ライフサイエンスコーパス: hydroxyproline

1 -amino acids), and plant protein biomarkers (hydroxyproline).

2 of (DOG)10, (PKG)10, and (POG)10 chains (O = hydroxyproline).

3 ing Stickland acceptor (glycine, proline, or hydroxyproline).

4 arabinogalactan polysaccharides O-linked to hydroxyproline.

5 the racemization of free proline or trans-4-hydroxyproline.

6 pendent manner and without a requirement for hydroxyproline.

7 ins of type I, II, and III collagens to (3S)-hydroxyproline.

8 e two closely related molecules, proline and hydroxyproline.

9 rs of the pentasaccharide cap formed on Skp1 hydroxyproline.

10 lowing sufficient room for the 4-hydroxyl of hydroxyproline.

11 CAGLRGGCVLPONLROKFKE-NH2, where O is 4-trans-hydroxyproline.

12 st-translationally modified residue, 4-trans-hydroxyproline.

13 inhibition by sugars; and a requirement for hydroxyproline.

14 hydrogen-bonded hydration networks involving hydroxyproline.

15 nous domains of bacterial proteins that lack hydroxyproline.

16 a hydrogen bond to the hydroxyl group of 4(R)hydroxyproline.

17 1 is responsible for converting proline to 3-hydroxyproline.

18 bers of the proline racemase superfamily, 4R-hydroxyproline 2-epimerase (UniProt ID A0NXQ7 ; 4HypE) a

19 he Calpha atom of a Pro residue to produce 2-hydroxyproline (2-Hyp).

20 yr540 increases the catalytic efficiency for hydroxyproline 3-fold and decreases the specificity for

21 function is known for the much less common 3-hydroxyproline (3Hyp), although genetic defects inhibiti

22 and Yaa are typically proline and (2S,4R)-4-hydroxyproline (4(R)Hyp), respectively.

23 (2S,4R)-4-Hydroxyproline(4-nitrobenzoate) was synthesized.

24 -phase peptide synthesis to incorporate Fmoc-hydroxyproline (4R-Hyp).

25 n X is (2S)-proline (Pro) and Y is (2S,4R)-4-hydroxyproline (4R-Hyp).

26 All extracts contained hydroxyproline (61-73 residues/1000 residues) and hydrox

27 repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for the stabili

28 rastructural changes, as well as attenuating hydroxyproline accumulation and inhibiting myofibroblast

29 mice treated with CO had significantly lower hydroxyproline accumulation than controls.

30 combinant Skp1 by recombinant (Skp1-protein)-hydroxyproline alpha-N-acetyl-d-glucosaminyltransferase.

31 A20FMDV2 peptide correlated positively with hydroxyproline, alphavbeta6 protein, and itgb6 messenger

32 n content of SPARC-null skin, as measured by hydroxyproline analysis, was substantially reduced in ad

33 aration of the cis- and trans- forms of both hydroxyproline and fluoroproline was achieved using TWIM

34 e residue each of 6-bromotryptophan, 4-trans-hydroxyproline and glycosylated threonine.

35 chiral imidazolium salt derived from trans-L-hydroxyproline and its applications as a catalyst for th

36 eplacement of the canonical amino acids (4R)-hydroxyproline and proline by cysteine or homocysteine,

37 dicate that fibril formation greatly affects hydroxyproline and proline prolyl pucker ring conformati

38 e chondrocytes was impaired, the amount of 4-hydroxyproline and the Tm of collagen II were reduced, a

39 ive, the calix[4]resorcinarenes with trans-4-hydroxyproline and trans-3-hydroxyproline moieties gener

40 The absence of 3-hydroxyproline and/or the increased glycosylation of hyd

41 KO mice, as measured by collagen deposition (hydroxyproline) and histopathological features.

42 XX'GER motifs (GROGER and GMOGER, where O is hydroxyproline) and one containing two adjacent GXX'GEN

43 .1]hexane analogues of 2S-proline, (2S,4S)-4-hydroxyproline, and (2S,4S)-4-fluoroproline residues wer

44 tions in collagen density, collagen content, hydroxyproline, and collagen advanced glycation end prod

45 The sulfated glycosaminoglycan (S-GAG), hydroxyproline, and DNA contents were determined using b

46 None of the peptides contain hydroxyproline, and furthermore the zwitterionic peptide

47 atin increased circulating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h after the

48 ridines from commercially available proline, hydroxyproline, and pipecolinate esters.

49 Hepatic TGF-beta1 mRNA, tissue hydroxyproline, and plasminogen activator inhibitor 1 (P

50 quence GCCGSFACRFGCVOCCV, where O is trans-4-hydroxyproline, and the chain is cross-linked with disul

51 lationally modified to 3-hydroxyproline or 4-hydroxyproline, and the rate-limiting step in formation

52 Mass spectrometry and anti-hydroxyproline antibody assays demonstrate PKM2 hydroxyl

53 rella hpat mutants lack cell-wall associated hydroxyproline arabinosides and can be rescued with exog

54 irst steps in the degradation of proline and hydroxyproline are catalyzed by proline oxidase (POX) an

55 epeating sequence -G-X-Y-, where proline and hydroxyproline are major constituents in X and Y positio

56 Proline and hydroxyproline are metabolized by distinct pathways.

57 n collagen synthesis because the resulting 4-hydroxyprolines are necessary for the stability of all c

58 Herein, we introduce natural hydroxyproline as a convertible unit for the production

59 ysine, phenylalanine, arginine, alanine, and hydroxyproline as the sole carbon and nitrogen sources.

60 exhibited strong epimerization activity with hydroxyproline as the substrate.

61 gregata to utilize several isomeric 3- and 4-hydroxyprolines as sole carbon sources.

62 urine, pyruvate and octadecenoic acid with 4-hydroxyproline, aspartate, cysteine, glutamine, lysine,

63 veloped more severe fibrosis, as measured by hydroxyproline assay and histological scoring, than wild

64 n collagen content of CP muscles measured by hydroxyproline assay and observed using immunohistochemi

65 action, collagen composition was measured by hydroxyproline assay as soluble collagen (1 mol/L NaCl e

66 ty profile was examined using a colorimetric hydroxyproline assay to determine the amount of soluble

67 s measured by acetic acid extraction and the hydroxyproline assay, and correlated with the decreased

68 ) and were confirmed by hepatic morphometry, hydroxyproline assay, and IFM.

69 Collagens were assessed by a hydroxyproline assay.

70 y morphometry, picrosirius red staining, and hydroxyproline assay.

71 ex vivo by means of histologic analysis and hydroxyproline assay.

72 and r = 0.8429 and rho = 0.7607 [P = .001 vs hydroxyproline assay]).

73 ron microscopy, fluorescence microscopy, and hydroxyproline assays demonstrated that the expression o

74 ron microscopy, fluorescence microscopy, and hydroxyproline assays were used to demonstrate that DDR

75 ere assessed with dimethylmethylene blue and hydroxyproline assays, respectively.

76 nt as measured by acetic acid extraction and hydroxyproline assays.

77 son's trichrome and Sirius red staining, and hydroxyproline assays.

78 e that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus.

79 controlled synthesis of novel oligomers from hydroxyproline-based building blocks and conjugated thes

80 luoro-phenoxy)-pyrrolidin-1-y l]-ethanone, a hydroxyproline-based H(3) receptor antagonist, on 100 g

81 Hydroxyproline-based monomers enable the incorporation o

82 The synthesis of a series of 3-hydroxyproline benzyl esters from alpha-alkyl and alpha-

83 tetramer of the beta-l-arabinofuranosylated hydroxyproline (beta-l-Araf-Hyp) glycocluster is describ

84 FO motif in fibrillar collagens (O denotes 4-hydroxyproline) binds 3 unrelated proteins: von Willebra

85 cturally, it serves as a negative filter for hydroxyproline by clashing with the 4-hydroxyl group of

86 erine residue participates in recognition of hydroxyproline by forming a hydrogen bond with the 4-hyd

87 hat the hydroxyl groups of threonine and 4(R)hydroxyproline can form direct or water-mediated hydroge

88 olyl-4-hydroxylase (PhyA), and the resulting hydroxyproline can subsequently be modified by a five-su

89 fibroblasts was inhibited, and the levels of hydroxyproline, COL1A1, COL3A1, IL-1beta, IL-18, and alp

90 d a 3-point flexural test, quantification of hydroxyproline (collagen solubilization), static and dyn

91 ung collagen deposition (Masson's trichrome, hydroxyproline, collagen type I alpha 1 chain, and colla

92 ivity (marker for osteoblasts), collagen and hydroxyproline composition, and histological and quantit

93 parameters and quantitative fibrosis extent (hydroxyproline concentration) and portal pressure.

94 c/homotrimeric mixtures.As the proportion of hydroxyproline-containing chains in the trimers increase

95 and FKBP65 showed increased activity toward hydroxyproline-containing peptide substrates.

96 Hydroxyproline-containing peptides exhibited an IgE-bind

97 0 +/- 368 vs. 842 +/- 342; P < 0.05) and low hydroxyproline content (0.79 +/- 0.17 microL/mL/g versus

98 HSCs vs control mice; P < .001), and hepatic hydroxyproline content (328 mg/g in mice given HSCs vs 4

99 0.001), histological hepatic fibrosis, liver hydroxyproline content (P = 0.006), collagen 1 messenger

100 e lungs of FAP-deficient mice decreases lung hydroxyproline content after intratracheal bleomycin to

101 s but a profound, 5-fold lower procollagen 4-hydroxyproline content and enhanced cysteinyl sulfenic a

102 CR) of fibrotic marker genes, measurement of hydroxyproline content and histological methods.

103 The latter was accompanied by elevated hydroxyproline content and mRNA levels of collagen-1 and

104 Hydroxyproline content and Sirius red staining of VX-166

105 aining, and low collagen production based on hydroxyproline content and Sirius Red staining.

106 fibrillation (AF) exhibited 4-fold increased hydroxyproline content compared with patients in sinus r

107 At day 40 the hydroxyproline content had increased further (48.91 +/-

108 The presence of normal collagen decreased hydroxyproline content in bones, altered the apatite cry

109 r P4H mRNA levels were associated with lower hydroxyproline content in root and shoot tissues indicat

110 afts at day 28 showed a significantly higher hydroxyproline content than the isografts (33.21 +/- 1.8

111 treatment significantly decreased granuloma hydroxyproline content to a greater extent than the anti

112 uctions in the bile salt pool size and liver hydroxyproline content were also seen with treatment wit

113 hepatic fibrosis (collagen 1alpha1 mRNA and hydroxyproline content), as well as elevated inflammatio

114 Development of fibrosis was assessed by lung hydroxyproline content, and alphavbeta6 protein and itgb

115 Fibrosis was detected by IHC, hydroxyproline content, and by qPCR for fibrotic markers

116 osis, as indicated by histological analysis, hydroxyproline content, and immunoblot analysis.

117 ntilation was associated with increased lung hydroxyproline content, and increased expression of tran

118 rats versus EP1, CP1, and CP3 by histology, hydroxyproline content, and mRNA expression for collagen

119 es, histopathology of the liver, the hepatic hydroxyproline content, and the expression of various he

120 in doses, histologic score of fibrosis, lung hydroxyproline content, and weight loss.

121 Indices of lung fibrosis (hydroxyproline content, collagen accumulation, fibrotic

122 trichrome blue staining and biochemically by hydroxyproline content, in wild-type but not in recombin

123 sgenic mice, as demonstrated by staining and hydroxyproline content, is preceded by activation and pr

124 improved NASH-related fibrosis markers (FR: hydroxyproline content, P < 0.01; EX: collagen 1alpha1 m

125 otrimers are further discouraged by reducing hydroxyproline content, which would otherwise lead to no

126 rosis, hepatic collagen gene expression, and hydroxyproline content.

127 ung injury as assessed by lung histology and hydroxyproline content.

128 -smooth muscle actin expression, and hepatic hydroxyproline content.

129 sue was analyzed for Sirius Red staining and hydroxyproline content.

130 alysis of picrosirius red stained slides and hydroxyproline content.

131 Finally, MSC transplantation decreased bone hydroxyproline content.

132 and type III collagen, and normalized total hydroxyproline content.

133 accumulation by histological examination and hydroxyproline content.

134 e overall size of the egg granuloma, and its hydroxyproline content.

135 use of their origins in plants, small sizes, hydroxyproline contents (tomato systemin is proline-rich

136 elatines had higher imino acids (proline and hydroxyproline) contents compared to those extracted aft

137 The absence of hydroxyprolines could then affect the accuracy of compon

138 e calix[4]resorcinarenes containing 3- and 4-hydroxyproline, d-nipecotic acid, (S)-2-(methoxymethyl)p

139 compared with female Spp1+/+ mice, and lung hydroxyproline decreased in male Spp1-/- mice compared w

140 rate specificity of the related enzyme human hydroxyproline dehydrogenase, which has serine in place

141 biologically relevant l-proline and l-trans-hydroxyproline, delivering unique 2,5-dialkylated amino

142 Moreover, FKBP22 showed a hydroxyproline-dependent effect by increasing the amount

143 activation of caspase-9 with adriamycin in a hydroxyproline-dependent manner.

144 ng the structure of the (2S,4S)-configured 4-hydroxyproline derivative 4, a selective picomolar inhib

145 oselective synthesis of alpha-alkylated-beta-hydroxyproline derivatives to access the substituted pro

146 ver tissues were analyzed by histochemistry, hydroxyproline determination, reverse-transcription poly

147 phenylacetylglutamine, hippurate, and prolyl-hydroxyproline did not reach statistical significance in

148 In contrast, corresponding peptides without hydroxyprolines displayed a very weak IgE-binding capaci

149 ite is mutated back into cysteine regained 3-hydroxyproline epimerase activity.

150 PR utilized only d-proline but not l-hydroxyproline, even in the presence of an expressed and

151 ncreased connective tissue growth factor and hydroxyproline expression in cardiac fibroblasts, which

152 Hydroxyproline expression was increased in cardiac fibro

153 positions 260 (alanine for isoleucine), 261 (hydroxyproline for alanine), and 263 (asparagine for phe

154 ntiation of osteoblasts, collagen synthesis, hydroxyproline formation, and biomineralization.

155 yp-Gly)(10)-OH (where '4(R)Hyp' is (2S,4R)-4-hydroxyproline) forms a trimeric structure, whereas H-(4

156 Here we describe a method to date hydroxyproline found in collagen (~10% of collagen carbo

157 Here we report a thermally stable hydroxyproline-free ABC heterotrimeric collagen mimetic

158 s of the secondary amino acids proline and 4-hydroxyproline from gelatin hydrolysates using anion-exc

159 Oxidation of proline to 5-hydroxyproline furnishes a versatile intermediate that c

160 modifications characteristic of conotoxins (hydroxyproline, gamma-carboxyglutamate) are present.

161 ity to a recently cloned soluble polypeptide hydroxyproline GlcNAc-transferase that modifies Skp1 in

162 gamma-Aminobutyric acid, 4-hydroxyproline, glycine, leucine+isoleucine and putresci

163 e features collagen's characteristic proline-hydroxyproline-glycine repeating unit, complemented by d

164 hich the content of critical glycine-proline-hydroxyproline (GPO) triplets was varied in relation to

165 The derivatives with the hydroxyproline groups are especially effective at causin

166 xyphenylalanine, Arg > Val > Lys, Tyr, Pro > hydroxyproline > alpha-aminobutyric acid > Gln, Thr, Ser

167 tereospecific; replacement of ProB28 by (4R)-hydroxyproline (Hyp) causes little change in the rates o

168 The Hyp diastereomer (2S,4S)-4-hydroxyproline (hyp) has not been observed in a protein,

169 ncode activity for adding galactose (Gal) to hydroxyproline (Hyp) in AGP protein backbones.

170 this work, we investigated the function of 4-hydroxyproline (Hyp) in conotoxins from three distinct g

171 The resulting product trans-4-hydroxyproline (Hyp) is of critical importance for the s

172 The resulting (2 S,4 R)-4-hydroxyproline (Hyp) residues are essential for the fold

173 The resulting (2S,4R)-4-hydroxyproline (Hyp) residues are essential for the fold

174 ified systematically through substitution by hydroxyproline (Hyp), (S)-beta-homoproline (betaPro), 2-

175 ce in an invertebrate collagen has (2S,4R)-4-hydroxyproline (Hyp), a C(gamma)-exo-puckered Pro deriva

176 and Y are most commonly proline (Pro) and 4R-hydroxyproline (Hyp), respectively.

177 fusion glycoprotein yielded a population of hydroxyproline (Hyp)-arabinogalactan polysaccharides ran

178 Among them, hydroxyproline (Hyp)-rich glycoproteins constitute a com

179 ctan-proteins (AGPs) are highly glycosylated hydroxyproline (Hyp)-rich glycoproteins that are frequen

180 elective detection and quantification of L-4-Hydroxyproline (Hyp).

181 lastin, and other proteins to form (2S,4R)-4-hydroxyproline (Hyp).

182 ber of these peptides additionally contain 4-hydroxyproline (Hyp).

183 equence, where Xaa is often proline and Yaa, hydroxyproline (Hyp/O).

184 eat, Ser-Hyp4, serine and the consecutive C4-hydroxyprolines (Hyps) are substituted with an alpha-gal

185 n 28 of the insulin B-chain (ProB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin th

186 fibril swelling and evidence for excess cis-hydroxyproline in the 6.45-microm debris.

187 To further study the role of 4(R)-hydroxyproline in the Xaa position, we made a series of

188 4(R)-Hydroxyproline in the Yaa position of the -Gly-Xaa-Yaa-r

189 It is known that hydroxyproline in the Yaa position stabilises the triple

190 In studies of the distribution of 3-hydroxyproline in type I collagen of rat bone, skin, and

191 quence analysis, the presence of repeating 3-hydroxyprolines in consecutive GPP triplets adjacent to

192 als unexpectedly large numbers of X-position hydroxyprolines in Gly-X-Y amino acid triplets.

193 Hydroxyproline, in contrast, is not reutilized for prote

194 binding recombinant collagen did not contain hydroxyproline, indicating hydroxyproline is not essenti

195 letter amino acid nomenclature is used, P* = hydroxyproline) inhibited tube formation, whereas a pept

196 xpression systems where the incorporation of hydroxyproline is challenging.

197 We show here that TgSkp1 hydroxyproline is modified by a similar pentasaccharide,

198 ated protist, Dictyostelium discoideum, Skp1 hydroxyproline is modified by five sugars via the action

199 n did not contain hydroxyproline, indicating hydroxyproline is not essential for binding.

200 ollagen, consisting of glycine, proline, and hydroxyproline, is a fibrous protein that can form a rop

201 tion of a vinylogous malonate derived from 4-hydroxyproline, is described.

202 r side chains amino acids that were proline, hydroxyproline, leucine, isoleucine and valine on the ne

203 D treatment group showed consistently lower hydroxyproline level but still higher than that of the c

204 epatic fibrosis, as evidenced by a decreased hydroxyproline level in the liver and a reduced incidenc

205 The bleomycin group had rising hydroxyproline level on days 14, 21 and 28, whereas the

206 iaphragm muscle fiber density, and decreased hydroxyproline levels (significant improvement for 1D11

207 osis in mdx mice, as determined by measuring hydroxyproline levels and collagen deposition in diaphra

208 diffuse interstitial fibrosis and increased hydroxyproline levels at both times, but injected normal

209 by changes in lung function, histology, and hydroxyproline levels in mice.

210 carring by Masson trichrome staining, kidney hydroxyproline levels, and collagen immunofluorescence d

211 Collagen content was measured by determining hydroxyproline levels, and collagen type I synthesis by

212 had increased Trichrome staining and tissue hydroxyproline levels.

213 t a high degree of proline hydroxylation and hydroxyproline-linked arabinosides, on a mucin (MUC1)-de

214 as characterized mainly by peaks assigned to hydroxyproline, lipids, and collagen.

215 Silica-induced lung collagen and hydroxyproline (markers of fibrosis), and SPP1 levels de

216 in reaction of fibrosis-related genes, liver hydroxyproline measurement, and Picro-Sirius red stainin

217 increased production of hepatic collagen by hydroxyproline measurement.

218 lagen ultrafiltration and single amino acid (hydroxyproline) methods, these specimens consistently da

219 .36+/-0.87 versus control 3.89+/-1.79 microg hydroxyproline/mg tissue, P<0.05).

220 The observed hydroxyproline modifications, however, call for addition

221 Therefore, we propose that hydroxyproline modulates the rate of Ziploc-ing of the t

222 enes with trans-4-hydroxyproline and trans-3-hydroxyproline moieties generally produce the largest no

223 modified by a pentasaccharide attached to a hydroxyproline near its C terminus.

224 dification of CLE peptides by enzymes of the hydroxyproline O-arabinosyltransferase (HPAT/RDN) family

225 The most extreme mutant is disrupted in a hydroxyproline O-arabinosyltransferase and can be rescue

226 Hydroxyproline O-arabinosyltransferases (HPATs) are memb

227 , and the glycosyltransferases that cap Skp1 hydroxyproline occur also in the genomes of Toxoplasma a

228 jor amino acid with imino acids (proline and hydroxyproline) of 194-195 residues/1000 residues).

229 ptide fragment of collagen type II with five hydroxyprolines (OH) can be selectively produced by the

230 that are post-translationally modified to 3-hydroxyproline or 4-hydroxyproline, and the rate-limitin

231 e are catalyzed by proline oxidase (POX) and hydroxyproline oxidase (OH-POX), respectively.

232 tion of Sirius red staining (P = 0.0003) and hydroxyproline (P = 0.007) than wild-type mice after BDL

233 Hydroxyproline plays a major role in stabilizing collage

234 Crystal structures of Y540S complexed with hydroxyproline, proline, and the proline analogue l-tetr

235 erences, with (2S,4R)-perfluoro-tert-butyl 4-hydroxyproline promoting polyproline helix.

236 promotes pathology, immunohistochemical and hydroxyproline quantification studies on aged RAGE-null

237 rosis were analyzed by histology and hepatic hydroxyproline quantification.

238 Total collagen level was estimated by hydroxyproline quantification.

239 for quantitative RT-PCR, and immunoblot and hydroxyproline release assays.

240 Hydroxyproline release by differentiating pre-adipocytes

241 A central hydroxyproline residue anchors IDA to the receptor.

242 s in each chain, which include no proline or hydroxyproline residues and contain a chymotrypsin cleav

243 Lacking hydroxyproline residues and telopeptides, two factors im

244 the precursor gene were synthesized but with hydroxyproline residues at positions found in the native

245 o be influenced by the number of proline and hydroxyproline residues in the triple helix structure.

246 ve related collagen-like molecules that have hydroxyproline residues occupying positions not observed

247 s of the peptide sequence indicated that the hydroxyproline residues play a significant role in suppo

248 H-II, and C-P4H-III) catalyze formation of 4-hydroxyproline residues required to form triple-helical

249 Notably, an unexpectedly large number of hydroxyproline residues were mapped to the X-positions o

250 has an abundance of 2S-proline and (2S,4R)-4-hydroxyproline residues, and can be stabilized by (2S,4R

251 Collagen triple helices are stabilized by 4-hydroxyproline residues.

252 ylases and subsequent O-glycosylation of the hydroxyproline residues.

253 which Xaa and Yaa frequently are proline and hydroxyproline, respectively.

254 phenylacetylglutamine, hippurate, and prolyl-hydroxyproline, respectively.

255 e tomato leaf polyprotein precursor of three hydroxyproline-rich glycopeptide defense signals (called

256 osttranslationally modified to produce three hydroxyproline-rich glycopeptide signals (HypSys peptide

257 Hydroxyproline-rich glycopeptides (HypSys peptides) are

258 Hydroxyproline-rich glycopeptides (HypSys peptides) have

259 A mixture of three homologous bioactive hydroxyproline-rich glycopeptides (HypSys peptides) of 1

260 We report here the isolation of three hydroxyproline-rich glycopeptides from tomato leaves, of

261 ana arabinogalactan protein (AGP) encoded by hydroxyproline-rich glycoprotein family protein gene At3

262 The identification of hydroxyproline-rich glycoprotein systemins in tomato ind

263 genesis transcriptome are cell wall enzymes, hydroxyproline-rich glycoproteins (extensins) and arabin

264 Hydroxyproline-rich glycoproteins (HRGPs) are a superfam

265 Genes encoding hydroxyproline-rich glycoproteins (HRGPs) in green organ

266 is a major posttranslational modification of hydroxyproline-rich glycoproteins (HRGPs) that is cataly

267 A superfamily of cell wall proteins, the hydroxyproline-rich glycoproteins (HRGPs), have characte

268 accharides, plant cell walls are composed of hydroxyproline-rich glycoproteins (HRGPs), which include

269 amily of developmentally expressed cell wall hydroxyproline-rich glycoproteins (HRGPs).

270 nogalactan proteins (AGPs), a superfamily of hydroxyproline-rich glycoproteins present in the extrace

271 Extensins are hydroxyproline-rich glycoproteins that can be cross link

272 Extensins are cell wall hydroxyproline-rich glycoproteins that form covalent net

273 ctan proteins (AGPs), a superfamily of plant hydroxyproline-rich glycoproteins, are present at cell s

274 Arabinogalactan proteins (AGPs), a family of hydroxyproline-rich glycoproteins, occur throughout the

275 More recently, two new hydroxyproline-rich, glycosylated peptide defense signal

276 evident on screening the spectrum of known 3-hydroxyproline sites from all major tissue collagen type

277 e presence of a relatively large number of 3-hydroxyproline sites with less than 100% occupancy, sugg

278 cium diet with 5% trans-4-hydroxy-l-proline (hydroxyproline) so that the rats would exclusively form

279 The unexpected abundance of X-position hydroxyprolines suggests a mechanism for differential mo

280 Hydroxyproline-supplemented GHS rats were used to test t

281 n endo ring conformation, whilst when Yaa is hydroxyproline, the Xaa proline adopts a range of endo a

282 ntrast, even though bacterial collagens lack hydroxyproline, their thermal stability is comparable to

283 Skp1 hydroxyproline then becomes the target of five sequentia

284 ectra suggest that the carbohydrate links to hydroxyproline through the galactose (galactosylation).

285 f a common amino acid and oxalate precursor, hydroxyproline, to the diet of the GHS rats leads to for

286 Regarding the organic phase of bone, the hydroxyproline-to-proline ratio was increased by 18% in

287 bit a pronounced preference for proline over hydroxyproline (trans-4-hydroxy-l-proline) as the substr

288 translational modifications, namely, trans-4-hydroxyproline, trans-2,3-cis-3,4-dihydroxyproline, and

289 ch based on the extraction of the amino acid hydroxyproline, using preparative high-performance liqui

290 es in consecutive GPP triplets adjacent to 4-hydroxyproline was confirmed as a unique feature of the

291 From this, 4-hydroxyproline was revealed as a regulating hub in low o

292 Morphometric features and levels of hydroxyproline were determined as measures of dermal fib

293 , patchy interstitial fibrosis and increased hydroxyproline were present in the lungs of immunodefici

294 (2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and fre

295 lant-specific O-glycosylation; unsubstituted hydroxyprolines were identified in our MUC1 construct.

296 phenylacetylglutamine, hippurate, and prolyl-hydroxyproline-were associated with impaired executive f

297 ase inhibition by Y-27632 prevented CTGF and hydroxyproline, whereas the RhoA activator CN03 increase

298 proline residues in a peptide chain into R-4-hydroxyproline, which is essential for collagen cross-li

299 double fluorination of N-protected (2S,4R)-4-hydroxyproline with 4-tert-butyl-2,6-dimethylphenylsulfu

300 Derivatives of 4-hydroxyproline with a series of hydrophobic groups in we