ライフサイエンスコーパス: hydroxylate

1 type IV collagen, these sites are normally 3-hydroxylated.

2 with kappa rings, both hydroxylated and not hydroxylated.

3 liquid water at the interface with natively hydroxylated (001) surfaces of InP and GaP photoelectrod

4 vel annulation reaction for the synthesis of hydroxylated 1,3-cyclohexadiones in a single step.

5 and regioselective synthesis of a series of hydroxylated 1-methylphenanthrenes 9 by a combined direc

6 17A1 and CYP21A2 mutation V359A both 16alpha-hydroxylate 16alpha-[(2)H]-progesterone with 33-44% deut

7 (with catalytically competent kinetics) plus hydroxylated 17alpha-hydroxysteroids.

8 of the still-bioactive primary photoproduct hydroxylated 17alpha-TBOH, produced via phototransformat

9 thyl and ethylbutenoate-2-diazeniumdiolate-3-hydroxylate (3(2-) and 4(2-)), are isolated in good yiel

10 f these cytochrome P450s had the capacity to hydroxylate 4-coumaroyl shikimate or 4-coumaroyl quinate

11 factor for Tet methylcytosine dioxygenase to hydroxylate 5-mC.

12 is related to the mammalian TET enzymes that hydroxylate 5-methylcytosine in DNA.

13 ished by esterification or etherification of hydroxylated 5alpha/beta-pregnane-3,20-dione or 5beta-ch

14 mediate a wide variety of cellular events by hydroxylating a growing list of protein substrates.

15 phosphoryl-1,4-dioxobutane) (DOB) and the C4-hydroxylated abasic site (C4-AP), are formed reversibly.

16 rent species, including species accumulating hydroxylated acyl groups in their seed oil, with a prefe

17 we demonstrate that sphingolipids with alpha-hydroxylated acyl-chains of at least 24 carbon atoms are

18 Besides interconversion of hydroxylated acyl-CoA esters, wild-type HCM as well as H

19 iopinines and pseudoargiopinines I and II, N-hydroxylated Agel-489 and Agel-505, as well as N-methyla

20 ppel-Lindau protein (pVHL) bound directly to hydroxylated Akt and inhibited Akt activity.

21 Agrocybe aegerita (AaeAPO) has been shown to hydroxylate alkanes and numerous other substrates using

22 f the VHL E3 ubiquitin ligase, which targets hydroxylated alpha subunit of hypoxia inducible factors

23 val includes a high proportion of acidic and hydroxylated amino acid residues, suggesting a similarit

24 termediate that, in the case of AlkB, slowly hydroxylates an alkylated nucleobase.

25 o the discovery of the biologically active 2-hydroxylated analogue and 3-hydroxylated metabolite, thu

26 Both the alpha-azido-analogue and the alpha-hydroxylated analogue proved most promising, and docking

27 Hydroxylated analogues of the anticancer topoisomerase I

28 ular oxygen as co-substrate of oxygenases to hydroxylate and cleave the sterane ring system.

29 measured postbioremediation is likely due to hydroxylated and carboxylated transformation products of

30 Finally, comparing the gas adsorption of hydroxylated and dehydroxylated UiO-66, we found that th

31 phous water are found to coexist at adjacent hydroxylated and hydroxyl-free domains of the moire stru

32 xynitrite, however, decayed to radicals that hydroxylated and nitrated other active-site residues (Tr

33 ed by ketocarotenoids with kappa rings, both hydroxylated and not hydroxylated.

34 19:0 metabolite was formed by CYP4F2 and one hydroxylated and one carboxylated C19:0 were tentatively

35 ther arginine residue in the PSST subunit is hydroxylated and probably lies near to the quinone.

36 affinities for a group of LC-PCBs and their hydroxylated and sulfated derivatives by selective displ

37 he amounts of nonpolar, aliphatic, aromatic, hydroxylated and sulfur-rich amino acids were higher in

38 d (methylated, glycosylated, phosphorylated, hydroxylated), and labeled (fluorinated, isotopically la

39 emperature-programmed desorption on reduced, hydroxylated, and oxidized rutile TiO2(110) surfaces.

40 ain, medium-chain, long-chain, dicarboxylic, hydroxylated, and unsaturated acyl moieties) were used t

41 Several acetylated, hydroxylated, and/or sulfated metabolites were identifie

42 JBP1 then binds to J and hydroxylates another T 13 bp downstream (but not upstrea

43 primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their correspon

44 -hydroxylase (ASPH), which has been found to hydroxylate aspartic acid and asparagine residues on epi

45 of PLN, interacts with PHD2 and PHD3 and is hydroxylated at 2 proline residues.

46 e (IR) was associated with increased 12alpha-hydroxylated BAs (cholic acid, deoxycholic acid, and the

47 These findings suggest a role for 12alpha-hydroxylated BAs in metabolic abnormalities in the natur

48 , ratios of 12alpha-hydroxylated/non-12alpha-hydroxylated BAs were associated with key features of IR

49 bserve disproportionate increases in 12alpha-hydroxylated BAs.

50 ARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the

51 with the model compound catechol and further hydroxylated benzenes were performed to examine a common

52 es, benzonitriles, phenols, methoxylated, or hydroxylated benzoic acids, pyridines, thiophenes, furoi

53 Apart from 1,4-diketones and alpha-hydroxylated beta-oxoesters formed as byproducts, the yi

54 ul synthons for the synthesis of chiral beta-hydroxylated, beta-fluorinated, and beta-arylated carbox

55 and increased liver cholesterol and 12alpha-hydroxylated bile acids in the bile acid pool and serum.

56 mation, the regioselective oxidation of 8,8'-hydroxylated binaphthols to binaphtho-para-quinones, and

57 lly applied on several sensitive and complex hydroxylated bioactive compounds including 7-deacetylaza

58 This article describes the effects of hydroxylated biodiesel (castor oil methyl ester - COME)

59 e) was used to identify two novel isomers of hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-T

60 Highly hydroxylated block copolymer worms are shown to be a sui

61 PMO3s hydroxylate both C1 and C4.

62 terially expressed TgPhyA protein can prolyl hydroxylate both Toxoplasma and Dictyostelium Skp1s.

63 for binding, and may explain why only 3beta-hydroxylated bufadienolides are present as a toxic chemi

64 counterparts, Skp1 from Toxoplasma gondii is hydroxylated by an O2-dependent prolyl-4-hydroxylase (Ph

65 The HIFalpha subunit is usually prolyl-hydroxylated by EglN family members under normoxic condi

66 A1 site in type I collagen is exclusively 3-hydroxylated by P3H1, and presumably, this enzyme is req

67 ehydroepiandrosterone, pregnenolone is first hydroxylated by P450 CYP17A1 at the 17-carbon, followed

68 Cep192 is hydroxylated by PHD1 on proline residue 1717.

69 g mutations in the proline residues that are hydroxylated by PHD2 induces dedifferentiation.

70 otein CLK-2 (HCLK2), associated with and was hydroxylated by prolyl hydroxylase domain protein 3 (PHD

71 ver 50% of GalCer and sulfatide in myelin is hydroxylated by the integral membrane enzyme fatty acid

72 We found that Akt was prolyl-hydroxylated by the oxygen-dependent hydroxylase EglN1.

73 t two different carbon centers, and CYP76AK1 hydroxylates C-20 of two of the resulting intermediates.

74 A subgroup of PMO3s (PMO3*) hydroxylate C1.

75 iral glycosphingolipids, composed of unusual hydroxylated C17 sphingoid bases (t17:0) were highly enr

76 One hydroxylated C19:0 metabolite was formed by CYP4F2 and o

77 respondingly, the DeltaecdG strain failed to hydroxylate C3 of the homoTyr residue, and purified EcdG

78 appended to the carrier protein, SyrB1, but hydroxylates C5 of l-norvaline and, to a lesser extent,

79 When the rate drops, the amount of hydroxylated Ca3SiO5 decreases, thus demonstrating the p

80 rome P450cam (CYP101Fe(3+)) regioselectively hydroxylates camphor.

81 CoA mutase showing substrate specificity for hydroxylated carboxylic acids.

82 binoids and N-acyl ethanolamides, and 21 non-hydroxylated ceramides and sphingoid bases, several demo

83 tions establish that Cpd I is the agent that hydroxylates CH, rather than the hydroperoxy-ferric heme

84 While possessing a hydroxylated chain at C-7, the compounds retained their

85 main side chain at C12 and a shorter second hydroxylated chain at C17.

86 therapeutically useful synthetic mimics) and hydroxylated cholesterol derivatives (oxysterols); Smo i

87 0 27A1 (CYP27A1) is a ubiquitous enzyme that hydroxylates cholesterol and other sterols.

88 xy-P450scc-CH is catalytically competent and hydroxylates cholesterol to form 22-HC with no detectabl

89 n) mouse eye tissues was significantly under-hydroxylated compared with their wild-type littermates.

90 rating them in the present case, and (2) the hydroxylated compounds could conceivably serve as synthe

91 e b5 (CYB5), it catalyzes the reduction of N-hydroxylated compounds such as amidoximes.

92 (2) and alpha-ketoglutarate as substrates to hydroxylate conserved proline residues in target protein

93 For instance, the existence of hydroxylated CTTs (OH-CTTs) in authentic environmental a

94 ormation of a highly reactive OH radical and hydroxylated cysteine.

95 ral role of CYP735A1/2 in synthesizing trans-hydroxylated cytokinins, which specify shoot growth, vit

96 ia) N-acetylneuraminic acid (Neu5Ac) and its hydroxylated derivative N-glycolylneuraminic acid (Neu5G

97 (derived from either vitamin A1 or A2) or a hydroxylated derivative, bound to a protein (opsin) via

98 bolize polychlorinated biphenyls (PCBs) into hydroxylated derivatives (OH-PCBs), which are sometimes

99 lied to provide direct access to the desired hydroxylated derivatives at preparative scales (0.4 g) a

100 C-C activation of cyclobutanols resident in hydroxylated derivatives of pinene, which proceed in a c

101 associated with levels of 19 sterols and 25-hydroxylated derivatives of vitamin D (P < 10(-7)).

102 ar Mn(II) complex with ((H)O)L-L(OH) and its hydroxylated derivatives.

103 igated during the production of their 1alpha-hydroxylated derivatives.

104 onounsaturated fatty acids into mono- and di-hydroxylated derivatives.

105 peracid, and other directed epoxidations of hydroxylated dienes.

106 e encoding a PAS/PAC sensor protein and ring-hydroxylating dioxygenase genes.

107 This study determined that hydroxylated docosahexaenoic acid metabolites (HDoHEs) a

108 pproach led to the structural elucidation of hydroxylated docosapentaenoic acid-containing diacyl-pho

109 lethality involves the interaction of non-3-hydroxylated embryonic type IV collagen with the materna

110 I) by a terminal histidine residue in copper hydroxylating enzymes activates dioxygen to form unknown

111 ha, showed a severe defect in binding prolyl hydroxylated EPOR peptides.

112 LinB hydroxylated epsilon-HCH to pentachlorocyclohexanol and

113 Nevertheless, branched hydroxylated esters, such as ethyl 2-hydroxy-3-methylbut

114 astor oil are mediated by ricinoleic acid, a hydroxylated fatty acid released from castor oil by inte

115 ds were further esterified by long (omega-1)-hydroxylated fatty acids comprising 26-34 carbon atoms.

116 the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of total fatty acids

117 cture, the number of ester-linked long chain hydroxylated fatty acids, as well as the presence of a t

118 The oxidation of hydroxylated fatty acids, such as the conversion of pros

119 The so formed Cpd I subsequently hydroxylates fatty acids at their alpha-position with S-

120 h isopropyl 2-iodoxybenzoate to give the C-F hydroxylated Fe(III)-OAr products.

121 te- and iron(II)-dependent dioxygenases that hydroxylate four sp(3) carbons; one flavin-dependent deh

122 Here we report that EglN2 can hydroxylate FOXO3a on two specific prolyl residues in vi

123 Failure to hydroxylate FOXO3a promotes its accumulation in cells, w

124 C3 of the homoTyr residue, and purified EcdG hydroxylated free L-homoTyr at C3.

125 Water-soluble, hydroxylated fullerene (fullerol) materials have recentl

126 ral product comprising a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 6'-amino-ps

127 PMO1s and PMO2s hydroxylate glycosidic positions C1 and C4, respectively

128 es single-stranded target sequences using 5'-hydroxylated guide RNAs rather than the 5'-phosphorylate

129 class with noncanonical specificity for a 5'-hydroxylated guide.

130 l halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.

131 f prolyl hydroxyl dioxygenase enzymes, which hydroxylate HIF-1alpha and HIF-2alpha to destabilize HIF

132 Furthermore, albumin reduced the level of hydroxylated HIF-1alpha, indicating an inhibition of the

133 ading to selective on-target accumulation of hydroxylated HIF-alpha in a concentration- and time-depe

134 a 2-oxoglutarate-dependent dioxygenase that hydroxylates HIF-1alpha and targets it for recognition b

135 ice deficient in prolyl hydroxylase 2, which hydroxylates hypoxia-inducible factor-1alpha, rescued th

136 unmodified OLs, a variety of OL derivatives hydroxylated in different structural positions has been

137 in of type I collagen is almost completely 3-hydroxylated in every tissue of the wild type mice.

138 5-hydroxyvitamin D species, and then further hydroxylated in the kidney to various dihydroxyvitamin D

139 s extension to the synthesis of many natural hydroxylated indolizidine alkaloids as demonstrated in t

140 The hydroxylated indotecan and indimitecan metabolites and a

141 y calculations provide insights into why the hydroxylated intermediate undergoes an aldol-like phenox

142 Metabolomic analysis identified two hydroxylated intermediates as well as a glucuronidated h

143 whether they suppress hydroxylation or form hydroxylated intermediates on the pathways to other outc

144 on that controls the configuration at C-5 of hydroxylated intermediates.

145 Possible hydroxylating intermediates in the catalytic cycle of th

146 The interplay between hydroxylated interphase on the surface and the unique bi

147 citor electrode material with a well-ordered hydroxylated interphase.

148 monolayer islands form on the bare film, the hydroxylated iron oxide film acts as a hydrophilic nanot

149 In particular, the enzyme that hydroxylates JA to 12-OH-JA, an inactive form of JA that

150 by solvent immersion, which deprotonates the hydroxylated LAO surface; interface conductivity is rest

151 Hydroxylated linoleic acid, specifically the ratio of 13

152 UVR produces vitamin D in skin, which is hydroxylated locally to 1alpha,25-dihydroxyvitamin D(3)

153 g more superoxide and hydrogen peroxide than hydroxylated Lys.

154 dependent oxygenase Jmjd6 has been shown to hydroxylate lysine residues in the essential splice fact

155 However, SidA is also able to hydroxylate lysine with lower efficiency.

156 antly diminished HLCCs and increased the non-hydroxylated lysine-aldehyde-derived collagen cross-link

157 agen-lysine, 2-oxoglutarate 5-dioxygenase 2) hydroxylates lysine residues in collagen telopeptides an

158 The ratio of a non-beta-hydroxylated metabolite in the catecholamine biosyntheti

159 s formed is biologically important, as the 4-hydroxylated metabolite is carcinogenic, whereas the 2-h

160 ed metabolite is carcinogenic, whereas the 2-hydroxylated metabolite is not.

161 way, dihydroxyphenylacetic acid, to the beta-hydroxylated metabolite, dihydroxyphenylglycol, improved

162 gically active 2-hydroxylated analogue and 3-hydroxylated metabolite, thus providing strategically pl

163 radation by Sphingobium sp. BiD32 detected a hydroxylated metabolite.

164 3',6,6'-hexachlorobiphenyl (PCB 136) and its hydroxylated metabolites (HO-PCBs) in mice with defectiv

165 e polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (HO-PCBs), pentachlorophenol (P

166 nd enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl

167 enyl ring is expected to form axially chiral hydroxylated metabolites (OH-PCBs); however, the formati

168 PBDEs and their hydroxylated metabolites appear to primarily target the

169 Some of these hydroxylated metabolites are chiral, and chiral compound

170 The primary hydroxylated metabolites formed from atRA by CYP26A1, an

171 Also detected were two polybrominated hydroxylated metabolites having polybenzofuran structure

172 nti-miR-23b also significantly increased the hydroxylated metabolites of BDE47 (3-OH-BDE47, 4-OH-BDE4

173 iver, and plasma; both isomers and potential hydroxylated metabolites of beta-TBECH (plasma) were und

174 /z 353 and 355 are proposed to correspond to hydroxylated metabolites of glyceollins, wherein the lat

175 Some hydroxylated metabolites of ketamine correlated with psy

176 PCB3) has been proven to be transformed into hydroxylated metabolites of PCB3 (OH-PCB3s) in whole pop

177 However, hydroxylated metabolites of PCBs, including OH-PCB3s, as

178 Hydroxylated metabolites of polychlorinated biphenyls (O

179 Some POPs, i.e., hydroxylated metabolites of polychlorinated biphenyls (O

180 endazole and its sulphoxide, sulphone, and p-hydroxylated metabolites was carried out isocratically w

181 In mice exposed to alpha-HBCD, four hydroxylated metabolites were detected in fecal extracts

182 on of the exocyclic amine group to produce N-hydroxylated metabolites, which are critical intermediat

183 was highly selective for BDE-47 and selected hydroxylated metabolites.

184 nic activity contained hetero-PAHs and their hydroxylated metabolites.

185 t beta- and delta-HCH to a variety of mainly hydroxylated metabolites.

186 brominate or stereoisomerize, but formed two hydroxylated metabolites; ss- and gamma-HBCD were both e

187 his regard, having an outstanding ability to hydroxylate methane rapidly at room temperature to form

188 r and iron zeolites are remarkably reactive, hydroxylating methane and benzene selectively at low tem

189 high-yielding, one-pot labeling protocol for hydroxylated molecules using Yamaguchi coupling as the k

190 Peptidylglycine alpha-hydroxylating monooxygenase (PHM) and dopamine beta-mono

191 ron transfer center in peptidylglycine alpha-hydroxylating monooxygenase (PHM) or a catalytic center

192 separation of soluble peptidylglycine alpha-hydroxylating monooxygenase from membrane-associated PAL

193 Peptidylglycine alpha-hydroxylating monooxygenase is a noninteracting bicopper

194 SidA (siderophore A) is a flavin-dependent N-hydroxylating monooxygenase that is essential for virule

195 of its monooxygenase (peptidylglycine alpha-hydroxylating monooxygenase) and lyase (peptidyl-alpha-h

196 beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase.

197 N-Hydroxylating monooxygenases (NMOs) are essential for pa

198 N-Hydroxylating monooxygenases are involved in the biosynt

199 lic health through a novel poly(eosin Y, EY)/hydroxylated multi-walled carbon nanotubes composite mod

200 has been shown that JMJD6 interacts with and hydroxylates multiple serine/arginine-rich (SR) proteins

201 I chains, whereas P3h2 is responsible for 3-hydroxylating multiple proline sites in collagen types I

202 Furthermore, ratios of 12alpha-hydroxylated/non-12alpha-hydroxylated BAs were associate

203 ifunctional cytochrome P450 monooxygenase, a hydroxylating nonheme-iron-dependent dioxygenase, and an

204 N-Hydroxylated nucleobases and nucleosides as N-hydroxylam

205 rential reactivity of 2'-O-methylated and 2'-hydroxylated nucleosides to periodate oxidation to devel

206 Hydroxylated (OH-) and methoxylated (MeO-) polybrominate

207 show that erythropoietin receptor (EPOR) is hydroxylated on proline 419 and 426 via prolyl hydroxyla

208 although with less regiospecificity, and was hydroxylated on the 13- and 16-carbons.

209 rs to form different but overlapping sets of hydroxylated or epoxidized products.

210 been shown to regulate cellular processes by hydroxylating or demethylating histone and non-histone t

211 ip between the structure and fluctuations of hydroxylated organic surfaces and the temperature at whi

212 SidA selectively hydroxylates ornithine to produce N(5)-hydroxyornithine.

213 efective in pdoA2, encoding an aromatic ring-hydroxylating oxygenase (RHO).

214 about the functions and the biosynthesis of hydroxylated oxylipins remains scarce.

215 Biliary metabolites included the hydroxylated PAH metabolites (OH-PAHs) 1-naphthol, 2-nap

216 urrence of very low levels or the absence of hydroxylated PBDE metabolites in the cats.

217 nts in humans, resulting in the formation of hydroxylated PBDEs (OH-PBDEs) that are potentially more

218 09), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and 2,4,6-TBP in order to

219 Ps), polybrominated diphenyl ethers (PBDEs), hydroxylated PBDEs (OH-PBDEs), and perfluorinated compou

220 It is not clear whether hydroxylated PBDEs (OH-PBDEs), with greater hydrophilici

221 ate, halogenated bisphenols and phenols, and hydroxylated PBDEs were found to be potent PPARgamma lig

222 in containing protein EGLN3 (or PHD3), which hydroxylates PC1.

223 Previous research has discovered hydroxylated PCB metabolites (OH-PCBs) as high-affinity

224 ue to species-dependent oxidation of PCBs to hydroxylated PCB metabolites (OH-PCBs).

225 sting the sequential transformation of these hydroxylated PCB3 metabolites into PCB3 sulfates in whol

226 summation operatorPCBs = 45 ng/g lw) and 12 hydroxylated PCBs (median summation operatorOH-PCBs = 0.

227 Sera were analyzed for all 209 PCBs and 4 hydroxylated PCBs (OH-PCBs).

228 d positively with the cubs' plasma levels of hydroxylated PCBs (OH-PCBs).

229 recapitulated with an equimolar mixture of a hydroxylated peptide and the deletion variant.

230 Hydroxylated peptides of 15 and 27 amino acid residues w

231 ion of 1-methylpyrene generated the benzylic hydroxylated phase I product, 1-pyrenecarboxylic acid th

232 ynthetase (PheRS) proofreads the non-protein hydroxylated phenylalanine derivative m-Tyr after its at

233 Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) a

234 The photochemical conversion of selected hydroxylated polybrominated diphenyl ethers (OH-PBDEs) t

235 active natural brominated compounds, such as hydroxylated polybrominated diphenyl ethers (OH-PBDEs),

236 droxylated polychlorobiphenyls (OH-PCBs) and hydroxylated polybromodiphenyl-ethers (OH-PBDEs) can be

237 this work, the aminated aptamer selected for hydroxylated polychlorinated biphenyl (OH-PCB) was coval

238 Hydroxylated polychlorinated biphenyls (OH-PCBs) were me

239 ogenated phenolic compounds (HPCs) including hydroxylated polychlorobiphenyls (OH-PCBs) and hydroxyla

240 Concentrations of 12 hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs)

241 asil (Ocimum basilicum L.) cultivars readily hydroxylate position 6 of 7-O-methylated apigenin but no

242 endent monooxygenase Coq6, which is known to hydroxylate position C5, also deaminates position C4 in

243 h Arthrobacter, suggesting that formation of hydroxylated PQS may be a common mechanism of inactivati

244 ated by a unique pentasaccharide attached to hydroxylated Pro-143 within its C-terminal F-box-binding

245 Also observed were higher-order hydroxylated products probably formed via subsequent rea

246 LC-HRMS/MS analysis identified a range of hydroxylated products that were no longer photoactive, w

247 rm 16-hydroxylation reactions on its 17alpha-hydroxylated products to yield 16,17alpha-dihydroxypregn

248 and can catalyze reactions that form stable hydroxylated products.

249 oglutarate that, under normoxia, selectively hydroxylate proline residues of HIF, initiating proteoso

250 studies revealed that P3h1 preferentially 3-hydroxylates proline at a single site in collagen type I

251 droxylase that regio- and stereospecifically hydroxylates proline residues in a peptide chain into R-

252 results in the formation of polyphenols and hydroxylated quinones.

253 The silanols can be hydroxylated (regenerated) to their original state upon

254 ty for, and forms a stable complex with, the hydroxylated RPS23 substrate.

255 Ceres' dry exterior displays hydroxylated silicates, including ammoniated clays of en

256 sing performance originates from UVO-derived hydroxylated species on the dielectric surface and not f

257 ral packing relative to common saturated and hydroxylated species.

258 trong triplet excited state sensitizers from hydroxylating species such as hydroxyl radical ((*)OH) p

259 n of the C4a-hydroperoxyflavin, which is the hydroxylating species.

260 Prolyl hydroxylase domain proteins hydroxylate substrate proline residues and have been lin

261 both mARC proteins are capable of reducing N-hydroxylated substrates in cell metabolism.

262 metabolites of PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and glucuronidated PCMC) we

263 Four new metabolites of PCMC (hydroxylated, sulfated/hydroxylated, sulfated PCMC, and

264 ain of JBP1 to make contact with the DNA and hydroxylate T's in spatial proximity, resulting in regio

265 ures of the two compounds were identified as hydroxylated TBPH with a hydroxyl group on the aromatic

266 showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptidyl lysine residues on collagen, s

267 ane prolyl 4-hydroxylase (P4H-TM) is able to hydroxylate the alpha subunit of the hypoxia-inducible f

268 droxylase enzyme that was initially found to hydroxylate the HIF-alpha, preventing its transcriptiona

269 (II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFalpha subunit, facilitating its prote

270 3',5'-hydroxylase (F3'5'H), the enzyme that hydroxylates the 5' position of the B ring, was a good c

271 endent manner, PHD2 site-specifically prolyl hydroxylates the master transcription factor of the hypo

272 adical abstracts a hydrogen and subsequently hydroxylates the substrate via an oxygen-rebound mechani

273 rome II), which encodes LH2, the enzyme that hydroxylates the telopeptide lysyl residues.

274 ting bicopper enzyme that stereospecifically hydroxylates the terminal glycine of small peptides for

275 is catalyzed by an unprecedented enzyme that hydroxylates the tertiary C25 atom of the side chain wit

276 PHD site specifically prolyl hydroxylates the transcription factor HIF-alpha, thereby

277 ty and selectivity are also attained by meta hydroxylating the 3-pyridyl and the phenyl ethers of (S)

278 dent dioxygenase that inhibits HIF-1alpha by hydroxylating the C-terminal transactivation domain (CTA

279 e C4a-hydroxyflavin intermediate, instead of hydroxylating the substrate, can decompose to produce H(

280 tion of the PHD2 isoform, preventing it from hydroxylating the transcription factor hypoxia inducible

281 ere previously underestimated, as they might hydroxylate their--so far unknown--natural substrates in

282 We report the SAR evolution of hydroxylated thienopyrimidinone ethers culminating in th

283 esis is initiated by the JBP1/2 enzymes that hydroxylate thymine, forming 5-hydroxymethyluracil (hmU)

284 We now demonstrate recombinant JBP1 hydroxylates thymine specifically in the context of dsDN

285 I) 2 O2 species, where the bonded phenolates hydroxylate to catecholates in high yields.

286 (i) HNA is omega-hydroxylated to 4,9-dihydroxynonanoic acid, which is sub

287 ato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different meta

288 A variety of compounds, namely TPHP, hydroxylated TPHP and RDP (meta-HO-TPHP and meta-HO-RDP)

289 an airborne pollutant, can be metabolized to hydroxylated transformation products (OH-PCB3s) in whole

290 that the interaction between GPVI and non-3-hydroxylated type IV collagen might also play a role in

291 tudies indicated that in vitro activated PPO hydroxylates Tyr inefficiently.

292 ta(2):eta(2)-peroxo-dicopper(II) core, which hydroxylates tyrosine to a catechol in the first committ

293 This finding is of great importance because hydroxylated UiO-66 is the practically more relevant, no

294 O)(OAc)(PyNMe3)](2+) (2b) species capable of hydroxylating unactivated alkyl C-H bonds with stereoret

295 When D(2)-camphor was hydroxylated under the same condition in H(2)O or D(2)O

296 We further show that BaP4H can hydroxylate unique peptidyl proline sites in collagen-de

297 f DIMs with the PM showed an enrichment of 2-hydroxylated very-long-chain fatty acid-containing GIPCs

298 e hydroxylase, a cytochrome P450 enzyme that hydroxylates vinorine to form vomilenine, which was foun

299 in addition to the total syntheses of the 3-hydroxylated welwitindolinones.

300 ted flavones except cirsimaritin, which is 8-hydroxylated with less than 0.2% relative activity.