ライフサイエンスコーパス: hydroxylation

1 m singular transformations (for example, C-H hydroxylation).

2 D2 to the HSP90 pathway to promote HIF-alpha hydroxylation.

3 ttranslational modifications, such as lysine hydroxylation.

4 (HAA) of substrate C-H bonds and subsequent hydroxylation.

5 might be responsible for the observed arene hydroxylation.

6 ing of the pro-S C-H bond, thus preferring R hydroxylation.

7 d that this process is controlled by surface hydroxylation.

8 xplored to achieve regio- and chemoselective hydroxylation.

9 he mutant Phe87Ala predict predominant omega hydroxylation.

10 (3-fold) in CYP46A1-mediated cholesterol 24-hydroxylation.

11 layed a significant rate enhancement for C-F hydroxylation.

12 with progesterone, a substrate in adrenal 21-hydroxylation.

13 consuming process to be regulated by proline hydroxylation.

14 er, representing the reaction product of 5mC hydroxylation.

15 g histone and DNA methylation, and HIF1alpha hydroxylation.

16 icient cells and accompanied by its enhanced hydroxylation.

17 xide formation to the more commonly observed hydroxylation.

18 ypoxia-inducible transcription factor prolyl hydroxylation.

19 tric oxide synthesis and aromatic amino acid hydroxylation.

20 ro-62 in humans) undergoes posttranslational hydroxylation.

21 on of constitutive protein and phenylalanine hydroxylation.

22 influence the regioselectivity of enzymatic hydroxylation.

23 pa1p homolog OGFOD1 catalyzes prolyl trans-3-hydroxylation.

24 y retained high preferences for octane omega-hydroxylation.

25 with the observed regio- and stereoselective hydroxylation.

26 isotope effect for 3-hydroxylation but not 4-hydroxylation.

27 urface termination and the extent of surface hydroxylation.

28 ed reducing equivalents to support substrate hydroxylation.

29 ning the terminal carbon of octane for omega-hydroxylation.

30 several peroxygenases that favor fatty acid hydroxylation.

31 te that contribute to a preference for omega-hydroxylation.

32 es chlorination effectively competitive with hydroxylation.

33 e generated ferryl species to catalyze l-Arg hydroxylation.

34 se component and an indication of HIF-1alpha hydroxylation.

35 th a unique tricopper cluster as the site of hydroxylation.

36 ic switching, with no observable effect on 4-hydroxylation.

37 brafish P450 17A2 catalyzes only the 17alpha-hydroxylations.

38 on pathway metabolites, or in the ratio of 2-hydroxylation:16-hydroxylation pathway metabolites, were

39 al PCDs play an important role in amino acid hydroxylation, a reaction not associated with carbon fix

40 Finally, we postulate that the hydroxylation ability of RdmB originates from a previous

41 hol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation

42 rate to produce norwogonin, although minor 6-hydroxylation activity can also be detected.

43 We describe here a so far unknown Pro hydroxylation activity which occurs in active sites of p

44 mination activity, whereas preserving the C5-hydroxylation activity.

45 Proline hydroxylation, an early post-translational modification

46 duced from ectoine through a stereo-specific hydroxylation, an enzymatic reaction catalyzed by the ec

47 BOA-Glc) by an uncommon reaction involving a hydroxylation and a likely ortho-rearrangement of a meth

48 le enzyme, P450 17A1, catalyzes both 17alpha-hydroxylation and a subsequent 17alpha,20-lyase reaction

49 The enzyme catalyzes both 17alpha-hydroxylation and a subsequent 17alpha,20-lyase reaction

50 o the discovery of enhanced flavonoid B-ring hydroxylation and an increased proportion of prodelphini

51 s effect is the result of an increase in the hydroxylation and degradation of the transcription facto

52 hypoxia-inducible factor-1alpha (HIF-1alpha) hydroxylation and degradation.

53 or alternariol monomethyl ether (AME)) while hydroxylation and glucuronidation had the opposite effec

54 nsights on the relative influence of surface hydroxylation and hydrate precipitation on the hydration

55 ; zebrafish P450 17A1 catalyzes both 17alpha-hydroxylation and lyase reactions with Prog and Preg, an

56 ed in detail the processivity of the 17alpha-hydroxylation and lyase steps.

57 Similar reductions in debrisoquine 4-hydroxylation and metoprolol alpha-hydroxylation were ob

58 Tyrosinases catalyze theo-hydroxylation and oxidation of phenolic compounds, where

59 thyl glucosinolate (I3M), can be modified by hydroxylation and subsequent methoxylation of the indole

60 cer-associated Akt mutations that impair Akt hydroxylation and subsequent recognition by pVHL, thus l

61 translationally modified by prolyl and lysyl hydroxylation and subsequently by glycosylation of hydro

62 PCB sulfates derived from metabolic hydroxylation and sulfation of LC-PCBs have been implica

63 Thus, hydroxylation and sulfation of LC-PCBs result in selecti

64 was observed as a consequence of interfacial hydroxylation and the N-acyl chain length, although an a

65 IP5 promotes HIF-1alpha prolyl hydroxylation and thus pVHL-dependent degradation of HIF

66 IP5 acts by enhancing HIF-1alpha hydroxylation and thus pVHL-dependent degradation of HIF

67 is increased in hypoxia via reduced proline hydroxylation and, hence, inefficient degradation by the

68 acid are directly employed in photocatalyzed hydroxylations and nitrohydroxylations of benzenes.

69 ctionalization (azidation, alkoxylation, and hydroxylation) and selective oxidative cleavage of thus

70 iety of analog 2 (available from valinomycin hydroxylation) and the isocyanate group of pentafluoroph

71 ation by Microbacterium sp. strain BR1 (ipso-hydroxylation) and upon direct photolysis was investigat

72 operoxo species is responsible for substrate hydroxylation, and a mechanism wherein a copper-oxyl rad

73 ylation increases alpha-ketoglutarate, HIF-1 hydroxylation, and interaction with von Hippel-Lindau pr

74 -site residues constraining octane for omega-hydroxylation are conserved in family 4 P450s.

75 The effects of hydroxylation are stereospecific; replacement of ProB28

76 f the antidepressant fluoxetine using remote hydroxylation as a key step is presented.

77 fied to be responsible for the difference in hydroxylation at C-8.

78 The level of prolyl 3-hydroxylation at multiple substrate sites from type I co

79 he evolution of synthetic strategy to access hydroxylation at the C19 position of a steroid skeleton.

80 of these modifications are species-specific, hydroxylation at the C3(2) position is commonly found in

81 ytochrome P450s play key roles in fatty acid hydroxylation at the terminal, or omega, carbon, but the

82 tope ratios caused by anaerobic ethylbenzene hydroxylation both mathematically and experimentally, de

83 A2 is more efficient in pregnenolone 17alpha-hydroxylation but does not catalyze the lyase reaction,

84 oduced a strong kinetic isotope effect for 3-hydroxylation but not 4-hydroxylation.

85 and its influence on the kinetics of 1alpha-hydroxylation by CYP27B1 were determined.

86 binding protein 1 (OTUB1) is a substrate for hydroxylation by FIH on N22.

87 hesize that OTUB1 is a target for functional hydroxylation by FIH.

88 ir effect on CYP27A1-mediated cholesterol 27-hydroxylation by in vitro enzyme assay.

89 -protein interaction downstream of HIF-alpha hydroxylation by PHD enzymes.

90 cid substrate and its enantio/regioselective hydroxylation by the active species of the enzyme, Compo

91 We find that the undesired hydroxylation byproducts, typically obtained in aqueous

92 Observations that HIFalpha hydroxylation can be impaired even when oxygen is suffic

93 translation termination factor eRF3, Rps23p hydroxylation can either increase or decrease translatio

94 Here we give an overview of protein hydroxylation catalyzed by 2OG oxygenases, focusing on r

95 GalCer hydroxylation contributes to the compact nature of the m

96 to vitamin D synthesis), CYP2R1 (hepatic 25-hydroxylation), DBP (also known as GC; transport), and C

97 tion of TBECH via cyctochrome P450-catalyzed hydroxylation, debromination, and alpha-oxidation.

98 e affinity has a direct correlation with the hydroxylation degree of each compound.

99 ses (besides PAO) uncovered that phyllobilin hydroxylation depends on TRANSLOCON AT THE INNER CHLOROP

100 uctural isomerization of NHPI and concurrent hydroxylation/detoxication of TCBQ.

101 ation at C-4 produced a 4-fold increase in 3-hydroxylation due to metabolic switching, with no observ

102 nock-out mice revealed a common lysine under-hydroxylation effect at helical domain cross-linking sit

103 CYP27A1 and had Ki values for cholesterol 27-hydroxylation either in the submicromolar (clevidipine,

104 The key intermediate prior to C-F hydroxylation, [Fe(IV)(O)(N4Py(2Ar1))](BF4)2 (1-O, Ar1 =

105 Fe(II)/2OG-dependent reactions are detailed: hydroxylation, halogenation, ring formation, and desatur

106 The full extent of proline (Pro) hydroxylation has yet to be established, as it is largel

107 O(MeAN)-RPhO(-) species that leads to ortho-hydroxylation in a tyrosinase-like fashion and (ii) addi

108 and Cyp27a1, along with increased hepatic BA hydroxylation in association with Cyp2b10 induction.

109 d histones and DNA and inhibition of proline hydroxylation in collagen, respectively.

110 tic analyses suggest that the role of prolyl-hydroxylation in human hypoxia sensing has ancient origi

111 s that favor decarboxylation over fatty acid hydroxylation in OleTJE could enable protein engineering

112 rences in the role of prolyl and asparaginyl hydroxylation in regulating hypoxia-responsive genes in

113 O2 activation and substrate hydroxylation in the presence of all four protein compon

114 Almost every known site of prolyl 3-hydroxylation in types I and IV collagen from P3h2(n/n)

115 s the triple helix, and that lack of proline hydroxylation in vivo leads to dysfunctional collagen ex

116 iffered considerably from those for benzylic hydroxylation, indicating an alternative anaerobic activ

117 Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent m

118 Proline hydroxylation is a major posttranslational modification

119 Hydroxylation is an emerging modification generally cata

120 chromoplasts, we establish that phyllobilin hydroxylation is catalyzed by a membrane-bound, molecula

121 Proline hydroxylation is catalyzed by proline hydroxylases, oxyg

122 We conclude that altered collagen prolyl 3-hydroxylation is caused by loss of P3H2.

123 on of a new catalytic protocol for sp(3) C-H hydroxylation is described.

124 Ribosomal protein hydroxylation is emerging as an important 2OG oxygenase

125 octane reveals that the propensity for omega-hydroxylation is orchestrated by active-site sterics, pa

126 EPOR hydroxylation is required for binding to the beta domain

127 le for stereospecific and site selective C-H hydroxylation is spectroscopically trapped, and its cata

128 Tertiary and benzylic C-H hydroxylation is strongly favored over N-oxidation for n

129 Proline hydroxylation is the most prevalent post-translational m

130 From this ferric intermediate, hydroxylation is thermodynamically favored, but chlorina

131 One of these modifications, prolyl 3-hydroxylation, is accomplished by a family of prolyl 3-h

132 Our results indicated that the di-hydroxylation (M1) and hydroxylation (M2) of GLB are the

133 indicated that the di-hydroxylation (M1) and hydroxylation (M2) of GLB are the major metabolites.

134 In this study, the hydroxylation mechanism and substrate selectivity of Sid

135 he resting enzymes are known, details of the hydroxylation mechanism and timing of long-range electro

136 n this collaborative article, we studied the hydroxylation mechanism in great detail, resulting in th

137 elected as a model system to investigate the hydroxylation mechanism of heteroatom-containing molecul

138 the data fully support an electrophilic C-F hydroxylation mechanism.

139 identify and quantify a broad range of PTMs (hydroxylation, methylation, citrullination, acetylation,

140 for hydrogen abstraction and polysaccharide hydroxylation; namely, a mechanism that employs a eta(1)

141 We demonstrate that this hydroxylation occurs in senescent chloroplasts of Arabid

142 d CYP76AA25 as the enzymes that catalyze the hydroxylation of (+)-sabinene to trans-sabin-3-ol.

143 The 6beta-hydroxylation of 16alpha,17alpha-dihydroxyprogesterone a

144 e degradation, hydroxylation of benzoate and hydroxylation of 2'-deoxyguanosine to give 8-hydroxy-2'-

145 e-3-carboxylic acids were active against the hydroxylation of 2'-deoxyguanosine.

146 r all six P450 21A2 variants examined for 21-hydroxylation of 21-d3-progesterone, indicating that C-H

147 ses urinary phosphate excretion and inhibits hydroxylation of 25-hydroxyvitamin D.

148 Alternatively, 3-hydroxylation of 4-coumaric acid to caffeic acid may occ

149 on of 4-coumaric acid is essential for the 3-hydroxylation of 4-coumaroyl shikimic acid.

150 iodosobenzene results in the regioselective hydroxylation of a bridging pyrazolate ligand, convertin

151 lished by the late-stage, amide-directed C-H hydroxylation of a lycoricidine intermediate.

152 stitution severely impaired OGFOD1-dependent hydroxylation of a neighboring proline residue resulting

153 The hydroxylation of a range of substrates and the methoxyla

154 nd menthol-based substrates to the selective hydroxylation of a variety of substrate cores ranging fr

155 of FAO in response to nutrient abundance via hydroxylation of acetyl-coA carboxylase 2 (ACC2).

156 Mild conditions are reported for the hydroxylation of aliphatic C-H bonds through radical tra

157 mes catalyze the NADPH- and oxygen-dependent hydroxylation of amines such as those found on the side

158 as an electrophilic oxidant in the initial N-hydroxylation of an arylamine and then becoming a nucleo

159 traightforward palladium-catalyzed oxidative hydroxylation of azobenzenes is reported.

160 rt here a practical method for the ortho C-H hydroxylation of benzamides with inexpensive copper(II)

161 different methods: deoxyribose degradation, hydroxylation of benzoate and hydroxylation of 2'-deoxyg

162 Hydroxylation of chiral tertiary centers is enantiospeci

163 Cu(II) ion that catalyzes the regioselective hydroxylation of crystalline cellulose, leading to glyco

164 henylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyro

165 enzyme catalyzing regio- and stereospecific hydroxylation of different sterols.

166 bis(pyridine)silver(I) permanganate promoted hydroxylation of diketopiperazines has served as a pivot

167 vely catalyse epimerization, methylation and hydroxylation of diverse amino acids.

168 An N-heterocyclic carbene-catalyzed beta-hydroxylation of enals is developed.

169 droxylation of phenol by pure Fe2(dobdc) and hydroxylation of ethane by its magnesium-diluted analogu

170 mechanism and selectivity of H2O2-dependent hydroxylation of fatty acids by the P450SPalpha class of

171 olved by introducing a ligand-directed ortho hydroxylation of haloarenes and aryl methyl ethers.

172 y experiments showed that omega- and omega-1-hydroxylation of HNA in rat liver were dramatically up-r

173 D) proteins catalyze oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor 1alpha and 2al

174 0 17A1 (CYP17A1) first catalyzes the typical hydroxylation of its primary substrate, pregnenolone (PR

175 dentification of the enzymes responsible for hydroxylation of JA reveals a missing step in JA metabol

176 excellent catalysts for the oxidative alpha-hydroxylation of ketones with formation of chiral acyloi

177 e CO2 molecules while also catalyzing the C5 hydroxylation of l-arginine (l-Arg) driven by the oxidat

178 Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of

179 Oxidative C-H hydroxylation of methyl groups, followed by their remova

180 ethylated histone lysyl residues, as well as hydroxylation of multiple other residues.

181 ochrome P-450 CYP82Y1, which catalyzes the 1-hydroxylation of N-methylcanadine to 1-hydroxy-N-methylc

182 d range of difficult chemical reactions e.g. hydroxylation of non-activated C-H Bonds and stereoselec

183 obdc), containing open Fe(II) sites, include hydroxylation of phenol by pure Fe2(dobdc) and hydroxyla

184 Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of

185 lfonation and/or denitrification, as well as hydroxylation of photo-oxidized heterocyclic rings, have

186 roid metabolism, catalyzing both the 17alpha-hydroxylation of pregnenolone and progesterone and the s

187 pregnenolone to DHEA than toward the 17alpha-hydroxylation of pregnenolone.

188 (FMO) PhnB, which catalyzes the C2 aromatic hydroxylation of prephenalenone and ring opening of the

189 Posttranslational hydroxylation of proline residues occurs in DPYSP(OH)S m

190 itopes of Ara h 2 requires posttranslational hydroxylation of proline residues.

191 The post-translational hydroxylation of prolyl and lysyl residues, as catalyzed

192 ia-sensing mechanism involves oxygen limited hydroxylation of prolyl residues in the N- and C-termina

193 y basic conditions and enable the late-stage hydroxylation of several functionally-dense drug-like ar

194 Prolyl hydroxylation of Skp1 contributes to O2-dependent Dictyo

195 ioxygenases that catalyze post-translational hydroxylation of specific prolyl and asparaginyl residue

196 igate the effect of both N-methylation and N-hydroxylation of spider polyamine toxins by the synthesi

197 ecker showed that copper and O2 promoted the hydroxylation of steroid-containing ligands.

198 for using O-rich ligand environments for the hydroxylation of strong C-H bonds in enzymatic reactions

199 eagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroar

200 roxyl radicals (OH( *)) were detected by the hydroxylation of terephthalate.

201 This report examines the selective aerobic hydroxylation of tertiary alpha-C-H bonds in ketones wit

202 The side reactions-chlorination and hydroxylation of the 1,3-dicarbonyl partners-may be mini

203 sma metabolites of 230 as products of omega2-hydroxylation of the alkyl side chain.

204 ead is completed by cytochrome P450-mediated hydroxylation of the alpha-methyl-alpha,beta-epoxyketone

205 products (OPs) were primarily the result of hydroxylation of the aromatic ring, double bond of the m

206 4-Hydroxylation of the biphenyl scaffold, formed by biphen

207 ug is well defined and oriented suitably for hydroxylation of the C1 atom, the major site of metaboli

208 Further, hydroxylation of the collagen lysine residue (K87) criti

209 t alter the binding properties, whereas hemi-hydroxylation of the equivalent cytosine in an mCG site

210 The enzymatic beta-C-H hydroxylation of the feedstock chemical isobutyric acid

211 genases also catalyze prolyl and asparaginyl hydroxylation of the hypoxia-inducible factors that play

212 n to virulence is dependent on LpxO-mediated hydroxylation of the LpxL2-transferred myristate.

213 mpicin monooxygenase (RIFMO) catalyzes the N-hydroxylation of the natural product antibiotic rifampic

214 avastatin can be produced by stereoselective hydroxylation of the natural product compactin.

215 rase (COMT), which can effect the sequential hydroxylation of the phenolic group to give an intermedi

216 the prochiral alpha-CH2, thereby leading to hydroxylation of the pro-S C-H bond.

217 ively, we identified Sud1 to catalyze prolyl-hydroxylation of the small ribosomal subunit protein RPS

218 We show that the catalytic nonheme-Fe hydroxylation of the strong C-H bond of ethane proceeds

219 We show that hydroxylation of the Yaa proline causes the Xaa proline

220 Following initial hydroxylation of these less-chlorinated PCBs, metabolic

221 responsible for the specific modification by hydroxylation of three amino acids found in the TEM back

222 <200 fs lifetime of radical pairs from DMDO hydroxylation of trans-1-phenyl-2-ethylcyclopropane meas

223 ntly, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA and ribosomal proteins hav

224 Tyrosine hydroxylase (TyrH) catalyzes the hydroxylation of tyrosine to form 3,4-dihydroxyphenylala

225 committed step in the pathway, namely the 3-hydroxylation of tyrosine to form l-3,4-dihydroxyphenyla

226 egulated splicing, and JMJD6-mediated lysine hydroxylation of U2AF65 could account for, at least part

227 zing the hydroxylation or demethylation (via hydroxylation) of DNA, RNA, or protein.

228 been shown to catalyze N-demethylation (via hydroxylation) of N()-methylated histone lysyl residues,

229 rt a model in which correct peptidyl-proline hydroxylation on EXTs, and possibly in other HRGPs, is r

230 We investigated the effect of proline hydroxylation on IgE binding and the relative contributi

231 hols, employing an oxyacetamide-directed C-H hydroxylation on phenols.

232 Here, we show that eEF2K is subject to hydroxylation on proline-98.

233 , we explore the impact of deficient proline hydroxylation on the cell wall architecture.

234 amental cellular processes by catalyzing the hydroxylation or demethylation (via hydroxylation) of DN

235 n other Fe/2OG enzymes whether they suppress hydroxylation or form hydroxylated intermediates on the

236 It was metabolized in human hepatocytes by hydroxylation, oxidation, cleavage, and conjugation; mos

237 Its hydroxylation partially impairs the binding of calmoduli

238 sor, and that TPHP is also metabolized via a hydroxylation pathway in CEH.

239 ound that a relative increase in levels of 2-hydroxylation pathway metabolites, or in the ratio of 2-

240 lites, or in the ratio of 2-hydroxylation:16-hydroxylation pathway metabolites, were associated inver

241 re shown to involve higher barriers than the hydroxylation pathway.

242 data suggest that both C-C cleavage and C-H hydroxylation pathways proceed via a common key intermed

243 nicity of ten flavonoids, differing in their hydroxylation patterns against direct-acting and indirec

244 tivity of novel bile acids bearing different hydroxylation patterns at the C ring are reported and di

245 in collagen-derived peptides with asymmetric hydroxylation patterns.

246 The dramatic hydroxylation phenotype of MYB115 overexpressors is like

247 catabolic pathway/modification included ring-hydroxylation preparing the substrate for subsequent rin

248 In vitro triazolam 4-hydroxylation (probe reaction for CYP3A4) was reduced by

249 t be responsible for the critical bifurcated hydroxylation process in the biosynthesis pathway.

250 Furthermore, 4-hydroxyphenylalanine, a hydroxylation product of phenylalanine, was identified a

251 Prolyl hydroxylation promotes binding of HIFalpha to the von Hi

252 iary steps as well as direct, late stage C-7 hydroxylation provides both natural products in six and

253 Complex 2-O displayed a C-F hydroxylation rate similar to that of 1-O.

254 revealed the activation barriers for the C-F hydroxylation reaction for the three complexes, consiste

255 The data show that the hydroxylation reaction is initiated by homolytic cleavag

256 s that carry out intramolecular aromatic C-F hydroxylation reactions is reported.

257 occurs by a mechanism involving consecutive hydroxylation reactions of the C-7 methyl group to form

258 t majority of flavin monooxygenases catalyze hydroxylation reactions on a single position of their su

259 P450 17A1 was found to perform 16-hydroxylation reactions on its 17alpha-hydroxylated prod

260 (mu-O)2 Co(III) ](2+) core through aromatic hydroxylation reactions represent a new domain for high-

261 the same range as AKIE in previously studied hydroxylation reactions.

262 nant oxidation is a desaturation and in that hydroxylation represents only a minor pathway.

263 ecular level by a loss of telopeptide lysine hydroxylation, resulting in reduced collagen pyridinolin

264 This hydroxylation results from sequential reactions of 4-hyd

265 Further transformation reactions included hydroxylation, ring cleavage, loss of carbamoyl group, a

266 posed that involves epoxidation, hydrolysis, hydroxylation, ring contraction, or loss of the carbamoy

267 e, consistent with the level of lysine under-hydroxylation seen in individual chains at cross-linking

268 ution of the two FMOs to chlorination versus hydroxylation selectivity in SyrB2 is related to a react

269 Chlorination versus hydroxylation selectivity is then determined by the orie

270 ng an atypical finger 3 and oxygen-dependent hydroxylation site.

271 How differences in HIFalpha hydroxylation status relate to variations in the inducti

272 dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine.

273 The first hydroxylation step is typically catalyzed by monooxygena

274 substrate binding, and demonstrate that the hydroxylation step occurs prior to chloride elimination.

275 was isolated to catalyze the final compactin hydroxylation step.

276 xidized benzene via pathways involving fewer hydroxylation steps compared to HO(*) or CO3(*-).

277 rgo either oxidative rearrangement or simple hydroxylation, suggesting that the C1 carbocation is not

278 formation from pregnenolone and for 17alpha-hydroxylation, suggestive of processivity.

279 prehensive mechanism for diiron enzyme arene hydroxylation that accounts for many prior experimental

280 B1 exhibits structural adaptations for omega-hydroxylation that include changes in the conformation o

281 zed, and they undergo aryl methoxylation and hydroxylation that is favored by addition of oxidant, wh

282 structure varied with regard to interfacial hydroxylation, the identity of the headgroup, the length

283 ptor) through copper-mediated C-H amination, hydroxylation, thiolation, arylation, and trifluoromethy

284 min D2, are metabolized in the liver through hydroxylation to 25-hydroxyvitamin D species, and then f

285 bis(trimethylsilyl) peroxide results in ring hydroxylation to give products that exist mainly as the

286 im of investigating the initial step for C-F hydroxylation, two new ligands were synthesized, N4Py(2A

287 Alkyl and aryl enals undergo beta-hydroxylation via oxygen atom transfer from electron-def

288 Regio- and stereoselective 11beta-hydroxylation was achieved on the basic limonoid skeleto

289 iate in SyrB2 to perform chlorination versus hydroxylation was computationally evaluated for differen

290 The preference for omega-hydroxylation was decreased in an E310A mutant having a

291 No effect on prolyl 3-hydroxylation was evident on screening the spectrum of k

292 The rebound mechanism for alkane hydroxylation was invoked over 40 years ago to help expl

293 The lysine under-hydroxylation was shown to alter the divalent aldimine c

294 rent kinetic isotope effects (AKIE) for ipso-hydroxylation were 1.006 +/- 0.001; these fall in the sa

295 m mouse eyes, and multiple sites of prolyl 3-hydroxylation were identified by mass spectrometry.

296 soquine 4-hydroxylation and metoprolol alpha-hydroxylation were observed using CYP2D6-HBN microsomes,

297 In this study, differences in prolyl 3-hydroxylation were screened in eye tissues from P3h2-nul

298 o directly suppresses PHD2-induced HIF1alpha hydroxylation, which has a mutually dependent interplay

299 HIF-1alpha prolyl hydroxylation, which is prerequisite for pVHL recognitio

300 ) species, which are responsible for key C-H hydroxylation within the solvent cage.