ライフサイエンスコーパス: hydroxymethylglutaryl-CoA

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1 ration of (E)-3-methylglutaconyl-CoA to (3S)-hydroxymethylglutaryl-CoA.

2 f acetyl-CoA, acetoacetyl-CoA, succinyl-CoA, hydroxymethylglutaryl-CoA, and malonyl-CoA confirmed tha

3 In this study, the comparative effects of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors

4 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the pri

5 Avian hydroxymethylglutaryl-CoA (HMG-CoA) synthase is inactiva

6 acetoacetyl-CoA, succinyl-CoA, malonyl-CoA, hydroxymethylglutaryl-CoA (HMG-CoA), and acetyl-CoA in I

7 dicate that HMGCLL1 is an extramitochondrial hydroxymethylglutaryl-CoA lyase.

8 iNOS expression, and NF-kappaB activation by hydroxymethylglutaryl-CoA, mevalonate, and farnesyl pyro

9 The pleiotropic actions of hydroxymethylglutaryl CoA reductase inhibitors (statins)

10 d that "high-risk" patients are treated with hydroxymethylglutaryl CoA reductase inhibitors to reduce

11 nhibited by both lovastatin, an inhibitor of hydroxymethylglutaryl CoA reductase, and alendronate.

12 REBP binding to three specific target genes: hydroxymethylglutaryl-CoA reductase (Red), fatty acid sy

13 (AMPK), phosphorylates and regulates in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carbo

14 main, we made a fusion protein between yeast hydroxymethylglutaryl-CoA reductase and GFP.

15 protein pathway and increases expression of hydroxymethylglutaryl-CoA reductase and low density lipo

16 ed in the regulated degradation of wild-type hydroxymethylglutaryl-CoA reductase in the ER membrane.

17 or the hepatic uptake of this liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in rat and

18 hamster ovary cell lines with lovastatin (a hydroxymethylglutaryl-CoA reductase inhibitor) and meval

19 sulfate, and thyroid hormone, as well as the hydroxymethylglutaryl-CoA reductase inhibitor, pravastat

20 dence suggests that long term treatment with hydroxymethylglutaryl-CoA reductase inhibitors, or stati

21 ord "surgery" and the MeSH term for statins "hydroxymethylglutaryl-CoA reductase inhibitors." Studies

22 lated degradation consistent with the native hydroxymethylglutaryl-CoA reductase proteins.

23 ion (cytochrome c) or cholesterol synthesis (hydroxymethylglutaryl-CoA reductase).

24 carboxykinase, and type I deiodinase but not hydroxymethylglutaryl-CoA reductase, cytochrome c, and a

25 e stimulated the rapid inactivation of their hydroxymethylglutaryl-CoA reductase, presumably through

26 of gamma-tocotrienol, indicating the role of hydroxymethylglutaryl-CoA reductase.

27 -binding protein-2 and reduced expression of hydroxymethylglutaryl-CoA reductase.

28 ding protein cleavage-activating protein and hydroxymethylglutaryl-CoA reductase.

29 tein maturation and promoting degradation of hydroxymethylglutaryl-CoA reductase.

30 e, we evaluated mice lacking mitochondrial 3-hydroxymethylglutaryl CoA synthase (HMGCS2) to determine

31 his enzyme is unique in that it is the first hydroxymethylglutaryl CoA synthase that is insensitive t

32 e, the first characterization of an archaeal hydroxymethylglutaryl CoA synthase.

33 n regulatory factor 1 (IRF-1), mitochondrial hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase), a

34 pecific beta-lactone inhibitor of eukaryotic hydroxymethylglutaryl-CoA synthase (HMGCS).

35 an effective competitive inhibitor of avian hydroxymethylglutaryl-CoA synthase (Ki = 28 microm).

36 nd catalase, and show that these, as well as hydroxymethylglutaryl-CoA synthase and sarcosine dehydro

37 nding cassette transporters ABCA1 and ABCG5, hydroxymethylglutaryl-CoA synthase and the LDL receptor)

38 odular polyketide synthase (PKS) proteins, a hydroxymethylglutaryl-CoA synthase cassette and three fl

39 -methyl and beta-ethyl branches catalyzed by hydroxymethylglutaryl-CoA synthase homologues that utili

40 ency resulted in up-regulation of intestinal hydroxymethylglutaryl-CoA synthase mRNA and an increase

41 Hydroxymethylglutaryl-CoA synthase-catalyzed condensatio

42 nzymes that enolize this analog, occurs with hydroxymethylglutaryl-CoA synthase.

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