glycine amide ( 3).

94 n the discovery of Suggs and Pires that N-(2-hydroxyethyl)glycine amides undergo rapid amide cleavage

95 by coupling PEG to [(N-2-naphthalenyl)-2-(2-hydroxyethyl)]-glycine-2-[(3,5-dibromo-2,4-dihydr oxyphe

96 mitting rotation of the carbapenem 6alpha-1R-hydroxyethyl group and abolishing this contact.

97 nd also suggest that elimination of the C(6) hydroxyethyl group by retroaldolic reaction leads to a s

98 acylenzyme complex, the meropenem 6alpha-1R-hydroxyethyl group interacts with Asn132, but not with t

99 f the vinyl side chains of the former with a hydroxyethyl group of the latter.

100 triphosphate linkage via the metal-activated hydroxyethyl group of the THED ligand.

101 yll a biosynthesis requires formation of a 3-hydroxyethyl group on pyrrole ring A that gets subsequen

102 tion leads to the flipping of the carbapenem hydroxyethyl group to hydrogen bond to carboxyl O2 of Gl

103 C-4a-hydroperoxide functionality, and a beta-hydroxyethyl group to model the effect of the 2'-OH grou

104 t carbapenem and carbapenem lacking the C(6) hydroxyethyl group.

105 m(III) macrocyclic complexes having appended hydroxyethyl groups were investigated.

106 DNA adduct formed by VC, was reduced to 7-(2-hydroxyethyl)guanine and measured by liquid chromatograp

107 ining O6-methyl, -benzyl, -4-bromothenyl or -hydroxyethyl-guanine but does not remove the alkyl group

108 During the reaction between 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine and hydrogen sulphide,

109 ar reaction proportions between 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine and hydrogen sulphide,

110 nt, and there is some unreacted 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine remaining; the only so

111 5-carboxamides into the hydroxyethylene and (hydroxyethyl)hydrazine dipeptide isosteres as P2 and P2'

112 red from 1-[2-(oleoyloxy)ethyl]-2-oleyl-3-(2-hydroxyethyl)imidazolinium chloride (DOTIM)/dioleoylphos

113 The assay provided Kd values for FK520, 32-hydroxyethyl indolyl FK520, and 18-ene, 20-oxa FK520 tha

114 s,trans-1,3,5-cyclohexanetriol, 1,3,5-tris(2-hydroxyethyl)isocyanurate, tetraethyleneglycol, and hexa

115 pounds S-benzyl-l-cysteine sulfoxide and S-2-hydroxyethyl-l-cysteine sulfoxide.

116 A new gel-forming monomer, 2-(hydroxyethyl) methacrylamide (HEMAA), was used.

117 mass ratio of 1:1 (PE); and PE plus 10% of 2-hydroxyethyl methacrylate (HEMA) and 5% of bisphenol A g

118 2-Hydroxyethyl methacrylate (HEMA) and glycidyl methacryla

119 We polymerized hydroxyethyl methacrylate (HEMA) around the CCA to form

120 methacrylate (DMAEMA), in combination with 2-hydroxyethyl methacrylate (HEMA) as functional monomers,

121 ethacryloyl-L-histidine methylester (MAH), 2-Hydroxyethyl methacrylate (HEMA) as monomers and ethylen

122 crylate, a result that was not observed in a hydroxyethyl methacrylate (HEMA) homopolymer or in netwo

123 Mechanisms by which the resin monomer 2-hydroxyethyl methacrylate (HEMA) induces hypersensitivit

124 This initiator was employed in the ATRP of 2-hydroxyethyl methacrylate (HEMA), and kinetic studies in

125 uced to undergo cell death when exposed to 2-hydroxyethyl methacrylate (HEMA).

126 HEMA/BisGMA neat resins containing 45 wt% 2-hydroxyethyl methacrylate (HEMA).

127 rticles in the lens material, such as poly-2-hydroxyethyl methacrylate (p-HEMA) hydrogels.

128 hacrylate with ethylene dimethacrylate, or 2-hydroxyethyl methacrylate and [2-(methacryloyloxy)ethyl]

129 Using the same catalyst, polymerization of 2-hydroxyethyl methacrylate and methyl methacrylate yielde

130 Copolymers of hydroxyethyl methacrylate and styrene sulfonate complex

131 hers were synthesized and copolymerized with hydroxyethyl methacrylate and the cross-linker ethylene

132 lamido-2-methyl-1-propanesulfonic acid and 2-hydroxyethyl methacrylate carried out through a mask aff

133 methacrylate, and glycidyl methacrylate or 2-hydroxyethyl methacrylate in the presence of mixture of

134 , N,N-dimethylaminoethyl methacrylate, and 2-hydroxyethyl methacrylate lead to the introduction of co

135 lamido-2-methyl-1-propanesulfonic acid and 2-hydroxyethyl methacrylate on top of the generic hydropho

136 hacrylate polymer segment into a hydrophilic hydroxyethyl methacrylate structure.

137 Hyaluronic acid was chemically modified with hydroxyethyl methacrylate to form hydrolytically degrada

138 o polymer brushes: hydroxy-functional poly(2-hydroxyethyl methacrylate) (pHEMA) and carboxy-functiona

139 rs subsequently triggered the growth of poly(hydroxyethyl methacrylate) (PHEMA) at the end of immobil

140 orption/ionization plates coated with poly(2-hydroxyethyl methacrylate) (PHEMA) brushes that are deri

141 actic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photop

142 integration of hydroxyapatite with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold.

143 Linear poly(2-hydroxyethyl methacrylate) (PHEMA) polymers were synthes

144 of poly(methyl methacrylate) (PMMA), poly(2-hydroxyethyl methacrylate) (PHEMA), and trifluoroacetic

145 2-aminoethyl methacrylate hydrochloride-co-2-hydroxyethyl methacrylate) (poly(AMA-co-HEMA)) was first

146 trifluoroacetic anhydride-derivatized poly(2-hydroxyethyl methacrylate) (TFAA-PHEMA) on silicon subst

147 roqui nidine-co-ethylene dimethacrylate-co-2-hydroxyethyl methacrylate) columns in the capillary elec

148 ll adhesion, whereas unfunctionalized poly(2-hydroxyethyl methacrylate) did not.

149 on of SNP-Ply500 conjugates into a thin poly(hydroxyethyl methacrylate) film; and affinity binding to

150 lyzed milk samples, an interface with poly(2-hydroxyethyl methacrylate) p(HEMA) brush was employed.

151 The glass was treated with poly(2-hydroxyethyl methacrylate) to control cell adherence.

152 (a stabilizer) and Hydron (poly-HEMA (poly(2-hydroxyethyl methacrylate)) to allow slow release).

153 materials, as well as copolymers of poly (2-hydroxyethyl methacrylate), have shown promise in approa

154 a dehydrated hydrogel of the polymer poly(2-hydroxyethyl methacrylate), which is then recovered usin

155 cytes (HFCs) were cultured either on poly-(2-hydroxyethyl methacrylate)-coated plates (differentiated

156 ve synthesized a GRGDS-functionalized poly(2-hydroxyethyl methacrylate).

157 antifouling hydrogel coatings, composed of 2-hydroxyethyl methacrylate, vinylpyrrolidinone, and poly(

158 s in suspension on plates coated with poly-2-hydroxyethyl methacrylate, which blocks access to the EC

159 oparticles were incorporated into the poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) mo

160 A poly(hydroxyethyl methacrylate-co-methacrylic acid) holograph

161 Microtemplating is used to shape poly(2-hydroxyethyl methacrylate-co-methacrylic acid) hydrogel

162 rdein digestion and biologic effects of poly(hydroxyethyl methacrylate-co-styrene sulfonate (P(HEMA-c

163 by demonstrating decreased survival on poly-hydroxyethyl methacrylate-coated dishes.

164 cell-matrix adhesion was reduced (in poly(2-hydroxyethyl methacrylate-coated plates), IGF1 induced i

165 lance (QCM) nanosensor, LOV imprinted poly(2-hydroxyethyl methacrylate-methacryloylamidoaspartic acid

166 Then, CIT-imprinted poly(2-hydroxyethyl methacrylate-methacryloylamidoglutamic acid

167 transfer radical polymerization (ATRP) of 2-hydroxyethyl methacrylate.

168 ethylene dimethacrylate, and acrylamide or 2-hydroxyethyl methacrylate.

169 n, sodium fluorescein, and theophylline in 2-hydroxyethyl methacrylate/methacrylic acid (HEMA/MAA) co

170 s containing test compounds with pHEMA (poly[hydroxyethyl methacrylate]) by ultraviolet light polymer

171 , Kd=57 mM) by a covering membrane of poly(2-hydroxyethyl) methacrylate.

172 yrene, poly(methyl methacrylate), and poly(2-hydroxyethyl)methacrylate were grown with controlled thi

173 A poly(2-hydroxyethyl-methacrylate) (pHEMA) hydrogel was develope

174 by transfer to suspension culture on poly-(2-hydroxyethyl-methacrylate) (polyHEMA)-coated dishes.

175 s, as well as a short middle block of poly(2-hydroxyethyl methacrylates) (PHEMA) that is randomly fun

176 thyl methanethiosulfonate, but not neutral 2-hydroxyethyl methanethiosulfonate, positively charged 2-

177 tic decomposition to the expected alcohol, 2-hydroxyethyl methyl phosphate, and the 2-nitrosoacetophe

178 The alcohol of the 6alpha hydroxyethyl moiety is directed away from the general ba

179 a hydrogen bond to the alcohol of the 6alpha-hydroxyethyl moiety of doripenem.

180 rt on the structure-based discovery of a C-2 hydroxyethyl moiety which provided consistently high lev

181 rted, this key water is not displaced by the hydroxyethyl moiety.

182 of the central mannose unit is replaced by a hydroxyethyl moiety.

183 omplexed with the cationic lipid, (+/-)-N-(2-hydroxyethyl)-N,N-dimethyl-2, 3-bis(tetradecyloxy)-1-pro

184 l-1-oxo-10-carbo xylate (K-252a) and 2-[N-(2-hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-ch

185 the formation of N-(2-aminoethyl)- and N-(2-hydroxyethyl)-N-nitrosoformamides 15 and 16, respectivel

186 was blocked by the CaMKII inhibitor 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-c

187 er cdk5 by roscovitine or of CaMK by 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-c

188 ely blocked by the CaMKII inhibitor, 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-c

189 by two doses of the CAMKII inhibitor 2-(N-[2-hydroxyethyl])-N-(4-methoxybenzenesulfonyl)amino-N-(4-ch

190 The 2'-O-(2-hydroxyethyl) nucleosides were converted, in excellent y

191 ns of the PPIX molecule to either the larger hydroxyethyl or smaller hydrogen side chains.

192 erfluorooctanamide (MeFOAE) and N-ethyl-N-(2-hydroxyethyl)perfluorooctanamide (EtFOAE), were not dete

193 Two disubstituted PFAMs, N-methyl-N-(2-hydroxyethyl)perfluorooctanamide (MeFOAE) and N-ethyl-N-

194 the rate of oxidation of the substrate 10-(2-hydroxyethyl)phenoxazine, varied over 2 orders of magnit

195 uoromethoxy-phenyl)urea (3FMTDZ) and 1-[2-(2-hydroxyethyl)phenyl]-3-(1,2,3-thiadiazol-5-yl)urea (HETD

196 acid-based small-molecule N-hydroxy-4-(2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl)benzamide (HPOB)

197 mus catalyses the biosynthesis of MPn from 2-hydroxyethyl phosphonate and the bacterial C-P lyase com

198 s, the reduction of phosphonoacetaldehyde to hydroxyethyl-phosphonate may represent a common step in

199 contain an unexpected common intermediate, 2-hydroxyethyl-phosphonate, which is synthesized from phos

200 rain-permeable iron chelator, VK-28 [5-(4-(2-hydroxyethyl) piperazin-1-yl (methyl)-8-hydroxyquinoline

201 culminated in the identification of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1

202 phase, which contains an organic alkali 1-(2-hydroxyethyl) piperazine (HEP), is used for CO2 absorpti

203 protonation of 2-NO(2)() by piperazine, 1-(2-hydroxyethyl)piperazine, and morpholine in the same solv

204 that for the reactions with piperazine, 1-(2-hydroxyethyl)piperazine, and morpholine it is deprotonat

205 -piperazineethanesulfonic acid (HEPES), 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (HEPPS),

206 (68)Ga labeling was performed in N-(2-hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid) buffe

207 ine-1-propanesulfonic acid (HEPPS), and N-(2-hydroxyethyl)piperazine-N'-(2-hydroxypropanesulfonic aci

208 ve inhibitor of this enzyme, as well as N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid (HEPES)

209 orpholino]propanesulfonic acid), Hepes (N-[2-hydroxyethyl]piperazine-N'-[2-ethanesulfonic acid]), Bes

210 n unidentified ligand resembling Hepes (N-[2-hydroxyethyl]piperazine-N'-[2-ethanesulfonic acid]).

211 -2-chlorophenoxazine (10B) and 10-[4'-[(beta-hydroxyethyl)piperazino]butyl]-2-chlorophenoxazine (15B)

212 2 and 0.2% are achieved for the formation of hydroxyethyl propionate from hydroxyethyl acrylate and e

213 ulted in a (1) H polarization of P=0.25% for hydroxyethyl propionate, a known contrast agent for magn

214 effects of DNA damaging agents that generate hydroxyethyl, propyl, and hydroxypropyl adducts.

215 an iron(II) catalyst assembled by a hindered hydroxyethyl-pybox ligand, is described.

216 quent iodination of the 4-(2,2,2-trifluoro-1-hydroxyethyl)pyrazole intermediate.

217 with 2-(hydroxymethyl)pyridine (hmpH) or 2-(hydroxyethyl)pyridine (hepH) gives the Mn(II)(2)Mn(III)(

218 2ClO(4) (1) containing bidentate (hep-H=2-(2-hydroxyethyl)pyridine) ligand was synthesized and charac

219 6-[(2R,5R)-2-methyl-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl]-4-trif luoromethylquinolin

220 an antibiotic, 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione (C(12)-TA), derived f

221 dation product, 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione, are potent antibacte

222 hydrobenzofuran heterocycles (14) from 2-(2'-hydroxyethyl)quinone precursors 10 is presented.

223 y 60% of total adducts were due to the alpha-hydroxyethyl radical adduct.

224 gainst the toxicity of superoxide anions and hydroxyethyl radicals in HepG2 cells and in a mouse mode

225 ducts of acetaldehyde, other aldehydes and 1-hydroxyethyl radicals; and activation of Kupffer cells b

226 (Neoral) plus the macrolide SDZ RAD 40-0 (2-hydroxyethyl) rapamycin (RAD) in a stringent cynomolgus

227 Three groups (n = 5) received 40-O-(2-hydroxyethyl)-rapamycin (RAD, 2.5 mg/kg/d, by gavage): G

228 sion cyclosporine (CsA) and SDZ RAD (40-O-(2-hydroxyethyl)-rapamycin).

229 We have tested rapamycin and RAD001 [40-O-(2-hydroxyethyl)-rapamycin], both mammalian target of rapam

230 ontrast, addition of cyclosporine or 40-O-[2-Hydroxyethyl]rapamycin did not significantly increase gr

231 The effects of three doses of RAD (40-O-[2-hydroxyethyl]-rapamycin), a novel macrolide with potent

232 These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromat

233 ystal structure of BACE in complex with this hydroxyethyl secondary amine isostere inhibitor is also

234 of Con A with 1 and 2 demonstrated that the hydroxyethyl side chain of 2 can establish the same hydr

235 log of the natural trisaccharide, in which a hydroxyethyl side chain replaces the hydroxyl group at t

236 roups and then hemodiluted by exchange of 6% hydroxyethyl starch (130,000:0.4) for whole blood to the

237 eive either 7.2% saline/6% hypertonic saline hydroxyethyl starch (4 mL/kg) or vehicle (NaCl 0.9 %) af

238 is study evaluated whether administration of hydroxyethyl starch (HES) 130/0.4 affects coagulation co

239 Hydroxyethyl starch (HES) [corrected] is widely used for

240 The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have n

241 on in the caudal vein of albumin, saline, or hydroxyethyl starch (HES).

242 effects of intravenous administration of 6% hydroxyethyl starch (maize-derived) in 0.9% saline (Volu

243 renal replacement therapy was greater after hydroxyethyl starch (odds ratio, 2.29; 95% CI, 1.47-3.60

244 Kingdom) and a "balanced" preparation of 6% hydroxyethyl starch (potato-derived) [Plasma Volume Redi

245 py directed at preset hemodynamic goals with hydroxyethyl starch (predominantly 6% hydroxyethyl starc

246 ICU directed at preset hemodynamic goals: 1) hydroxyethyl starch (predominantly 6% hydroxyethyl starc

247 < 0.001), 32.9+/-4.3 and 29.5+/-4.4mL/kg for hydroxyethyl starch 130/0.4 (p < 0.05), 31.8+/-3.9 and 2

248 ls: 1) hydroxyethyl starch (predominantly 6% hydroxyethyl starch 130/0.4) in 2004-2006, n = 2,137; 2)

249 s with hydroxyethyl starch (predominantly 6% hydroxyethyl starch 130/0.4) in the first period, 4% gel

250 hich was not influenced by hypertonic saline hydroxyethyl starch administration.

251 Both low molecular weight hydroxyethyl starch and gelatin may impair renal functio

252 ater use of renal replacement therapy in the hydroxyethyl starch and gelatin periods compared to the

253 Hydroxyethyl starch and gelatin were independent risk fa

254 Resuscitation comprised hydroxyethyl starch and norepinenephrine infusion titrat

255 Resuscitation comprised of hydroxyethyl starch and norepinephrine infusion titrated

256 Resuscitation with hydroxyethyl starch and sham treatment significantly dec

257 Clinical trials of hydroxyethyl starch are conflicting.

258 s are shown to be a suitable replacement for hydroxyethyl starch as a extracellular matrix for red bl

259 requiring acute volume resuscitation, use of hydroxyethyl starch compared with other resuscitation so

260 pha-lipoic acid as a diet supplement or with hydroxyethyl starch deferoxamine (HES-DFO) by weekly int

261 ypertonic solutions, it is hypothesized that hydroxyethyl starch enhances cerebral blood flow and imp

262 er models of brain injury, hypertonic saline hydroxyethyl starch failed to improve the outcome when a

263 Clinical use of hydroxyethyl starch for acute volume resuscitation is no

264 This might explain why hypertonic saline hydroxyethyl starch has failed to improve outcome in the

265 Hydroxyethyl starch is commonly used for volume resuscit

266 Hydroxyethyl starch is no longer recommended, and debate

267 comparable at baseline in all study periods (hydroxyethyl starch n = 360, gelatin n = 352, only cryst

268 ocortex with no effects of hypertonic saline hydroxyethyl starch on neuronal survival.

269 Total fluid requirement was 163 mL/kg in the hydroxyethyl starch period, 207 mL/kg in the gelatin per

270 from SCT products was not possible by using hydroxyethyl starch sedimentation but was achievable wit

271 f blood volume using a high-molecular-weight hydroxyethyl starch solution (Hextend, Hospira, MW 670 k

272 We included 38 eligible trials comparing hydroxyethyl starch to crystalloids, albumin, or gelatin

273 Hypertonic saline hydroxyethyl starch treatment resulted in an accentuated

274 r death among patients randomized to receive hydroxyethyl starch was 1.07 (95% CI, 1.00 to 1.14; I2,

275 retracted because of scientific misconduct, hydroxyethyl starch was associated with a significant in

276 d these 7 trials that involved 590 patients, hydroxyethyl starch was found to be associated with incr

277 me expanders tested (e.g., dextran, gelatin, hydroxyethyl starch, and hypertonic saline).

278 preserved using 5% dimethyl sulfoxide and 6% hydroxyethyl starch.

279 nding properties of the 2 preparations of 6% hydroxyethyl starch.

280 is observed that matches the performance of hydroxyethyl starch.

281 d group (fluid ratios 1.4:1 [crystalloids to hydroxyethyl starch] and 1.1:1 [crystalloids to gelatin]

282 data are available concerning the impact of hydroxyethyl starches and saline on pulmonary microperfu

283 Colloids (n = 1414; gelatins, dextrans, hydroxyethyl starches, or 4% or 20% of albumin) or cryst

284 Conjugates possessing bis(2-hydroxyethyl)stilbene 4,4'-diether linkers form the most

285 Synthetic conjugates possessing bis(2-hydroxyethyl)stilbene-4,4'-diether linkers (Sd2) form th

286 stituent (ZnPc-S16) and the other with the 2-hydroxyethyl substituent (EtOH-S4), were synthesized to

287 -lactamase-catalyzed elimination of the C(6) hydroxyethyl substituent.

288 by interaction with the carbapenem 6alpha-1R-hydroxyethyl substituent.

289 ne bearing a 5-endo-[2,2-bis(trifluoromethyl)hydroxyethyl] substituent is reported.

290 ynthetic strategies were explored to prepare hydroxyethyl substituted piperazines with different subs

291 In addition, an intermediary monomer, bis(2-hydroxyethyl)terephthalate, was found but only in PET-bo

292 The PFOR reaction includes a hydroxyethyl-thiamin pyrophosphate (HE-TPP) radical inte

293 e catalyzes the coupling of 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate (Thz-P) and 4-amino-5-(h

294 red for the synthesis of the 4-methyl-5-beta hydroxyethyl-thiazole monophosphate moiety of TPP.

295 6,6-Dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzoth

296 In particular, 6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzoth

297 atized with 2-mercaptoethanol to form S,S-(2-hydroxyethyl)thiocysteine.

298 the Lactobacillus casei enzyme produced 5-(2-hydroxyethyl)thiomethyl-dUMP (HETM-dUMP).

299 (Hydroxyethyl)urea peptidomimetics systematically altered

300 oxidases, we incorporated Fe(III)-2,4 (4,2) hydroxyethyl vinyl deuterioporphyrin IX, as a heme o mim