ライフサイエンスコーパス: hydroxysteroid dehydrogenase

1 her, nor is it active as a 17beta- or 11beta-hydroxysteroid dehydrogenase.

2 receptor level by the two isozymes of 11beta-hydroxysteroid dehydrogenase.

3 rt chain dehydrogenase, DHS-16, as a novel 3-hydroxysteroid dehydrogenase.

4 and access to nuclear receptors by acting as hydroxysteroid dehydrogenases.

5 a conversion catalyzed by one or more 17beta-hydroxysteroid dehydrogenases.

6 11beta-Hydroxysteroid dehydrogenase 1 (11beta-HSD1) has been a

7 e metabolism through its induction of 11beta-hydroxysteroid dehydrogenase 1 (HSD1) and glucocorticoid

8 Regulation of 11 beta-hydroxysteroid dehydrogenase 1 expression is important s

9 The 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17

10 8[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta-hydroxysteroid dehydrogenase 1 gene HSD17B1 (Ser312Gly)

11 Lower relative abundance of 11-beta-hydroxysteroid dehydrogenase 1 mRNA in HG explants sugge

12 loid A3, stearoyl-CoA desaturase, and 11beta-hydroxysteroid dehydrogenase 1 were induced while actin

13 lucose elimination, and inhibitors of 11beta-hydroxysteroid dehydrogenase 1, which reduce the glucoco

14 hich was induced by both agents, and 11 beta-hydroxysteroid dehydrogenase 1, which was decreased by t

15 gous and are most closely related to 17-beta-hydroxysteroid dehydrogenase 1.

16 converted to active corticosterone by 11beta-hydroxysteroid dehydrogenase 1.

17 GR), mineralocorticoid receptor (MR), 11beta-hydroxysteroid dehydrogenases 1 and 2 (11beta-HSD1 and 1

18 cocorticoid (GC) metabolising enzyme, 11beta-hydroxysteroid dehydrogenase-1 (11beta-HSD1) converts in

19 d compounds, acting by inhibition of 11-beta-hydroxysteroid dehydrogenase-1 (11beta-HSD1), gave rise

20 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the

21 Two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) interconvert

22 target receptors and the isozymes of 11beta-hydroxysteroid dehydrogenase (11 beta-HSD) that regulate

23 rolled by two isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) which interco

24 renal axis, and the activities of the 11beta-hydroxysteroid dehydrogenases (11-HSDs) that interconver

25 Isozymes of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) act at a prere

26 The 11beta-hydroxysteroid dehydrogenase (11beta-HSD) enzymes contro

27 11beta-Hydroxysteroid dehydrogenase (11beta-HSD) is thought to

28 ly of systemic levels, by isozymes of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) that interconv

29 verting cortisone to cortisol via the 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 pathway

30 ,12(2)H3] cortisol (D3-cortisol) via 11-beta hydroxysteroid dehydrogenase (11beta-HSD) type 1, D3-cor

31 ra with a luminal signaling sequence (11beta-hydroxysteroid dehydrogenase (11beta-HSD1)(1-41)/Rdh1(23

32 ery of potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1).

33 had high sequence similarity to human 11beta-hydroxysteroid dehydrogenase (11beta-HSD; 24/30 amino ac

34 11Beta-hydroxysteroid dehydrogenases (11beta-HSD) catalyse the

35 11beta-hydroxysteroid dehydrogenases (11beta-HSD) perform prere

36 11beta-hydroxysteroid dehydrogenases (11beta-HSDs) catalyse the

37 ptor metabolism of glucocorticoids by 11beta-hydroxysteroid dehydrogenases (11beta-HSDs) modulates ce

38 one levels, but also by intracellular 11beta-hydroxysteroid dehydrogenases (11beta-HSDs), which inter

39 R), glucocorticoid receptor (GR), and 11beta-hydroxysteroid dehydrogenases (11beta-HSDs).

40 The kidney also expresses both of the 11beta-hydroxysteroid dehydrogenase (11betaHSD) enzymes.

41 11beta-Hydroxysteroid dehydrogenase (11betaHSD) isozymes cataly

42 17Beta-hydroxysteroid dehydrogenase (17beta-HSD) interconverts

43 s study, we have examined the role of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 2 in the

44 tive metabolizing enzyme, the type II 17beta-hydroxysteroid dehydrogenase (17beta-HSD), in the ZR-75-

45 ls in HEK293 cells expressing type 10 17beta-hydroxysteroid dehydrogenase (17beta-HSD10), but not its

46 drogenases (3alpha-HSD) and oxidative 17beta-hydroxysteroid dehydrogenases (17beta-HSD), respectively

47 The 17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyze the

48 steroid-5alpha-reductase (SRD5A) and 17beta-hydroxysteroid dehydrogenase (17betaHSD) isoenzymes.

49 controls negative feedback mechanism, 11beta-hydroxysteroid dehydrogenase 2 (11betaHSD2).

50 17beta-Hydroxysteroid dehydrogenase 2 (17beta-HSD2) catalyzes t

51 e inner mitochondrial membrane protein 3beta-hydroxysteroid dehydrogenase 2 (3betaHSD2) synthesizes p

52 ated by the inner mitochondrial enzyme 3beta-hydroxysteroid dehydrogenase 2 (3betaHSD2).

53 the glucocorticoid receptor and the 11-beta hydroxysteroid dehydrogenase 2 isozyme were significantl

54 f the glucocorticoid receptor or the 11-beta hydroxysteroid dehydrogenase 2 isozyme.

55 Deficiency of placental 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2), which inac

56 in E3-ligase, AMFR, mediating loss of 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2), which othe

57 Human ECs also express the enzyme 11-beta-hydroxysteroid dehydrogenase-2 (11betaHSD2), and inhibit

58 ess the cortisol-inactivating enzyme 11-beta-hydroxysteroid-dehydrogenase-2 (11betaHSD2).

59 ctivation of a steroidogenic enzyme, 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which in tur

60 ssor of the P(4)-metabolizing enzyme 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD).

61 he progesterone inactivating enzyme 20-alpha-hydroxysteroid dehydrogenase (20alpha-HSD; median, 2.5 a

62 tive loss of AKR1C1, which encodes a 20alpha-hydroxysteroid dehydrogenase [20alpha-HSD (EC 1.1.1.149)

63 eductase (5 beta-reductase) precedes 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) in steroid ho

64 Human PGFS is 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) type II and h

65 cytosolic bile acid-binding protein 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD), and a putati

66 Rat liver 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD, E.C. 1.1.1.21

67 for the O-GlcNAc mark identified the 17 beta hydroxysteroid dehydrogenase-3 (Hsd17b3) locus in male E

68 Rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), a member of t

69 Rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), an aldo-keto

70 DH-4 from a related enzyme, RoDH-like 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), which is 3-fo

71 lpha-reductase type I (5alpha-RI) and 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD).

72 alpha-reductase (5alpha-R) type I and 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD).

73 tion to allopregnanolone, mediated by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD).

74 these enzymes were analyzed using rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD, AKR1C9) as the

75 In rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD, AKR1C9), a wel

76 androsterone is mediated by reductive 3alpha-hydroxysteroid dehydrogenases (3alpha-HSD) and oxidative

77 3Alpha-hydroxysteroid dehydrogenases (3alpha-HSDs) catalyze the

78 anolone biosynthesis, is catalyzed by 3alpha-hydroxysteroid dehydrogenases (3alpha-HSDs).

79 .1.149)], and AKR1C2, which encodes a 3alpha-hydroxysteroid dehydrogenase [3alpha-HSD (EC 1.1.1.52)],

80 he human steroidogenic enzyme, type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD II), the major g

81 he source of NADPH-dependent cytosolic 3beta-hydroxysteroid dehydrogenase (3beta-HSD) activity is unk

82 The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play

83 converts cholesterol to pregnenolone), 3beta-hydroxysteroid dehydrogenase (3beta-HSD, converts pregne

84 We identified hydroxysteroid dehydrogenase-3beta isotype 4 and osteopo

85 of differentiated function, including 3beta-hydroxysteroid dehydrogenase (3betaHSD) activity.

86 We identified the 3-beta-hydroxysteroid dehydrogenase (3betaHSD) family member HS

87 Six isoforms of the enzyme 3beta-hydroxysteroid dehydrogenase (3betaHSD) have been identi

88 mmonly requires enzymatic reactions by 3beta-hydroxysteroid dehydrogenase (3betaHSD), steroid-5alpha-

89 dipose tissue compared to SC, whereas 17beta-hydroxysteroid dehydrogenase 5 (AKR1C3) showed predomina

90 ainly with mRNA and protein levels of 17beta-hydroxysteroid dehydrogenase 6 (17beta-HSD6), one of sev

91 %), but does not have the retinol and 3alpha-hydroxysteroid dehydrogenase activity of either, nor is

92 operative kinetics with 3alpha-adiol (3alpha-hydroxysteroid dehydrogenase activity) and testosterone

93 ens with high positional selectivity (17beta-hydroxysteroid dehydrogenase activity) as well as 3-keto

94 is-Menten kinetics with androsterone (3alpha-hydroxysteroid dehydrogenase activity), 11-cis-retinol,

95 drogenase activity) and testosterone (17beta-hydroxysteroid dehydrogenase activity), but Michaelis-Me

96 oblasts express significant oxidative 3alpha-hydroxysteroid dehydrogenase activity, which can convert

97 by reduced progesterone secretion and 3beta-hydroxysteroid dehydrogenase activity.

98 50, aldehyde dehydrogenase (ALDH3A2), and 21-hydroxysteroid dehydrogenase (AKR1C18) were found to be

99 Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significan

100 Type 5 17beta-hydroxysteroid dehydrogenase, aldo-keto reductase 1C3 (A

101 The mRNA for cytochrome P450scc and 3beta-hydroxysteroid dehydrogenase also were found to be induc

102 report, we have shown that Ke 6 is a 17beta-hydroxysteroid dehydrogenase and can regulate the concen

103 3beta-Hydroxysteroid dehydrogenase and steroid Delta5-->4-isom

104 zymes are closely related to the short-chain hydroxysteroid dehydrogenases and differ substantially f

105 hydroxylase, 11 beta-hydroxylase, and 3 beta-hydroxysteroid dehydrogenase, and less often, 17 alpha-h

106 teroidogenic acute regulatory protein, 3beta-hydroxysteroid dehydrogenase, and P450c17) was impaired.

107 a-reductase, 6alpha-hydroxylase, 3alpha/beta-hydroxysteroid dehydrogenase, and reverse Delta4minus si

108 ature distinguishes it from all known 17beta-hydroxysteroid dehydrogenases, and endows mitochondria w

109 oteins involved in steroid biogenesis (e.g., hydroxysteroid dehydrogenase), antioxidant functions (e.

110 The enzyme is most efficient as a 3alpha-hydroxysteroid dehydrogenase, converting 3alpha-tetrahyd

111 converts cholesterol to pregnenolone), 3beta-hydroxysteroid dehydrogenase (converts pregnenolone to p

112 rent mineralocorticoid excess due to 11 beta-hydroxysteroid dehydrogenase deficiency.

113 HSD-1 is orthologous to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase

114 As skin expresses 3alpha/beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerases, c

115 or P450 side chain cleavage and Delta5-3beta-hydroxysteroid dehydrogenase/Delta5-Delta4- isomerase en

116 with inhibitors of type 1- and type 2-17beta hydroxysteroid dehydrogenase did not affect the previous

117 studies demonstrated that rat liver 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase (

118 r polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed

119 ervation was observed between the vertebrate hydroxysteroid dehydrogenase enzymes, prostaglandin F sy

120 s derived from DHT by 3-keto reductase/3beta-hydroxysteroid dehydrogenase enzymes.

121 in expression of 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase, especially in cerebellum.

122 Disruption of the 3beta-hydroxysteroid dehydrogenase gene in Mtb abrogates mycob

123 The enzyme 11beta-hydroxysteroid dehydrogenase (HSD) type 1 converts inact

124 Flux through the 11beta hydroxysteroid dehydrogenase (HSD) type 1 pathway can be

125 e crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding pro

126 3beta-hydroxysteroid dehydrogenases (HSD3Bs), encoded by the H

127 Hydroxysteroid dehydrogenases (HSDs) are essential for t

128 s high selectivity in living cells for human hydroxysteroid dehydrogenases (HSDs) of the aldo-keto re

129 forms have been shown to act as 3alpha/3beta-hydroxysteroid dehydrogenases (HSDs) on 5alpha-dihydrote

130 Hydroxysteroid dehydrogenases (HSDs) regulate the occupa

131 4)-3-ketosteroids, whereas AKR1C enzymes are hydroxysteroid dehydrogenases (HSDs).

132 ted levels of P4-metabolizing enzyme 20alpha-hydroxysteroid dehydrogenase in corpora lutea (CL) inact

133 he Rv1106c gene that is annotated as a 3beta-hydroxysteroid dehydrogenase in Mtb has been cloned and

134 The expression of the 3beta-hydroxysteroid dehydrogenase in Mtb is intracellular.

135 e acid binder, and type I and type II 3alpha-hydroxysteroid dehydrogenases) indicates that it is more

136 aldo-keto reductase AKR1C1 (20alpha(3alpha)-hydroxysteroid dehydrogenase) is induced by electrophili

137 do-keto reductase 1C3 (AKR1C3; type 5 17beta-hydroxysteroid dehydrogenase) is overexpressed in castra

138 Rv1106c (hsd; 3beta-hydroxysteroid dehydrogenase) is required by Mycobacteri

139 The enzyme 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD) is e

140 Human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta-HSD/isome

141 tissues) and type 2 (adrenals, gonads) 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD/isomer

142 pe 2 (adrenals and gonads) isoforms of 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1 and 3

143 es of unknown function (e.g., D127 in 3 beta-hydroxysteroid dehydrogenase/isomerase-1).

144 endoplasmic reticulum (ER) proteins, 11beta-hydroxysteroid dehydrogenase, isozyme 1 (11beta-HSD) and

145 chain cleavage enzyme, P450 aromatase, 3beta-hydroxysteroid dehydrogenase, luteinization hormone rece

146 te expression of 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase mRNAs in the NTS, and this

147 monstrating significant homology to an alpha-hydroxysteroid dehydrogenase of Eubacterium sp. strain V

148 Several hydroxysteroid dehydrogenases of the AKR1C subfamily cat

149 Human type 3 3alpha-hydroxysteroid dehydrogenase, or aldo-keto reductase (AK

150 the eicosanoid biosynthetic pathway from the hydroxysteroid dehydrogenase pathway and furthermore tha

151 GR and NF1 binding on the endogenous 11beta-hydroxysteroid dehydrogenase promoter, also regulated by

152 In summary, in addition to 3alpha-hydroxysteroid dehydrogenase, rat osteoblasts express si

153 dihydrotestosterone (DHT) and/or its 3alpha-hydroxysteroid dehydrogenase reduced metabolite 3alpha-a

154 tion enzyme was identified as a novel 17beta-hydroxysteroid dehydrogenase responsible for the inactiv

155 rogenase 4 (RoDH4, SDR9C8), RoDH-like 3alpha-hydroxysteroid dehydrogenase (RL-HSD, SDR9C6), and RDH-l

156 ocorticoid binding by the absence of 11-beta hydroxysteroid dehydrogenase, salt-mineralocorticoid-ind

157 enveloped virus host range protein, dUTPase, hydroxysteroid dehydrogenase, superoxide dismutase, serp

158 and encodes a protein with homology to 3beta-hydroxysteroid dehydrogenases that functions in one of t

159 than reported for 3alpha-reduction by 3alpha-hydroxysteroid dehydrogenase, the major enzyme known to

160 r glucocorticoid reamplifying enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) foun

161 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catal

162 tive 11-keto forms through the enzyme 11beta hydroxysteroid dehydrogenase type 1 (11beta HSD-1).

163 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catal

164 In adipocytes, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) conve

165 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) intra

166 ion of D4 cortisol to D3 cortisol via 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) occur

167 11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) amplif

168 The cortisol-regenerating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) amplif

169 11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) cataly

170 In vivo, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) cataly

171 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) conver

172 heses of AMG 221 (2), an inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) discov

173 novel, potent inhibitor against human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme

174 The 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme

175 urs through increased activity of the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme

176 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) has be

177 the glucocorticoid-generating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in adi

178 xpression of the GC-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in cul

179 tion of glucocorticoids by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in fat

180 neration of active glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in met

181 from a rapidly metabolized adamantane 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibi

182 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the

183 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the

184 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the

185 ve glucocorticoid by NADPH-dependent, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) oxored

186 glucocorticoids in vivo by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) plays

187 ification of glucocorticoids (GCs) by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) plays

188 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regene

189 The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regene

190 a defect in the gene HSD11B1 encoding 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), a pri

191 cocorticoid (GC) regenerating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), in ad

192 nd that tissue regeneration of GCs by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), rathe

193 glucocorticoid metabolism, including 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which

194 to be potent inhibitors of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

195 sulin resistance and are regulated by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

196 racellular cortisone-cortisol shuttle 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

197 regulated by the GC-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

198 We investigated whether inhibition of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, also k

199 ular glucocorticoid-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1(-/-)) ha

200 CP2, glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and 2 (

201 culum by an enzyme complex containing 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) and hex

202 11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) catalyz

203 11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a th

204 P2), glucocorticoid receptor (GR) and 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) mRNA in

205 11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) perform

206 tion of glucocorticoids by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1).

207 17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is tho

208 Human estrogenic 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), which

209 nt estrogen in human, is catalyzed by 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).

210 on that leads to a gain-of-function in 3beta-hydroxysteroid dehydrogenase type 1 (3betaHSD1), which c

211 11 beta-Hydroxysteroid dehydrogenase type 1 (E.C. 1.1.1.146) (11

212 I-MS/MS) was used to observe in vitro 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) enzyme-cataly

213 family 11, subfamily A1 (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) also down-r

214 oid secretion and metabolism (notably 11beta-hydroxysteroid dehydrogenase type 1 and 5alpha-reductase

215 er reviews the functional role(s) of 11 beta-hydroxysteroid dehydrogenase type 1 and examines factors

216 polymorphisms in the genes encoding 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phospha

217 trate that the reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 depends on reduced n

218 In mice, overexpression of 11 beta-hydroxysteroid dehydrogenase type 1 in adipose or liver

219 Thus, 11 beta-hydroxysteroid dehydrogenase type 1 is a promising drug

220 In obese humans, 11 beta-hydroxysteroid dehydrogenase type 1 is relatively highly

221 Hexose-6-phosphate dehydrogenase and 11 beta-hydroxysteroid dehydrogenase type 1 may play important r

222 d activity because global deletion of 11beta-hydroxysteroid dehydrogenase type 1 normalized Ca(2+) an

223 , respectively, whereas mice lacking 11 beta-hydroxysteroid dehydrogenase type 1 resist diet-induced

224 ortisol by the reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1, which can thus incr

225 d for the 11-oxoreductase activity of 11beta-hydroxysteroid dehydrogenase type 1, which converts inac

226 17beta-Hydroxysteroid dehydrogenase type 10 (HSD10) is multifun

227 The enzyme 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), also known

228 ion, and metabolic functions of human 17beta-hydroxysteroid dehydrogenase type 10/short chain L-3-hyd

229 glucocorticoid binding by an enzyme, 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2).

230 Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in hum

231 cental glucocorticoid inactivation by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) plays

232 The expression of 11beta hydroxysteroid dehydrogenase type 2 (11beta-HSD2) was ag

233 centa) or inhibitors of fetoplacental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), the p

234 Expression of MR was similar, as was 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which

235 th >10000-fold selectivity over human 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2).

236 11b2(-/-) mice, which lack the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) and thu

237 The reduced activity of 11beta hydroxysteroid dehydrogenase type 2 (11betaHSD2) contrib

238 nction mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2), allowi

239 fects of GCs, in part by induction of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2).

240 In the adrenals, testes, and ovaries, 3beta-hydroxysteroid dehydrogenase type 2 (3betaHSD2) catalyze

241 c acute regulatory protein (StAR), and 3beta-hydroxysteroid dehydrogenase type 2 (3betaHSD2) via its

242 zyme with sequence homology to CD13), 11beta-hydroxysteroid dehydrogenase type 2 (a steroid pathway e

243 These neurons express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) and are activ

244 terone-sensitive neurons that express 11beta-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleu

245 e glucocorticoid-inactivating enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a signature

246 abel neurons in the NTS that express 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), an enzyme th

247 locorticoid receptors and the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), which makes

248 n of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), which makes

249 of the NTS, which express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

250 n of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

251 ue to their expression of the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

252 ive neurons which contain the enzyme 11 beta-hydroxysteroid dehydrogenase type 2 (HSD2).

253 TS neurons, which express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2).

254 3beta-Hydroxysteroid dehydrogenase type 2 (HSD3B2) is a steroi

255 mangiomas were identified, including 17-beta hydroxysteroid dehydrogenase type 2 and tissue factor pa

256 ns in the gene (HSD11B2) encoding the 11beta-hydroxysteroid dehydrogenase type 2 enzyme (11beta-HSD2)

257 Mutations in 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) cause

258 ptors, transgenic mice overexpressing 11beta-hydroxysteroid dehydrogenase type 2 in cardiomyocytes we

259 t the ability of the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 to inactivate cortis

260 izin (a potent inhibitor of placental 11beta-hydroxysteroid dehydrogenase type 2, the "barrier" to ma

261 ctus solitarius expresses the enzyme 11-beta-hydroxysteroid dehydrogenase type 2, which makes them se

262 The HSD2 (11-beta-hydroxysteroid dehydrogenase type 2-expressing) neurons

263 lasts via transgenic (tg) expression of 11ss-hydroxysteroid dehydrogenase type 2.

264 gene, which result in a deficiency of 11beta-hydroxysteroid dehydrogenase type 2.

265 onal variants: HSD17B4, which encodes 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4), also know

266 s comparable with that of peroxisomal 17beta-hydroxysteroid dehydrogenase type 4.

267 response element-luciferase reporter, 17beta-hydroxysteroid dehydrogenase type 6 (17betaHSD6) convert

268 Human 11beta-hydroxysteroid dehydrogenase type I (11beta-HSD1) is an

269 lucocorticoid receptor (GR)-alpha and 11beta-hydroxysteroid dehydrogenase type I (11beta-HSD1)-mediat

270 cortisone to cortisol is catalyzed by 11beta-hydroxysteroid dehydrogenase type I (11beta-HSD1).

271 We found that expression of 11beta-hydroxysteroid dehydrogenase type II (11betaHSD2), which

272 Androgen biosynthesis requires 3beta-hydroxysteroid dehydrogenase type II (3betaHSDII) and th

273 to show that inhibition of the enzyme 11beta-hydroxysteroid dehydrogenase type II(11betaHSD2) reduces

274 to as the human bile acid binder and 3alpha-hydroxysteroid dehydrogenase type III, is a multifunctio

275 aa with 82% identity to the porcine 17 beta-hydroxysteroid dehydrogenase type IV (HSD IV).

276 ffects of exogenous estradiol (E2) on 17beta-hydroxysteroid dehydrogenase type IV (HSD17B4) and the c

277 We focused on a Z-linked gene, 17beta-hydroxysteroid dehydrogenase type IV (HSD17B4), coding f

278 11beta-Hydroxysteroid dehydrogenase type-1 (11beta-HSD1) conver

279 11beta-hydroxysteroid dehydrogenase type-1 (HSD1) regulates con

280 ucose-6-phosphatase, glucokinase, and 11beta-hydroxysteroid dehydrogenase type-1) are unaltered.

281 of glucocorticoids by feto-placental 11beta-hydroxysteroid dehydrogenase type-2 (11beta-HSD2) which

282 opment of a fluorogenic substrate for 17beta-hydroxysteroid-dehydrogenase type 10 (17beta-HSD10), whi

283 We tested this by expressing 11-beta-hydroxysteroid dehydrogenase (type II) in dentate gyrus

284 Expression of 11-beta-hydroxysteroid dehydrogenase (type II), mostly in mature

285 17-beta-Hydroxysteroid dehydrogenase, type 7, was identified onl

286 The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing n

287 cholestan-3beta,5alpha-diol (OCDO) by 11beta-hydroxysteroid-dehydrogenase-type-2 (11betaHSD2).

288 s similar to the lumenal glycoprotein 11beta-hydroxysteroid dehydrogenase was identified in detergent

289 In addition, the specific activity of 3beta-hydroxysteroid dehydrogenase was measured and found to i

290 esizing enzymes (5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase) was increased in the hypot

291 roteins including cytochrome b(5) and 11beta-hydroxysteroid dehydrogenase were degraded slowly or not

292 l type of microsomal NAD(+)-dependent 3alpha-hydroxysteroid dehydrogenase with unique catalytic prope