ライフサイエンスコーパス: hydroxymethylglutaryl

1 The pleiotropic actions of hydroxymethylglutaryl CoA reductase inhibitors (statins)

2 d that "high-risk" patients are treated with hydroxymethylglutaryl CoA reductase inhibitors to reduce

3 nhibited by both lovastatin, an inhibitor of hydroxymethylglutaryl CoA reductase, and alendronate.

4 e, we evaluated mice lacking mitochondrial 3-hydroxymethylglutaryl CoA synthase (HMGCS2) to determine

5 his enzyme is unique in that it is the first hydroxymethylglutaryl CoA synthase that is insensitive t

6 e, the first characterization of an archaeal hydroxymethylglutaryl CoA synthase.

7 In this study, the comparative effects of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors

8 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the pri

9 Avian hydroxymethylglutaryl-CoA (HMG-CoA) synthase is inactiva

10 acetoacetyl-CoA, succinyl-CoA, malonyl-CoA, hydroxymethylglutaryl-CoA (HMG-CoA), and acetyl-CoA in I

11 dicate that HMGCLL1 is an extramitochondrial hydroxymethylglutaryl-CoA lyase.

12 REBP binding to three specific target genes: hydroxymethylglutaryl-CoA reductase (Red), fatty acid sy

13 (AMPK), phosphorylates and regulates in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carbo

14 main, we made a fusion protein between yeast hydroxymethylglutaryl-CoA reductase and GFP.

15 protein pathway and increases expression of hydroxymethylglutaryl-CoA reductase and low density lipo

16 ed in the regulated degradation of wild-type hydroxymethylglutaryl-CoA reductase in the ER membrane.

17 or the hepatic uptake of this liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in rat and

18 hamster ovary cell lines with lovastatin (a hydroxymethylglutaryl-CoA reductase inhibitor) and meval

19 sulfate, and thyroid hormone, as well as the hydroxymethylglutaryl-CoA reductase inhibitor, pravastat

20 dence suggests that long term treatment with hydroxymethylglutaryl-CoA reductase inhibitors, or stati

21 ord "surgery" and the MeSH term for statins "hydroxymethylglutaryl-CoA reductase inhibitors." Studies

22 lated degradation consistent with the native hydroxymethylglutaryl-CoA reductase proteins.

23 ion (cytochrome c) or cholesterol synthesis (hydroxymethylglutaryl-CoA reductase).

24 carboxykinase, and type I deiodinase but not hydroxymethylglutaryl-CoA reductase, cytochrome c, and a

25 e stimulated the rapid inactivation of their hydroxymethylglutaryl-CoA reductase, presumably through

26 tein maturation and promoting degradation of hydroxymethylglutaryl-CoA reductase.

27 of gamma-tocotrienol, indicating the role of hydroxymethylglutaryl-CoA reductase.

28 -binding protein-2 and reduced expression of hydroxymethylglutaryl-CoA reductase.

29 ding protein cleavage-activating protein and hydroxymethylglutaryl-CoA reductase.

30 n regulatory factor 1 (IRF-1), mitochondrial hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase), a

31 pecific beta-lactone inhibitor of eukaryotic hydroxymethylglutaryl-CoA synthase (HMGCS).

32 an effective competitive inhibitor of avian hydroxymethylglutaryl-CoA synthase (Ki = 28 microm).

33 nd catalase, and show that these, as well as hydroxymethylglutaryl-CoA synthase and sarcosine dehydro

34 nding cassette transporters ABCA1 and ABCG5, hydroxymethylglutaryl-CoA synthase and the LDL receptor)

35 odular polyketide synthase (PKS) proteins, a hydroxymethylglutaryl-CoA synthase cassette and three fl

36 -methyl and beta-ethyl branches catalyzed by hydroxymethylglutaryl-CoA synthase homologues that utili

37 ency resulted in up-regulation of intestinal hydroxymethylglutaryl-CoA synthase mRNA and an increase

38 Hydroxymethylglutaryl-CoA synthase-catalyzed condensatio

39 nzymes that enolize this analog, occurs with hydroxymethylglutaryl-CoA synthase.

40 f acetyl-CoA, acetoacetyl-CoA, succinyl-CoA, hydroxymethylglutaryl-CoA, and malonyl-CoA confirmed tha

41 iNOS expression, and NF-kappaB activation by hydroxymethylglutaryl-CoA, mevalonate, and farnesyl pyro

42 ration of (E)-3-methylglutaconyl-CoA to (3S)-hydroxymethylglutaryl-CoA.

43 oid biosynthesis, is catalyzed by the enzyme hydroxymethylglutaryl-CoAreductase (HMGR).

44 domized trials, calcium channel blockers and hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inh

45 Hydroxymethylglutaryl coenzyme A reductase (HMGCoAR) is

46 Mevalonate depletion by inhibition of hydroxymethylglutaryl coenzyme A reductase impairs post-

47 his study aimed to investigate the impact of hydroxymethylglutaryl coenzyme A reductase inhibitor (st

48 nse of C-reactive protein to initiation of a hydroxymethylglutaryl coenzyme A reductase inhibitor (st

49 Hydroxymethylglutaryl coenzyme A reductase inhibitors (s

50 Long-term therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (s

51 We sought to determine whether therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (s

52 f the most recent clinical trials with the 3-hydroxymethylglutaryl coenzyme A reductase inhibitors (s

53 Clinical trials suggest that hepatic hydroxymethylglutaryl coenzyme A reductase inhibitors ma

54 Hydroxymethylglutaryl coenzyme A reductase inhibitors re

55 , including cholesterol metabolic processes, hydroxymethylglutaryl-coenzyme A (CoA) reductase activit

56 sterol pathways, I found that mRNA levels of hydroxymethylglutaryl-coenzyme A (HMG-CoA) synthase, squ

57 (FPP), which are lipids downstream from the hydroxymethylglutaryl-coenzyme A block, were also examin

58 ylase [At1g03090 and At4g34030] and putative hydroxymethylglutaryl-coenzyme A lyase [At2g26800]) base

59 the computational annotation of At2g26800 as hydroxymethylglutaryl-coenzyme A lyase.

60 of previously reported methods for screening hydroxymethylglutaryl-coenzyme A reductase (HMGR) inhibi

61 Inhibitors of hydroxymethylglutaryl-coenzyme A reductase (statins) inc

62 Hydroxymethylglutaryl-coenzyme A reductase degradation o

63 nate, indicating a direct effect of vascular hydroxymethylglutaryl-coenzyme A reductase inhibition.

64 Pretreatment of Jurkat T-cells with the 3-hydroxymethylglutaryl-coenzyme A reductase inhibitor, lo

65 In earlier studies of the influence of hydroxymethylglutaryl-coenzyme A reductase inhibitors (a

66 sterol regulatory element-binding protein 1, hydroxymethylglutaryl-coenzyme A reductase, and apolipop

67 We also observed lower activity of hydroxymethylglutaryl-coenzyme A reductase, the key enzy

68 he degradation of the yeast Hmg2p isozyme of hydroxymethylglutaryl-coenzyme A reductase.

69 ame deletion mutants confirmed the role of a hydroxymethylglutaryl-coenzyme A synthase cassette, thre

70 Hydroxymethylglutaryl (HMG) CoA reductase inhibitors (st

71 l1L) is an adaptor protein for the E3 ligase hydroxymethylglutaryl reductase degradation protein 1 (H

72 lean proof for the reversible dehydration of hydroxymethylglutaryl-S-PksL via incorporation of 2H or