ライフサイエンスコーパス: hydroxylysine

1 e form of galactosyl- and glucosylgalactosyl-hydroxylysine.

2 ase in hydroxylysine and glucosyl-galactosyl hydroxylysine.

3 ylation and subsequently by glycosylation of hydroxylysine.

4 w that a sulfilimine bond (-S=N-) crosslinks hydroxylysine-211 and methionine-93 of adjoining protome

5 xyproline (61-73 residues/1000 residues) and hydroxylysine (5-6 residues/1000 residues) and were iden

6 ng cancer by increasing the amount of stable hydroxylysine aldehyde-derived collagen cross-links (HLC

7 sues, tumor stroma contains higher levels of hydroxylysine aldehyde-derived collagen cross-links (HLC

8 ctivity and is critical for the formation of hydroxylysine-aldehyde derived intermolecular collagen c

9 Such cross-links based on hydroxylysine aldehydes are particularly important in ca

10 y in folding and secretion and a decrease in hydroxylysine and glucosyl-galactosyl hydroxylysine.

11 esults indicate that the slight increases in hydroxylysine and hexose content observed occasionally i

12 (*) is 3,4-dihydroxyphenylalanine, K(*) is 5-hydroxylysine, and K(**) is dihydroxylysine.

13 in the mitochondrial degradation of lysine, hydroxylysine, and tryptophan.

14 and LH3, explaining why in BS triple-helical hydroxylysines are not affected.

15 The final Fmoc-protected (2S,5R)-6-azido-5-hydroxylysine derivative can be used in solid-phase pept

16 process and treated with copper sulfate and hydroxylysine, either alone or in combination, following

17 nal collagen-modifying enzyme possessing LH, hydroxylysine galactosyltransferase (GT), and galactosyl

18 ce of significant amounts of hydroxyproline, hydroxylysine, glycine, and carbohydrate suggesting the

19 cantly improved when a degree of theoretical hydroxylysine glycosylation was applied, showing for the

20 e tensile properties of the copper sulfate + hydroxylysine group.

21 The hydroxylysine, hydroxyproline, glycine, and hexose conte

22 was no significant increase in the amount of hydroxylysine, hydroxyproline, or in the hydroxylysine-l

23 and Lys211 post-translationally modified to hydroxylysine (Hyl211).

24 glycan structure Glc(alpha1-2)Gal linked to hydroxylysine in animals, the functional significance of

25 The increase in glycosylation of hydroxylysine in P3H1 null mice in bone was found to be

26 roline and/or the increased glycosylation of hydroxylysine in type I collagen disturbs the lateral gr

27 howed that glycosylation of non-cross-linked hydroxylysine is different from that involved in cross-l

28 of hydroxylysine, hydroxyproline, or in the hydroxylysine-linked glycoside glucosyl-galactose in the

29 Lysine was converted to hydroxylysine or carbonylysine by radiolysis.

30 lating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h after the supplement was give

31 ommonly conjugated to a serine, threonine or hydroxylysine residue of the polypeptide, the chemical n

32 N) that covalently cross-link methionine and hydroxylysine residues at the interface of adjoining tri

33 During collagen biosynthesis, specific hydroxylysine residues become glycosylated in the form o

34 oxidative deamination of peptidyl-lysine and hydroxylysine residues in collagens and lysine residues

35 yridinoline collagen crosslinks derived from hydroxylysine residues in the collagen telopeptide domai

36 limine bonds between opposing methionine and hydroxylysine residues to structurally reinforce the col

37 ylhydroxylysine, whereas the total number of hydroxylysine residues was essentially unchanged.

38 deamination of epsilon-amines of lysine and hydroxylysine residues within collagen and elastin, gene

39 Furthermore, key glycosylated hydroxylysine residues, alpha1/2-87, are involved in cov

40 erns of 3-hydroxylation and glycosylation of hydroxylysine residues.

41 within type IV collagen contain glycosylated hydroxylysine residues.

42 ymes which hydroxylate lysine or glycosylate hydroxylysine, respectively.

43 ata elucidate the role of copper sulfate and hydroxylysine toward improving the biomechanical propert

44 ecursor to the modified amino acid (2S,5R)-5-hydroxylysine was developed on the basis of the use of a

45 When copper sulfate and hydroxylysine were combined, the result was synergistic,

46 edium with copper sulfate and the amino acid hydroxylysine would enhance the activity of lysyl oxidas