ライフサイエンスコーパス: hydroxyprogesterone

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1 2)H]-progesterone; and 21,21,21-[(2)H(3)]-17-hydroxyprogesterone.

2 ydroxylase and no lyase activity for 17alpha-hydroxyprogesterone.

3 th progesterone as substrate and not 17alpha-hydroxyprogesterone.

4 ted serum levels of its enzymatic product 17-hydroxyprogesterone (17-OHP).

5 terone to 11-deoxycorticosterone and 17alpha-hydroxyprogesterone (17alpha-OH-progesterone) to 11-deox

6 al structure complexed with the substrate 17-hydroxyprogesterone (17OHP) was determined to 3.0 A reso

7 We reinvestigated the 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone 17al

8 nediol, 17alpha-hydroxypregnanolone, 17alpha-hydroxyprogesterone, and 21alpha-hydroxyprogesterone) we

9 hormone into its inactive metabolite 20alpha-hydroxyprogesterone, and toxicologically this enzyme act

10 ely, restored the rate of formation of 6beta-hydroxyprogesterone by the hybrid to that of 3A12.

11 In singleton gestations, 17 alpha-hydroxyprogesterone caproate (17P) has been shown to red

12 al small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk o

13 Treatment with 17 alpha-hydroxyprogesterone caproate did not reduce the rate of

14 etabolize ammonia, testosterone, and 17alpha-hydroxyprogesterone caproate, and expressed inducible fe

15 with a reduction in the basal serum 17 alpha-hydroxyprogesterone concentration from 135 +/- 21 to 66

16 he leuprolide-stimulated peak serum 17 alpha-hydroxyprogesterone concentration from 455 +/- 54 to 281

17 Screening of neonates with elevated 17-hydroxyprogesterone concentrations for classic (severe)

18 o seen in treated children (reductions of 17-hydroxyprogesterone, corticosterone, 11-deoxycortisol an

19 ining two molecules of the substrate 17alpha-hydroxyprogesterone, has been used as a template for und

20 rated conversion of progesterone to 17 alpha-hydroxyprogesterone in response to stimulation by gonado

21 Although 17alpha-hydroxyprogesterone is only observed farther from the ca

22 A similar stimulation of 17alpha-hydroxyprogesterone metabolism is seen when studying the

23 nor conformation may yield the minor 16alpha-hydroxyprogesterone metabolite.

24 rogesterone to 17-hydroxypregnenolone and 17-hydroxyprogesterone, respectively (17alpha-hydroxylase a

25 ciency (kcat/Km) for the cleavage of 17alpha-hydroxyprogesterone to androstenedione compared with wil

26 ntrations and the response of serum 17 alpha-hydroxyprogesterone to leuprolide, a gonadotrophin-relea

27 The serum 17 alpha-hydroxyprogesterone values increased slightly in the pla

28 that androstenedione formation from 17alpha-hydroxyprogesterone via the minor delta4-steroid pathway

29 ne, 17alpha-hydroxyprogesterone, and 21alpha-hydroxyprogesterone) were detected and removed effective

30 alpha-hydroxypregn-4-ene-3,20-dione (11alpha-hydroxyprogesterone) were used as starting materials for

31 acenta by converting progesterone to 20alpha-hydroxyprogesterone, where progesterone is essential for

32 glucuronide, testosterone-glucuronide and 17-hydroxyprogesterone), which belonged to the steroid bios

33 d-type CYP21A2 also forms a trace of 16alpha-hydroxyprogesterone, which increased with 21,21,21-[(2)H

34 0 alpha-dihydroprogesterone and [3H]17 alpha-hydroxyprogesterone, which reached 61% (median, 14%) and

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