ライフサイエンスコーパス: hydroxymethyl

1 oxidation that converted the C16 methyl to a hydroxymethyl.

2 ic hydroxymethyl functions in 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-d-ribofuranose

3 hyl group at the ring junction, namely, C-8a-hydroxymethyl-1-deoxycastanospermine congeners 1a, 2a, 3

4 by [3+3] condensation of 10,10'-bis[(p-toly)hydroxymethyl]-1,3-bis(2-thienyl)benzenediol with variou

5 der basic conditions the formation of the 12-hydroxymethyl, 12-formyl, and 12-methylene analogues as

6 phan (ARP), Tryptophol (TRO), 2-(2-formyl-5-(hydroxymethyl-1H-pyrrole-1-yl)butanoic acid (PBA) and Tr

7 rom matched human samples showed that the 5-(hydroxymethyl)-2'-deoxycytidine level was 5-fold lower i

8 urement of the 5-methyl-2'-deoxycytidine, 5-(hydroxymethyl)-2'-deoxycytidine, 5-formyl-2'-deoxycytidi

9 hat the yield of Tg is similar as that of 5-(hydroxymethyl)-2'-deoxycytidine.

10 eoxycytidine, 5-carboxy-2'-deoxycytidine, 5-(hydroxymethyl)-2'-deoxyuridine, 2'-deoxyuridine, and 8-o

11 erences was found for 2'-deoxyuridine and 5-(hydroxymethyl)-2'-deoxyuridine.

12 e includes structures with Bis-Tris (2,2-bis(hydroxymethyl)-2,2',2''-nitrilotriethanol) and L-ribose

13 thyl-1-butanol and furan derivatives like 5-(hydroxymethyl)-2-furaldehyde and 2-furaldehyde has been

14 5-(Hydroxymethyl)-2-furaldehyde and 2-furaldehyde were dete

15 ation of the sucrose and the formation of 5-(hydroxymethyl)-2-furfural (HMF).

16 FAMP is then converted to 4-amino-5-(hydroxymethyl)-2-methylpyrimidine (HMP) and recycled int

17 responsible for the synthesis of 4-amino-5-(hydroxymethyl)-2-methylpyrimidine phosphate in the thiam

18 ous solution of a substrate conjugated to 3-(hydroxymethyl)-2-naphthol (NQMP).

19 eous solution of substrates conjugated to 3-(hydroxymethyl)-2-naphthol (NQMP).

20 ivatized with a vinyl ether moiety, while 3-(hydroxymethyl)-2-naphthol is attached to the other via a

21 y efficient photodehydration (Phi=0.2) of 3-(hydroxymethyl)-2-naphthol undergo facile hetero-Diels-Al

22 Analysis of 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-2',3'-endo-methylene-uridine by X-ray crys

23 t contains a carbohydrate-like 4'-hydroxy-5'-hydroxymethyl-2',7'-dioxane moiety attached to the aglyc

24 ns an extraordinary sugar-like 4'-hydroxy-5'-hydroxymethyl-2',7'-dioxane moiety attached via a carbon

25 athway to transform the 5hmC into glucosyl-5-hydroxymethyl-2'-deoxycytidine (5-gmC) and achieved 20%

26 replacement of 2'-deoxycytidine (dC) with 5-hydroxymethyl-2'-deoxycytidine (5hmC) in the E. coli gen

27 d quantitative methods to assess levels of 5-hydroxymethyl-2'-deoxycytidine (5hmdC) and 5-methyl-2'-d

28 ee new cytosine derived DNA modifications, 5-hydroxymethyl-2'-deoxycytidine (hmdC), 5-formyl-2'-deoxy

29 ctrometry, we identified the nucleotide as 5-hydroxymethyl-2'-deoxycytidine (hmdC).

30 , only 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine are predicted to be effic

31 pounds 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine were found to increase th

32 ounds, 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deoxycytidine, should be mutagenic.

33 A may be enzymatically deaminated to yield 5-hydroxymethyl-2'-deoxyuridine (5-HmdU).

34 replaced around 75% of thymidine (T) with 5'-hydroxymethyl-2'-deoxyuridine (5hmU) in the Escherichia

35 eaving reactions or deamination of hmdC to 5-hydroxymethyl-2'-deoxyuridine (hmdU).

36 Once again, only 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deo

37 y, we predicted that two of our compounds, 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deo

38 nds in cell culture because only compounds 5-hydroxymethyl-2'-deoxyuridine and 5-hydroxymethyl-2'-deo

39 This terminator is based on 5-hydroxymethyl-2'-deoxyuridine triphosphate (HOMedUTP), a

40 to both methyl methanesulfonate (MMS) and 5-hydroxymethyl-2'-deoxyuridine, agents that introduce bas

41 The benzylindazole derivative 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) is an a

42 YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an HIF-1 inh

43 a small molecule HIF-inhibitor, YC-1 (3-[5'-Hydroxymethyl-2'-furyl]-1-benzyl-indazole), or vehicle t

44 ecently identified oxidized forms of 5mdC: 5-hydroxymethyl-2'deoxycytidine (5hmdC), 5-formy-2'deoxycy

45 -glyceraldehyde and 2,3-dideoxy-2-fluoro-3-C-hydroxymethyl-2,3-endo-methylene-pentofuranoses from d-i

46 For the first time 5-hydroxymethyl-2-furaldehyde (HMF) was separated from cru

47 The mean values of all IFs for potential 5-hydroxymethyl-2-furaldehyde (HMF)+2-furaldehyde (F) were

48 Y-12632 and its transcriptomic response to 5-hydroxymethyl-2-furaldehyde (HMF), a commonly encountere

49 e to promote a whiter color and a low free 5-hydroxymethyl-2-furaldehyde content (HMF).

50 Carboxylic acids, 2-furaldehyde, 5-hydroxymethyl-2-furaldehyde, furfuryl alcohol, 2-furoic

51 orbance at 420nm (A420) and the content of 5-hydroxymethyl-2-furfural (5-HMF).

52 The heterocyclic aldehyde 5-hydroxymethyl-2-furfural (5HMF) interacts allosterically

53 e industries, often contain high levels of 5-hydroxymethyl-2-furfural (HMF), a toxic contaminant.

54 ermal treatment result in the formation of 5-hydroxymethyl-2-furfural (HMF), and changes in the antio

55 vated temperatures with glucose (GLC), and 5-hydroxymethyl-2-furfural (HMF).

56 Formation of 5-hydroxymethyl-2-furfural from fructose was found to be a

57 e, 3-deoxyglucosone, 3,4-dideoxyglucosone, 5-hydroxymethyl-2-furfural, glyoxal, methylglyoxal and dia

58 dentified the hitherto unknown compound as 5-hydroxymethyl-2-furfuraldehyde (5-HMF).

59 and final stages, the measurement of free 5-hydroxymethyl-2-furfuraldehyde and color, proved not to

60 i compound from the determination of total 5-hydroxymethyl-2-furfuraldehyde would have correlate well

61 2-furoylglycine and 5-hydroxymethyl-2-furoic acid - potential biomarkers for c

62 )-2,3-butanediol (N7G-N1A-BD), and 1,N(6)-(1-hydroxymethyl-2-hydroxypropan-1,3-diyl)-2'-deoxyadenosin

63 e a defect in the synthesis of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamin

64 In bacteria, the 4-amino-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamin

65 tide (AIR) is the precursor of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) pyrophosphate moi

66 ormation of the pyrimidine moiety (4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synth

67 ThiC (4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; EC

68 diate 5-aminoimidazole ribotide to 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate, an intermedi

69 ires the independently synthesized 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate (HMP-PP)

70 in that catalyzes the formation of 4-amino-5-hydroxymethyl-2-methylpyrimidine.

71 sm, T(s) shifts induced by the nitro-triol 2-hydroxymethyl-2-nitro-1,3-propanediol (HNPD) were superi

72 nduction of tumor cell apoptosis) [2,5-bis(5-hydroxymethyl-2-thienyl) furan] (NSC-652287) inhibits HI

73 substituted 3-hydroxymorphinans, including 2-hydroxymethyl-, 2-aminomethyl-, and N-substituted 2-amin

74 nd 33b, ethenyl 14b and 34, ethyl 16 and 35, hydroxymethyl 20 and 41, hydroxyethyl 22, fluoroethyl 23

75 2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-(2S,3S)-1,4-benzodiox in-6-propanol, thre

76 All 16 stereoisomeric N-methyl 5-(hydroxymethyl)-3,4-dihydroxyproline amides have been syn

77 66), and (2S,3R,11bR)-9-(3-fluoropropoxy)-2-(hydroxymethyl)-3-isobutyl-10-methoxy-2,3,4,6, 7,11b-hexa

78 biosynthetic precursor, (1E,3S,4R,5E)-1-(2-(hydroxymethyl)-3-methoxyphenyl)hepta-1,5-diene-3,4-diol,

79 s led to the identification of (S)-(-)-4-(4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1

80 triphosphate (GMPCPP) or the activator 3-(5'-hydroxymethyl-3'-furyl)-1-benzylindazole (YC-1).

81 The debate whether statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhi

82 n, whereas the CERT inhibitor N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (1R,3R isomer)

83 (5aS,6R,7R,8R,9aR)-2-amino-6,7-dihydroxy-8-(hydroxymethyl)-3H,4H,5H,5aH,6H,7H,8H, 9aH,10H-pyrano[3,2

84 by purine-rich TFOs on the processing of 4'-(hydroxymethyl)-4,5',8-trimethylpsoralen (HMT) ICLs by th

85 t and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-und

86 [4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta [g]quinazolin-6-yl]am

87 [(+/-)-1-[(3R*,4R*)-1-(cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl -1,3-dihydro-2H-be

88 -[1-(cyclooctylmethyl)-1,2,3,6-tetrahydro-5-(hydroxymethyl)-4-pyridinyl]-3-ethyl -1,3-dihydro-2H-benz

89 tivation mechanism of the related compound 2-hydroxymethyl-4-chloropyridine is probed here in more de

90 onist J-113397 [(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H benzim

91 -deoxycytidine (5-mdC) in DNA to yield the 5-hydroxymethyl, 5-formyl and 5-carboxyl derivatives of 2'

92 C), or to undergo further oxidation to the 5-hydroxymethyl (5hmC), 5-formyl (5fC), or 5-carboxyl (5ca

93 namely, butyl-2-[(6aR,9R,10aR)-1-hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-h exahydro-6

94 2,5-Diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1) is a nove

95 ioxygenase MhpB from Escherichia coli with 6-hydroxymethyl-6-methylcyclohexa-2,4-dienone led to the f

96 was isolated from incubation of CatA with 6-hydroxymethyl-6-methylcyclohexa-2,4-dienone, an analogue

97 conversion of 7,8-dihydroneopterin (1) to 6-hydroxymethyl-7,8-dihydropterin (4) in the folate biosyn

98 nversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and the epimerizati

99 the transfer of pyrophosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP), leading to the bio

100 es the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin and is a yet-to-be-drugg

101 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

102 cule intensity-time trajectories of enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

103 zymes dihydroneopterin aldolase (DHNA) and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

104 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

105 step in folate biosynthesis (catalysed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK)

106 re of Mtb FolB complexed with its product, 6-hydroxymethyl-7,8-dihydropterin, reveals an octameric as

107 rable amounts, the predominant of which is 6-hydroxymethyl-7,8-dihydropterin, the substrate for the f

108 with the potent MAIT cell ligand, reduced 6-hydroxymethyl-8-D-ribityllumazine (rRL-6-CH(2)OH), speci

109 doperoxides that can be reduced to produce 1-hydroxymethyl-9,10-anthraquinones.

110 cylfulvene is 25 times more potent than (+)-(hydroxymethyl)acylfulvene in cells transfected with an A

111 (-)-(Hydroxymethyl)acylfulvene is 25 times more potent than (

112 ized: (-)-acylfulvene, (+)-acylfulvene, (-)-(hydroxymethyl)acylfulvene, and (+)-(hydroxymethyl)acylfu

113 ne, (-)-(hydroxymethyl)acylfulvene, and (+)-(hydroxymethyl)acylfulvene.

114 the synthetically more accessible C-terminus hydroxymethyl aglycon derivatives and full details of th

115 c acid and (S)-SEGPHOS delivers products of (hydroxymethyl)allylation 4a-4i in good isolated yields (

116 eneral method for enantioselective carbonyl (hydroxymethyl)allylation, a process that has no highly s

117 imitations of the ring expansion of cyclic 2-hydroxymethyl amines induced by diethylaminosulfur trifl

118 difference by increasing plasma sodium, tris-hydroxymethyl aminomethane acts by increasing plasma wea

119 Buffers based on pyridine (py) and tris(hydroxymethyl)aminomethane (TRIS) are catalytically inac

120 ange of 0.1 mM to 1 mM, using the bases tris(hydroxymethyl)aminomethane, ammonia, carbonate, hydroxid

121 uble HbS (aromatic aldehydes o-vanillin or 5-hydroxymethyl, and urea) reduced haemolysis, an effect n

122 ta-lactam intermediates, (5S,6S)-5-hydroxy-6-hydroxymethyl- and (5S,6S)-5-hydroxy-6-methylpiperidin-2

123 reaction, between pH 10 and 14, of eight N-(hydroxymethyl)benzamide derivatives in water at 25 degre

124 Similar treatment of o- and p-(hydroxymethyl)benzoate derivatives results largely in lo

125 Birch reductive alkylation of methyl m-(hydroxymethyl)benzoate derivatives, using lithium in amm

126 des from resin beads whereby exposure of a 4-hydroxymethyl benzoic acid (HMBA)-linked peptide to high

127 duce the Diels-Alder dehydration product, 4-(hydroxymethyl)benzoic acid (HMBA), with 31% selectivity

128 Hydroxymethyl benzotriazole, which is an inexpensive and

129 nsferase by the gamma-folate ester of O6-[4-(hydroxymethyl)benzyl]guanine was similar to that of the

130 of O6-benzyl-2'-deoxyguanosine and of O6-[4-(hydroxymethyl)benzyl]guanine were synthesized and tested

131 is quantitatively converted to two products, hydroxymethyl BHT (1) and 3-hydroxy- tert-butyl BHT (2).

132 dehyde in order to introduce selectively the hydroxymethyl branch, and second, a tandem beta-fragment

133 invasive microPET using 9-[4-(18)F-fluoro-3-(hydroxymethyl)butyl]guanine ((18)F-FHBG) as a reporter p

134 PET with (18)F-FEAU and (18)F-9-[4-fluoro-3-(hydroxymethyl)butyl]guanine ((18)F-FHBG) was performed i

135 etected by 18F-FDG PET, 9-[4-(18)F-fluoro-3-(hydroxymethyl)butyl]guanine (18F-FHBG) PET, CT, and BLI

136 he acycloguanosine analog 9-4-[18F]fluoro-3-(hydroxymethyl)butyl]guanine ([18F]FHBG).

137 acil (FEAU), penciclovir, and 9-[4-fluoro-3-(hydroxymethyl)butyl]guanine (FHBG) and clinically applie

138 beled PET reporters FHBG [9-(4-18F-fluoro-3-[hydroxymethyl] butyl) guanine] and FLT (18F-3'-deoxy-3-'

139 9-(4-(18)F-Fluoro-3-[hydroxymethyl]butyl)guanine ((18)F-FHBG) is a sensitive

140 imaging reporter probe 9-(4-(18)F-fluoro-3-[hydroxymethyl]butyl)guanine ((18)F-FHBG), the herpes sim

141 cloguanosine derivative 9-(4-(18)F-fluoro-3-[hydroxymethyl]butyl)guanine ((18)F-FHBG).

142 in tumor cells using 9-(4-[(18)F]-fluoro-3-[hydroxymethyl]butyl)guanine ([(18)F]FHBG) as the substra

143 scriptional activity by 9-(4-(18)F-fluoro-3-[hydroxymethyl]butyl)guanine PET, in both mouse and canin

144 roteins could convert 5-methyl C (5-mC) to 5-hydroxymethyl C (5-hmC).

145 with DNA containing methyl-CG, methyl-CA and hydroxymethyl-CA are all reduced in vivo.

146 In the cAMP assay, the 9-hydroxymethyl cannabinol analogue 24 (AM4089) had a part

147 ed alkenes to give terminal and internal 1,3-hydroxymethyl chirons.

148 l-CpG-binding domain of MeCP2 interacts with hydroxymethyl-CpG.

149 The pseudorotaxane complex of the new hydroxymethyl cryptand 3 with N,N'-dimethyl-4,4'-bipyrid

150 l (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate 2, an essential interm

151 1-({[1-(Hydroxymethyl)cyclopentyl]amino}acetyl)pyrrolidine-2,5-c

152 ns, providing access to synthetically useful hydroxymethyl cyclopropanes.

153 identification of 3-(4-chlorophenyl)-3-((1-(hydroxymethyl)cyclopropyl)methoxy)-2-(4-nitrobenzyl)iso

154 e conversion of 5-methyl cytosine (5mC) to 5-hydroxymethyl cytosine (5hmC) and play important roles d

155 The recent discovery of 5-hydroxymethyl-cytosine (5 hmC) in embryonic stem cells a

156 sts (CAF), along with increased amounts of 5-hydroxymethyl-cytosine (5-HmC) in CAFs, in progression f

157 f 5mC in CpG dinucleotides is converted to 5-hydroxymethyl-cytosine (hmC) by the action of 2-oxogluta

158 hyl-cytosines (glc-5hmC) and T4gt DNA with 5-hydroxymethyl-cytosines (5hmC).

159 ted REase activity on T4 DNA with glucosyl-5-hydroxymethyl-cytosines (glc-5hmC) and T4gt DNA with 5-h

160 -ethylenedioxythiophene) (PEDOT:TsO) and the hydroxymethyl derivative PEDOT-OH:TsO, which was covalen

161 nd that it is converted to adenine via its 6-hydroxymethyl derivative.

162 ted in the development of a new series of 4-(hydroxymethyl)diarylhydantoin analogues as potent, parti

163 Herein, we describe a C2-hydroxymethyl dihydropyrrole KSP inhibitor ( 11) that ci

164 dem deprotection/rearrangement of O-silyl 2-(hydroxymethyl)dimethylglutarate.

165 identified as 4,4'-dihydroxy-3,5,3',5'-tetra(hydroxymethyl)diphenylmethane.

166 lectrocatalytic response in the presence of (hydroxymethyl)ferrocene as redox mediator.

167 To this end, (hydroxymethyl)-ferrocene (FcCH2OH) was employed to provi

168 ng ADC that use poly-1-hydroxymethylethylene hydroxymethyl-formal (PHF), also known as Fleximer.

169 the cytosine bases is replaced with methyl-, hydroxymethyl-, formyl-, or carboxylcytosine.

170 anslocated via its distal carbon atom to the hydroxymethyl functionality.

171 acetylation of one of the two diastereotopic hydroxymethyl functions in 3-O-benzyl-4-C-hydroxymethyl-

172 The physicochemical parameters (moisture, hydroxymethyl furfural, colour, electrical conductivity,

173 ng a mixture of two furanic (furfural, FF; 5-hydroxymethyl furfural, HMF) and three phenolic (syringi

174 5-(Hydroxymethyl)furfural (HMF) and levulinic acid producti

175 anuka honey, the kinetics of formation of 5-(hydroxymethyl)furfural (HMF) was studied at temperatures

176 nillin, the natural baked marker compound 5-(hydroxymethyl)furfural (HMF), specific markers of oxidat

177 entified: Acortatarins A, Acortatarins C, 5-(hydroxymethyl)furfural(HMF), 2,3-dihydro-3,5-dihydroxy-6

178 glycosides were identified together with 5-(hydroxymethyl)furfural.

179 5-(Hydroxymethyl)-furfural content emerged as a critical fa

180 -free heterogeneous selective oxidation of 5-hydroxymethyl-furfural (HMF) to 2,5-furandicarboxylic ac

181 The partially oxidized HMF, 5-(hydroxymethyl)furoic acid (HMFA), is reacted with high p

182 d a short enantioselective synthesis of (2R)-hydroxymethyl glutamic acid (HMG) starting from Garner's

183 genase, 6-phosphogluconate dehydrogenase, 2-(hydroxymethyl)glutarate dehydrogenase, and phenylserine

184 Hydroxymethyl glutaryl-coenzyme A reductase degradation

185 1:01 and statins for the development of anti-hydroxymethyl glutaryl-coenzyme A reductase-positive sta

186 maldehyde detoxification by FrmA requires S-(hydroxymethyl)glutathione, yet glutathione inhibits form

187 [formaldehyde] than required to generate S-(hydroxymethyl)glutathione.

188 Lepadiformine A and B contain a hydroxymethyl group adjacent to the amine.

189 eveloped that defined our use of a protected hydroxymethyl group as the substituent that controls the

190 vindoline and defined our use of a protected hydroxymethyl group as the substituent used to control t

191 Polyhydroxylated quinolizidines bearing a hydroxymethyl group at the ring junction were synthesize

192 ew quaternary indolizidine iminosugars, with hydroxymethyl group at the ring junction, namely, C-8a-h

193 However, introduction of the C2-hydroxymethyl group caused 11 to be a substrate for cell

194 ng earlier studies on the role played by the hydroxymethyl group conformation on glycoside reactivity

195 The hydroxymethyl group in Ser originated from formate, whic

196 val of benzoyl protection, and conversion of hydroxymethyl group into mesyloxymethyl group.

197 ailable, deacetylation to access the free 3'-hydroxymethyl group is problematic when the carboxylic a

198 e towards the opposite direction because the hydroxymethyl group of 5hmC and formyl group of 5fC adop

199 re supposed to directly interact with the C6 hydroxymethyl group of D-glucose negatively affected tra

200 The hydroxymethyl group of serine is a primary source of tet

201 ving groups incorporated via coupling to a 5-hydroxymethyl group of the quinones, the photocyclizatio

202 The oxidation of the 16-hydroxymethyl group present in the axial position was ac

203 etic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of

204 cations, such as the addition of a methyl or hydroxymethyl group to cytosine, can also play a role.

205 hate (PLP)-dependent enzyme that catalyzes a hydroxymethyl group transfer from L-serine to tetrahydro

206 The hydroxymethyl group was then oxidized and then decarbony

207 ning the desymmetrization of a prochiral bis-hydroxymethyl group with the epimerization of a chiral f

208 formaldehyde to introduce the requisite C16 hydroxymethyl group.

209 subsequently reduced in two stages to the 5'-hydroxymethyl group.

210 based on a chemical tagging strategy for the hydroxymethyl group.

211 , and reduction in an one-pot operation to a hydroxymethyl group.

212 combination with 5'-N-ethylcarboxamido or 5'-hydroxymethyl groups.

213 sphingoid bases lacking the 1-hydroxyl- or 1-hydroxymethyl- groups.

214 rmaldehyde gives easily crystallized menthyl hydroxymethyl-H-phosphinate (1).

215 Of these, 9-hydroxymethyl hexahydrocannabinol 11 (AM4054) exhibited

216 nitric acid (HNO3), hydrogen cyanide (HCN), hydroxymethyl hydroperoxide, peroxyacetic acid, organic

217 The method gives access to 1-alkynyl-2-(hydroxymethyl)imidazoles which undergo 6-endo-dig or 5-e

218 A series of bis(hydroxymethyl)indolizino[6,7-b]indoles and their bis(alk

219 o acids are reduced to iodomethyl groups via hydroxymethyl intermediates.

220 Cyclic alpha-hydroxymethyl ketimines undergo highly diastereoselectiv

221 as a furfural-sensitive indicator monomer, 2-hydroxymethyl methacrylate as a comonomer, and ethylene

222 phosphates 11a and 11b derived from 2,2-bis(hydroxymethyl)methylenecyclopropane analogues 1a, 1b, 2a

223 ion of a linear trisaccharide, modified with hydroxymethyl moiety at C4 of glucopyranose moiety.

224 d for the preparation of 3,5-disubstituted 4-hydroxymethyl-N-arylpyrazole derivatives from the beta-e

225 faces were derivatized with photoreactive 3-(hydroxymethyl)naphthalene-2-ol (NQMP) moieties.

226 on a one-pot reduction/condensation of tris(hydroxymethyl)nitromethane with a benzaldehyde derivativ

227 ally distorted the ion binding sites, 2) the hydroxymethyl of Thr(772) rotates to stabilize bound For

228 In the crystal, the hydroxymethyl (OH-CH2-) moiety of 5hmC points to the met

229 e study the effects of the epigenetic mark 5-hydroxymethyl on cytosine on the structure of the Dicker

230 ynthesis of 2,2'-arylmethylene dimers from 3-hydroxymethyl or 3-methoxymethyl-5-halo-(S)-tyrosines an

231 (3)/sp(2))-H functionalizations of a methyl, hydroxymethyl, or aldehyde group has been developed prov

232 This review focuses on 4'-hydroxymethyl- or nucleobase-transposed nucleosides, nuc

233 The biological activities of all known 4'-hydroxymethyl- or nucleobase-transposed nucleosides, nuc

234 ro-1H-cyclopenta[a]phenanthren-3-yl]o xy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5

235 3-yl]o xy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol], an alkaloid isolated f

236 y-methoximes, vinyl-substituted oxiranes, or hydroxymethyl oxiranes.

237 C name: 2-{2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-oxolan-2-yl]-1-methylcarbamim idamido}ace

238 n be activated by an esterase to generate a "hydroxymethyl persulfide" intermediate, which rapidly co

239 by leveraging oxidative dearomatization of 2-hydroxymethyl phenols with concurrent N-hydroxycarbamate

240 The novel tracer molecule based on a 2-hydroxymethyl phenyl boronic acid derivative binds even

241 4-(Hydroxymethyl)phenyl benzyl selenoxide (4) sequestered i

242 soleucine, and l-phenylalanine esters of [3-(hydroxymethyl)phenyl]guanidine (3-HPG) were synthesized

243 and identified together with 1-(2-hydroxy-4-hydroxymethyl)-phenyl-6-O-caffeoyl-beta-d-gluco-pyranosi

244 Methyl, hydroxymethyl, phenyl, carboxyl, pyridyl, and cyclohexyl

245 the process, a new phenolic glycoside (E)-4-hydroxymethyl-phenyl-6-O-caffeoyl-beta-d-glucopyranoside

246 nzylamine (35), N, N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)-5-bromobenzylamine (36), and N

247 re synthesized: N, N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)-5-fluorobenzylamine (35), N, N

248 amine (36), and N, N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)-5-iodobenzylamine (37).

249 )(-) salt; bpy = 2,2'-bipyridine, thp = tris(hydroxymethyl)phosphine] is both strongly luminescent an

250 complex, [Ni(DHMPE)2](2+) (DHMPE = 2-bis(di(hydroxymethyl)phosphino)ethane), for the hydrogen evolut

251 A similar coupling between adenosine (hydroxymethyl)phosphonate 10 and phosphitylated mycophen

252 A coupling of the mycophenolic (hydroxymethyl)phosphonate 6 with the phosphitylated aden

253 t that, by addition of ionic liquid tetrakis(hydroxymethyl)phosphonium chloride solution to the alpha

254 nthesis of three differentially protected 2-(hydroxymethyl)piperazines is presented, starting from op

255 N-adamantanyl-4-((3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)piperidin-1-yl)-butana mide (3) and N-adam

256 N-adamantanyl-4-((3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)piperidin-1-yl)pentana mide (4), respectiv

257 volves generation of and chemistry at the 3'-hydroxymethyl position.

258 on channel potentiation by (3alpha,5alpha)-3-hydroxymethyl-pregnan-20-one, but mutation of the neighb

259 -9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hydroxymethyl)pro pane-1,3-diol (DCAP), a potent broad-s

260 ield from the commercially available 2,2-bis(hydroxymethyl)propionic acid and used as the starting bu

261 c wedges (generations 0-4), based on 2,2-bis(hydroxymethyl)propionic acid, was designed to bind Au na

262 on 5-hydroxymethyl-pyrimidines and 7-deaza-7-hydroxymethyl-purines lay the foundation for development

263 mp)4(mu-OAc)2(mu2-OAc)2(H2O)2] (1) (hmp = 2-(hydroxymethyl)pyridine) as the first Co(II)-based cubane

264 H2O] ({Co(II)3Ln(OR)4}; Ln = Ho-Yb, hmp = 2-(hydroxymethyl)pyridine) cubane WOC series is introduced

265 tes only one equiv of pyridine, and forms N-(hydroxymethyl)pyridinium ion.

266 ng linkers between the alpha-carbon and a 2-(hydroxymethyl)pyridyl group were synthesized in enantioe

267 erivatives and those using TET/JBP-generated hydroxymethyl pyrimidines as biosynthetic starting point

268 Modified nucleotides based on 5-hydroxymethyl-pyrimidines and 7-deaza-7-hydroxymethyl-pu

269 ne (topoisomerase inhibition moiety) and bis(hydroxymethyl)pyrrole (DNA cross-linking moiety).

270 InCl(3)-catalyzed condensation of 4-bromo-2-(hydroxymethyl)pyrrole and pyrrole to give the 8-bromodip

271 L-IsoDMDP [(2S,3S,4R)-2,4-bis(hydroxymethyl)pyrrolidine-3,4-diol], prepared in 11 step

272 ADP-ribose (ADPR), adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol (ADP-HPD) and 8-n-octyl-am

273 sing a sequence involving (1) AgNO3-mediated hydroxymethyl radical addition to 1,8-naphthyridine, (2)

274 he present case) and takes place through the hydroxymethyl radical formed from methanol oxidation by

275 s intramolecular 1,4-conjugate addition of a hydroxymethyl radical generated from Ti (III) mediated r

276 cols are used in combination with Merrifield hydroxymethyl resin and TFA/TMSBr cleavage.

277 We previously developed gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a tool to d

278 new fluorescent method using gamma-glutamyl hydroxymethyl rhodamine green to diagnose metastatic lym

279 A paromomycin analog lacking the hydroxymethyl ring I side chain is considerably less act

280 iously undescribed rotamer transition of the hydroxymethyl side chain of the absolutely conserved Thr

281 e effect of this modification is to lock the hydroxymethyl side chain of the neomycin or paromomycin

282 tions, a variable amount of oxidation of the hydroxymethyl substituent into an aldehyde was observed

283 Obviously, the 3-hydroxymethyl substituent shows similar reactivity and a

284 In contrast, the matching of hydroxymethyl substituents in the aminocyclitols and the

285 The resulting hydroxymethyl substituted aminocyclitols were tested as

286 ough chemoselective allyl transfer between 2-hydroxymethyl-substituted allylic silanes and imines is

287 The hydroxymethyl substrate 4 (R(3) = CH(2)OH), however, was

288 he synthetic base 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-perimidin-2(3H )

289 implicit solvent model are carried out on 5-(hydroxymethyl)tetrahydropyran to investigate the effects

290 of different constitutions, namely 4,4'-bis(hydroxymethyl)tetrathiafulvalene (OTTFO) and 4,4'-bisthi

291 Reaction of a galactosylated 2-C-(hydroxymethyl)-tetrofuranose with paramolybdate ion-exch

292 -restricted TCR that differ only in a buried hydroxymethyl that forms a common TCR beta-chain V regio

293 functional studies demonstrated that serine hydroxymethyl transferase 1 (SHMT1) was necessary for ov

294 ces of cysteine desulphurase, serine/glycine hydroxymethyl transferase, and components of the alpha-k

295 ligonucleotides containing nucleobase- or 4'-hydroxymethyl-transposed nucleotides are discussed.

296 ligonucleotides containing nucleobase- or 4'-hydroxymethyl-transposed nucleotides as small oligonucle

297 of a bromochlorin with a one-carbon synthon (hydroxymethyl tributyltin or CO) to give a 13-, 15-, or

298 The betaine lipid diacylglyceryl-hydroxymethyl-trimethyl-beta-alanine and phosphatidyldim

299 ation of the degradation was observed at the hydroxymethyl uracil and tricyclic guanidine groups; ura

300 ssibility of replacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5hmU) in the genomic DNA of Esche